JP2015513318A5 - - Google Patents
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- JP2015513318A5 JP2015513318A5 JP2014554880A JP2014554880A JP2015513318A5 JP 2015513318 A5 JP2015513318 A5 JP 2015513318A5 JP 2014554880 A JP2014554880 A JP 2014554880A JP 2014554880 A JP2014554880 A JP 2014554880A JP 2015513318 A5 JP2015513318 A5 JP 2015513318A5
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- JP
- Japan
- Prior art keywords
- leu
- ala
- seq
- cys
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000005557 antagonist Substances 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 239000003735 calcitonin gene related peptide receptor antagonist Substances 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 102100038518 Calcitonin Human genes 0.000 claims 1
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591236P | 2012-01-26 | 2012-01-26 | |
| US61/591,236 | 2012-01-26 | ||
| PCT/US2013/023260 WO2013112912A1 (en) | 2012-01-26 | 2013-01-25 | Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199234A Division JP6411425B2 (ja) | 2012-01-26 | 2016-10-07 | ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513318A JP2015513318A (ja) | 2015-05-07 |
| JP2015513318A5 true JP2015513318A5 (https=) | 2016-03-10 |
| JP6025871B2 JP6025871B2 (ja) | 2016-11-16 |
Family
ID=47682066
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554880A Active JP6025871B2 (ja) | 2012-01-26 | 2013-01-25 | ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用 |
| JP2016199234A Active JP6411425B2 (ja) | 2012-01-26 | 2016-10-07 | ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用 |
| JP2018177504A Pending JP2019006821A (ja) | 2012-01-26 | 2018-09-21 | ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199234A Active JP6411425B2 (ja) | 2012-01-26 | 2016-10-07 | ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用 |
| JP2018177504A Pending JP2019006821A (ja) | 2012-01-26 | 2018-09-21 | ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9193776B2 (https=) |
| EP (2) | EP2807187B1 (https=) |
| JP (3) | JP6025871B2 (https=) |
| KR (2) | KR101855242B1 (https=) |
| CN (2) | CN104271596B (https=) |
| AU (2) | AU2013211929B2 (https=) |
| CA (1) | CA2861392C (https=) |
| DK (1) | DK2807187T3 (https=) |
| ES (2) | ES2641325T3 (https=) |
| IL (2) | IL233655A (https=) |
| MX (1) | MX347229B (https=) |
| NO (1) | NO2864579T3 (https=) |
| RU (2) | RU2624016C2 (https=) |
| WO (1) | WO2013112912A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101855242B1 (ko) * | 2012-01-26 | 2018-05-09 | 크리스토퍼 제이. 소레스 | 펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 |
| EP3027644B1 (en) * | 2013-07-30 | 2019-08-21 | Christopher J. Soares | Cgrp agonist peptides |
| JO3669B1 (ar) | 2015-01-06 | 2020-08-27 | Ferring Bv | بيبتيدات مضَادَّة لببتيد المرتبط بجين الكالسيتونين |
| EP3400237A4 (en) * | 2016-01-04 | 2020-03-04 | Adepthera LLC | Peptide analogs |
| CA3035561A1 (en) | 2016-09-02 | 2018-03-08 | Christopher J. Soares | Use of cgrp receptor antagonists in neuroprotection and neurological disorders |
| CA2967616A1 (en) * | 2016-09-19 | 2018-03-19 | The Governors Of The University Of Alberta | Brain penetrant amylin receptor based peptides for alzheimer's disease |
| US20200353088A1 (en) * | 2017-11-06 | 2020-11-12 | Auckland Uniservices Limited | Peptide conjugate cgrp receptor antagonists and methods of preparation and uses thereof |
| JP7214100B2 (ja) * | 2019-01-18 | 2023-01-30 | 株式会社大一商会 | 遊技機 |
| JP7214104B2 (ja) * | 2019-01-18 | 2023-01-30 | 株式会社大一商会 | 遊技機 |
| JP7214102B2 (ja) * | 2019-01-18 | 2023-01-30 | 株式会社大一商会 | 遊技機 |
| CN116456981A (zh) * | 2020-11-19 | 2023-07-18 | 辉瑞爱尔兰制药公司 | 用于改善的grp抑制剂递送的组合物 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2046920B1 (https=) | 1969-06-19 | 1974-05-03 | Citizen Watch Co Ltd | |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| NO812612L (no) | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| CH657779A5 (de) | 1982-10-05 | 1986-09-30 | Sandoz Ag | Galenische zusammensetzungen enthaltend calcitonin. |
| IT1164225B (it) | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
| US4530838A (en) | 1983-07-08 | 1985-07-23 | The Salk Institute For Biological Studies | Synthetic calcitonin-gene-related peptides for lowering blood pressure or gastric acid secretion in mammals |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| JPS62129297A (ja) * | 1985-08-09 | 1987-06-11 | Toyo Jozo Co Ltd | カルシトニン遺伝子関連ペプチド誘導体 |
| JPS62231168A (ja) | 1986-03-21 | 1987-10-09 | ハイブリテツク・インコ−ポレイテツド | アナライト−レセプタ−分析用内部標準を設けるための改良法 |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| AU680422B2 (en) | 1992-06-11 | 1997-07-31 | Alkermes Controlled Therapeutics, Inc. | Erythropoietin drug delivery system |
| US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
| WO1994021665A1 (en) | 1993-03-24 | 1994-09-29 | Amylin Pharmaceuticals, Inc. | Cloned receptors and methods for screening |
| US5698401A (en) | 1995-11-14 | 1997-12-16 | Abbott Laboratories | Use of nuclear magnetic resonance to identify ligands to target biomolecules |
| US5910482A (en) * | 1996-03-19 | 1999-06-08 | Board Of Regents, The University Of Texas System | Treatment or prevention of preeclampsia, eclampsia with calcitonin gene related peptide, CGRP analog, progestational agent, nitric oxide source, and cyclooxygenase inhibitor |
| WO1997041223A1 (en) | 1996-04-15 | 1997-11-06 | The University Of Miami | Molecular clone of cgrp receptor component protein and uses thereof |
| US20050054557A1 (en) | 2002-05-09 | 2005-03-10 | Goldberg Michael M. | Compositions for delivering parathyroid hormone and calcitonin |
| WO2004084859A2 (en) | 2003-03-21 | 2004-10-07 | Nastech Pharmaceutical Company Inc. | Nasal calcitonin formulations containing chlorobutanol |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| ATE471340T1 (de) * | 2004-02-11 | 2010-07-15 | Amylin Pharmaceuticals Inc | Peptide der amylin familie, verfahren zu deren herstellung und verwendung |
| CN101094689B (zh) | 2004-11-01 | 2013-06-12 | 安米林药品有限责任公司 | 治疗肥胖以及肥胖相关疾病和病症的方法 |
| WO2007055728A1 (en) * | 2005-11-01 | 2007-05-18 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
| KR20070115947A (ko) * | 2005-02-11 | 2007-12-06 | 아밀린 파마슈티칼스, 인크. | 선택가능한 특성들을 가지는 ｇｉｐ 유사체 및 하이브리드폴리펩타이드 |
| US8263545B2 (en) * | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| CN101208098A (zh) * | 2005-03-31 | 2008-06-25 | 安米林药品公司 | 用于治疗精神病和精神障碍的胰淀素和胰淀素激动剂 |
| CN102343084A (zh) * | 2005-03-31 | 2012-02-08 | 安米林药品公司 | 用于治疗精神病和精神障碍的胰淀素和胰淀素激动剂 |
| WO2007055743A2 (en) * | 2005-11-01 | 2007-05-18 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
| EP3069731A1 (en) * | 2005-11-14 | 2016-09-21 | Labrys Biologics Inc. | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| UA97707C2 (ru) | 2007-11-14 | 2012-03-12 | Амилин Фармасьютикалз, Инк. | Способы лечения ожирения и заболеваний, расстройств, связанных с ожирением |
| WO2010107874A2 (en) | 2009-03-17 | 2010-09-23 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition using amylin agonists |
| US20140249076A1 (en) | 2011-10-18 | 2014-09-04 | Astrazeneca Pharmaceuticals Lp | Amylin-calcitonin chimeric peptides conjugated to duration enhancing moieties |
| KR101855242B1 (ko) * | 2012-01-26 | 2018-05-09 | 크리스토퍼 제이. 소레스 | 펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 |
| HUE047050T2 (hu) | 2012-02-27 | 2020-04-28 | Bristol Myers Squibb Co | N-(5S,6S,9R)-5-amino-6-(2,3-difluorfenil)-6,7,8,9-tetrahidro-5H-ciklohepta[B]piridin-9 -yl-4-(2-oxo-2,3-dihidro-1H-imidazo[4,5-B]piridin-1-il)piperidin-1-karboxilát só |
-
2013
- 2013-01-25 KR KR1020147023782A patent/KR101855242B1/ko active Active
- 2013-01-25 WO PCT/US2013/023260 patent/WO2013112912A1/en not_active Ceased
- 2013-01-25 CN CN201380010942.1A patent/CN104271596B/zh not_active Expired - Fee Related
- 2013-01-25 AU AU2013211929A patent/AU2013211929B2/en not_active Ceased
- 2013-01-25 CN CN201810931542.9A patent/CN108997490A/zh active Pending
- 2013-01-25 ES ES13703494.8T patent/ES2641325T3/es active Active
- 2013-01-25 CA CA2861392A patent/CA2861392C/en active Active
- 2013-01-25 ES ES17175988T patent/ES2819825T3/es active Active
- 2013-01-25 KR KR1020177016079A patent/KR102052983B1/ko active Active
- 2013-01-25 RU RU2014131605A patent/RU2624016C2/ru active
- 2013-01-25 US US13/821,936 patent/US9193776B2/en active Active
- 2013-01-25 EP EP13703494.8A patent/EP2807187B1/en active Active
- 2013-01-25 MX MX2014008960A patent/MX347229B/es active IP Right Grant
- 2013-01-25 DK DK13703494.8T patent/DK2807187T3/en active
- 2013-01-25 EP EP17175988.9A patent/EP3272769B1/en active Active
- 2013-01-25 JP JP2014554880A patent/JP6025871B2/ja active Active
- 2013-06-18 NO NO13806163A patent/NO2864579T3/no unknown
-
2014
- 2014-07-15 IL IL233655A patent/IL233655A/en active IP Right Grant
-
2015
- 2015-11-20 US US14/948,032 patent/US20160145315A1/en not_active Abandoned
-
2016
- 2016-07-18 AU AU2016205801A patent/AU2016205801A1/en not_active Abandoned
- 2016-10-07 JP JP2016199234A patent/JP6411425B2/ja active Active
-
2017
- 2017-04-03 US US15/478,053 patent/US10370425B2/en active Active
- 2017-05-28 IL IL252555A patent/IL252555B/en active IP Right Grant
- 2017-06-06 RU RU2017119773A patent/RU2742826C2/ru active
-
2018
- 2018-09-21 JP JP2018177504A patent/JP2019006821A/ja active Pending
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