JP2015516406A - 亜鉛を含む熱成形された不正使用防止医薬剤形 - Google Patents

亜鉛を含む熱成形された不正使用防止医薬剤形 Download PDF

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Publication number
JP2015516406A
JP2015516406A JP2015510834A JP2015510834A JP2015516406A JP 2015516406 A JP2015516406 A JP 2015516406A JP 2015510834 A JP2015510834 A JP 2015510834A JP 2015510834 A JP2015510834 A JP 2015510834A JP 2015516406 A JP2015516406 A JP 2015516406A
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Japan
Prior art keywords
pharmaceutical dosage
dosage form
polyalkylene oxide
zinc
ppm
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2015510834A
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English (en)
Japanese (ja)
Inventor
バルンシャイト・ルッツ
ガリア・エーリク
ガイスラー・アンヤ
ペッツ・ヤーナ
シュヴィーア・ゼバスティアン
バーロンスキー−プロープスト・ユーリア
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グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
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Publication of JP2015516406A publication Critical patent/JP2015516406A/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2015510834A 2012-05-11 2013-05-10 亜鉛を含む熱成形された不正使用防止医薬剤形 Pending JP2015516406A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003743.7 2012-05-11
EP12003743 2012-05-11
PCT/EP2013/059728 WO2013167735A1 (en) 2012-05-11 2013-05-10 Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc

Related Child Applications (1)

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JP2017211487A Division JP6541748B2 (ja) 2012-05-11 2017-11-01 亜鉛を含む熱成形された不正使用防止医薬製剤

Publications (1)

Publication Number Publication Date
JP2015516406A true JP2015516406A (ja) 2015-06-11

Family

ID=48407572

Family Applications (2)

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JP2015510834A Pending JP2015516406A (ja) 2012-05-11 2013-05-10 亜鉛を含む熱成形された不正使用防止医薬剤形
JP2017211487A Expired - Fee Related JP6541748B2 (ja) 2012-05-11 2017-11-01 亜鉛を含む熱成形された不正使用防止医薬製剤

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JP2017211487A Expired - Fee Related JP6541748B2 (ja) 2012-05-11 2017-11-01 亜鉛を含む熱成形された不正使用防止医薬製剤

Country Status (21)

Country Link
EP (1) EP2846835B1 (https=)
JP (2) JP2015516406A (https=)
CN (1) CN104428002B (https=)
AU (1) AU2013257943B2 (https=)
BR (1) BR112014026768A2 (https=)
CA (1) CA2870012A1 (https=)
CY (1) CY1119637T1 (https=)
DK (1) DK2846835T3 (https=)
EA (1) EA029171B1 (https=)
ES (1) ES2650945T3 (https=)
HR (1) HRP20171718T1 (https=)
HU (1) HUE035123T2 (https=)
IL (1) IL234815A0 (https=)
LT (1) LT2846835T (https=)
MX (1) MX357783B (https=)
NO (1) NO2846835T3 (https=)
PL (1) PL2846835T3 (https=)
PT (1) PT2846835T (https=)
RS (1) RS56685B1 (https=)
SI (1) SI2846835T1 (https=)
WO (1) WO2013167735A1 (https=)

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US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
KR101616246B1 (ko) 2008-01-25 2016-05-02 그뤼넨탈 게엠베하 약제학적 투여형
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WO2011009602A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Hot-melt extruded controlled release dosage form
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WO2012028318A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
ES2648129T3 (es) 2011-07-29 2017-12-28 Grünenthal GmbH Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
AU2012289764B2 (en) 2011-07-29 2017-03-02 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
PL2838512T3 (pl) 2012-04-18 2018-12-31 Grünenthal GmbH Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
JP6449871B2 (ja) 2013-07-12 2019-01-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エチレン−酢酸ビニルポリマーを含有する改変防止剤形
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
EP3142646A1 (en) 2014-05-12 2017-03-22 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
EA201692388A1 (ru) 2014-05-26 2017-05-31 Грюненталь Гмбх Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
MX2017013643A (es) 2015-04-24 2018-03-08 Gruenenthal Gmbh Combinacion de dosis fija resistente a la manipulacion que proporciona una liberacion rapida de dos farmacos desde particulas y una matriz.
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
US20160310437A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant fixed dose combination providing fast release of two drugs from particles
CA2983640A1 (en) 2015-04-24 2016-10-27 Grunenthal Gmbh Tamper-resistant fixed dose combination providing fast release of two drugs from different particles
US10183018B2 (en) 2015-05-28 2019-01-22 Lumosa Therapeutics Co., Ltd. Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester
US11234974B2 (en) 2015-05-28 2022-02-01 Lumosa Therapeutics Co., Ltd. Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester
WO2017042325A1 (en) 2015-09-10 2017-03-16 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations

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JPH0517566A (ja) * 1991-07-11 1993-01-26 Sumitomo Seika Chem Co Ltd アルキレンオキシド重合体の製造方法
JP2007501201A (ja) * 2003-08-06 2007-01-25 グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 乱用防止剤形
WO2011009603A1 (en) * 2009-07-22 2011-01-27 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive oploids
EP2402004A2 (en) * 2003-11-26 2012-01-04 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms

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DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
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JP2007501201A (ja) * 2003-08-06 2007-01-25 グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 乱用防止剤形
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WO2011009603A1 (en) * 2009-07-22 2011-01-27 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive oploids

Also Published As

Publication number Publication date
HUE035123T2 (en) 2018-05-02
CA2870012A1 (en) 2013-11-14
AU2013257943B2 (en) 2017-10-05
CN104428002B (zh) 2017-08-11
EA201401240A1 (ru) 2015-04-30
DK2846835T3 (en) 2017-12-04
CY1119637T1 (el) 2018-04-04
SI2846835T1 (en) 2018-01-31
RS56685B1 (sr) 2018-03-30
EP2846835A1 (en) 2015-03-18
IL234815A0 (en) 2014-12-31
HK1207978A1 (en) 2016-02-19
EA029171B1 (ru) 2018-02-28
ES2650945T3 (es) 2018-01-23
WO2013167735A1 (en) 2013-11-14
HRP20171718T1 (hr) 2017-12-29
PL2846835T3 (pl) 2018-02-28
BR112014026768A2 (pt) 2017-06-27
NO2846835T3 (https=) 2018-02-03
JP2018065810A (ja) 2018-04-26
EP2846835B1 (en) 2017-09-06
MX2014013095A (es) 2014-12-08
JP6541748B2 (ja) 2019-07-10
MX357783B (es) 2018-07-25
PT2846835T (pt) 2017-12-15
LT2846835T (lt) 2017-12-27
CN104428002A (zh) 2015-03-18
AU2013257943A1 (en) 2014-10-09

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