JP2015514809A5 - - Google Patents
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- Publication number
- JP2015514809A5 JP2015514809A5 JP2015509147A JP2015509147A JP2015514809A5 JP 2015514809 A5 JP2015514809 A5 JP 2015514809A5 JP 2015509147 A JP2015509147 A JP 2015509147A JP 2015509147 A JP2015509147 A JP 2015509147A JP 2015514809 A5 JP2015514809 A5 JP 2015514809A5
- Authority
- JP
- Japan
- Prior art keywords
- microspheres
- composition
- aspect ratio
- mannitol
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004005 microsphere Substances 0.000 claims description 168
- 239000000203 mixture Substances 0.000 claims description 99
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 34
- 229930195725 Mannitol Natural products 0.000 claims description 34
- 239000000594 mannitol Substances 0.000 claims description 34
- 235000010355 mannitol Nutrition 0.000 claims description 34
- 239000002245 particle Substances 0.000 claims description 31
- 229920005862 polyol Polymers 0.000 claims description 12
- 150000003077 polyols Chemical class 0.000 claims description 12
- 238000009826 distribution Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000004386 Erythritol Substances 0.000 claims description 5
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 5
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 5
- 235000019414 erythritol Nutrition 0.000 claims description 5
- 229940009714 erythritol Drugs 0.000 claims description 5
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000011324 bead Substances 0.000 description 14
- 239000007921 spray Substances 0.000 description 8
- 238000001878 scanning electron micrograph Methods 0.000 description 7
- 238000000576 coating method Methods 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000010191 image analysis Methods 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 230000008520 organization Effects 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 241000219109 Citrullus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 238000007431 microscopic evaluation Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
Images
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261638073P | 2012-04-25 | 2012-04-25 | |
| US61/638,073 | 2012-04-25 | ||
| US201361783603P | 2013-03-14 | 2013-03-14 | |
| US61/783,603 | 2013-03-14 | ||
| PCT/US2013/038257 WO2013163453A1 (en) | 2012-04-25 | 2013-04-25 | Crystalline microspheres and the process for manufacturing the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019043904A Division JP2019112438A (ja) | 2012-04-25 | 2019-03-11 | 結晶性マイクロスフェアおよびその同じ物を製造するためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514809A JP2015514809A (ja) | 2015-05-21 |
| JP2015514809A5 true JP2015514809A5 (https=) | 2017-08-10 |
| JP6577865B2 JP6577865B2 (ja) | 2019-09-18 |
Family
ID=49483900
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509147A Active JP6577865B2 (ja) | 2012-04-25 | 2013-04-25 | 結晶性マイクロスフェアおよびその同じ物を製造するためのプロセス |
| JP2019043904A Pending JP2019112438A (ja) | 2012-04-25 | 2019-03-11 | 結晶性マイクロスフェアおよびその同じ物を製造するためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019043904A Pending JP2019112438A (ja) | 2012-04-25 | 2019-03-11 | 結晶性マイクロスフェアおよびその同じ物を製造するためのプロセス |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20150140097A1 (https=) |
| EP (2) | EP3583935A1 (https=) |
| JP (2) | JP6577865B2 (https=) |
| BR (1) | BR112014026351B1 (https=) |
| CA (1) | CA2871429C (https=) |
| ES (1) | ES2729035T3 (https=) |
| IN (1) | IN2014DN09416A (https=) |
| MX (1) | MX359554B (https=) |
| WO (1) | WO2013163453A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL219362A (en) | 2012-04-23 | 2017-04-30 | Verint Systems Ltd | A system and method for predicting threatened points of interest |
| IN2014DN09416A (https=) | 2012-04-25 | 2015-07-17 | Spi Pharma Inc | |
| US10560842B2 (en) | 2015-01-28 | 2020-02-11 | Verint Systems Ltd. | System and method for combined network-side and off-air monitoring of wireless networks |
| IL242354B (en) | 2015-10-29 | 2019-09-26 | Verint Systems Ltd | System and method for identifying genuine base stations that serve rogue base stations |
| IL245299B (en) | 2016-04-25 | 2021-05-31 | Verint Systems Ltd | A system and method for decoding communication transmitted in a wireless local communication network |
| EP3917500A2 (en) * | 2019-01-31 | 2021-12-08 | Elektrofi, Inc. | Particle formation and morphology |
| WO2021050953A1 (en) | 2019-09-13 | 2021-03-18 | Elektrofi, Inc. | Compositions and methods for the delivery of therapeutic biologics for treatment of disease |
| US10639312B1 (en) * | 2019-12-06 | 2020-05-05 | Edenbridge Pharmaceuticals, LLC | Finished pharmaceutical dosage form of a methenamine salt such as methenamine mandelate |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820627A (en) * | 1986-03-24 | 1989-04-11 | Em Diagnostic Systems, Inc. | Method of preparing particles suitable for tabletting into diagnostic reagents |
| JPH0192403A (ja) | 1987-09-30 | 1989-04-11 | Aprica Kassai Inc | 使い捨ておむつ |
| FR2670398B1 (fr) * | 1990-12-14 | 1995-02-17 | Roquette Freres | Composition pulverulente directement compressible et procede d'obtention. |
| US5573783A (en) | 1995-02-13 | 1996-11-12 | Nano Systems L.L.C. | Redispersible nanoparticulate film matrices with protective overcoats |
| US6548095B1 (en) | 1996-08-24 | 2003-04-15 | Südzucker Aktiengesellschaft | Sugar-free compressed products |
| US6235947B1 (en) * | 1997-04-14 | 2001-05-22 | Takeda Chemical Industries, Ltd. | D-mannitol and its preparation |
| US5780055A (en) | 1996-09-06 | 1998-07-14 | University Of Maryland, Baltimore | Cushioning beads and tablet comprising the same capable of forming a suspension |
| JPH1092403A (ja) | 1996-09-17 | 1998-04-10 | Sanyo Electric Co Ltd | 電池収納機構及びこれを具えた電子機器 |
| JP3447042B2 (ja) * | 1997-07-23 | 2003-09-16 | フロイント産業株式会社 | 単一物質球形粒の製造方法 |
| GB9716432D0 (en) * | 1997-08-05 | 1997-10-08 | Cerestar Holding Bv | Tableting of erythritol |
| JP2000128774A (ja) | 1998-10-26 | 2000-05-09 | Tanabe Seiyaku Co Ltd | 薬物を含有する球形微粒子の製法 |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| AU2002226098A1 (en) * | 2000-10-30 | 2002-05-15 | The Board Of Regents, The University Of Texas System | Spherical particles produced by a hot-melt extrusion/spheronization process |
| AU2002346472A1 (en) * | 2001-11-20 | 2003-06-10 | Advanced Inhalation Research, Inc. | Particulate compositions for improving solubility of poorly soluble agents |
| US7118765B2 (en) | 2001-12-17 | 2006-10-10 | Spi Pharma, Inc. | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
| AU2003226021B2 (en) * | 2002-03-26 | 2008-07-17 | Teva Pharmaceutical Industries Ltd. | Drug microparticles |
| GB0228826D0 (en) * | 2002-12-11 | 2003-01-15 | Okpala Joseph | Hair technology in creating particles with improved delivery capabilities |
| WO2004067595A2 (en) * | 2003-01-29 | 2004-08-12 | Spi Polyols, Inc. | Compositions of polyol granules and processes of manufacture |
| US20050048127A1 (en) * | 2003-07-22 | 2005-03-03 | Larry Brown | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
| WO2005044193A2 (en) * | 2003-10-28 | 2005-05-19 | Spi Pharma, Inc. | Product and process for increasing compactibility of carbohydrates |
| US20070092562A1 (en) | 2003-10-28 | 2007-04-26 | Spi Pharma, Inc. | Product and process for increasing compactibility of carbohydrates |
| CA2549225A1 (en) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride |
| US8333995B2 (en) * | 2004-05-12 | 2012-12-18 | Baxter International, Inc. | Protein microspheres having injectable properties at high concentrations |
| EP1817009A2 (en) | 2004-11-24 | 2007-08-15 | Spi Pharma, Inc. | Orally disintegrating compositions |
| CN101155859B (zh) | 2005-04-06 | 2012-04-25 | 三洋化成工业株式会社 | 树脂颗粒和树脂分散体 |
| JP2007217651A (ja) * | 2006-02-20 | 2007-08-30 | Daicel Chem Ind Ltd | 環状ポリオレフィン系樹脂の球状粒子およびその製造方法 |
| EP2046269B1 (en) * | 2006-08-01 | 2010-12-15 | The Procter & Gamble Company | Benefit agent containing delivery particle |
| WO2008065504A1 (en) | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Multiparticulates of spray-coated drug and polymer on a meltable core |
| WO2008094877A2 (en) | 2007-01-30 | 2008-08-07 | Drugtech Corporation | Compositions for oral delivery of pharmaceuticals |
| WO2008146590A1 (ja) * | 2007-05-28 | 2008-12-04 | Mitsubishi Shoji Foodtech Co., Ltd. | 球形マンニトール結晶粒子 |
| JP5258268B2 (ja) | 2007-11-19 | 2013-08-07 | フロイント産業株式会社 | 球形粒の製造方法 |
| WO2010021300A1 (ja) * | 2008-08-18 | 2010-02-25 | 三菱商事フードテック株式会社 | 新規マンニトール打錠用賦形剤 |
| MX2011009053A (es) | 2009-03-09 | 2012-04-02 | Spi Pharma Inc | Excipientes de compresion directa con alta capacidad de compactacion y durables y sistemas de excipiente. |
| KR101830080B1 (ko) * | 2009-05-08 | 2018-02-21 | 엠플리큐어 아베 | 지오폴리머성 결합제를 포함하는 지속형 약물 전달 조성물 |
| JP2011157348A (ja) * | 2010-01-05 | 2011-08-18 | Fuji Chem Ind Co Ltd | 崩壊性高強度球状粒子組成物 |
| DE102010045479A1 (de) | 2010-09-16 | 2014-10-30 | Brace Capital Gmbh | Verfahren zur Mikroverkapselung, Herstellung von festen Formen mehrphasiger mischbarer und nichtmischbarer Materialien und Methode zur Herstellung vorgenannter Systeme |
| AU2011305572B2 (en) | 2010-09-20 | 2016-08-04 | Diane Goll | Microencapsulation process and product |
| IN2014DN09416A (https=) | 2012-04-25 | 2015-07-17 | Spi Pharma Inc |
-
2013
- 2013-04-25 IN IN9416DEN2014 patent/IN2014DN09416A/en unknown
- 2013-04-25 EP EP19163519.2A patent/EP3583935A1/en not_active Withdrawn
- 2013-04-25 MX MX2014012805A patent/MX359554B/es active IP Right Grant
- 2013-04-25 US US14/397,011 patent/US20150140097A1/en not_active Abandoned
- 2013-04-25 WO PCT/US2013/038257 patent/WO2013163453A1/en not_active Ceased
- 2013-04-25 ES ES13781897T patent/ES2729035T3/es active Active
- 2013-04-25 US US13/870,556 patent/US9089487B2/en active Active
- 2013-04-25 JP JP2015509147A patent/JP6577865B2/ja active Active
- 2013-04-25 CA CA2871429A patent/CA2871429C/en active Active
- 2013-04-25 BR BR112014026351-5A patent/BR112014026351B1/pt active IP Right Grant
- 2013-04-25 EP EP13781897.7A patent/EP2841057B1/en active Active
-
2015
- 2015-07-27 US US14/809,362 patent/US10245232B2/en active Active
-
2019
- 2019-03-11 JP JP2019043904A patent/JP2019112438A/ja active Pending
- 2019-04-01 US US16/371,262 patent/US11278496B2/en active Active
-
2022
- 2022-02-08 US US17/666,608 patent/US12233163B2/en active Active
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