JP2015513901A5 - - Google Patents
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- Publication number
- JP2015513901A5 JP2015513901A5 JP2015503230A JP2015503230A JP2015513901A5 JP 2015513901 A5 JP2015513901 A5 JP 2015513901A5 JP 2015503230 A JP2015503230 A JP 2015503230A JP 2015503230 A JP2015503230 A JP 2015503230A JP 2015513901 A5 JP2015513901 A5 JP 2015513901A5
- Authority
- JP
- Japan
- Prior art keywords
- raf
- cancer
- polypeptide
- inhibitor
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616999P | 2012-03-28 | 2012-03-28 | |
| US61/616,999 | 2012-03-28 | ||
| US201261708372P | 2012-10-01 | 2012-10-01 | |
| US61/708,372 | 2012-10-01 | ||
| PCT/US2013/029513 WO2013148100A1 (en) | 2012-03-28 | 2013-03-07 | C-raf mutants that confer resistance to raf inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018048824A Division JP6661685B2 (ja) | 2012-03-28 | 2018-03-16 | Ｒａｆ阻害剤に対する耐性を付与するｃ−ｒａｆ突然変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513901A JP2015513901A (ja) | 2015-05-18 |
| JP2015513901A5 true JP2015513901A5 (https=) | 2016-04-21 |
| JP6348898B2 JP6348898B2 (ja) | 2018-06-27 |
Family
ID=47892065
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503230A Active JP6348898B2 (ja) | 2012-03-28 | 2013-03-07 | Ｒａｆ阻害剤に対する耐性を付与するｃ−ｒａｆ突然変異体 |
| JP2018048824A Active JP6661685B2 (ja) | 2012-03-28 | 2018-03-16 | Ｒａｆ阻害剤に対する耐性を付与するｃ−ｒａｆ突然変異体 |
| JP2020019636A Pending JP2020103291A (ja) | 2012-03-28 | 2020-02-07 | Ｒａｆ阻害剤に対する耐性を付与するｃ−ｒａｆ突然変異体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018048824A Active JP6661685B2 (ja) | 2012-03-28 | 2018-03-16 | Ｒａｆ阻害剤に対する耐性を付与するｃ−ｒａｆ突然変異体 |
| JP2020019636A Pending JP2020103291A (ja) | 2012-03-28 | 2020-02-07 | Ｒａｆ阻害剤に対する耐性を付与するｃ−ｒａｆ突然変異体 |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US9629839B2 (https=) |
| EP (3) | EP3333575B1 (https=) |
| JP (3) | JP6348898B2 (https=) |
| KR (1) | KR20140139510A (https=) |
| CN (1) | CN104204806B (https=) |
| AU (1) | AU2013240483B2 (https=) |
| BR (1) | BR112014023496A2 (https=) |
| CA (1) | CA2864169A1 (https=) |
| EA (1) | EA028135B1 (https=) |
| ES (3) | ES2673070T3 (https=) |
| MX (1) | MX351945B (https=) |
| PL (1) | PL2831589T3 (https=) |
| PT (1) | PT2831589T (https=) |
| TR (1) | TR201808010T4 (https=) |
| WO (1) | WO2013148100A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3333575B1 (en) * | 2012-03-28 | 2020-02-26 | Dana Farber Cancer Institute, Inc. | C-raf mutants that confer resistance to raf inhibitors |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| KR102537840B1 (ko) | 2018-07-13 | 2023-05-31 | 삼성전자 주식회사 | 서버 장치 및 다른 장치들의 위치 정보를 수집하는 방법 |
| WO2020163771A1 (en) * | 2019-02-08 | 2020-08-13 | Portage Glasgow Limited | Structure, manufacturing and uses of hoxd12-pde8a cell-penetrating peptides |
| WO2021225980A1 (en) * | 2020-05-04 | 2021-11-11 | Dna-Seq, Inc. | Methods and systems for determination of an effective therapeutic regimen and drug discovery |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618670A (en) * | 1988-08-26 | 1997-04-08 | The United States Of America As Represented By The Department Of Health & Human Services | Detection method for c-raf-1 genes |
| US20060234931A1 (en) | 2003-07-17 | 2006-10-19 | Biggs William H Iii | Treatment of diseases with kinase inhibitors |
| WO2005012875A2 (en) | 2003-07-29 | 2005-02-10 | Bristol-Myers Squibb Company | Biomarkers of cyclin-dependent kinase modulation |
| AU2007299080B2 (en) | 2006-09-18 | 2013-04-18 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
| CN101516376A (zh) | 2006-09-18 | 2009-08-26 | 贝林格尔.英格海姆国际有限公司 | 用于治疗携带egfr突变的癌症的方法 |
| EP2102362B1 (en) * | 2006-11-16 | 2012-07-04 | Mount Sinai School of Medicine of New York University | Compositions and methods for detecting noonan syndrome |
| WO2010068738A1 (en) | 2008-12-10 | 2010-06-17 | Dana-Farber Cancer Institute, Inc. | Mek mutations conferring resistance to mek inhibitors |
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| BR112012022801B8 (pt) * | 2010-03-09 | 2019-10-29 | Dana Farber Cancer Inst Inc | método de identificar um indivíduo que tem câncer que é provável beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor e uso de um inibidor de raf e um segundo inibidor para a fabricação de um medicamento para tratar câncer |
| EP3333575B1 (en) * | 2012-03-28 | 2020-02-26 | Dana Farber Cancer Institute, Inc. | C-raf mutants that confer resistance to raf inhibitors |
-
2013
- 2013-03-07 EP EP18153021.3A patent/EP3333575B1/en active Active
- 2013-03-07 MX MX2014011686A patent/MX351945B/es active IP Right Grant
- 2013-03-07 ES ES13710263.8T patent/ES2673070T3/es active Active
- 2013-03-07 ES ES18153021T patent/ES2790896T3/es active Active
- 2013-03-07 EP EP20159381.1A patent/EP3693741B1/en active Active
- 2013-03-07 US US14/387,735 patent/US9629839B2/en active Active
- 2013-03-07 JP JP2015503230A patent/JP6348898B2/ja active Active
- 2013-03-07 AU AU2013240483A patent/AU2013240483B2/en not_active Ceased
- 2013-03-07 KR KR1020147026716A patent/KR20140139510A/ko not_active Ceased
- 2013-03-07 BR BR112014023496A patent/BR112014023496A2/pt not_active IP Right Cessation
- 2013-03-07 EA EA201491780A patent/EA028135B1/ru not_active IP Right Cessation
- 2013-03-07 CA CA2864169A patent/CA2864169A1/en not_active Abandoned
- 2013-03-07 ES ES20159381T patent/ES2908078T3/es active Active
- 2013-03-07 EP EP13710263.8A patent/EP2831589B1/en active Active
- 2013-03-07 PT PT137102638T patent/PT2831589T/pt unknown
- 2013-03-07 WO PCT/US2013/029513 patent/WO2013148100A1/en not_active Ceased
- 2013-03-07 PL PL13710263T patent/PL2831589T3/pl unknown
- 2013-03-07 CN CN201380014747.6A patent/CN104204806B/zh active Active
- 2013-03-07 TR TR2018/08010T patent/TR201808010T4/tr unknown
-
2017
- 2017-03-29 US US15/472,934 patent/US20170204383A1/en not_active Abandoned
-
2018
- 2018-03-16 JP JP2018048824A patent/JP6661685B2/ja active Active
-
2019
- 2019-01-23 US US16/255,251 patent/US20190142830A1/en not_active Abandoned
-
2020
- 2020-02-07 JP JP2020019636A patent/JP2020103291A/ja active Pending
-
2021
- 2021-08-11 US US17/399,563 patent/US11788151B2/en active Active
-
2023
- 2023-09-11 US US18/464,360 patent/US12146196B2/en active Active
-
2024
- 2024-10-14 US US18/914,634 patent/US20250034652A1/en active Pending
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