JP2015510891A - Ｔｏｒキナーゼ阻害剤を用いた癌の治療 - Google Patents

Ｔｏｒキナーゼ阻害剤を用いた癌の治療 Download PDF

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Publication number
JP2015510891A
JP2015510891A JP2015500596A JP2015500596A JP2015510891A JP 2015510891 A JP2015510891 A JP 2015510891A JP 2015500596 A JP2015500596 A JP 2015500596A JP 2015500596 A JP2015500596 A JP 2015500596A JP 2015510891 A JP2015510891 A JP 2015510891A
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JP
Japan
Prior art keywords
substituted
unsubstituted
pyrazin
tor kinase
kinase inhibitor
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JP2015500596A
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English (en)
Japanese (ja)
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JP2015510891A5 (enExample
Inventor
シュ，スイチャン
ヘゲ，クリステン，マエ
レイモン，ヘザー
ロレイン ウォン，リリー
ロレイン ウォン，リリー
Original Assignee
シグナル ファーマシューティカルズ，エルエルシー
シグナル ファーマシューティカルズ，エルエルシー
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Publication of JP2015510891A publication Critical patent/JP2015510891A/ja
Publication of JP2015510891A5 publication Critical patent/JP2015510891A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015500596A 2012-03-15 2013-03-14 Ｔｏｒキナーゼ阻害剤を用いた癌の治療 Pending JP2015510891A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261611361P 2012-03-15 2012-03-15
US61/611,361 2012-03-15
US201261715323P 2012-10-18 2012-10-18
US61/715,323 2012-10-18
PCT/US2013/031206 WO2013138557A1 (en) 2012-03-15 2013-03-14 Treatment of cancer with tor kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019038434A Division JP2019108368A (ja) 2012-03-15 2019-03-04 Ｔｏｒキナーゼ阻害剤を用いた癌の治療

Publications (2)

Publication Number Publication Date
JP2015510891A true JP2015510891A (ja) 2015-04-13
JP2015510891A5 JP2015510891A5 (enExample) 2016-03-31

Family

ID=48014336

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015500596A Pending JP2015510891A (ja) 2012-03-15 2013-03-14 Ｔｏｒキナーゼ阻害剤を用いた癌の治療
JP2019038434A Pending JP2019108368A (ja) 2012-03-15 2019-03-04 Ｔｏｒキナーゼ阻害剤を用いた癌の治療
JP2021050188A Pending JP2021102637A (ja) 2012-03-15 2021-03-24 Ｔｏｒキナーゼ阻害剤を用いた癌の治療

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019038434A Pending JP2019108368A (ja) 2012-03-15 2019-03-04 Ｔｏｒキナーゼ阻害剤を用いた癌の治療
JP2021050188A Pending JP2021102637A (ja) 2012-03-15 2021-03-24 Ｔｏｒキナーゼ阻害剤を用いた癌の治療

Country Status (21)

Country Link
US (1) US20130245026A1 (enExample)
EP (1) EP2825170B1 (enExample)
JP (3) JP2015510891A (enExample)
KR (3) KR20210071101A (enExample)
CN (2) CN108992446A (enExample)
AU (1) AU2013203153B2 (enExample)
BR (1) BR112014022703A2 (enExample)
CA (1) CA2866872A1 (enExample)
EA (1) EA028414B1 (enExample)
ES (1) ES2677874T3 (enExample)
IL (1) IL234602B (enExample)
MX (1) MX360878B (enExample)
MY (1) MY174022A (enExample)
NI (1) NI201400111A (enExample)
NZ (1) NZ628416A (enExample)
PH (1) PH12014502029A1 (enExample)
SG (1) SG11201405707XA (enExample)
TW (1) TWI583385B (enExample)
UA (1) UA114315C2 (enExample)
WO (1) WO2013138557A1 (enExample)
ZA (1) ZA201406706B (enExample)

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ES2677874T3 (es) * 2012-03-15 2018-08-07 Signal Pharmaceuticals, Llc Tratamiento del cáncer con inhibidores de la cinasa TOR
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
EP2945636B1 (en) 2013-01-16 2017-06-28 Signal Pharmaceuticals, LLC Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
KR102242505B1 (ko) * 2013-04-17 2021-04-20 시그날 파마소티칼 엘엘씨 암 치료용 tor 키나제 억제제 및 시티딘 유사체를 포함하는 병용 요법
AU2014254057A1 (en) 2013-04-17 2015-11-05 Signal Pharmaceuticals, Llc Combination therapy comprising a TOR kinase inhibitor and N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
JP2016522177A (ja) * 2013-04-17 2016-07-28 シグナル ファーマシューティカルズ，エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
SG11201508527VA (en) 2013-04-17 2015-11-27 Signal Pharm Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
NZ629411A (en) 2013-04-17 2017-06-30 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
ES2944478T3 (es) 2013-04-17 2023-06-21 Signal Pharm Llc 1-etil-7-(2-metil-6-(1H-1,2,4-triazol-3-il)piridin-3-il)-3,4-dihidropirazino[2,3-b]pirazin-2(1H)-ona para tratar el glioblastoma multiforme
MX368286B (es) 2013-04-17 2019-09-27 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer.
BR112015026257B1 (pt) 2013-04-17 2022-12-20 Signal Pharmaceuticals, Llc Uso de um composto dihidropirazino-pirazina e enzalutamida, composição farmacêutica que os compreende, e kit
JP6401250B2 (ja) 2013-05-29 2018-10-10 シグナル ファーマシューティカルズ，エルエルシー ７−（６−（２−ヒドロキシプロパン−２−イル）ピリジン−３−イル）−１−（（ｔｒａｎｓ）−４−メトキシシクロヘキシル）−３，４−ジヒドロピラジノ［２，３−ｂ］ピラジン−２（１Ｈ）−オン、その固体形態の医薬組成物、及びその使用方法
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
US9512129B2 (en) 2014-04-16 2016-12-06 Signal Pharmaceuticals, Llc Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer
US9737535B2 (en) 2014-04-16 2017-08-22 Signal Pharmaceuticals, Llc Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines
NZ629796A (en) 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
AU2015289929A1 (en) 2014-07-14 2017-03-02 Signal Pharmaceuticals, Llc Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
EP3641772B1 (en) 2017-06-22 2023-08-02 Celgene Corporation Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway
US20120028972A1 (en) * 2010-07-30 2012-02-02 Lilly Wong Biomarker assays for detecting or measuring inhibition of tor kinase activity

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ES2383370T3 (es) 2006-10-19 2012-06-20 Signal Pharmaceuticals Llc Compuestos de heteroarilo, sus composiciones y uso de los mismos como inhibidores de proteína quinasa
EP2457913B1 (en) * 2006-10-19 2017-04-19 Signal Pharmaceuticals, LLC Heteroaryl compounds, compositions thereof, and methods of treatment therewith
US20110200556A1 (en) * 2008-08-20 2011-08-18 The United States Of America, As Represented By Th E Secretary, Department Of Health And Human Servi Chemoprevention of head and neck squamous cell carcinomas
JP2013508456A (ja) 2009-10-26 2013-03-07 シグナル ファーマシューティカルズ， エルエルシー ヘテロアリール化合物の合成方法および精製方法
ES2677874T3 (es) * 2012-03-15 2018-08-07 Signal Pharmaceuticals, Llc Tratamiento del cáncer con inhibidores de la cinasa TOR

Patent Citations (2)

* Cited by examiner, † Cited by third party
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WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway
US20120028972A1 (en) * 2010-07-30 2012-02-02 Lilly Wong Biomarker assays for detecting or measuring inhibition of tor kinase activity

Non-Patent Citations (5)

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Title
AMORNPHIMOLTHAM PANOMWAT: "A RETROINHIBITION APPROACH REVEALS A TUMOR CELL-AUTONOMOUS RESPONSE 以下省略", CANCER RESEARCH, vol. V68 N4, JPN5015004800, 15 February 2008 (2008-02-15), US, pages 1144 - 1153, ISSN: 0003429944 *
LORI BERK: "ANALYSIS OF PHARMACODYNAMIC ACTIVITY OF THE MTOR 以下省略", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. V69 N5, JPN5015004803, 10 January 2012 (2012-01-10), DE, pages 1369 - 1377, ISSN: 0003429945 *
OLEKSANDR EKSHYYAN, HEAD & NECK, vol. V32 N12, JPN5015004798, 1 December 2010 (2010-12-01), pages 1619 - 1628, ISSN: 0003429943 *
医学のあゆみ, vol. 222, no. 13, JPN6017024427, 2007, pages 1006 - 1009, ISSN: 0003589822 *
医学のあゆみ, vol. 222, no. 13, JPN6018001822, 2007, pages 1006 - 1009, ISSN: 0003724722 *

Also Published As

Publication number Publication date
US20130245026A1 (en) 2013-09-19
JP2019108368A (ja) 2019-07-04
IL234602A0 (en) 2014-11-30
EP2825170A1 (en) 2015-01-21
KR102122617B1 (ko) 2020-06-12
IL234602B (en) 2020-05-31
UA114315C2 (uk) 2017-05-25
KR20200070416A (ko) 2020-06-17
HK1201750A1 (en) 2015-09-11
CN108992446A (zh) 2018-12-14
CN104519885A (zh) 2015-04-15
KR20140138927A (ko) 2014-12-04
AU2013203153B2 (en) 2015-09-03
NI201400111A (es) 2015-01-15
TWI583385B (zh) 2017-05-21
AU2013203153A1 (en) 2013-10-03
KR20210071101A (ko) 2021-06-15
MY174022A (en) 2020-03-04
BR112014022703A2 (pt) 2021-05-04
WO2013138557A1 (en) 2013-09-19
PH12014502029B1 (en) 2014-11-24
TW201343168A (zh) 2013-11-01
CA2866872A1 (en) 2013-09-19
EA201491699A1 (ru) 2015-02-27
EA028414B1 (ru) 2017-11-30
SG11201405707XA (en) 2014-10-30
ES2677874T3 (es) 2018-08-07
JP2021102637A (ja) 2021-07-15
PH12014502029A1 (en) 2014-11-24
MX2014011077A (es) 2014-10-14
MX360878B (es) 2018-11-21
EP2825170B1 (en) 2018-05-09
ZA201406706B (en) 2016-05-25
NZ628416A (en) 2016-04-29

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