JP2015512630A - 急性骨髄性白血病の診断、予後、及び治療用の方法及び組成物 - Google Patents
急性骨髄性白血病の診断、予後、及び治療用の方法及び組成物 Download PDFInfo
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- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101877607B1 (ko) * | 2016-03-03 | 2018-07-12 | 포항공과대학교 산학협력단 | 인슐린/igf―1 수용체 결핍 돌연변이체의 발달결함만 특이적으로 억제된 예쁜꼬마선충 |
| JP2019507721A (ja) * | 2015-12-04 | 2019-03-22 | アジオス ファーマシューティカルズ, インコーポレイテッド | 悪性腫瘍の処置の方法 |
| JP2023521927A (ja) * | 2020-07-30 | 2023-05-25 | ソウル大学校産学協力団 | Phf6を標的にするヒストンh2bエピジェネティクスス調節剤スクリーニング方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20220070066A (ko) | 2014-03-14 | 2022-05-27 | 아지오스 파마슈티컬스 아이엔씨. | 치료적으로 활성인 화합물의 약제학적 조성물 |
| EP3224380A1 (en) | 2014-11-25 | 2017-10-04 | The Broad Institute Inc. | Clonal haematopoiesis |
| EP3626832B1 (en) | 2014-11-25 | 2024-06-12 | The Brigham and Women's Hospital, Inc. | Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease |
| CN104774954A (zh) * | 2015-04-23 | 2015-07-15 | 上海允英医疗科技有限公司 | 用于hras突变检测的引物、探针及检测试剂盒 |
| PT3362065T (pt) | 2015-10-15 | 2024-06-21 | Servier Lab | Terapia de combinação compreendendo ivosidenib, citarabina e daunorubicina ou idarubicina para o tratamento de leucemia mielóide aguda |
| US10653710B2 (en) | 2015-10-15 | 2020-05-19 | Agios Pharmaceuticals, Inc. | Combination therapy for treating malignancies |
| MX2018005771A (es) * | 2015-11-11 | 2019-03-14 | Celator Pharmaceuticals Inc | Ensayos y metodos para seleccionar un regimen de tratamiento para un sujeto con leucemia. |
| WO2017084027A1 (zh) * | 2015-11-17 | 2017-05-26 | 安诺优达基因科技(北京)有限公司 | 一种用于急性髓细胞白血病预后分层的试剂盒及检测方法 |
| CN105861674A (zh) * | 2016-04-27 | 2016-08-17 | 上海荻硕贝肯生物科技有限公司 | 用于检测与aml预后相关的基因突变的引物、试剂盒及方法 |
| CN105969892B (zh) * | 2016-07-14 | 2019-07-19 | 北京大学人民医院 | Csrp2在作为评估成人b-all患者预后风险标记物中的应用 |
| CN106381332A (zh) * | 2016-08-31 | 2017-02-08 | 天津协和华美医学诊断技术有限公司 | 一种检测aml相关基因群的检测试剂盒 |
| AU2017353925A1 (en) * | 2016-11-02 | 2018-09-27 | Arog Pharmaceuticals, Inc. | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
| CN107641650B (zh) * | 2017-08-24 | 2020-05-08 | 中国人民解放军总医院 | Nr1h3在急性髓系白血病精准靶向检测及预后评估中的应用 |
| US10460446B2 (en) * | 2017-10-16 | 2019-10-29 | Nant Holdings Ip, Llc | Image-based circular plot recognition and interpretation |
| CN107841556B (zh) * | 2017-12-19 | 2020-12-01 | 武汉大学 | 一种基于C/EBPα和IGF1R基因筛选药物发育毒性的试剂盒及应用 |
| CN107893118A (zh) * | 2017-12-25 | 2018-04-10 | 合肥艾迪康临床检验所有限公司 | 检测phf6点突变的方法和引物 |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
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| CN111560438B (zh) * | 2020-06-11 | 2024-01-19 | 迈杰转化医学研究(苏州)有限公司 | 检测aml预后相关基因突变的引物组合物、试剂盒及其应用 |
| CN112708675A (zh) * | 2020-12-25 | 2021-04-27 | 中山大学肿瘤防治中心 | 骨髓nk细胞联合mcl1抑制剂在抗白血病中的应用 |
| CN112626215B (zh) * | 2020-12-30 | 2023-03-24 | 武汉康圣达医学检验所有限公司 | Aml预后相关基因表达检测试剂盒 |
| CN115216541A (zh) * | 2021-04-15 | 2022-10-21 | 复旦大学附属华山医院 | 一组白血病标志物及应用 |
| CN113764038B (zh) * | 2021-08-31 | 2023-08-22 | 华南理工大学 | 构建骨髓增生异常综合征转白基因预测模型的方法 |
| CN115323051B (zh) * | 2022-02-22 | 2023-04-07 | 天津见康华美医学诊断技术有限公司 | 一种急性髓系白血病检测探针组合物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919623A (en) * | 1994-04-27 | 1999-07-06 | St. James's And Seacroft University Hospitals Nhs Trust | Nucleic acid mutation assays |
| JP5937520B2 (ja) * | 2010-02-12 | 2016-06-22 | イプソゲン | 骨髄性腫瘍の新規診断マーカーとしてのasxl1 |
| JP6054303B2 (ja) * | 2010-12-30 | 2016-12-27 | ファウンデーション メディシン インコーポレイテッドFoundation Medicine, Inc. | 腫瘍試料の多重遺伝子分析の最適化 |
-
2013
- 2013-03-11 AU AU2013232379A patent/AU2013232379A1/en not_active Abandoned
- 2013-03-11 JP JP2015500494A patent/JP2015512630A/ja active Pending
- 2013-03-11 US US14/384,580 patent/US20150031641A1/en not_active Abandoned
- 2013-03-11 CN CN201380024896.0A patent/CN104508143A/zh active Pending
- 2013-03-11 WO PCT/US2013/030208 patent/WO2013138237A1/en not_active Ceased
- 2013-03-11 EP EP13760340.3A patent/EP2825669A4/en not_active Withdrawn
- 2013-03-11 CA CA2867375A patent/CA2867375A1/en not_active Abandoned
Non-Patent Citations (3)
| Title |
|---|
| JPN6017000433; The Hematology Journal, 2003, Vol. 4, No. 1, pp. 31-40 * |
| JPN6017000434; BLOOD, 2011, Vol. 118, No. 20, pp. 5593-5603 * |
| JPN6017000436; BLOOD, 2011, Vol. 118, No. 14, pp. 3803-3810 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019507721A (ja) * | 2015-12-04 | 2019-03-22 | アジオス ファーマシューティカルズ, インコーポレイテッド | 悪性腫瘍の処置の方法 |
| KR101877607B1 (ko) * | 2016-03-03 | 2018-07-12 | 포항공과대학교 산학협력단 | 인슐린/igf―1 수용체 결핍 돌연변이체의 발달결함만 특이적으로 억제된 예쁜꼬마선충 |
| JP2023521927A (ja) * | 2020-07-30 | 2023-05-25 | ソウル大学校産学協力団 | Phf6を標的にするヒストンh2bエピジェネティクスス調節剤スクリーニング方法 |
| JP7501879B2 (ja) | 2020-07-30 | 2024-06-18 | ソウル大学校産学協力団 | Phf6を標的にするヒストンh2bエピジェネティクスス調節剤スクリーニング方法 |
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| CA2867375A1 (en) | 2013-09-19 |
| AU2013232379A1 (en) | 2014-09-25 |
| CN104508143A (zh) | 2015-04-08 |
| EP2825669A4 (en) | 2016-02-24 |
| US20150031641A1 (en) | 2015-01-29 |
| WO2013138237A9 (en) | 2015-01-29 |
| EP2825669A1 (en) | 2015-01-21 |
| WO2013138237A1 (en) | 2013-09-19 |
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