RU2014147975A - Композиции и способы биофотонной реконструкции кости - Google Patents

Композиции и способы биофотонной реконструкции кости Download PDF

Info

Publication number
RU2014147975A
RU2014147975A RU2014147975A RU2014147975A RU2014147975A RU 2014147975 A RU2014147975 A RU 2014147975A RU 2014147975 A RU2014147975 A RU 2014147975A RU 2014147975 A RU2014147975 A RU 2014147975A RU 2014147975 A RU2014147975 A RU 2014147975A
Authority
RU
Russia
Prior art keywords
composition
calcium phosphate
mineral
hyaluronic acid
weight
Prior art date
Application number
RU2014147975A
Other languages
English (en)
Russian (ru)
Inventor
Николаос Лоупис
Ремиджо Пьергаллини
Original Assignee
Клокс Текнолоджиз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Клокс Текнолоджиз Инк. filed Critical Клокс Текнолоджиз Инк.
Publication of RU2014147975A publication Critical patent/RU2014147975A/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/898—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0041—Optical brightening agents, organic pigments
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/442—Colorants, dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A61N2005/0663—Coloured light
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • C08K2003/321—Phosphates
    • C08K2003/325—Calcium, strontium or barium phosphate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Composite Materials (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2014147975A 2012-05-30 2013-05-30 Композиции и способы биофотонной реконструкции кости RU2014147975A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261653101P 2012-05-30 2012-05-30
US61/653,101 2012-05-30
US201361777894P 2013-03-12 2013-03-12
US61/777,894 2013-03-12
PCT/CA2013/000532 WO2013177686A1 (en) 2012-05-30 2013-05-30 Compositions and methods for biophotonic bone reconstruction

Publications (1)

Publication Number Publication Date
RU2014147975A true RU2014147975A (ru) 2016-07-20

Family

ID=49672237

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014147975A RU2014147975A (ru) 2012-05-30 2013-05-30 Композиции и способы биофотонной реконструкции кости

Country Status (17)

Country Link
US (1) US11426463B2 (enExample)
EP (1) EP2854853B1 (enExample)
JP (1) JP2015519134A (enExample)
KR (1) KR20150023294A (enExample)
CN (1) CN104394888A (enExample)
AU (1) AU2013270353A1 (enExample)
BR (1) BR112014029801A2 (enExample)
CA (1) CA2873068A1 (enExample)
HK (1) HK1207300A1 (enExample)
IL (1) IL235687A0 (enExample)
IN (1) IN2014DN09950A (enExample)
MX (1) MX2014014458A (enExample)
NZ (1) NZ701667A (enExample)
RU (1) RU2014147975A (enExample)
SG (1) SG11201407276RA (enExample)
WO (1) WO2013177686A1 (enExample)
ZA (1) ZA201408483B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9834740B2 (en) * 2014-01-24 2017-12-05 The Procter & Gamble Company Photoactivators
JP2017509433A (ja) * 2014-04-01 2017-04-06 クロックス テクノロジーズ インコーポレイテッドＫｌｏｘ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． 組織充填剤組成物および使用方法
JP6158885B2 (ja) * 2015-10-14 2017-07-05 三菱電機株式会社 光源ユニット及び照明装置
ES2941364T3 (es) 2018-06-11 2023-05-22 Procter & Gamble Dispositivo fotoactivador para lavadora
KR102482319B1 (ko) * 2020-09-29 2022-12-29 주식회사 시지바이오 고탄성의 인산 칼슘계 주입형 골 이식재 조성물 및 이의 제조방법
KR20260032794A (ko) * 2024-08-30 2026-03-10 주식회사 덴큐임플란트 임플란트 서지컬 키트의 드릴링 온도를 이용한 인공지능 기반 골질 판별 시스템
CN119935694A (zh) * 2025-01-24 2025-05-06 北京大学第三医院（北京大学第三临床医学院） 一种骨组织多重特殊染色分析方法及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1259090B (it) 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
GB9721585D0 (en) 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
DE60020526T2 (de) * 1999-02-04 2006-05-11 SDGI Holdings, Inc., Wilmington Osteogene pastenzusammensetzungen und ihre verwendung
CN1172681C (zh) 1999-08-18 2004-10-27 凌沛学 透明质酸口服美肤保健品
US7842300B2 (en) 2002-07-31 2010-11-30 Dentsply International, Inc. Bone repair putty
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
JP2006508126A (ja) 2002-11-06 2006-03-09 アザヤ セラピューティクス インコーポレイティッド 薬学的製剤のタンパク質安定化されたリポソーム製剤
CN102579162A (zh) 2003-09-23 2012-07-18 奥索康公司 可吸收的植入体和它们用于止血和治疗骨缺损的方法
ITPD20030286A1 (it) 2003-11-27 2005-05-28 Fidia Advanced Biopolymers Srl Strutture composite multistrato contenenti acido ialuronico
US20080199512A1 (en) 2005-09-02 2008-08-21 Steffi Dudek Oral Composition For Moisturizing Skin
US9132208B2 (en) * 2008-08-07 2015-09-15 Lifenet Health Composition for a tissue repair implant and methods of making the same
ATE487459T1 (de) 2005-12-28 2010-11-15 Dentsply Int Inc Lichthärtbares knochenwachstumsmaterial zur behandlung von zahnknochendefekten
US8999933B2 (en) 2006-01-18 2015-04-07 Biolitec Pharma Marketing Ltd Photodynamic cosmetic procedure and healing method
JP2007197371A (ja) 2006-01-26 2007-08-09 Yaizu Suisankagaku Industry Co Ltd 美肌促進剤及び美容健康食品
US20110206768A1 (en) 2006-12-08 2011-08-25 The University Of Waikato Medical preparation
CN101677957A (zh) * 2007-02-05 2010-03-24 卡比兰生物外科公司 用于递送生物活性试剂的聚合物制剂
CA2695386A1 (en) 2007-08-01 2009-02-05 The Johns Hopkins University Photoinitiated tissue filler
US9314545B2 (en) * 2008-04-15 2016-04-19 Life Science Enterprises, Inc. Minimally invasive treatment of vertebra (MITV) using a calcium phosphate combination bone cement
SG177635A1 (en) 2009-07-17 2012-03-29 Klox Technologies Inc Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease

Also Published As

Publication number Publication date
EP2854853A4 (en) 2016-01-13
JP2015519134A (ja) 2015-07-09
US20150119789A1 (en) 2015-04-30
WO2013177686A1 (en) 2013-12-05
CA2873068A1 (en) 2013-12-05
US11426463B2 (en) 2022-08-30
NZ701667A (en) 2017-05-26
EP2854853B1 (en) 2019-08-21
EP2854853A1 (en) 2015-04-08
IN2014DN09950A (enExample) 2015-08-14
IL235687A0 (en) 2015-01-29
BR112014029801A2 (pt) 2017-06-27
HK1207300A1 (en) 2016-01-29
AU2013270353A1 (en) 2014-11-27
KR20150023294A (ko) 2015-03-05
CN104394888A (zh) 2015-03-04
MX2014014458A (es) 2015-08-14
SG11201407276RA (en) 2015-03-30
ZA201408483B (en) 2015-12-23

Similar Documents

Publication Publication Date Title
BRPI0911176B8 (pt) método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea
Wolf et al. Naturally derived and synthetic scaffolds for skeletal muscle reconstruction
WO2008019024A3 (en) Bone graft composites and methods of treating bone defects
BR112018007982A2 (pt) composição, reação enzimática e método para preparar um copolímero de enxerto
Rahaman Bioactive ceramics and glasses for tissue engineering
EP4257202A3 (en) Injectable silk fibroin particles and uses thereof
PE20130425A1 (es) Metodos para aumentar la tolerancia al estres abiotico en plantas
BRPI0809663B8 (pt) composição de vírus vivo atenuado, usos da mesma, métodos de diminuição da inativação de vírus vivo atenuado, e kit para diminuir a inativação de uma composição de vírus vivo atenuado.
RU2010137106A (ru) Композиции и способы для дистракциионного остеогенеза
MX339658B (es) Combinaciones y metodos para administracion subcutanea de inmunoglobulina y hialuronidasa.
BR112016004287A8 (pt) polímero aniônico, produto agrícola, método de fertilização do solo, produto de semente, método para reduzir a amônia da atmosfera, composição operável para reduzir a amônia da atmosfera e método para sintetizar um polímero
WO2009086305A3 (en) Osteoinductive putties and methods of making and using such putties
BRPI0818183A2 (pt) reparo e regeneração do tecido renal usando células derivadas do tecido do cordão umbilical humano
CN105107019A (zh) 一种用于关节软骨修复的红外响应高强水凝胶的制备方法
AR089569A1 (es) Procedimiento para preparar polimerizados que son apropiados para absorber y almacenar liquidos acuosos
BR112015014635A2 (pt) composição para cuidado pessoal, e, método para reduzir a perda de deposição de silicona de uma composição condicionadora detersiva em substratos queratinoso
PA8841901A1 (es) Compuestos orgánicos
MX2013014014A (es) Colorantes tiofeno azocarboxilato y composicione para el cuidado de ropa que los contienen.
BR112015014679A2 (pt) polímeros termotrópicos
JP2015519134A5 (enExample)
BR112012013544A2 (pt) método para cimentação em uma formação subterrânea, e, composição para uso em uma formação subterrânea.
CL2009000246A1 (es) Compuestos derivados de 1h-imidazo[4,5-b]piridin-2-ol; moduladores de la contraccion sarcomero; composicion farmaceutica que comprende; kit farmaceutico; y uso en el tratamiento de enfermedades neuromusculares, tales como atrofia, fatiga, claudicacion, en entre otras.
NZ701667A (en) Compositions and methods for biophotonic bone reconstruction
MX376294B (es) Composición de revestimiento curable mediante ultravioleta (uv) con mayor estabilidad a la luz solar.
RU2009149684A (ru) Комбинации вазоактивных веществ с эстрогенами и их применение для лечения сексуальных дисфункций у женщин

Legal Events

Date Code Title Description
FA94 Acknowledgement of application withdrawn (non-payment of fees)

Effective date: 20190123