JP2015514718A - スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 - Google Patents
スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 Download PDFInfo
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- JP2015514718A JP2015514718A JP2015504603A JP2015504603A JP2015514718A JP 2015514718 A JP2015514718 A JP 2015514718A JP 2015504603 A JP2015504603 A JP 2015504603A JP 2015504603 A JP2015504603 A JP 2015504603A JP 2015514718 A JP2015514718 A JP 2015514718A
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- protein
- lysine
- nitroxylated
- hemoglobin
- peg
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- 0 *C(CC(*)(*)N(C1(*)*)[O+])*1=N Chemical compound *C(CC(*)(*)N(C1(*)*)[O+])*1=N 0.000 description 2
- UTNXGFRRLPKXOH-UHFFFAOYSA-N CC(C)(CC(CC1(C)C)C(OCCC(CC(CC2)=O)C2=O)=O)N1O Chemical compound CC(C)(CC(CC1(C)C)C(OCCC(CC(CC2)=O)C2=O)=O)N1O UTNXGFRRLPKXOH-UHFFFAOYSA-N 0.000 description 1
- YNGXSUIXIITBFN-UHFFFAOYSA-O CC(C)(CC(CC1(C)C)OC(ON(C(CC2)=O)C2=O)=O)N1[OH2+] Chemical compound CC(C)(CC(CC1(C)C)OC(ON(C(CC2)=O)C2=O)=O)N1[OH2+] YNGXSUIXIITBFN-UHFFFAOYSA-O 0.000 description 1
- KCSZPESEWPIGJQ-UHFFFAOYSA-N O=C(CC1)C(CCN=O)C1=O Chemical compound O=C(CC1)C(CCN=O)C1=O KCSZPESEWPIGJQ-UHFFFAOYSA-N 0.000 description 1
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- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
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- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261619783P | 2012-04-03 | 2012-04-03 | |
| US201261619768P | 2012-04-03 | 2012-04-03 | |
| US61/619,768 | 2012-04-03 | ||
| US61/619,783 | 2012-04-03 | ||
| PCT/US2013/032704 WO2013151776A1 (en) | 2012-04-03 | 2013-03-15 | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018089859A Division JP6686067B2 (ja) | 2012-04-03 | 2018-05-08 | スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015514718A true JP2015514718A (ja) | 2015-05-21 |
| JP2015514718A5 JP2015514718A5 (enExample) | 2016-04-28 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504603A Pending JP2015514718A (ja) | 2012-04-03 | 2013-03-15 | スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 |
| JP2018089859A Expired - Fee Related JP6686067B2 (ja) | 2012-04-03 | 2018-05-08 | スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018089859A Expired - Fee Related JP6686067B2 (ja) | 2012-04-03 | 2018-05-08 | スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20150094267A1 (enExample) |
| EP (1) | EP2834329B1 (enExample) |
| JP (2) | JP2015514718A (enExample) |
| KR (1) | KR102076874B1 (enExample) |
| CN (1) | CN104411807B (enExample) |
| AU (2) | AU2013243875B2 (enExample) |
| CA (1) | CA2908238C (enExample) |
| MX (1) | MX358784B (enExample) |
| WO (1) | WO2013151776A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015514718A (ja) * | 2012-04-03 | 2015-05-21 | サンガート, インコーポレイテッド | スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 |
| JP6657070B2 (ja) * | 2013-03-15 | 2020-03-04 | ウィリアム・シンドラーWilliam Schindler | ポリアルキレンオキシド吉草酸ヘモグロビン接合体 |
| EP2894476A1 (en) * | 2014-01-14 | 2015-07-15 | Universität Konstanz | Genetically Encoded Spin Label |
| EP3380107B1 (en) * | 2015-11-24 | 2023-03-15 | Antiradical Therapeutics LLC | Compositions and methods of use of nano anti-radical therapeutics to inhibit cancer |
| CN105777893B (zh) * | 2016-03-24 | 2019-10-25 | 杭州亚慧生物科技有限公司 | 一种高强度血清白蛋白骨修复材料及其制备方法 |
| CA3070172A1 (en) | 2017-07-18 | 2019-01-24 | VirTech Bio, Inc. | Blood substitutes comprising hemoglobin and methods of making |
| CN114279777A (zh) * | 2020-09-28 | 2022-04-05 | 深圳市瑞图生物技术有限公司 | 一种含有脒基类化合物的溶血剂及其血液分析试剂盒 |
| CU24689B1 (es) * | 2020-10-05 | 2023-12-07 | Ct Inmunologia Molecular | CONJUGADOS COVALENTES DEL DOMINIO DE UNIÓN AL RECEPTOR DEL VIRUS SARS-CoV-2 Y UNA PROTEÍNA PORTADORA Y PROCEDIMIENTO DE OBTENCIÓN |
| CN118684612B (zh) * | 2024-08-26 | 2025-11-18 | 浙江瑞奥生物科技有限公司 | 一种马来聚乙二醇药物偶联剂的合成方法 |
| CN120682395B (zh) * | 2025-08-20 | 2025-11-07 | 复星安特金(成都)生物制药有限公司 | 一种活化细菌荚膜多糖的方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05504133A (ja) * | 1989-11-22 | 1993-07-01 | エンゾン,インコーポレーテッド | 効果的で、安定した、非免疫原性の赤血球代替物としての化学的修飾ヘモグロビン |
| JPH08502023A (ja) * | 1992-10-13 | 1996-03-05 | エンゾン,インコーポレーテッド | ポリアルキレンオキシド複合化ヘモグロビン溶液の分画 |
| JPH09501681A (ja) * | 1993-08-16 | 1997-02-18 | シャー、ジェン−チャン | ニトロキシドを用いる酸素毒性の防止用組成物と防止法 |
| JP2006502250A (ja) * | 2002-07-24 | 2006-01-19 | エフ.ホフマン−ラ ロシュ アーゲー | ポリアルキレングリコール酸添加剤 |
| JP2008074876A (ja) * | 1995-03-31 | 2008-04-03 | Synzyme Technologies Inc | ニトロキシドを生体適合性高分子と併用する組成物および方法 |
| WO2011106396A1 (en) * | 2010-02-25 | 2011-09-01 | Sangart, Inc. | Methods for preparing peg-hemoglobin conjugates using reduced reactant ratios |
| CN102249987A (zh) * | 2011-05-06 | 2011-11-23 | 兰州大学 | 一种考布他汀类化合物及其制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4240797A (en) | 1977-10-18 | 1980-12-23 | The Governing Council Of The University Of Toronto | Assay for reserve bilirubin binding capacity |
| US4529719A (en) | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| US5004809A (en) * | 1986-02-04 | 1991-04-02 | University Of Cincinnati | Nitroxide labeled nucleotides and nitroxide labeled hybridization probes |
| CA1312009C (en) | 1986-11-10 | 1992-12-29 | Carl W. Rausch | Extra pure semi-synthetic blood substitute |
| GB8710598D0 (en) | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
| US5650388A (en) | 1989-11-22 | 1997-07-22 | Enzon, Inc. | Fractionated polyalkylene oxide-conjugated hemoglobin solutions |
| US5250665A (en) | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
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| US6458758B1 (en) | 1993-08-16 | 2002-10-01 | Synzyme Technologies, Inc. | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5585484A (en) | 1995-04-19 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hemoglobin crosslinkers |
| US6627738B2 (en) | 1995-09-15 | 2003-09-30 | Duke University | No-modified hemoglobins and uses therefor |
| DE10031740A1 (de) | 2000-06-29 | 2002-02-14 | Sanguibio Tech Ag | Künstliche Sauerstoffträger aus vernetztem modifizierten Human- oder Schweinehämoglobin mit verbesserten Eigenschaften, Verfahren zu ihrer technisch einfachen Herstellung aus gereinigtem Material in hohen Ausbeuten, sowie deren Verwendung |
| US20030153491A1 (en) | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| DE10393955T5 (de) * | 2002-12-23 | 2005-12-29 | L'oreal | Zusammensetzung zum Färben von Keratinfasern, die mindestens eine freiradikalische Verbindung vom Nitroxyl-Typ und mindestens einen primären oder sekundären Alkohol enthält |
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| AU2013243875B2 (en) | 2017-11-30 |
| AU2018201285B2 (en) | 2020-05-14 |
| US20150094267A1 (en) | 2015-04-02 |
| JP2018150335A (ja) | 2018-09-27 |
| AU2018201285A1 (en) | 2018-03-22 |
| EP2834329A4 (en) | 2015-12-23 |
| MX358784B (es) | 2018-09-04 |
| CA2908238A1 (en) | 2013-10-10 |
| CA2908238C (en) | 2023-01-10 |
| KR102076874B1 (ko) | 2020-02-12 |
| CN104411807A (zh) | 2015-03-11 |
| US11359004B2 (en) | 2022-06-14 |
| AU2013243875A1 (en) | 2014-11-20 |
| HK1207659A1 (en) | 2016-02-05 |
| JP6686067B2 (ja) | 2020-04-22 |
| EP2834329A1 (en) | 2015-02-11 |
| KR20140144262A (ko) | 2014-12-18 |
| US20230026348A1 (en) | 2023-01-26 |
| US20190127445A1 (en) | 2019-05-02 |
| MX2014011944A (es) | 2015-06-05 |
| WO2013151776A1 (en) | 2013-10-10 |
| CN104411807B (zh) | 2018-10-02 |
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