JP2015516240A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015516240A5 JP2015516240A5 JP2015511774A JP2015511774A JP2015516240A5 JP 2015516240 A5 JP2015516240 A5 JP 2015516240A5 JP 2015511774 A JP2015511774 A JP 2015511774A JP 2015511774 A JP2015511774 A JP 2015511774A JP 2015516240 A5 JP2015516240 A5 JP 2015516240A5
- Authority
- JP
- Japan
- Prior art keywords
- vivo
- ophthalmic
- arm
- electrophilic
- nucleophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001727 in vivo Methods 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 11
- 238000009472 formulation Methods 0.000 claims 10
- 239000000178 monomer Substances 0.000 claims 10
- 229920005862 polyol Polymers 0.000 claims 10
- 150000003077 polyols Chemical class 0.000 claims 9
- 230000000269 nucleophilic effect Effects 0.000 claims 8
- 238000002360 preparation method Methods 0.000 claims 8
- 239000000499 gel Substances 0.000 claims 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- PTJWCLYPVFJWMP-UHFFFAOYSA-N 2-[[3-hydroxy-2-[[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]methyl]-2-(hydroxymethyl)propoxy]methyl]-2-(hydroxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC(CO)(CO)COCC(CO)(CO)CO PTJWCLYPVFJWMP-UHFFFAOYSA-N 0.000 claims 3
- 235000010443 alginic acid Nutrition 0.000 claims 3
- 229920000615 alginic acid Polymers 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 229920000609 methyl cellulose Polymers 0.000 claims 3
- 239000001923 methylcellulose Substances 0.000 claims 3
- 235000010981 methylcellulose Nutrition 0.000 claims 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- 206010038848 Retinal detachment Diseases 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 2
- 229940045110 chitosan Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 125000003827 glycol group Chemical group 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 2
- 229960002900 methylcellulose Drugs 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 229940068984 polyvinyl alcohol Drugs 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 230000004264 retinal detachment Effects 0.000 claims 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 2
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 150000003923 2,5-pyrrolediones Chemical class 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920001817 Agar Polymers 0.000 claims 1
- 241000416162 Astragalus gummifer Species 0.000 claims 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims 1
- 240000007472 Leucaena leucocephala Species 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 1
- 229920001100 Polydextrose Polymers 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 229920001615 Tragacanth Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 229940023476 agar Drugs 0.000 claims 1
- 235000010419 agar Nutrition 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- 229940009868 aluminum magnesium silicate Drugs 0.000 claims 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims 1
- 239000000440 bentonite Substances 0.000 claims 1
- 229940092782 bentonite Drugs 0.000 claims 1
- 229910000278 bentonite Inorganic materials 0.000 claims 1
- 235000012216 bentonite Nutrition 0.000 claims 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims 1
- 229940082500 cetostearyl alcohol Drugs 0.000 claims 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 1
- 229940086555 cyclomethicone Drugs 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 229960004667 ethyl cellulose Drugs 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229940014259 gelatin Drugs 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 238000001879 gelation Methods 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 229940049654 glyceryl behenate Drugs 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 229910000271 hectorite Inorganic materials 0.000 claims 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000001341 hydroxy propyl starch Substances 0.000 claims 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- 229940100655 ophthalmic gel Drugs 0.000 claims 1
- 229950005134 polycarbophil Drugs 0.000 claims 1
- 235000013856 polydextrose Nutrition 0.000 claims 1
- 239000001259 polydextrose Substances 0.000 claims 1
- 229940035035 polydextrose Drugs 0.000 claims 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 229960003975 potassium Drugs 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 claims 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 229910000275 saponite Inorganic materials 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229960002668 sodium chloride Drugs 0.000 claims 1
- 229940012831 stearyl alcohol Drugs 0.000 claims 1
- -1 succinimidyl Chemical group 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 229960004793 sucrose Drugs 0.000 claims 1
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 235000010487 tragacanth Nutrition 0.000 claims 1
- 239000000196 tragacanth Substances 0.000 claims 1
- 229940116362 tragacanth Drugs 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261646227P | 2012-05-11 | 2012-05-11 | |
| US61/646,227 | 2012-05-11 | ||
| US201261669577P | 2012-07-09 | 2012-07-09 | |
| US61/669,577 | 2012-07-09 | ||
| US201361785358P | 2013-03-14 | 2013-03-14 | |
| US61/785,358 | 2013-03-14 | ||
| PCT/US2013/040619 WO2013170195A1 (en) | 2012-05-11 | 2013-05-10 | Biocompatible hydrogel treatments for retinal detachment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516240A JP2015516240A (ja) | 2015-06-11 |
| JP2015516240A5 true JP2015516240A5 (https=) | 2016-06-30 |
| JP6206987B2 JP6206987B2 (ja) | 2017-10-04 |
Family
ID=49551314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511774A Active JP6206987B2 (ja) | 2012-05-11 | 2013-05-10 | 網膜剥離の処置のための生体適合性ヒドロゲル製剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US9072809B2 (https=) |
| EP (1) | EP2846847B1 (https=) |
| JP (1) | JP6206987B2 (https=) |
| CN (1) | CN104428014B (https=) |
| AU (1) | AU2013259166B2 (https=) |
| CA (1) | CA2873105C (https=) |
| WO (1) | WO2013170195A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10227289B2 (en) | 2010-05-07 | 2019-03-12 | Medicus Biosciences, Llc | Methods for treating diseases of the lung |
| US10111985B2 (en) * | 2011-08-10 | 2018-10-30 | Medicus Biosciences, Llc | Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules |
| US11083821B2 (en) * | 2011-08-10 | 2021-08-10 | C.P. Medical Corporation | Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules |
| ES2658897T3 (es) | 2011-08-24 | 2018-03-12 | Novan, Inc. | Macromoléculas de liberación de óxido nítrico ajustables que tienen múltiples estructuras donantes de óxido nítrico |
| JP6206987B2 (ja) | 2012-05-11 | 2017-10-04 | メディカス バイオサイエンシーズ，エルエルシー | 網膜剥離の処置のための生体適合性ヒドロゲル製剤 |
| CA2903829C (en) | 2013-03-14 | 2021-09-07 | Medicus Biosciences Llc | Biocompatible hydrogel polymer matrix for delivery of cells |
| US11813284B2 (en) | 2013-08-08 | 2023-11-14 | Novan, Inc. | Topical compositions and methods of using the same |
| CN106232618A (zh) | 2013-10-11 | 2016-12-14 | 马萨诸塞眼科耳科诊所 | 预测祖先病毒序列的方法及其用途 |
| US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
| WO2016100355A1 (en) * | 2014-12-15 | 2016-06-23 | The Regents Of The University Of Colorado, A Body Corporate | Biocompatible hydrogels, systems including the hydrogels, and methods of using and forming same |
| EP3291765A4 (en) | 2015-05-07 | 2019-01-23 | Massachusetts Eye & Ear Infirmary | METHOD FOR THE DELIVERY OF AN ACTIVE SUBSTANCE TO THE EYE |
| CA2993415A1 (en) * | 2015-10-28 | 2017-05-04 | Technology Innovation Momentum Fund (Israel) Limited Partnership | Composite bioadhesive sealant |
| US20170165109A1 (en) * | 2015-12-14 | 2017-06-15 | Novartis Ag | Patch for sealing retinal breaks and associated devices, systems, and methods |
| WO2018013819A1 (en) | 2016-07-13 | 2018-01-18 | Massachusetts Eye And Ear Infirmary | Methods and polymer compositions for treating retinal detachment and other ocular disorders |
| WO2018213433A1 (en) * | 2017-05-16 | 2018-11-22 | Biocure, Inc. | Hydrogel medical adhesives |
| US11981619B2 (en) * | 2017-07-07 | 2024-05-14 | Basf Se | Alkoxylated esteramines and salts thereof |
| WO2019017491A1 (ja) * | 2017-07-20 | 2019-01-24 | 国立研究開発法人理化学研究所 | 神経組織の保存方法 |
| EP3737431A4 (en) * | 2018-01-12 | 2021-10-27 | Pykus Therapeutics, Inc. | METHODS, POLYMER-CONTAINING FORMULATIONS AND POLYMER COMPOSITIONS FOR TREATMENT OF RETAIN DETECTION AND OTHER EYE DISEASES |
| US12037707B2 (en) | 2018-04-05 | 2024-07-16 | Massachusetts Eye And Ear Infirmary | Methods of making and using combinatorial barcoded nucleic acid libraries having defined variation |
| BR112021000180A2 (pt) | 2018-07-09 | 2021-05-11 | Regeneron Pharmaceuticals, Inc. | método de produção de um hidrogel, e, hidrogel |
| US12414761B2 (en) | 2018-07-19 | 2025-09-16 | Sanulus Medical, LLC | Devices and methods for targeted delivery of a substance |
| US12089893B2 (en) | 2018-07-19 | 2024-09-17 | Sanulus Medical, LLC | Devices and methods for targeted delivery of a substance |
| EP4090317A4 (en) * | 2020-01-16 | 2024-02-21 | The Hong Kong University of Science and Technology | COMPOSITIONS AND METHODS FOR THE CONTROLLED RELEASE OF A TARGET AGENT |
| TW202139993A (zh) * | 2020-03-16 | 2021-11-01 | 瑞士商辛鐵堤卡公司 | 具有經改良之功能性的眼用氯普魯卡因(chloroprocaine)凝膠 |
| CN115209926B (zh) * | 2020-03-25 | 2024-05-14 | 学校法人福冈大学 | 用于眼内膜剥离术的制剂 |
| US20210346208A1 (en) * | 2020-05-05 | 2021-11-11 | Meghana Sai Sunkara | AlgaeAid |
| CN115666511A (zh) * | 2020-05-13 | 2023-01-31 | 斯皮拉尔诊疗有限公司 | 用于将化合物施用于内耳的胶凝化溶液 |
| WO2023086098A1 (en) * | 2021-11-12 | 2023-05-19 | Ocular Therapeutix, Inc. | Ocular sealant formulations and systems and methods of preparation and use thereof |
| US11883378B2 (en) | 2021-11-24 | 2024-01-30 | Pykus Therapeutics, Inc. | Hydrogel formulations and methods and devices for focal administration of the same |
| CN120459009A (zh) * | 2024-04-29 | 2025-08-12 | 浙江瑞瞳生物科技有限公司 | 可降解泪小管插入剂及制备方法 |
| US12233157B1 (en) | 2024-07-24 | 2025-02-25 | Pykus Therapeutics, Inc. | Hydrogel formulations and methods and devices for administration of the same |
| CN120571053A (zh) * | 2025-06-19 | 2025-09-02 | 青岛大学附属医院 | 一种用于密封视网膜裂孔的可荧光示踪的水凝胶材料及其制备方法与应用 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037384B2 (en) | 1988-01-12 | 1995-12-26 | Cornell Res Foundation Inc | Method and apparatus for the treatment of complicated retinal detachments |
| DE3903672C1 (https=) * | 1989-02-08 | 1990-02-01 | Lohmann Gmbh & Co Kg | |
| US5336175A (en) | 1992-10-29 | 1994-08-09 | Mames Robert N | Method for the treatment of retinal detachments |
| US6458889B1 (en) | 1995-12-18 | 2002-10-01 | Cohesion Technologies, Inc. | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
| WO1997022371A1 (en) | 1995-12-18 | 1997-06-26 | Collagen Corporation | Crosslinked polymer compositions and methods for their use |
| US5858345A (en) | 1996-04-08 | 1999-01-12 | Alcon Laboratories, Inc. | In vivo polymerizable ophthalmic compositions |
| US6180687B1 (en) | 1996-04-08 | 2001-01-30 | Alcon Laboratories, Inc. | In vivo polymerizable ophthalmic compositions and methods of using |
| US6194531B1 (en) * | 1996-06-05 | 2001-02-27 | Nippon Shokubai Co., Ltd. | Method for production of cross-linked polymer |
| US5710137A (en) | 1996-08-16 | 1998-01-20 | The Trustees Of Columbia University In The City Of New York | Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype |
| WO1998012274A1 (en) | 1996-09-23 | 1998-03-26 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
| US7009034B2 (en) | 1996-09-23 | 2006-03-07 | Incept, Llc | Biocompatible crosslinked polymers |
| US6135118A (en) | 1997-05-12 | 2000-10-24 | Dailey; James P. | Treatment with magnetic fluids |
| GEP20022707B (en) | 1997-07-18 | 2002-06-25 | Infimed Inc Us | Biodegrading Macromers for the Controlled Release of Biologically Active Substances |
| WO1999021512A1 (en) | 1997-10-27 | 1999-05-06 | The Regents Of The University Of California | Methods and pharmaceutical compositions for the closure of retinal breaks |
| US20050255039A1 (en) | 1998-06-26 | 2005-11-17 | Pro Surg, Inc., A California Corporation | Gel injection treatment of breast, fibroids & endometrial ablation |
| US6703047B2 (en) | 2001-02-02 | 2004-03-09 | Incept Llc | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use |
| US6632457B1 (en) | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US6605294B2 (en) | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| US6818018B1 (en) * | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| JP2002531217A (ja) | 1998-12-04 | 2002-09-24 | チャンドラシェカー ピー． パサック， | 生体適合性架橋ポリマー |
| US6312725B1 (en) | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
| WO2001010416A1 (en) | 1999-08-11 | 2001-02-15 | Alkermes Controlled Therapeutics, Inc. | Method of delivering a chemotherapeutic agent to a solid tumor |
| US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
| SE0101523L (sv) | 2000-12-29 | 2002-06-30 | Artimplant Ab | Linjär polymer |
| US7255874B1 (en) * | 2001-12-21 | 2007-08-14 | Closure Medical Corporation | Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto |
| US20030223957A1 (en) * | 2002-04-10 | 2003-12-04 | Schwartz Daniel M. | Biodegradable PEG based polymer formulations in ocular applications |
| JP4167039B2 (ja) | 2002-04-10 | 2008-10-15 | 三菱重工業株式会社 | ガスタービン単独プラントの改造方法、触媒の再利用方法 |
| WO2004021983A2 (en) | 2002-09-03 | 2004-03-18 | Promethean Surgical Devices Llc | In situ polymerizing medical compositions |
| US6703378B1 (en) | 2002-09-19 | 2004-03-09 | Bausch & Lomb Incorporated | Vitreoretinal tamponades based on fluorosilicone fluids |
| MXPA05005545A (es) * | 2002-11-25 | 2005-10-18 | Attenuon Llc | Peptidos que se dirigen a celulas tomurales y endoteliales, composiciones y usos de los mismos. |
| KR101113201B1 (ko) | 2003-02-19 | 2012-04-12 | 나트릭스 세퍼레이션즈, 인코포레이티드 | 지지된 다공성 젤을 함유하는 복합재 |
| US20050208102A1 (en) | 2003-04-09 | 2005-09-22 | Schultz Clyde L | Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases |
| US20050203333A1 (en) | 2003-12-15 | 2005-09-15 | Dailey James P. | Magnetized scleral buckle, polymerizing magnetic polymers, and other magnetic manipulations in living tissue |
| GB0404693D0 (en) * | 2004-03-02 | 2004-04-07 | Univ London | Pharmaceutical preparations for the treatment of ocular surface and other disorders |
| US7009343B2 (en) | 2004-03-11 | 2006-03-07 | Kevin Len Li Lim | System and method for producing white light using LEDs |
| CN104174071A (zh) | 2004-04-28 | 2014-12-03 | 安希奥设备国际有限责任公司 | 用于形成交联生物材料的组合物和系统及关联的制备方法与用途 |
| US7553810B2 (en) | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
| US8361490B2 (en) | 2004-09-16 | 2013-01-29 | Theracoat Ltd. | Biocompatible drug delivery apparatus and methods |
| US20060062768A1 (en) | 2004-09-23 | 2006-03-23 | Olexander Hnojewyj | Biocompatible hydrogel compositions |
| US20060065199A1 (en) | 2004-09-24 | 2006-03-30 | Davis Waldon E | Gravity filled animal feeder with a method and means for collapsing while simultaneously closing the feed container and for expanding while simultaneously opening and dispensing animal feed |
| WO2012050591A1 (en) * | 2010-10-15 | 2012-04-19 | Rutgers, The State University Of New Jersey | Hydrogel formulation for dermal and ocular delivery |
| US7659260B2 (en) | 2005-01-14 | 2010-02-09 | Eddie Francis Kadrmas | Tamponade compositions and methods for retinal repair |
| US8388995B1 (en) | 2006-02-03 | 2013-03-05 | Auburn University | Controlled and extended delivery of hyaluronic acid and comfort molecules via a contact lens platform |
| US7667063B2 (en) * | 2005-03-23 | 2010-02-23 | Nichia Corporation | Method for producing trialkyl gallium |
| US20060222596A1 (en) | 2005-04-01 | 2006-10-05 | Trivascular, Inc. | Non-degradable, low swelling, water soluble radiopaque hydrogel polymer |
| GB0510196D0 (en) | 2005-05-19 | 2005-06-22 | Univ Liverpool | Composition for treatment of a detached retina and method of production thereof |
| US20070031498A1 (en) * | 2005-08-02 | 2007-02-08 | Wright Medical Technology, Inc. | Gel composition for cellular adhesion inhibition |
| US7815418B2 (en) | 2005-08-03 | 2010-10-19 | Mitsubishi Heavy Industries, Ltd. | Shroud and rotary vane wheel of propeller fan and propeller fan |
| CN101466408A (zh) | 2005-11-02 | 2009-06-24 | 艾里斯治疗公司 | 聚阳离子-聚阴离子络合物、组合物及其使用方法 |
| US7861710B2 (en) | 2006-06-30 | 2011-01-04 | Aeris Therapeutics, Inc. | Respiratory assistance apparatus and method |
| AU2007297776A1 (en) | 2006-09-21 | 2008-03-27 | Tissue Genesis, Inc. | Cell delivery matrices |
| WO2008039827A2 (en) | 2006-09-26 | 2008-04-03 | Aeris Therapeutics, Inc. | Polymer systems for lung volume reduction therapy |
| US20080159975A1 (en) | 2006-12-20 | 2008-07-03 | Sunbio, Inc. | Hair treatment composition, hair treatment agent and method for treating hair by using the same |
| AR065404A1 (es) | 2007-02-21 | 2009-06-03 | Medarex Inc | Conjugados farmaco-ligando, los que se unen a citotoxinas potentes, composicion farmaceutica que los contienen y su uso para retardar o detener el crecimiento de un tumor en un mamifero |
| US8911750B2 (en) | 2007-04-03 | 2014-12-16 | Larry W. Tsai | Lung volume reduction therapy using crosslinked biopolymers |
| CA2686563A1 (en) | 2007-05-11 | 2008-11-20 | Aeris Therapeutics, Llc | Lung volume reduction therapy using crosslinked non-natural polymers |
| US20090087443A1 (en) | 2007-09-27 | 2009-04-02 | Bartels Stephen P | Pharmacological Adjunctive Treatment Associated with Glaucoma Filtration Surgery |
| US8114883B2 (en) | 2007-12-04 | 2012-02-14 | Landec Corporation | Polymer formulations for delivery of bioactive materials |
| AU2009214615B2 (en) * | 2008-02-13 | 2014-06-12 | Hyperbranch Medical Technology, Inc. | Crosslinked polyalkyleneimine hydrogels with tunable degradation rates |
| CA2720474A1 (en) | 2008-04-04 | 2009-10-08 | Rutgers University | Nanocarrier and nanogel compositions |
| US9125814B2 (en) | 2008-04-22 | 2015-09-08 | Angiotech Pharmaceuticals, Inc. | Biocompatible crosslinked hydrogels, drug-loaded hydrogels and methods of using the same |
| US20100055078A1 (en) | 2008-08-15 | 2010-03-04 | The Government of the U.S.A, as represented by the Department of Veterans Affairs | Methods of making a transplantable bone repair system using multipotent stem cells |
| WO2010059894A1 (en) | 2008-11-21 | 2010-05-27 | Bridge Pharma, Inc. | Ocular formulations of norketotifen |
| US20110293722A1 (en) | 2008-12-04 | 2011-12-01 | Techion Research And Development Foundation Ltd. | Hydrogel sponges, methods of producing them and uses thereof |
| FR2940616A1 (fr) | 2008-12-30 | 2010-07-02 | Lfb Biotechnologies | Utilisation d'un anticorps anti-cd20 pour le traitement du lymphome primaire intraoculaire. |
| JP5890182B2 (ja) | 2009-02-12 | 2016-03-22 | インセプト エルエルシー | ヒドロゲルプラグによる薬物送達 |
| US20110104280A1 (en) * | 2009-05-20 | 2011-05-05 | Olexander Hnojewyj | Wound treatment systems, devices, and methods using biocompatible synthetic hydrogel compositions |
| US20110081701A1 (en) | 2009-10-02 | 2011-04-07 | Timothy Sargeant | Surgical compositions |
| DE102009049506A1 (de) * | 2009-10-15 | 2011-04-21 | Schülke & Mayr GmbH | Octenidindihydrochlorid enthaltende Wundauflage zur Anwendung bei der Antiseptik von Kathetereintrittsstellen |
| CN106913902A (zh) | 2009-11-09 | 2017-07-04 | 聚光灯技术合伙有限责任公司 | 多糖基水凝胶 |
| PT2503995T (pt) | 2009-11-24 | 2017-11-23 | Grifols Therapeutics Inc | Métodos de liofilização, composições e kits |
| US8283463B2 (en) | 2010-02-09 | 2012-10-09 | Bausch & Lomb Incorporated | Sterile hyaluronic acid solutions |
| US10227289B2 (en) | 2010-05-07 | 2019-03-12 | Medicus Biosciences, Llc | Methods for treating diseases of the lung |
| CN103429268B (zh) * | 2011-01-04 | 2015-11-25 | 本德尔分析控股有限公司 | 从亲电活化的聚噁唑啉衍生的经交联的聚合物和植入物 |
| US10111985B2 (en) | 2011-08-10 | 2018-10-30 | Medicus Biosciences, Llc | Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules |
| JP6206987B2 (ja) | 2012-05-11 | 2017-10-04 | メディカス バイオサイエンシーズ，エルエルシー | 網膜剥離の処置のための生体適合性ヒドロゲル製剤 |
| CA2903829C (en) | 2013-03-14 | 2021-09-07 | Medicus Biosciences Llc | Biocompatible hydrogel polymer matrix for delivery of cells |
-
2013
- 2013-05-10 JP JP2015511774A patent/JP6206987B2/ja active Active
- 2013-05-10 EP EP13787696.7A patent/EP2846847B1/en active Active
- 2013-05-10 WO PCT/US2013/040619 patent/WO2013170195A1/en not_active Ceased
- 2013-05-10 CA CA2873105A patent/CA2873105C/en active Active
- 2013-05-10 AU AU2013259166A patent/AU2013259166B2/en active Active
- 2013-05-10 CN CN201380037109.6A patent/CN104428014B/zh active Active
-
2014
- 2014-05-08 US US14/273,408 patent/US9072809B2/en active Active
-
2015
- 2015-05-27 US US14/722,829 patent/US9623144B2/en active Active
-
2017
- 2017-03-23 US US15/467,019 patent/US10507262B2/en active Active
-
2019
- 2019-12-06 US US16/705,811 patent/US11596710B2/en active Active
-
2023
- 2023-01-10 US US18/152,430 patent/US20230218799A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015516240A5 (https=) | ||
| Zahir-Jouzdani et al. | In situ gelling and mucoadhesive polymers: why do they need each other? | |
| ES2794048T3 (es) | Composición que comprende un agente gelificante más glucano | |
| US20240293327A1 (en) | Monolithic tablets based on carboxyl polymeric complexes for controlled drug release | |
| Wang et al. | In situ gel-forming system: an attractive alternative for nasal drug delivery | |
| Mahajan et al. | Mucoadhesive drug delivery system: a review | |
| Khare et al. | Mucoadhesive polymers for enhancing retention in ocular drug delivery: a critical review | |
| JP2018040002A5 (https=) | ||
| JP2013544817A5 (https=) | ||
| JP2016006108A5 (https=) | ||
| JP2010523480A5 (https=) | ||
| RU2016151163A (ru) | Композиции, включающие электрогидродинамически полученные волокна, для нанесения заданных доз активного вещества на кожу или слизистую оболочку | |
| JP2012506904A5 (https=) | ||
| RU2012101818A (ru) | Наноструктурированное основание силденафила, его фармацевтически приемлемые соли и со-кристаллы, их композиции, способ их получения и содержащие их фармацевтические композиции | |
| JP2016539953A5 (https=) | ||
| JP2023503524A (ja) | 生分解性ポリマーを有する溶解性ポリマー眼科用インサート | |
| JPWO2017022248A1 (ja) | 腸溶性カプセル | |
| CN104888224A (zh) | 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法 | |
| JP2013506728A (ja) | ビタミンｂ部分構造を持つ粘膜付着性ポリマー | |
| Boateng et al. | Polysaccharide based formulations for mucosal drug delivery: a review | |
| JP2019519570A5 (https=) | ||
| Konatham et al. | In situ gel polymers: A review | |
| WO2011018800A2 (en) | A novel in-situ gel forming solution for ocular drug delivery | |
| Osmałek et al. | Gadzi nski | |
| Kavitha et al. | Cellulose-derived materials for drug delivery applications |