JP2015514718A5 - - Google Patents

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Publication number
JP2015514718A5
JP2015514718A5 JP2015504603A JP2015504603A JP2015514718A5 JP 2015514718 A5 JP2015514718 A5 JP 2015514718A5 JP 2015504603 A JP2015504603 A JP 2015504603A JP 2015504603 A JP2015504603 A JP 2015504603A JP 2015514718 A5 JP2015514718 A5 JP 2015514718A5
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JP
Japan
Prior art keywords
lysine
protein
hemoglobin
subunit
peg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015504603A
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English (en)
Japanese (ja)
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JP2015514718A (ja
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Publication date
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Priority claimed from PCT/US2013/032704 external-priority patent/WO2013151776A1/en
Publication of JP2015514718A publication Critical patent/JP2015514718A/ja
Publication of JP2015514718A5 publication Critical patent/JP2015514718A5/ja
Pending legal-status Critical Current

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JP2015504603A 2012-04-03 2013-03-15 スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 Pending JP2015514718A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261619783P 2012-04-03 2012-04-03
US201261619768P 2012-04-03 2012-04-03
US61/619,768 2012-04-03
US61/619,783 2012-04-03
PCT/US2013/032704 WO2013151776A1 (en) 2012-04-03 2013-03-15 Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018089859A Division JP6686067B2 (ja) 2012-04-03 2018-05-08 スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法

Publications (2)

Publication Number Publication Date
JP2015514718A JP2015514718A (ja) 2015-05-21
JP2015514718A5 true JP2015514718A5 (enExample) 2016-04-28

Family

ID=49300942

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015504603A Pending JP2015514718A (ja) 2012-04-03 2013-03-15 スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法
JP2018089859A Expired - Fee Related JP6686067B2 (ja) 2012-04-03 2018-05-08 スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018089859A Expired - Fee Related JP6686067B2 (ja) 2012-04-03 2018-05-08 スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法

Country Status (9)

Country Link
US (3) US20150094267A1 (enExample)
EP (1) EP2834329B1 (enExample)
JP (2) JP2015514718A (enExample)
KR (1) KR102076874B1 (enExample)
CN (1) CN104411807B (enExample)
AU (2) AU2013243875B2 (enExample)
CA (1) CA2908238C (enExample)
MX (1) MX358784B (enExample)
WO (1) WO2013151776A1 (enExample)

Families Citing this family (10)

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JP2015514718A (ja) * 2012-04-03 2015-05-21 サンガート， インコーポレイテッド スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法
JP6657070B2 (ja) * 2013-03-15 2020-03-04 ウィリアム・シンドラーＷｉｌｌｉａｍ Ｓｃｈｉｎｄｌｅｒ ポリアルキレンオキシド吉草酸ヘモグロビン接合体
EP2894476A1 (en) * 2014-01-14 2015-07-15 Universität Konstanz Genetically Encoded Spin Label
EP3380107B1 (en) * 2015-11-24 2023-03-15 Antiradical Therapeutics LLC Compositions and methods of use of nano anti-radical therapeutics to inhibit cancer
CN105777893B (zh) * 2016-03-24 2019-10-25 杭州亚慧生物科技有限公司 一种高强度血清白蛋白骨修复材料及其制备方法
CA3070172A1 (en) 2017-07-18 2019-01-24 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making
CN114279777A (zh) * 2020-09-28 2022-04-05 深圳市瑞图生物技术有限公司 一种含有脒基类化合物的溶血剂及其血液分析试剂盒
CU24689B1 (es) * 2020-10-05 2023-12-07 Ct Inmunologia Molecular CONJUGADOS COVALENTES DEL DOMINIO DE UNIÓN AL RECEPTOR DEL VIRUS SARS-CoV-2 Y UNA PROTEÍNA PORTADORA Y PROCEDIMIENTO DE OBTENCIÓN
CN118684612B (zh) * 2024-08-26 2025-11-18 浙江瑞奥生物科技有限公司 一种马来聚乙二醇药物偶联剂的合成方法
CN120682395B (zh) * 2025-08-20 2025-11-07 复星安特金(成都)生物制药有限公司 一种活化细菌荚膜多糖的方法

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US5650388A (en) 1989-11-22 1997-07-22 Enzon, Inc. Fractionated polyalkylene oxide-conjugated hemoglobin solutions
US5234903A (en) 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
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US5250665A (en) 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
US5840701A (en) 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
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CN102859364A (zh) * 2010-02-25 2013-01-02 桑格特公司 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法
CN102249987B (zh) * 2011-05-06 2013-07-24 兰州大学 一种考布他汀类化合物及其制备方法和用途
JP2015514718A (ja) 2012-04-03 2015-05-21 サンガート， インコーポレイテッド スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法

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