KR102076874B1 - 숙신이미드-활성화 나이트록실 화합물 및 단백질의 나이트록실화를 위한 이의 사용 방법 - Google Patents
숙신이미드-활성화 나이트록실 화합물 및 단백질의 나이트록실화를 위한 이의 사용 방법 Download PDFInfo
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- KR102076874B1 KR102076874B1 KR1020147030716A KR20147030716A KR102076874B1 KR 102076874 B1 KR102076874 B1 KR 102076874B1 KR 1020147030716 A KR1020147030716 A KR 1020147030716A KR 20147030716 A KR20147030716 A KR 20147030716A KR 102076874 B1 KR102076874 B1 KR 102076874B1
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- 0 *C(*)(CC(*(C(ON(C(CC1)=O)C1=O)=O)=N)*(C1(*)*)=N)N1O Chemical compound *C(*)(CC(*(C(ON(C(CC1)=O)C1=O)=O)=N)*(C1(*)*)=N)N1O 0.000 description 2
- NLXHFGMPZIUAIS-UHFFFAOYSA-O CC(C)(CC(C1(C)C)C(ON(C(CC2)=O)C2=O)=O)N1[OH2+] Chemical compound CC(C)(CC(C1(C)C)C(ON(C(CC2)=O)C2=O)=O)N1[OH2+] NLXHFGMPZIUAIS-UHFFFAOYSA-O 0.000 description 1
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- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
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- A61K38/41—Porphyrin- or corrin-ring-containing peptides
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- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
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- Cardiology (AREA)
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- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261619783P | 2012-04-03 | 2012-04-03 | |
| US201261619768P | 2012-04-03 | 2012-04-03 | |
| US61/619,768 | 2012-04-03 | ||
| US61/619,783 | 2012-04-03 | ||
| PCT/US2013/032704 WO2013151776A1 (en) | 2012-04-03 | 2013-03-15 | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140144262A KR20140144262A (ko) | 2014-12-18 |
| KR102076874B1 true KR102076874B1 (ko) | 2020-02-12 |
Family
ID=49300942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147030716A Expired - Fee Related KR102076874B1 (ko) | 2012-04-03 | 2013-03-15 | 숙신이미드-활성화 나이트록실 화합물 및 단백질의 나이트록실화를 위한 이의 사용 방법 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20150094267A1 (enExample) |
| EP (1) | EP2834329B1 (enExample) |
| JP (2) | JP2015514718A (enExample) |
| KR (1) | KR102076874B1 (enExample) |
| CN (1) | CN104411807B (enExample) |
| AU (2) | AU2013243875B2 (enExample) |
| CA (1) | CA2908238C (enExample) |
| MX (1) | MX358784B (enExample) |
| WO (1) | WO2013151776A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015514718A (ja) * | 2012-04-03 | 2015-05-21 | サンガート, インコーポレイテッド | スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 |
| JP6657070B2 (ja) * | 2013-03-15 | 2020-03-04 | ウィリアム・シンドラーWilliam Schindler | ポリアルキレンオキシド吉草酸ヘモグロビン接合体 |
| EP2894476A1 (en) * | 2014-01-14 | 2015-07-15 | Universität Konstanz | Genetically Encoded Spin Label |
| EP3380107B1 (en) * | 2015-11-24 | 2023-03-15 | Antiradical Therapeutics LLC | Compositions and methods of use of nano anti-radical therapeutics to inhibit cancer |
| CN105777893B (zh) * | 2016-03-24 | 2019-10-25 | 杭州亚慧生物科技有限公司 | 一种高强度血清白蛋白骨修复材料及其制备方法 |
| CA3070172A1 (en) | 2017-07-18 | 2019-01-24 | VirTech Bio, Inc. | Blood substitutes comprising hemoglobin and methods of making |
| CN114279777A (zh) * | 2020-09-28 | 2022-04-05 | 深圳市瑞图生物技术有限公司 | 一种含有脒基类化合物的溶血剂及其血液分析试剂盒 |
| CU24689B1 (es) * | 2020-10-05 | 2023-12-07 | Ct Inmunologia Molecular | CONJUGADOS COVALENTES DEL DOMINIO DE UNIÓN AL RECEPTOR DEL VIRUS SARS-CoV-2 Y UNA PROTEÍNA PORTADORA Y PROCEDIMIENTO DE OBTENCIÓN |
| CN118684612B (zh) * | 2024-08-26 | 2025-11-18 | 浙江瑞奥生物科技有限公司 | 一种马来聚乙二醇药物偶联剂的合成方法 |
| CN120682395B (zh) * | 2025-08-20 | 2025-11-07 | 复星安特金(成都)生物制药有限公司 | 一种活化细菌荚膜多糖的方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013151776A1 (en) | 2012-04-03 | 2013-10-10 | Sangart, Inc. | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4240797A (en) | 1977-10-18 | 1980-12-23 | The Governing Council Of The University Of Toronto | Assay for reserve bilirubin binding capacity |
| US4529719A (en) | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| US5004809A (en) * | 1986-02-04 | 1991-04-02 | University Of Cincinnati | Nitroxide labeled nucleotides and nitroxide labeled hybridization probes |
| CA1312009C (en) | 1986-11-10 | 1992-12-29 | Carl W. Rausch | Extra pure semi-synthetic blood substitute |
| GB8710598D0 (en) | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
| US5650388A (en) | 1989-11-22 | 1997-07-22 | Enzon, Inc. | Fractionated polyalkylene oxide-conjugated hemoglobin solutions |
| US5234903A (en) | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
| US5312808A (en) * | 1989-11-22 | 1994-05-17 | Enzon, Inc. | Fractionation of polyalkylene oxide-conjugated hemoglobin solutions |
| US5250665A (en) | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
| US5840701A (en) | 1993-08-16 | 1998-11-24 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| TW381022B (en) | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
| US6458758B1 (en) | 1993-08-16 | 2002-10-01 | Synzyme Technologies, Inc. | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| SG95590A1 (en) * | 1995-03-31 | 2003-04-23 | Synzyme Technologies Inc | Compositions and method utilizing nitroxides in combination with biocompatible macromolecules |
| US5585484A (en) | 1995-04-19 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hemoglobin crosslinkers |
| US6627738B2 (en) | 1995-09-15 | 2003-09-30 | Duke University | No-modified hemoglobins and uses therefor |
| DE10031740A1 (de) | 2000-06-29 | 2002-02-14 | Sanguibio Tech Ag | Künstliche Sauerstoffträger aus vernetztem modifizierten Human- oder Schweinehämoglobin mit verbesserten Eigenschaften, Verfahren zu ihrer technisch einfachen Herstellung aus gereinigtem Material in hohen Ausbeuten, sowie deren Verwendung |
| US20030153491A1 (en) | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| MXPA05000796A (es) | 2002-07-24 | 2005-04-19 | Hoffmann La Roche | Aditivos de acidos polialquilenglicolicos. |
| DE10393955T5 (de) * | 2002-12-23 | 2005-12-29 | L'oreal | Zusammensetzung zum Färben von Keratinfasern, die mindestens eine freiradikalische Verbindung vom Nitroxyl-Typ und mindestens einen primären oder sekundären Alkohol enthält |
| CA2511494A1 (en) | 2002-12-23 | 2004-07-15 | Seetharama A. Acharya | Non-hypertensive polyethylene glycol-modified hemoglobin as oxygen carrier |
| KR100512483B1 (ko) | 2003-05-07 | 2005-09-05 | 선바이오(주) | 신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법 |
| WO2006014968A2 (en) | 2004-07-27 | 2006-02-09 | Teva Pharmaceutical Industries, Ltd. | Propargyl nitroxydes and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders |
| TW200616604A (en) * | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| WO2006096774A2 (en) | 2005-03-07 | 2006-09-14 | Sangart, Inc. | Composition and methods for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers |
| US8741832B2 (en) * | 2005-06-10 | 2014-06-03 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated albumin and uses thereof |
| EP2184987A4 (en) * | 2007-07-31 | 2011-09-28 | Burnham Inst Medical Research | BIDENTATE COMPOUNDS AS KINASEHEMMER |
| EP2030624A1 (en) * | 2007-08-28 | 2009-03-04 | Johannes Gutenberg Universität | Antioxidant and paramagnetic heparin-nitroxide derivatives |
| NO2440239T3 (enExample) | 2009-06-09 | 2018-02-10 | ||
| US8273857B2 (en) | 2009-09-22 | 2012-09-25 | Jen-Chang Hsia | Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine |
| CN102859364A (zh) * | 2010-02-25 | 2013-01-02 | 桑格特公司 | 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法 |
| CN102249987B (zh) * | 2011-05-06 | 2013-07-24 | 兰州大学 | 一种考布他汀类化合物及其制备方法和用途 |
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2013
- 2013-03-15 JP JP2015504603A patent/JP2015514718A/ja active Pending
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- 2013-03-15 MX MX2014011944A patent/MX358784B/es active IP Right Grant
- 2013-03-15 KR KR1020147030716A patent/KR102076874B1/ko not_active Expired - Fee Related
- 2013-03-15 US US14/390,559 patent/US20150094267A1/en not_active Abandoned
- 2013-03-15 CN CN201380028719.XA patent/CN104411807B/zh not_active Expired - Fee Related
- 2013-03-15 EP EP13771756.7A patent/EP2834329B1/en active Active
- 2013-03-15 AU AU2013243875A patent/AU2013243875B2/en not_active Ceased
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2018
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2022
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013151776A1 (en) | 2012-04-03 | 2013-10-10 | Sangart, Inc. | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins |
Non-Patent Citations (3)
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| Archives of Biochemistry & Biophysics 320(1):155-161 (1995) |
| J. Org. Chem. 58:2573-2577 (1993) |
| Journal of Controlled Release 111:73-80 (2006) |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2834329B1 (en) | 2018-10-17 |
| AU2013243875B2 (en) | 2017-11-30 |
| AU2018201285B2 (en) | 2020-05-14 |
| US20150094267A1 (en) | 2015-04-02 |
| JP2018150335A (ja) | 2018-09-27 |
| AU2018201285A1 (en) | 2018-03-22 |
| EP2834329A4 (en) | 2015-12-23 |
| MX358784B (es) | 2018-09-04 |
| CA2908238A1 (en) | 2013-10-10 |
| CA2908238C (en) | 2023-01-10 |
| CN104411807A (zh) | 2015-03-11 |
| US11359004B2 (en) | 2022-06-14 |
| AU2013243875A1 (en) | 2014-11-20 |
| HK1207659A1 (en) | 2016-02-05 |
| JP6686067B2 (ja) | 2020-04-22 |
| EP2834329A1 (en) | 2015-02-11 |
| KR20140144262A (ko) | 2014-12-18 |
| JP2015514718A (ja) | 2015-05-21 |
| US20230026348A1 (en) | 2023-01-26 |
| US20190127445A1 (en) | 2019-05-02 |
| MX2014011944A (es) | 2015-06-05 |
| WO2013151776A1 (en) | 2013-10-10 |
| CN104411807B (zh) | 2018-10-02 |
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