JP2015517311A5 - - Google Patents
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- JP2015517311A5 JP2015517311A5 JP2015511803A JP2015511803A JP2015517311A5 JP 2015517311 A5 JP2015517311 A5 JP 2015517311A5 JP 2015511803 A JP2015511803 A JP 2015511803A JP 2015511803 A JP2015511803 A JP 2015511803A JP 2015517311 A5 JP2015517311 A5 JP 2015517311A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- oct4
- mrna
- reprogramming
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 42
- 108020004999 messenger RNA Proteins 0.000 claims description 18
- 230000008672 reprogramming Effects 0.000 claims description 16
- 210000001082 somatic cell Anatomy 0.000 claims description 12
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 claims description 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 6
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims description 6
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims description 6
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims description 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 4
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 claims description 4
- 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 claims description 4
- 101000984042 Homo sapiens Protein lin-28 homolog A Proteins 0.000 claims description 4
- 102100020677 Krueppel-like factor 4 Human genes 0.000 claims description 4
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims description 4
- 102100025460 Protein lin-28 homolog A Human genes 0.000 claims description 4
- 101001023030 Toxoplasma gondii Myosin-D Proteins 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- 101100239628 Danio rerio myca gene Proteins 0.000 claims description 3
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims description 3
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims description 3
- 101150111214 lin-28 gene Proteins 0.000 claims description 3
- 210000002894 multi-fate stem cell Anatomy 0.000 claims description 3
- 101100411708 Danio rerio rarga gene Proteins 0.000 claims description 2
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 claims description 2
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 230000032459 dedifferentiation Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 230000004927 fusion Effects 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 108091070501 miRNA Proteins 0.000 claims description 2
- 239000002679 microRNA Substances 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261646292P | 2012-05-13 | 2012-05-13 | |
| US61/646,292 | 2012-05-13 | ||
| PCT/US2013/040814 WO2013173248A2 (en) | 2012-05-13 | 2013-05-13 | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017137655A Division JP6530452B2 (ja) | 2012-05-13 | 2017-07-14 | 合成メッセンジャーｒｎａを使用したヒト人工多能性幹細胞のフィーダーフリー誘導 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517311A JP2015517311A (ja) | 2015-06-22 |
| JP2015517311A5 true JP2015517311A5 (https=) | 2016-06-23 |
| JP6448531B2 JP6448531B2 (ja) | 2019-01-09 |
Family
ID=49548771
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511803A Active JP6448531B2 (ja) | 2012-05-13 | 2013-05-13 | 合成メッセンジャーｒｎａを使用したヒト人工多能性幹細胞のフィーダーフリー誘導 |
| JP2017137655A Active JP6530452B2 (ja) | 2012-05-13 | 2017-07-14 | 合成メッセンジャーｒｎａを使用したヒト人工多能性幹細胞のフィーダーフリー誘導 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017137655A Active JP6530452B2 (ja) | 2012-05-13 | 2017-07-14 | 合成メッセンジャーｒｎａを使用したヒト人工多能性幹細胞のフィーダーフリー誘導 |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP3561054B1 (https=) |
| JP (2) | JP6448531B2 (https=) |
| KR (2) | KR102215413B1 (https=) |
| CN (2) | CN110241087B (https=) |
| AU (2) | AU2013263101B2 (https=) |
| CA (1) | CA2872688C (https=) |
| DK (1) | DK2850179T3 (https=) |
| ES (2) | ES2729563T3 (https=) |
| WO (1) | WO2013173248A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| AU2012347919B2 (en) | 2011-12-05 | 2017-02-02 | Factor Bioscience Inc. | Methods and products for transfecting cells |
| EP3561054B1 (en) * | 2012-05-13 | 2023-07-05 | Allele Biotechnology And Pharmaceuticals, Inc. | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna |
| US10119150B2 (en) | 2012-05-13 | 2018-11-06 | Allele Biotechnology & Pharmaceuticals, Inc. | Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA |
| US10155929B2 (en) | 2012-05-13 | 2018-12-18 | Allele Biotechnology & Pharmaceuticals, Inc. | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA |
| KR102121086B1 (ko) | 2012-11-01 | 2020-06-09 | 팩터 바이오사이언스 인크. | 세포에서 단백질을 발현시키는 방법들과 생성물들 |
| EP3099801B1 (en) | 2014-01-31 | 2020-03-18 | Factor Bioscience Inc. | Synthetic rna for use in the treatment of dystrophic epidermolysis bullosa |
| CA2976376A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| CA3011692A1 (en) * | 2015-11-23 | 2017-06-01 | The Regents Of The University Of Colorado, A Body Corporate | Methods and compositions for reprogramming cells |
| IL308824A (en) | 2016-08-17 | 2024-01-01 | Factor Bioscience Inc | Nucleic acid products and methods of administration thereof |
| KR102586507B1 (ko) | 2016-11-16 | 2023-10-11 | 알렐 바이오테크놀로지 앤 파마슈티칼스, 인크. | Ｒｎａ를 사용한 줄기 세포 분화에 의한 간세포의 유도 |
| US12338462B2 (en) | 2016-11-16 | 2025-06-24 | Allele Biotechnology And Pharmaceuticals, Inc. | Induction of pancreatic beta cells by stem cell differentiation with RNA |
| KR102122336B1 (ko) * | 2018-10-26 | 2020-06-12 | 서울시립대학교 산학협력단 | 세포전환용 rna 나노입자를 이용한 유도만능줄기세포의 제조방법 |
| EP3969571A4 (en) | 2019-05-14 | 2023-05-24 | Aleph Farms Ltd. | PLURIPOTENTE CELL AGGREGATES AND THEIR USE |
| CA3145425A1 (en) | 2019-07-03 | 2021-01-07 | Factor Bioscience Inc. | Cationic lipids and uses thereof |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| WO2021149822A1 (ja) * | 2020-01-24 | 2021-07-29 | アイ ピース， インコーポレイテッド | 人工多能性幹細胞の作製方法 |
| JP2022104813A (ja) | 2020-12-29 | 2022-07-11 | アイ ピース，インコーポレイテッド | リプログラミング因子を導入された細胞の培養方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260432A (en) * | 1989-06-22 | 1993-11-09 | Sloan-Kettering Institute For Cancer Research | Human gamma retinoic acid receptor DNA |
| EP3231869A1 (en) * | 2008-06-13 | 2017-10-18 | Whitehead Institute for Biomedical Research | Programming and reprogramming of cells |
| EP2881461A1 (en) * | 2008-11-21 | 2015-06-10 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Reprogramming cells toward a pluripotent state |
| WO2011056971A2 (en) * | 2009-11-04 | 2011-05-12 | Cellular Dynamics International, Inc. | Episomal reprogramming with chemicals |
| US8808982B2 (en) * | 2009-12-07 | 2014-08-19 | Cellscript, Llc | Compositions and methods for reprogramming eukaryotic cells |
| CN102190731B (zh) * | 2010-03-09 | 2016-01-27 | 中国科学院上海生命科学研究院 | 用人工转录因子诱导产生多能干细胞 |
| US9580689B2 (en) * | 2010-07-22 | 2017-02-28 | Regents Of The University Of Minnesota | Induced pluripotent stem cells |
| US8940945B2 (en) * | 2010-07-23 | 2015-01-27 | University Of South Florida | Materials and methods for reduction of protein tau and treatment of neurodegenerative diseases |
| CN102417894B (zh) * | 2011-10-21 | 2013-06-05 | 中国科学院广州生物医药与健康研究院 | 一种提高诱导生成多能性干细胞效率的方法 |
| EP3561054B1 (en) * | 2012-05-13 | 2023-07-05 | Allele Biotechnology And Pharmaceuticals, Inc. | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna |
| US10155929B2 (en) * | 2012-05-13 | 2018-12-18 | Allele Biotechnology & Pharmaceuticals, Inc. | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA |
| CN103739718B (zh) * | 2014-01-16 | 2017-02-08 | 中国科学院动物研究所 | 用于诱导多能干细胞的融合蛋白及其使用方法 |
-
2013
- 2013-05-13 EP EP19163001.1A patent/EP3561054B1/en active Active
- 2013-05-13 EP EP13790064.3A patent/EP2850179B1/en active Active
- 2013-05-13 KR KR1020207004988A patent/KR102215413B1/ko active Active
- 2013-05-13 ES ES13790064T patent/ES2729563T3/es active Active
- 2013-05-13 AU AU2013263101A patent/AU2013263101B2/en active Active
- 2013-05-13 CN CN201910468645.0A patent/CN110241087B/zh active Active
- 2013-05-13 ES ES19163001T patent/ES2951822T3/es active Active
- 2013-05-13 JP JP2015511803A patent/JP6448531B2/ja active Active
- 2013-05-13 CA CA2872688A patent/CA2872688C/en active Active
- 2013-05-13 KR KR1020147034726A patent/KR102081811B1/ko active Active
- 2013-05-13 DK DK13790064.3T patent/DK2850179T3/da active
- 2013-05-13 WO PCT/US2013/040814 patent/WO2013173248A2/en not_active Ceased
- 2013-05-13 CN CN201380025010.4A patent/CN104520424B/zh active Active
-
2017
- 2017-07-14 JP JP2017137655A patent/JP6530452B2/ja active Active
-
2019
- 2019-05-13 AU AU2019203335A patent/AU2019203335B2/en active Active
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