JP2015516983A5 - - Google Patents
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- Publication number
- JP2015516983A5 JP2015516983A5 JP2015509095A JP2015509095A JP2015516983A5 JP 2015516983 A5 JP2015516983 A5 JP 2015516983A5 JP 2015509095 A JP2015509095 A JP 2015509095A JP 2015509095 A JP2015509095 A JP 2015509095A JP 2015516983 A5 JP2015516983 A5 JP 2015516983A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- xaa
- par4
- trp
- peptide according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 30
- 101001113471 Homo sapiens Proteinase-activated receptor 4 Proteins 0.000 claims 19
- 102100023710 Proteinase-activated receptor 4 Human genes 0.000 claims 19
- 101000613565 Homo sapiens PRKC apoptosis WT1 regulator protein Proteins 0.000 claims 13
- 239000000556 agonist Substances 0.000 claims 13
- 150000001413 amino acids Chemical group 0.000 claims 9
- 230000004913 activation Effects 0.000 claims 5
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 2
- JPNRPAJITHRXRH-BQBZGAKWSA-N Lys-Asn Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC(N)=O JPNRPAJITHRXRH-BQBZGAKWSA-N 0.000 claims 2
- HQVDJTYKCMIWJP-YUMQZZPRSA-N Lys-Asn-Gly Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(O)=O HQVDJTYKCMIWJP-YUMQZZPRSA-N 0.000 claims 2
- KAFHLONDOVSENM-HNNXBMFYSA-N O-Benzyl-L-tyrosine Chemical compound C1=CC(C[C@H](N)C(O)=O)=CC=C1OCC1=CC=CC=C1 KAFHLONDOVSENM-HNNXBMFYSA-N 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261638577P | 2012-04-26 | 2012-04-26 | |
| US61/638,577 | 2012-04-26 | ||
| US201361781538P | 2013-03-14 | 2013-03-14 | |
| US61/781,538 | 2013-03-14 | ||
| PCT/US2013/037897 WO2013163248A1 (en) | 2012-04-26 | 2013-04-24 | Par4 agonist peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015516983A JP2015516983A (ja) | 2015-06-18 |
| JP2015516983A5 true JP2015516983A5 (enExample) | 2015-08-20 |
Family
ID=48289680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509095A Pending JP2015516983A (ja) | 2012-04-26 | 2013-04-24 | Ｐａｒ４アゴニストペプチド |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8927688B2 (enExample) |
| EP (1) | EP2841448A1 (enExample) |
| JP (1) | JP2015516983A (enExample) |
| CN (1) | CN104411713A (enExample) |
| BR (1) | BR112014026644A2 (enExample) |
| CA (1) | CA2871640A1 (enExample) |
| EA (1) | EA201491959A1 (enExample) |
| MX (1) | MX2014012803A (enExample) |
| WO (1) | WO2013163248A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE060743T2 (hu) * | 2012-04-26 | 2023-04-28 | Bristol Myers Squibb Co | Gyógyszerészeti kompozíciók, amelyek tartalmaznak imidazothiadiazol- és imidazopiridazinszármazékokat mint proteáz aktívált receptor 4 (PAR4) inhibitorokat trombocitaaggregációk kezelésére |
| WO2015061733A1 (en) * | 2013-10-25 | 2015-04-30 | Bristol-Meyers Squibb Company | Diagnostic methods for par4 antagonist therapy |
| WO2016134450A1 (en) | 2015-02-26 | 2016-09-01 | Université de Montréal | Imidazopyridazine and imidazothiadiazole compounds |
| US9789087B2 (en) | 2015-08-03 | 2017-10-17 | Thomas Jefferson University | PAR4 inhibitor therapy for patients with PAR4 polymorphism |
| US9963466B2 (en) | 2016-03-07 | 2018-05-08 | Vanderbilt University | Substituted 5-membered heterocyclic analogs as protease activated receptor 4 (PAR-4) antagonists |
| US20190119300A1 (en) * | 2016-04-18 | 2019-04-25 | Vanderbilt University | Substituted and fused 6-membered protease activated receptor 4 (par-4) antagonists |
| WO2019149205A1 (zh) * | 2018-01-31 | 2019-08-08 | 江苏恒瑞医药股份有限公司 | 苯并杂芳基类衍生物、其制备方法及其在医药上的应用 |
| CN110218218B (zh) * | 2018-03-01 | 2022-04-08 | 江苏恒瑞医药股份有限公司 | 苯并呋喃类衍生物、其制备方法及其在医药上的应用 |
| CN110627817B (zh) * | 2018-06-25 | 2022-03-29 | 中国药科大学 | 咪唑并环类par4拮抗剂及其医药用途 |
| CN111349105B (zh) * | 2018-12-24 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 苯并呋喃类衍生物、其制备方法及其在医药上的应用 |
| CN111362970A (zh) * | 2018-12-25 | 2020-07-03 | 天津药物研究院有限公司 | 苯并呋喃类衍生物及其制备方法和用途 |
| US12077607B2 (en) | 2021-09-23 | 2024-09-03 | University Of Utah Research Foundation | Functional and therapeutic effects of PAR4 cleavage by cathepsin G |
| CN117285527A (zh) * | 2023-09-25 | 2023-12-26 | 中国药科大学 | 一种噌啉类par4拮抗剂及其医药应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2928079B2 (ja) * | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
| AU2001233333A1 (en) | 2000-02-09 | 2001-08-20 | Zymogenetics Inc. | Par4 peptides and polypeptides |
| WO2001094411A1 (en) | 2000-06-05 | 2001-12-13 | The Regents Of The University Of California | Peptides modulating protease activated receptors and methods of using same |
| US6387942B2 (en) | 2000-06-19 | 2002-05-14 | Yung Shin Pharmaceutical Ind. Co. Ltd | Method of treating disorders related to protease-activated receptors-induced cell activation |
| WO2003033515A1 (en) * | 2001-10-15 | 2003-04-24 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of acne vulgaris |
| DE602004006529T2 (de) | 2003-10-31 | 2008-01-31 | Janssen Pharmaceutica N.V. | Phenoxyessigsäure-derivate als peroxisom-proliferator-aktivierte rezeptor (ppar) dual-agonisten |
-
2013
- 2013-04-24 BR BR112014026644A patent/BR112014026644A2/pt not_active IP Right Cessation
- 2013-04-24 WO PCT/US2013/037897 patent/WO2013163248A1/en not_active Ceased
- 2013-04-24 CN CN201380034451.0A patent/CN104411713A/zh active Pending
- 2013-04-24 JP JP2015509095A patent/JP2015516983A/ja active Pending
- 2013-04-24 CA CA2871640A patent/CA2871640A1/en not_active Abandoned
- 2013-04-24 EP EP13720698.3A patent/EP2841448A1/en not_active Withdrawn
- 2013-04-24 MX MX2014012803A patent/MX2014012803A/es unknown
- 2013-04-24 US US13/869,093 patent/US8927688B2/en active Active
- 2013-04-24 EA EA201491959A patent/EA201491959A1/ru unknown
-
2014
- 2014-11-26 US US14/554,387 patent/US9303065B2/en active Active
-
2016
- 2016-02-23 US US15/051,067 patent/US9605024B2/en active Active
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