JP2015519339A5 - - Google Patents
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- JP2015519339A5 JP2015519339A5 JP2015511804A JP2015511804A JP2015519339A5 JP 2015519339 A5 JP2015519339 A5 JP 2015519339A5 JP 2015511804 A JP2015511804 A JP 2015511804A JP 2015511804 A JP2015511804 A JP 2015511804A JP 2015519339 A5 JP2015519339 A5 JP 2015519339A5
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- protein
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- cancer
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| EP1789391B1 (en) | 2004-07-23 | 2017-06-28 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| CN101678124A (zh) | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| EP3569251A1 (en) | 2007-06-25 | 2019-11-20 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| KR20150070318A (ko) | 2012-10-16 | 2015-06-24 | 엔도사이트, 인코포레이티드 | 비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법 |
| WO2014177771A1 (en) | 2013-05-02 | 2014-11-06 | Glykos Finland Oy | Conjugates of a glycoprotein or a glycan with a toxic payload |
| KR102356814B1 (ko) | 2013-10-15 | 2022-01-28 | 씨젠 인크. | 개선된 리간드-약물 컨쥬게이트 약물동력학을 위한 peg화된 약물-링커 |
| EA201692530A1 (ru) | 2014-06-13 | 2017-07-31 | Новартис Аг | Цитотоксические пептиды и их конъюгаты |
| WO2016193380A1 (en) | 2015-06-02 | 2016-12-08 | Novo Nordisk A/S | Insulins with polar recombinant extensions |
| CN108135881B (zh) * | 2015-08-11 | 2020-11-13 | 同宜医药（苏州）有限公司 | 多配体药物偶联体及其用途 |
| GB2542391A (en) * | 2015-09-17 | 2017-03-22 | Annexin Pharmaceuticals Ab | Process of manufacture |
| MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| AU2016363013B2 (en) | 2015-12-04 | 2022-03-10 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| WO2017165851A1 (en) | 2016-03-25 | 2017-09-28 | Seattle Genetics, Inc. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
| EP3570894A4 (en) * | 2017-01-17 | 2021-04-07 | The Texas A&M University System | ENDOLYSOSOMAL TARGETING CONJUGATES FOR BETTER LOAD MOLECULES DISTRIBUTION TO ENDOLYSOSOMAL COMPARTMENT OF TARGET CELLS |
| US11730822B2 (en) | 2017-03-24 | 2023-08-22 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| WO2018185131A2 (en) | 2017-04-05 | 2018-10-11 | Novo Nordisk A/S | Oligomer extended insulin-fc conjugates |
| MY208067A (en) | 2018-12-21 | 2025-04-11 | Regeneron Pharma | Tubulysins and protein-tubulysin conjugates |
| EP3980076A1 (en) * | 2019-06-05 | 2022-04-13 | Boston Scientific Scimed, Inc. | Click chemistry capturable platinum-based antineoplastic agents |
| AU2022307460A1 (en) * | 2021-07-09 | 2024-01-04 | Bright Peak Therapeutics Ag | Checkpoint inhibitors conjugated to il-2, and uses thereof |
| US20230201365A1 (en) * | 2021-07-09 | 2023-06-29 | Bright Peak Therapeutics Ag | Modified cd20 antibodies and uses thereof |
| CN116407640B (zh) * | 2023-03-03 | 2025-10-31 | 河南真实生物科技有限公司 | 包含阿兹夫定和化疗试剂的抗肿瘤药物组合物 |
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| US5066490A (en) | 1988-06-01 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Protein crosslinking reagents cleavable within acidified intracellular vesicles |
| DE69837170T2 (de) | 1997-06-13 | 2007-11-22 | Amylin Pharmaceuticals, Inc., San Diego | Festphasige native chemische Ligation von ungeschützten oder n-cystein-geschützten Peptiden in wässrigen Lösungen |
| US6017876A (en) | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
| US5900404A (en) | 1997-08-15 | 1999-05-04 | Amgen Inc. | Chemical modification of proteins to improve biocompatibility and bioactivity |
| US6787154B2 (en) | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
| WO2002042427A2 (en) | 2000-10-25 | 2002-05-30 | Surromed, Inc. | Mass tags for quantitative analysis |
| WO2002087497A2 (en) * | 2001-04-26 | 2002-11-07 | Board Of Regents, The University Of Texas System | Therapeutic agent/ligand conjugate compositions, their methods of synthesis and use |
| US20030215877A1 (en) | 2002-04-04 | 2003-11-20 | California Institute Of Technology | Directed protein docking algorithm |
| GB0209896D0 (en) | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
| US8030459B2 (en) * | 2002-07-19 | 2011-10-04 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
| US20110002978A1 (en) * | 2003-06-17 | 2011-01-06 | Harrison Roger G | Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof |
| US20070123465A1 (en) | 2004-06-18 | 2007-05-31 | Ipf Pharmaceuticals Gmbh | Oligomeric peptides and their use for the treatment of hiv infections |
| US8946391B2 (en) | 2006-03-24 | 2015-02-03 | The Regents Of The University Of California | Construction of a multivalent scFv through alkyne-azide 1,3-dipolar cycloaddition |
| EP2306986B1 (en) * | 2008-06-26 | 2018-03-21 | Prolynx Llc | Prodrugs and drug-macromolecule conjugates having controlled drug release rates |
| CA2739445A1 (en) * | 2008-10-03 | 2010-04-08 | Advanced Proteome Therapeutics, Inc. | Site specific n-terminal modifications of proteins and conjugate formation |
| EP2437773B1 (en) | 2009-06-03 | 2016-11-16 | MosaMedix B.V. | Method for enhancing phagocytosis of phosphatidylserine-exposing cells |
| EP2536287A4 (en) | 2010-02-18 | 2015-10-07 | Advanced Proteome Therapeutics Inc | SPECIFIC SITE SIZE OF PROTEINS USING CHEMICAL MODIFICATION TO PROMOTE PROTEIN CONJUGATE FORMATION, PROTEIN DIMER FORMATION, AND AGRAFTED PEPTIDES |
| DK2566334T3 (en) * | 2010-05-05 | 2018-07-23 | Prolynx Llc | MANAGED PHARMACEUTICAL RELEASE FROM SOLID CARRIERS |
| US9770515B2 (en) | 2010-06-01 | 2017-09-26 | Advanced Proteome Therapeutics Inc. | Crosslinking of proteins and other entities via conjugates of α-haloacetophenones, benzyl halides, quinones, and their derivatives |
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- 2013-05-13 CA CA2873112A patent/CA2873112A1/en not_active Abandoned
- 2013-05-13 WO PCT/US2013/040823 patent/WO2013170272A2/en not_active Ceased
- 2013-05-13 US US14/400,190 patent/US9545449B2/en active Active
- 2013-05-13 EP EP13787738.7A patent/EP2850201A4/en not_active Withdrawn
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