JP2015519134A - 生体光骨再建のための組成物および方法 - Google Patents

生体光骨再建のための組成物および方法 Download PDF

Info

Publication number
JP2015519134A
JP2015519134A JP2015514302A JP2015514302A JP2015519134A JP 2015519134 A JP2015519134 A JP 2015519134A JP 2015514302 A JP2015514302 A JP 2015514302A JP 2015514302 A JP2015514302 A JP 2015514302A JP 2015519134 A JP2015519134 A JP 2015519134A
Authority
JP
Japan
Prior art keywords
composition
hyaluronic acid
calcium phosphate
weight
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015514302A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015519134A5 (enExample
Inventor
ルピス、ニコラオス
ピエルガッリーニ、レミージョ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Klox Technologies Inc
Original Assignee
Klox Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klox Technologies Inc filed Critical Klox Technologies Inc
Publication of JP2015519134A publication Critical patent/JP2015519134A/ja
Publication of JP2015519134A5 publication Critical patent/JP2015519134A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/898—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0041—Optical brightening agents, organic pigments
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/442—Colorants, dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A61N2005/0663—Coloured light
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • C08K2003/321—Phosphates
    • C08K2003/325—Calcium, strontium or barium phosphate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Composite Materials (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015514302A 2012-05-30 2013-05-30 生体光骨再建のための組成物および方法 Pending JP2015519134A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261653101P 2012-05-30 2012-05-30
US61/653,101 2012-05-30
US201361777894P 2013-03-12 2013-03-12
US61/777,894 2013-03-12
PCT/CA2013/000532 WO2013177686A1 (en) 2012-05-30 2013-05-30 Compositions and methods for biophotonic bone reconstruction

Publications (2)

Publication Number Publication Date
JP2015519134A true JP2015519134A (ja) 2015-07-09
JP2015519134A5 JP2015519134A5 (enExample) 2016-07-14

Family

ID=49672237

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015514302A Pending JP2015519134A (ja) 2012-05-30 2013-05-30 生体光骨再建のための組成物および方法

Country Status (17)

Country Link
US (1) US11426463B2 (enExample)
EP (1) EP2854853B1 (enExample)
JP (1) JP2015519134A (enExample)
KR (1) KR20150023294A (enExample)
CN (1) CN104394888A (enExample)
AU (1) AU2013270353A1 (enExample)
BR (1) BR112014029801A2 (enExample)
CA (1) CA2873068A1 (enExample)
HK (1) HK1207300A1 (enExample)
IL (1) IL235687A0 (enExample)
IN (1) IN2014DN09950A (enExample)
MX (1) MX2014014458A (enExample)
NZ (1) NZ701667A (enExample)
RU (1) RU2014147975A (enExample)
SG (1) SG11201407276RA (enExample)
WO (1) WO2013177686A1 (enExample)
ZA (1) ZA201408483B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017511393A (ja) * 2014-01-24 2017-04-20 ザ プロクター アンド ギャンブル カンパニー 光活性剤
JP2017076494A (ja) * 2015-10-14 2017-04-20 三菱電機株式会社 光源ユニット及び照明装置
JP2023542733A (ja) * 2020-09-29 2023-10-11 シージー バイオ カンパニー，リミテッド 高弾性のリン酸カルシウム系注入型骨移植材組成物及びその製造方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015240385B2 (en) 2014-04-01 2019-02-28 Klox Technologies Inc. Tissue filler compositions and methods of use
ES2941364T3 (es) 2018-06-11 2023-05-22 Procter & Gamble Dispositivo fotoactivador para lavadora
CN119935694A (zh) * 2025-01-24 2025-05-06 北京大学第三医院（北京大学第三临床医学院） 一种骨组织多重特殊染色分析方法及其应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1285193A (zh) * 1999-08-18 2001-02-28 凌沛学 透明质酸口服美肤保健品的制备和应用
JP2005538757A (ja) * 2002-07-31 2005-12-22 デンツプライ インターナショナル インコーポレーテッド 多孔性粒子およびキャリアゲルを含む骨修復パテ
JP2007515196A (ja) * 2003-09-23 2007-06-14 オーソ・セラピューティクス・リミテッド・ライアビリティ・カンパニー 吸収性のインプラントならびに止血および骨欠損の処置における、それらの使用
JP2007197371A (ja) * 2006-01-26 2007-08-09 Yaizu Suisankagaku Industry Co Ltd 美肌促進剤及び美容健康食品
JP2009511425A (ja) * 2005-09-02 2009-03-19 キャンピナ・ネダーランド・ホールディング・ビー．ブイ． 皮膚を加湿するための経口組成物
JP2010511474A (ja) * 2006-12-08 2010-04-15 ザ ユニバーシティ オブ ワイカト 医療用調製物
JP2010535071A (ja) * 2007-08-01 2010-11-18 ジョンズ ホプキンス ユニバーシティ 光開始組織充填剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1259090B (it) * 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
GB9721585D0 (en) 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
WO2000045870A1 (en) * 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Osteogenic paste compositions and uses thereof
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
AU2003287526A1 (en) 2002-11-06 2004-06-03 Protein-stabilized liposomal formulations of pharmaceutical agents
ITPD20030286A1 (it) * 2003-11-27 2005-05-28 Fidia Advanced Biopolymers Srl Strutture composite multistrato contenenti acido ialuronico
US9132208B2 (en) 2008-08-07 2015-09-15 Lifenet Health Composition for a tissue repair implant and methods of making the same
ATE487459T1 (de) * 2005-12-28 2010-11-15 Dentsply Int Inc Lichthärtbares knochenwachstumsmaterial zur behandlung von zahnknochendefekten
US8999933B2 (en) 2006-01-18 2015-04-07 Biolitec Pharma Marketing Ltd Photodynamic cosmetic procedure and healing method
US8784893B2 (en) * 2007-02-05 2014-07-22 Carbylan Therapeutics, Inc. Polymer formulations for delivery of bioactive agents
KR101692911B1 (ko) * 2008-04-15 2017-01-17 라이프 사이언스 엔터프라이즈 칼슘 포스페이트 혼합 골 시멘트를 이용한 척추의 최소 침습적 치료방법
SMT201700575T1 (it) * 2009-07-17 2018-01-11 Klox Tech Inc Composizione orale antibatterica

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1285193A (zh) * 1999-08-18 2001-02-28 凌沛学 透明质酸口服美肤保健品的制备和应用
JP2005538757A (ja) * 2002-07-31 2005-12-22 デンツプライ インターナショナル インコーポレーテッド 多孔性粒子およびキャリアゲルを含む骨修復パテ
JP2007515196A (ja) * 2003-09-23 2007-06-14 オーソ・セラピューティクス・リミテッド・ライアビリティ・カンパニー 吸収性のインプラントならびに止血および骨欠損の処置における、それらの使用
JP2009511425A (ja) * 2005-09-02 2009-03-19 キャンピナ・ネダーランド・ホールディング・ビー．ブイ． 皮膚を加湿するための経口組成物
JP2007197371A (ja) * 2006-01-26 2007-08-09 Yaizu Suisankagaku Industry Co Ltd 美肌促進剤及び美容健康食品
JP2010511474A (ja) * 2006-12-08 2010-04-15 ザ ユニバーシティ オブ ワイカト 医療用調製物
JP2010535071A (ja) * 2007-08-01 2010-11-18 ジョンズ ホプキンス ユニバーシティ 光開始組織充填剤

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017511393A (ja) * 2014-01-24 2017-04-20 ザ プロクター アンド ギャンブル カンパニー 光活性剤
JP2017076494A (ja) * 2015-10-14 2017-04-20 三菱電機株式会社 光源ユニット及び照明装置
JP2023542733A (ja) * 2020-09-29 2023-10-11 シージー バイオ カンパニー，リミテッド 高弾性のリン酸カルシウム系注入型骨移植材組成物及びその製造方法
JP7522309B2 (ja) 2020-09-29 2024-07-24 シージー バイオ カンパニー，リミテッド 高弾性のリン酸カルシウム系注入型骨移植材組成物及びその製造方法

Also Published As

Publication number Publication date
MX2014014458A (es) 2015-08-14
KR20150023294A (ko) 2015-03-05
WO2013177686A1 (en) 2013-12-05
EP2854853A4 (en) 2016-01-13
EP2854853B1 (en) 2019-08-21
BR112014029801A2 (pt) 2017-06-27
US20150119789A1 (en) 2015-04-30
US11426463B2 (en) 2022-08-30
CN104394888A (zh) 2015-03-04
NZ701667A (en) 2017-05-26
CA2873068A1 (en) 2013-12-05
EP2854853A1 (en) 2015-04-08
AU2013270353A1 (en) 2014-11-27
SG11201407276RA (en) 2015-03-30
IL235687A0 (en) 2015-01-29
IN2014DN09950A (enExample) 2015-08-14
ZA201408483B (en) 2015-12-23
HK1207300A1 (en) 2016-01-29
RU2014147975A (ru) 2016-07-20

Similar Documents

Publication Publication Date Title
US11426463B2 (en) Compositions and methods for biophotonic bone reconstruction
Fada et al. Mechanical properties improvement and bone regeneration of calcium phosphate bone cement, Polymethyl methacrylate and glass ionomer
US11638777B2 (en) Compositions and methods for adhesion to surfaces
ES2270267T3 (es) Composicion osea maleable para rellenar defectos oseos.
US6593394B1 (en) Bioactive and osteoporotic bone cement
Korany et al. Evaluation of socket healing in irradiated rats after diode laser exposure (histological and morphometric studies)
US8470369B2 (en) Bone paste composition
Martínez‐Sanz et al. Minimally invasive mandibular bone augmentation using injectable hydrogels
TW201427697A (zh) 用於治療用途之含有交聯玻尿酸及羥磷灰石的無菌可注射水性調配物
CA2699487A1 (en) Composition for filling bone defects
CN106132449B (zh) 半合成复合材料制成的骨接合装置或植入物，及生产方法
ES2442271T3 (es) Método y aparato para reparación de hueso
Ezoddini-Ardakani et al. Effects of chitosan on dental bone repair
Majzoub et al. Guided bone regeneration using demineralized laminar bone sheets versus GTAM membranes in the treatment of implant‐associated defects. A clinical and histological study.
Abdel-Fattah et al. Reconstruction of resected mandibles using a hydroxyapatite veterinary bone graft
Miyata et al. An experimental study of bone grafting using rat milled tooth.
ES2688324T3 (es) Composiciones de cemento bioactivo autoendurecible con quitina parcialmente desacetilada como sustituyentes de los injertos óseos
Allam et al. Evaluating The Biostimulation Effect Of Diode Laser 650 Nm Combined With TEMPO Oxidized Nano-Cellulose Mixed With Biphasic Tricalcium Phosphate On Bone Healing: Experimental Animal Study
Supraja et al. In-vitro evaluation of multicomponent scaffold with kappa carrageenan, tendon extracellular matrix and calcium-magnesium silicate for periodontal bone regeneration
Tanrisever et al. Evaluation of the effectiveness of local Melatonin applied at different doses on healing of bone defect in rat tibias
Segal et al. The use of visible light-curing resin for vertebral body replacement

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160527

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160527

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170411

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170707

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170801