EA201491959A1 - Агонистические пептиды для par4 - Google Patents
Агонистические пептиды для par4Info
- Publication number
- EA201491959A1 EA201491959A1 EA201491959A EA201491959A EA201491959A1 EA 201491959 A1 EA201491959 A1 EA 201491959A1 EA 201491959 A EA201491959 A EA 201491959A EA 201491959 A EA201491959 A EA 201491959A EA 201491959 A1 EA201491959 A1 EA 201491959A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- par4
- peptides
- agonistic peptides
- agonistic
- applicable
- Prior art date
Links
- 101001113471 Homo sapiens Proteinase-activated receptor 4 Proteins 0.000 title abstract 3
- 102100023710 Proteinase-activated receptor 4 Human genes 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 101000613565 Homo sapiens PRKC apoptosis WT1 regulator protein Proteins 0.000 title abstract 2
- 230000001270 agonistic effect Effects 0.000 title abstract 2
- 238000003556 assay Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261638577P | 2012-04-26 | 2012-04-26 | |
| US201361781538P | 2013-03-14 | 2013-03-14 | |
| PCT/US2013/037897 WO2013163248A1 (en) | 2012-04-26 | 2013-04-24 | Par4 agonist peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201491959A1 true EA201491959A1 (ru) | 2016-05-31 |
Family
ID=48289680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201491959A EA201491959A1 (ru) | 2012-04-26 | 2013-04-24 | Агонистические пептиды для par4 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8927688B2 (enExample) |
| EP (1) | EP2841448A1 (enExample) |
| JP (1) | JP2015516983A (enExample) |
| CN (1) | CN104411713A (enExample) |
| BR (1) | BR112014026644A2 (enExample) |
| CA (1) | CA2871640A1 (enExample) |
| EA (1) | EA201491959A1 (enExample) |
| MX (1) | MX2014012803A (enExample) |
| WO (1) | WO2013163248A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6073464B2 (ja) * | 2012-04-26 | 2017-02-01 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 血小板凝集を治療するためのプロテアーゼ活性化受容体４（ｐａｒ４）阻害剤としてのイミダゾチアジアゾールおよびイミダゾピラジン誘導体 |
| EP3060233A4 (en) * | 2013-10-25 | 2017-04-12 | Bristol-Myers Squibb Company | Diagnostic methods for par4 antagonist therapy |
| EP3262053B1 (en) | 2015-02-26 | 2022-10-05 | Université de Montréal | Imidazothiadiazole compounds as par4-inhibitors |
| US9789087B2 (en) | 2015-08-03 | 2017-10-17 | Thomas Jefferson University | PAR4 inhibitor therapy for patients with PAR4 polymorphism |
| US9963466B2 (en) | 2016-03-07 | 2018-05-08 | Vanderbilt University | Substituted 5-membered heterocyclic analogs as protease activated receptor 4 (PAR-4) antagonists |
| US20190119300A1 (en) * | 2016-04-18 | 2019-04-25 | Vanderbilt University | Substituted and fused 6-membered protease activated receptor 4 (par-4) antagonists |
| WO2019149205A1 (zh) * | 2018-01-31 | 2019-08-08 | 江苏恒瑞医药股份有限公司 | 苯并杂芳基类衍生物、其制备方法及其在医药上的应用 |
| CN110218218B (zh) * | 2018-03-01 | 2022-04-08 | 江苏恒瑞医药股份有限公司 | 苯并呋喃类衍生物、其制备方法及其在医药上的应用 |
| CN110627817B (zh) * | 2018-06-25 | 2022-03-29 | 中国药科大学 | 咪唑并环类par4拮抗剂及其医药用途 |
| CN111349105B (zh) * | 2018-12-24 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 苯并呋喃类衍生物、其制备方法及其在医药上的应用 |
| CN111362970A (zh) * | 2018-12-25 | 2020-07-03 | 天津药物研究院有限公司 | 苯并呋喃类衍生物及其制备方法和用途 |
| US12077607B2 (en) | 2021-09-23 | 2024-09-03 | University Of Utah Research Foundation | Functional and therapeutic effects of PAR4 cleavage by cathepsin G |
| CN117285527A (zh) * | 2023-09-25 | 2023-12-26 | 中国药科大学 | 一种噌啉类par4拮抗剂及其医药应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2928079B2 (ja) | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
| WO2001058930A1 (en) | 2000-02-09 | 2001-08-16 | Zymogenetics, Inc. | Par4 peptides and polypeptides |
| WO2001094411A1 (en) * | 2000-06-05 | 2001-12-13 | The Regents Of The University Of California | Peptides modulating protease activated receptors and methods of using same |
| US6387942B2 (en) | 2000-06-19 | 2002-05-14 | Yung Shin Pharmaceutical Ind. Co. Ltd | Method of treating disorders related to protease-activated receptors-induced cell activation |
| WO2003033515A1 (en) * | 2001-10-15 | 2003-04-24 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of acne vulgaris |
| AU2004285530A1 (en) | 2003-10-31 | 2005-05-12 | Janssen Pharmaceutica N.V. | Phenoxyacetic acids derivatives useful as peroxisome proliferator-activated receptor (PPAR) dual agonists |
-
2013
- 2013-04-24 JP JP2015509095A patent/JP2015516983A/ja active Pending
- 2013-04-24 MX MX2014012803A patent/MX2014012803A/es unknown
- 2013-04-24 EP EP13720698.3A patent/EP2841448A1/en not_active Withdrawn
- 2013-04-24 CA CA2871640A patent/CA2871640A1/en not_active Abandoned
- 2013-04-24 EA EA201491959A patent/EA201491959A1/ru unknown
- 2013-04-24 CN CN201380034451.0A patent/CN104411713A/zh active Pending
- 2013-04-24 BR BR112014026644A patent/BR112014026644A2/pt not_active IP Right Cessation
- 2013-04-24 US US13/869,093 patent/US8927688B2/en active Active
- 2013-04-24 WO PCT/US2013/037897 patent/WO2013163248A1/en not_active Ceased
-
2014
- 2014-11-26 US US14/554,387 patent/US9303065B2/en active Active
-
2016
- 2016-02-23 US US15/051,067 patent/US9605024B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014026644A2 (pt) | 2017-06-27 |
| US8927688B2 (en) | 2015-01-06 |
| CA2871640A1 (en) | 2013-10-31 |
| US20150158910A1 (en) | 2015-06-11 |
| US20130289238A1 (en) | 2013-10-31 |
| US20160304560A1 (en) | 2016-10-20 |
| US9605024B2 (en) | 2017-03-28 |
| CN104411713A (zh) | 2015-03-11 |
| WO2013163248A1 (en) | 2013-10-31 |
| JP2015516983A (ja) | 2015-06-18 |
| US9303065B2 (en) | 2016-04-05 |
| MX2014012803A (es) | 2015-01-15 |
| EP2841448A1 (en) | 2015-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201491959A1 (ru) | Агонистические пептиды для par4 | |
| CY2024011I2 (el) | Αντισωματα anti-fcrn | |
| CL2016000460A1 (es) | Proteínas de unión al antígeno gitr | |
| CO7111294A2 (es) | Anticuerpo anti-fgfr2 | |
| UY34206A (es) | Anticuerpo monoclonal de interleucina-31 | |
| CO7061035A2 (es) | Péptido de tránsito al cloroplasto | |
| EP2847231A4 (en) | MULTISPECIFIC MONOCLONAL ANTIBODIES | |
| EP3427721C0 (en) | HIGH CONCENTRATION MONOCLONAL ANTIBODY FORMULATIONS | |
| BR112015004397A2 (pt) | formulações de anticorpos de receptor anti-prolactina. | |
| DK3636665T3 (da) | T-cellereceptorer, som genkender mhc klasse ii-begrænset mage-a3 | |
| DK2970374T3 (da) | Fastfase-peptidsyntese | |
| DK2934584T3 (da) | Anti-gdf15-antistoffer | |
| EP2869126A4 (en) | TONER | |
| HRP20181646T1 (hr) | Konjugati pirolobenzodiazepin - anti-psma protutijela | |
| DK3340626T3 (da) | Ensrettet design til billedopdelingssystemer | |
| EP2922874A4 (en) | BISPECIFIC ANTIBODIES | |
| UY34644A (es) | Polipéptidos de unión a cx3cr1 | |
| IL229618B (en) | Isolated antibody that binds fcrn | |
| UY34817A (es) | Tienopirimidinas | |
| UY4153Q (es) | Batería | |
| CR20150271A (es) | Peptidos como agonistas de oxitocina | |
| CR20140440A (es) | Anticuerpos frente a los ligandos del receptor b1 de bradicinina | |
| PL3004167T3 (pl) | Białka wiążące antygen receptora onkostatyny m | |
| DK2858563T3 (da) | Elektromedicinsk system til bestemmelse af neuromuskulkær lammelse | |
| LT3068800T (lt) | Fcrn receptoriui specifiniai antikūnai |