CA2867375A1 - Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia - Google Patents

Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia Download PDF

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Publication number
CA2867375A1
CA2867375A1 CA2867375A CA2867375A CA2867375A1 CA 2867375 A1 CA2867375 A1 CA 2867375A1 CA 2867375 A CA2867375 A CA 2867375A CA 2867375 A CA2867375 A CA 2867375A CA 2867375 A1 CA2867375 A1 CA 2867375A1
Authority
CA
Canada
Prior art keywords
patient
mutation
dnmt3a
mll
flt3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2867375A
Other languages
English (en)
French (fr)
Inventor
Ross L. LEVINE
Omar ABDEL-WAHEB
Jay P. PATEL
Mithat GONEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CA2867375A1 publication Critical patent/CA2867375A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2867375A 2012-03-12 2013-03-11 Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia Abandoned CA2867375A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261609723P 2012-03-12 2012-03-12
US61/609,723 2012-03-12
PCT/US2013/030208 WO2013138237A1 (en) 2012-03-12 2013-03-11 Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia

Publications (1)

Publication Number Publication Date
CA2867375A1 true CA2867375A1 (en) 2013-09-19

Family

ID=49161688

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2867375A Abandoned CA2867375A1 (en) 2012-03-12 2013-03-11 Methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia

Country Status (7)

Country Link
US (1) US20150031641A1 (enExample)
EP (1) EP2825669A4 (enExample)
JP (1) JP2015512630A (enExample)
CN (1) CN104508143A (enExample)
AU (1) AU2013232379A1 (enExample)
CA (1) CA2867375A1 (enExample)
WO (1) WO2013138237A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220070066A (ko) 2014-03-14 2022-05-27 아지오스 파마슈티컬스 아이엔씨. 치료적으로 활성인 화합물의 약제학적 조성물
EP3224380A1 (en) 2014-11-25 2017-10-04 The Broad Institute Inc. Clonal haematopoiesis
EP3626832B1 (en) 2014-11-25 2024-06-12 The Brigham and Women's Hospital, Inc. Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
CN104774954A (zh) * 2015-04-23 2015-07-15 上海允英医疗科技有限公司 用于hras突变检测的引物、探针及检测试剂盒
PT3362065T (pt) 2015-10-15 2024-06-21 Servier Lab Terapia de combinação compreendendo ivosidenib, citarabina e daunorubicina ou idarubicina para o tratamento de leucemia mielóide aguda
US10653710B2 (en) 2015-10-15 2020-05-19 Agios Pharmaceuticals, Inc. Combination therapy for treating malignancies
MX2018005771A (es) * 2015-11-11 2019-03-14 Celator Pharmaceuticals Inc Ensayos y metodos para seleccionar un regimen de tratamiento para un sujeto con leucemia.
WO2017084027A1 (zh) * 2015-11-17 2017-05-26 安诺优达基因科技(北京)有限公司 一种用于急性髓细胞白血病预后分层的试剂盒及检测方法
EP3383400B1 (en) * 2015-12-04 2022-01-05 Les Laboratoires Servier Methods of treatment of malignancies
KR101877607B1 (ko) * 2016-03-03 2018-07-12 포항공과대학교 산학협력단 인슐린／ｉｇｆ―1 수용체 결핍 돌연변이체의 발달결함만 특이적으로 억제된 예쁜꼬마선충
CN105861674A (zh) * 2016-04-27 2016-08-17 上海荻硕贝肯生物科技有限公司 用于检测与aml预后相关的基因突变的引物、试剂盒及方法
CN105969892B (zh) * 2016-07-14 2019-07-19 北京大学人民医院 Csrp2在作为评估成人b-all患者预后风险标记物中的应用
CN106381332A (zh) * 2016-08-31 2017-02-08 天津协和华美医学诊断技术有限公司 一种检测aml相关基因群的检测试剂盒
AU2017353925A1 (en) * 2016-11-02 2018-09-27 Arog Pharmaceuticals, Inc. Crenolanib for treating FLT3 mutated proliferative disorders associated mutations
CN107641650B (zh) * 2017-08-24 2020-05-08 中国人民解放军总医院 Nr1h3在急性髓系白血病精准靶向检测及预后评估中的应用
US10460446B2 (en) * 2017-10-16 2019-10-29 Nant Holdings Ip, Llc Image-based circular plot recognition and interpretation
CN107841556B (zh) * 2017-12-19 2020-12-01 武汉大学 一种基于C/EBPα和IGF1R基因筛选药物发育毒性的试剂盒及应用
CN107893118A (zh) * 2017-12-25 2018-04-10 合肥艾迪康临床检验所有限公司 检测phf6点突变的方法和引物
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
CN109172597B (zh) * 2018-09-06 2020-12-18 清华大学深圳研究生院 调节rDNA基因染色质组蛋白甲基化水平的物质及其应用
CN110124038A (zh) * 2019-05-08 2019-08-16 山东大学齐鲁医院 腺苷酸琥珀酸合成酶基因和/或其编码的蛋白的新应用
WO2021209517A1 (en) * 2020-04-15 2021-10-21 Centre National De La Recherche Scientifique Prognosis method of acute myeloid leukaemia
CN111560438B (zh) * 2020-06-11 2024-01-19 迈杰转化医学研究(苏州)有限公司 检测aml预后相关基因突变的引物组合物、试剂盒及其应用
KR102317670B1 (ko) * 2020-07-30 2021-10-26 서울대학교산학협력단 Phf6를 표적으로 하는 히스톤 h2b 에피제네틱 조절제 스크리닝 방법
CN112708675A (zh) * 2020-12-25 2021-04-27 中山大学肿瘤防治中心 骨髓nk细胞联合mcl1抑制剂在抗白血病中的应用
CN112626215B (zh) * 2020-12-30 2023-03-24 武汉康圣达医学检验所有限公司 Aml预后相关基因表达检测试剂盒
CN115216541A (zh) * 2021-04-15 2022-10-21 复旦大学附属华山医院 一组白血病标志物及应用
CN113764038B (zh) * 2021-08-31 2023-08-22 华南理工大学 构建骨髓增生异常综合征转白基因预测模型的方法
CN115323051B (zh) * 2022-02-22 2023-04-07 天津见康华美医学诊断技术有限公司 一种急性髓系白血病检测探针组合物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919623A (en) * 1994-04-27 1999-07-06 St. James's And Seacroft University Hospitals Nhs Trust Nucleic acid mutation assays
JP5937520B2 (ja) * 2010-02-12 2016-06-22 イプソゲン 骨髄性腫瘍の新規診断マーカーとしてのａｓｘｌ１
JP6054303B2 (ja) * 2010-12-30 2016-12-27 ファウンデーション メディシン インコーポレイテッドＦｏｕｎｄａｔｉｏｎ Ｍｅｄｉｃｉｎｅ， Ｉｎｃ． 腫瘍試料の多重遺伝子分析の最適化

Also Published As

Publication number Publication date
AU2013232379A1 (en) 2014-09-25
CN104508143A (zh) 2015-04-08
EP2825669A4 (en) 2016-02-24
US20150031641A1 (en) 2015-01-29
WO2013138237A9 (en) 2015-01-29
JP2015512630A (ja) 2015-04-30
EP2825669A1 (en) 2015-01-21
WO2013138237A1 (en) 2013-09-19

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FZDE Discontinued

Effective date: 20180313