JP2015514068A5 - - Google Patents
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- Publication number
- JP2015514068A5 JP2015514068A5 JP2015501002A JP2015501002A JP2015514068A5 JP 2015514068 A5 JP2015514068 A5 JP 2015514068A5 JP 2015501002 A JP2015501002 A JP 2015501002A JP 2015501002 A JP2015501002 A JP 2015501002A JP 2015514068 A5 JP2015514068 A5 JP 2015514068A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- rsv
- mpv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 25
- 102000036639 antigens Human genes 0.000 claims description 25
- 108091007433 antigens Proteins 0.000 claims description 25
- 239000012634 fragment Substances 0.000 claims description 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 208000015181 infectious disease Diseases 0.000 claims description 12
- 241001244708 Moroccan pepper virus Species 0.000 claims 18
- 241000724205 Rice stripe tenuivirus Species 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 4
- 241000710181 Potato virus M Species 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613197P | 2012-03-20 | 2012-03-20 | |
| US61/613,197 | 2012-03-20 | ||
| US201261655310P | 2012-06-04 | 2012-06-04 | |
| US61/655,310 | 2012-06-04 | ||
| PCT/IB2013/000627 WO2013140247A1 (en) | 2012-03-20 | 2013-03-14 | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224174A Division JP6722264B2 (ja) | 2012-03-20 | 2018-11-29 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514068A JP2015514068A (ja) | 2015-05-18 |
| JP2015514068A5 true JP2015514068A5 (OSRAM) | 2018-11-01 |
| JP6445423B2 JP6445423B2 (ja) | 2018-12-26 |
Family
ID=48471031
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501002A Active JP6445423B2 (ja) | 2012-03-20 | 2013-03-14 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2018224174A Expired - Fee Related JP6722264B2 (ja) | 2012-03-20 | 2018-11-29 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2020106004A Active JP7069251B2 (ja) | 2012-03-20 | 2020-06-19 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2022076023A Pending JP2022132244A (ja) | 2012-03-20 | 2022-05-02 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224174A Expired - Fee Related JP6722264B2 (ja) | 2012-03-20 | 2018-11-29 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2020106004A Active JP7069251B2 (ja) | 2012-03-20 | 2020-06-19 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2022076023A Pending JP2022132244A (ja) | 2012-03-20 | 2022-05-02 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9498531B2 (OSRAM) |
| EP (1) | EP2828293B1 (OSRAM) |
| JP (4) | JP6445423B2 (OSRAM) |
| KR (1) | KR102149069B1 (OSRAM) |
| CN (2) | CN104350069B (OSRAM) |
| AU (1) | AU2013237087B2 (OSRAM) |
| BR (1) | BR112014023063A2 (OSRAM) |
| CA (1) | CA2865856C (OSRAM) |
| DK (1) | DK2828293T3 (OSRAM) |
| EA (1) | EA030319B1 (OSRAM) |
| ES (1) | ES2657470T3 (OSRAM) |
| IL (1) | IL234710A (OSRAM) |
| IN (1) | IN2014DN07299A (OSRAM) |
| NZ (1) | NZ630920A (OSRAM) |
| PL (1) | PL2828293T3 (OSRAM) |
| WO (1) | WO2013140247A1 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ630920A (en) * | 2012-03-20 | 2017-01-27 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
| RU2015129655A (ru) | 2013-01-28 | 2017-03-07 | Эвек Инк. | Антитело человека, специфичное к матапневмовирусу человека, или антиген-связывающий фрагмент указанного антитела |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| WO2020160171A1 (en) * | 2019-01-29 | 2020-08-06 | Sanford Burnham Prebys Medical Discovery Institute | Topically formulated antibody compositions for reducing pathogen transmission and methods of using same |
| US20230085439A1 (en) * | 2019-05-21 | 2023-03-16 | University Of Georgia Research Foundation, Inc. | Antibodies that bind human metapneumovirus fusion protein and their use |
| TW202246317A (zh) * | 2021-02-09 | 2022-12-01 | 瑞士商休曼生物醫藥股份公司 | 針對呼吸道融合病毒及其他副黏液病毒的抗體以及使用其之方法 |
| JP2024507948A (ja) * | 2021-02-26 | 2024-02-21 | フレッド ハッチンソン キャンサー センター | 呼吸器ウイルス感染症に対する防御抗体 |
| CN115466326B (zh) * | 2021-06-11 | 2024-06-04 | 中国科学院微生物研究所 | 一种呼吸道合胞病毒的人源单克隆抗体及其应用 |
| WO2025015321A1 (en) * | 2023-07-13 | 2025-01-16 | Vir Biotechnology, Inc. | Broadly neutralizing antibodies against rsv and mpv paramyxoviruses |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3766162A (en) | 1971-08-24 | 1973-10-16 | Hoffmann La Roche | Barbituric acid antigens and antibodies specific therefor |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| EP0098110B1 (en) | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| CN1524088B (zh) | 2001-01-19 | 2012-11-07 | 维洛诺瓦蒂夫公司 | 在易感哺乳动物中引起呼吸道疾病的病毒 |
| WO2003080672A1 (en) | 2002-03-22 | 2003-10-02 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| WO2004010935A2 (en) | 2002-07-25 | 2004-02-05 | Medimmune, Inc. | Methods of treating and preventing rsv, hmpv, and piv using anti-rsv, anti-hmpv, and anti-piv antibodies |
| EP1597280B2 (en) | 2003-02-26 | 2016-08-24 | Institute for Research in Biomedicine | Monoclonal antibody production by ebv transformation of b cells |
| WO2004092207A2 (en) * | 2003-04-16 | 2004-10-28 | Algonomics N.V. | Respiratory syncytial virus (rsv) peptides |
| EP1473037A1 (en) | 2003-05-02 | 2004-11-03 | Vironovative B.V. | Treatment of hPMV infections with Ribavirin |
| AU2006234847A1 (en) * | 2005-04-08 | 2006-10-19 | Medimmune, Llc | Antibodies against mammalian metapneumovirus |
| EP1997830A1 (en) * | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| NZ592036A (en) | 2008-10-22 | 2012-12-21 | Inst Research In Biomedicine | Methods for producing antibodies from plasma cells |
| WO2010149743A2 (en) * | 2009-06-24 | 2010-12-29 | Id Biomedical Corporation Of Quebec | Vaccine |
| DK2464664T3 (da) * | 2009-08-13 | 2016-01-18 | Crucell Holland Bv | Antistoffer mod humant respiratorisk syncytialvirus (rsv) og fremgangsmåder til anvendelse deraf |
| BR112012031638B1 (pt) * | 2010-07-09 | 2021-01-12 | Janssen Vaccines & Prevention B.V. | anticorpo anti-rsv ou fragmento de ligação de antígeno do mesmo, anticorpo multivalente, composição farmacêutica, uso de anticorpo ou fragmento de ligação de antígeno, método de detectar infecção por rsv, e, ácido nucleico isolado |
| NZ630920A (en) | 2012-03-20 | 2017-01-27 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
-
2013
- 2013-03-14 NZ NZ630920A patent/NZ630920A/en not_active IP Right Cessation
- 2013-03-14 JP JP2015501002A patent/JP6445423B2/ja active Active
- 2013-03-14 EP EP13724357.2A patent/EP2828293B1/en active Active
- 2013-03-14 WO PCT/IB2013/000627 patent/WO2013140247A1/en not_active Ceased
- 2013-03-14 BR BR112014023063A patent/BR112014023063A2/pt active Search and Examination
- 2013-03-14 EA EA201491724A patent/EA030319B1/ru unknown
- 2013-03-14 US US13/827,845 patent/US9498531B2/en active Active
- 2013-03-14 ES ES13724357.2T patent/ES2657470T3/es active Active
- 2013-03-14 DK DK13724357.2T patent/DK2828293T3/en active
- 2013-03-14 CA CA2865856A patent/CA2865856C/en active Active
- 2013-03-14 CN CN201380026218.8A patent/CN104350069B/zh active Active
- 2013-03-14 CN CN201711120146.XA patent/CN107880121B/zh active Active
- 2013-03-14 PL PL13724357T patent/PL2828293T3/pl unknown
- 2013-03-14 KR KR1020147029324A patent/KR102149069B1/ko not_active Expired - Fee Related
- 2013-03-14 AU AU2013237087A patent/AU2013237087B2/en not_active Ceased
-
2014
- 2014-08-29 IN IN7299DEN2014 patent/IN2014DN07299A/en unknown
- 2014-09-17 IL IL234710A patent/IL234710A/en active IP Right Grant
-
2016
- 2016-08-10 US US15/233,026 patent/US10072071B2/en active Active
-
2018
- 2018-08-09 US US16/059,408 patent/US20190153073A1/en not_active Abandoned
- 2018-11-29 JP JP2018224174A patent/JP6722264B2/ja not_active Expired - Fee Related
-
2020
- 2020-05-27 US US16/885,009 patent/US11421020B2/en active Active
- 2020-06-19 JP JP2020106004A patent/JP7069251B2/ja active Active
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2022
- 2022-05-02 JP JP2022076023A patent/JP2022132244A/ja active Pending