JP2015516812A5 - - Google Patents
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- JP2015516812A5 JP2015516812A5 JP2015509109A JP2015509109A JP2015516812A5 JP 2015516812 A5 JP2015516812 A5 JP 2015516812A5 JP 2015509109 A JP2015509109 A JP 2015509109A JP 2015509109 A JP2015509109 A JP 2015509109A JP 2015516812 A5 JP2015516812 A5 JP 2015516812A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- pluripotent
- cytoplasm
- acth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004027 cell Anatomy 0.000 claims 97
- 238000000034 method Methods 0.000 claims 80
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 claims 14
- 101800000414 Corticotropin Proteins 0.000 claims 14
- 102100027467 Pro-opiomelanocortin Human genes 0.000 claims 14
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 14
- 229960000258 corticotropin Drugs 0.000 claims 14
- 210000000805 cytoplasm Anatomy 0.000 claims 13
- 230000035882 stress Effects 0.000 claims 12
- 210000000130 stem cell Anatomy 0.000 claims 8
- 239000002771 cell marker Substances 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 210000003470 mitochondria Anatomy 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 4
- 238000002659 cell therapy Methods 0.000 claims 3
- 230000001973 epigenetic effect Effects 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000000905 Cadherin Human genes 0.000 claims 2
- 108050007957 Cadherin Proteins 0.000 claims 2
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 2
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims 2
- 101150072501 Klf2 gene Proteins 0.000 claims 2
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 2
- 101710150336 Protein Rex Proteins 0.000 claims 2
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 2
- 101150086694 SLC22A3 gene Proteins 0.000 claims 2
- 101150111019 Tbx3 gene Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 206010063601 Exposure to extreme temperature Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 108010089610 Nuclear Proteins Proteins 0.000 claims 1
- 102000007999 Nuclear Proteins Human genes 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000011130 autologous cell therapy Methods 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 230000007910 cell fusion Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000003833 cell viability Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 210000002308 embryonic cell Anatomy 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000009894 physiological stress Effects 0.000 claims 1
- 230000003169 placental effect Effects 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- -1 transcripts Proteins 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 238000001665 trituration Methods 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261637631P | 2012-04-24 | 2012-04-24 | |
| US61/637,631 | 2012-04-24 | ||
| US201361779533P | 2013-03-13 | 2013-03-13 | |
| US61/779,533 | 2013-03-13 | ||
| PCT/US2013/037996 WO2013163296A1 (en) | 2012-04-24 | 2013-04-24 | Generating pluripotent cells de novo |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018117481A Division JP2018183145A (ja) | 2012-04-24 | 2018-06-20 | 多能性細胞のデノボ生成 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015516812A JP2015516812A (ja) | 2015-06-18 |
| JP2015516812A5 true JP2015516812A5 (https=) | 2016-06-16 |
Family
ID=49483852
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509109A Pending JP2015516812A (ja) | 2012-04-24 | 2013-04-24 | 多能性細胞のデノボ生成 |
| JP2018117481A Withdrawn JP2018183145A (ja) | 2012-04-24 | 2018-06-20 | 多能性細胞のデノボ生成 |
| JP2020122035A Withdrawn JP2020182480A (ja) | 2012-04-24 | 2020-07-16 | 多能性細胞のデノボ生成 |
| JP2022175459A Pending JP2023002805A (ja) | 2012-04-24 | 2022-11-01 | 多能性細胞のデノボ生成 |
| JP2025061922A Pending JP2025106394A (ja) | 2012-04-24 | 2025-04-03 | 多能性細胞のデノボ生成 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018117481A Withdrawn JP2018183145A (ja) | 2012-04-24 | 2018-06-20 | 多能性細胞のデノボ生成 |
| JP2020122035A Withdrawn JP2020182480A (ja) | 2012-04-24 | 2020-07-16 | 多能性細胞のデノボ生成 |
| JP2022175459A Pending JP2023002805A (ja) | 2012-04-24 | 2022-11-01 | 多能性細胞のデノボ生成 |
| JP2025061922A Pending JP2025106394A (ja) | 2012-04-24 | 2025-04-03 | 多能性細胞のデノボ生成 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11963977B2 (https=) |
| EP (2) | EP2844738A4 (https=) |
| JP (5) | JP2015516812A (https=) |
| KR (2) | KR20200084916A (https=) |
| CN (2) | CN104718283A (https=) |
| AU (2) | AU2013251649B2 (https=) |
| CA (1) | CA2885576A1 (https=) |
| ES (1) | ES2972525T3 (https=) |
| RU (1) | RU2696071C2 (https=) |
| SG (2) | SG11201407768QA (https=) |
| WO (1) | WO2013163296A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012347919B2 (en) | 2011-12-05 | 2017-02-02 | Factor Bioscience Inc. | Methods and products for transfecting cells |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| KR102121086B1 (ko) | 2012-11-01 | 2020-06-09 | 팩터 바이오사이언스 인크. | 세포에서 단백질을 발현시키는 방법들과 생성물들 |
| CA2895791A1 (en) | 2013-01-25 | 2014-07-31 | Xcell Biosciences, Inc. | Methods, compositions, kits, and systems for selective enrichment of target cells |
| JP6495658B2 (ja) | 2013-02-08 | 2019-04-03 | 国立大学法人京都大学 | 巨核球及び血小板の製造方法 |
| EP4292600A3 (en) | 2013-03-15 | 2024-04-10 | Astellas Institute for Regenerative Medicine | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| US11241460B2 (en) | 2013-03-15 | 2022-02-08 | Astellas Institute For Regenerative Medicine | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| WO2014201254A1 (en) | 2013-06-12 | 2014-12-18 | University Of Washington Through Its Center For Commercialization | Methods for maturing cardiomyocytes and uses thereof |
| EP3099801B1 (en) | 2014-01-31 | 2020-03-18 | Factor Bioscience Inc. | Synthetic rna for use in the treatment of dystrophic epidermolysis bullosa |
| KR102327986B1 (ko) * | 2014-03-19 | 2021-11-18 | 브이셀 세라퓨틱스 인코포레이티드 | 다능성 세포에 관한 방법 |
| JP6986968B2 (ja) * | 2014-12-04 | 2021-12-22 | ステモン・インコーポレイテッド | エネルギーを利用した多能性細胞誘導装置及び方法 |
| WO2016089178A1 (ko) * | 2014-12-04 | 2016-06-09 | 가톨릭관동대학교산학협력단 | 에너지를 이용한 다능성 세포 유도 장치 및 방법 |
| CA2976376A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| EP4026563B1 (en) * | 2015-06-18 | 2025-10-29 | Yeda Research and Development Co. Ltd | Conditioning protocols and use of same for tissue regeneration |
| KR102050852B1 (ko) * | 2016-03-11 | 2019-12-03 | 주식회사 스템온 | 세포 리프로그래밍 장치 |
| WO2017155166A1 (ko) * | 2016-03-11 | 2017-09-14 | 가톨릭관동대학교기술지주 주식회사 | 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법 |
| KR101855967B1 (ko) * | 2016-03-11 | 2018-05-10 | 가톨릭관동대학교산학협력단 | 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법 |
| WO2017155167A1 (ko) * | 2016-03-11 | 2017-09-14 | 가톨릭관동대학교산학협력단 | 세포 리프로그래밍 장치 |
| US10456423B2 (en) | 2016-06-13 | 2019-10-29 | SMART SURGICAL, Inc. | Compositions for biological systems and methods for preparing and using the same |
| US10426796B2 (en) | 2016-06-13 | 2019-10-01 | SMART SURGICAL, Inc. | Compositions for biological systems and methods for preparing and using the same |
| IL308824A (en) | 2016-08-17 | 2024-01-01 | Factor Bioscience Inc | Nucleic acid products and methods of administration thereof |
| US20180127738A1 (en) * | 2016-11-07 | 2018-05-10 | BiomediStem, LLC | Production and therapeutic uses of epinul pluripotent cells and differentiated cells derived therefrom |
| US20200131473A1 (en) * | 2017-03-20 | 2020-04-30 | Ifom Fondazione Istituto Firc Di Oncologia Molecolare | Method of generating 2 cell-like stem cells |
| WO2018226435A1 (en) * | 2017-06-10 | 2018-12-13 | SMART SURGICAL, Inc. | Compositions for biological systems and methods for preparing and using the same |
| CN107729932B (zh) * | 2017-10-10 | 2019-07-26 | 杭州智微信息科技有限公司 | 骨髓细胞标记方法和系统 |
| KR102416171B1 (ko) | 2018-10-02 | 2022-07-06 | 주식회사 스템온 | 세포의 리프로그래밍을 유도하는 리프로좀 및 그 제조 방법 |
| CA3145425A1 (en) | 2019-07-03 | 2021-01-07 | Factor Bioscience Inc. | Cationic lipids and uses thereof |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| JP2022546578A (ja) * | 2019-09-04 | 2022-11-04 | ブイセル セラピューティックス，インコーポレイテッド | 癌を処置するためのワクチンおよびストレスリプログラミングによるその作製方法 |
| US12091684B2 (en) | 2020-02-14 | 2024-09-17 | Hackensack Meridian Health, Inc. | Platelet-derived mitochondria treatment and method of generating multipotent cells |
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| US4963489A (en) | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| FR2687404B1 (fr) | 1992-02-19 | 1994-05-20 | Centre Nal Recherc Scientifique | Peptides immunologiquement apparentes aux proteines d'un agent viral et leurs applications biologiques. |
| AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| US5672346A (en) | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
| ES2157225T3 (es) | 1992-10-09 | 2001-08-16 | Advanced Tissue Sciences Inc | Celulas hepaticas de reserva. |
| US5753431A (en) * | 1993-10-13 | 1998-05-19 | Northeastern Ohio University | Cholesterol 7 α-hydroxdylase gene regulatory elements and transcription factors |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9502022D0 (en) | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| US20020151050A1 (en) | 2000-10-30 | 2002-10-17 | Vacanti Charles A. | Isolation of spore-like cells from tissues exposed to extreme conditions |
| GB0113118D0 (en) | 2001-05-31 | 2001-07-18 | Intercytex Ltd | Stem Cells |
| US7575321B2 (en) | 2003-10-30 | 2009-08-18 | Welch Allyn, Inc. | Apparatus and method of diagnosis of optically identifiable ophthalmic conditions |
| JP4676442B2 (ja) * | 2003-12-02 | 2011-04-27 | セラヴィー バイオサイエンシズ エルエルシー | 神経前駆細胞を増殖させるための組成物および方法 |
| US20090104158A1 (en) * | 2004-09-03 | 2009-04-23 | Moraga Biotechnology Corporation | Non-Embryonic Totipotent Blastomere-Like Stem Cells And Methods Therefor |
| US20060084167A1 (en) | 2004-10-16 | 2006-04-20 | Cohenford Menashi A | Formation of Hybrid Cells by Fusion of Lineage Committed Cells with Stem Cells |
| US20090298095A1 (en) * | 2005-04-15 | 2009-12-03 | The John Hopkins University | Immortalization of cells including neuronal cells |
| FR2885368A1 (fr) * | 2005-05-04 | 2006-11-10 | Fred Zacouto | Systemes et procedes de regeneration cellulaire et utilisations de telles cellules regenerees |
| WO2007030693A2 (en) * | 2005-09-08 | 2007-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for promoting stem cell proliferation and survival |
| US20070087437A1 (en) * | 2005-10-14 | 2007-04-19 | Jifan Hu | Methods for rejuvenating cells in vitro and in vivo |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US20070190646A1 (en) | 2006-02-10 | 2007-08-16 | The Trustees Of The University Of Pennsylvania | Regulating stem cell differentiation by controlling matrix elasticity |
| US20090252711A1 (en) | 2006-05-11 | 2009-10-08 | Andrew Craig Boquest | Stem Cells And Methods Of Making And Using Stem Cells |
| US20100135970A1 (en) | 2006-10-27 | 2010-06-03 | Caritas St. Elizabeth Medical Center Of Boston, In | Methods for Reprogramming Adult Somatic Cells and Uses Thereof |
| CN105861443A (zh) * | 2007-04-07 | 2016-08-17 | 怀特黑德生物医学研究所 | 体细胞重编程 |
| EP2220488B1 (en) * | 2007-10-30 | 2013-01-09 | Le Centre National De La Recherche Scientifique (CNRS) | Method for conducting an assay for neutralizing antibodies |
| KR101564044B1 (ko) | 2007-10-31 | 2015-10-28 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 핵초기화 방법 |
| US20090280518A1 (en) * | 2008-05-12 | 2009-11-12 | Massachusetts Institute Of Technology | System for high throughput measurement of mechanical properties of cells |
| US9550975B2 (en) | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
| EP2492715B1 (en) * | 2009-10-06 | 2019-01-09 | Canon Kabushiki Kaisha | Rear attachment lens, imaging optical system, and image pickup apparatus |
| WO2011125948A1 (ja) * | 2010-04-02 | 2011-10-13 | 独立行政法人理化学研究所 | Ｅｓ細胞の製造方法 |
| KR20120002134A (ko) | 2010-06-30 | 2012-01-05 | 서울대학교산학협력단 | 지방 기질 세포의 역분화를 유도하는 방법 |
| EP3366327B1 (en) | 2010-07-09 | 2022-09-21 | GID BIO, Inc. | Apparatus and methods relating to collecting and processing human biological material containing adipose |
-
2013
- 2013-04-24 SG SG11201407768QA patent/SG11201407768QA/en unknown
- 2013-04-24 JP JP2015509109A patent/JP2015516812A/ja active Pending
- 2013-04-24 EP EP13780959.6A patent/EP2844738A4/en not_active Ceased
- 2013-04-24 US US14/397,080 patent/US11963977B2/en active Active
- 2013-04-24 CN CN201380033613.9A patent/CN104718283A/zh active Pending
- 2013-04-24 WO PCT/US2013/037996 patent/WO2013163296A1/en not_active Ceased
- 2013-04-24 SG SG10201809901SA patent/SG10201809901SA/en unknown
- 2013-04-24 AU AU2013251649A patent/AU2013251649B2/en active Active
- 2013-04-24 CN CN202010907822.3A patent/CN112048466A/zh active Pending
- 2013-04-24 KR KR1020207019169A patent/KR20200084916A/ko not_active Ceased
- 2013-04-24 KR KR1020147032963A patent/KR20150045935A/ko not_active Ceased
- 2013-04-24 RU RU2014147093A patent/RU2696071C2/ru active
- 2013-04-24 EP EP18203532.9A patent/EP3483261B1/en active Active
- 2013-04-24 ES ES18203532T patent/ES2972525T3/es active Active
- 2013-04-24 CA CA2885576A patent/CA2885576A1/en active Pending
-
2018
- 2018-06-20 JP JP2018117481A patent/JP2018183145A/ja not_active Withdrawn
-
2019
- 2019-06-05 AU AU2019203943A patent/AU2019203943B2/en active Active
-
2020
- 2020-07-16 JP JP2020122035A patent/JP2020182480A/ja not_active Withdrawn
-
2022
- 2022-11-01 JP JP2022175459A patent/JP2023002805A/ja active Pending
-
2025
- 2025-04-03 JP JP2025061922A patent/JP2025106394A/ja active Pending
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