JP2015510760A5 - - Google Patents
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- Publication number
- JP2015510760A5 JP2015510760A5 JP2014561103A JP2014561103A JP2015510760A5 JP 2015510760 A5 JP2015510760 A5 JP 2015510760A5 JP 2014561103 A JP2014561103 A JP 2014561103A JP 2014561103 A JP2014561103 A JP 2014561103A JP 2015510760 A5 JP2015510760 A5 JP 2015510760A5
- Authority
- JP
- Japan
- Prior art keywords
- supplement
- fatty acids
- omega
- dha
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013589 supplement Substances 0.000 claims 53
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 20
- 235000014113 dietary fatty acids Nutrition 0.000 claims 13
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 13
- 229930195729 fatty acid Natural products 0.000 claims 13
- 239000000194 fatty acid Substances 0.000 claims 13
- 150000004665 fatty acids Chemical class 0.000 claims 13
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 11
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 11
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 11
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 11
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 10
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 10
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 10
- 235000015872 dietary supplement Nutrition 0.000 claims 9
- 235000021588 free fatty acids Nutrition 0.000 claims 8
- 150000003626 triacylglycerols Chemical class 0.000 claims 8
- 239000006014 omega-3 oil Substances 0.000 claims 6
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims 6
- 229940033080 omega-6 fatty acid Drugs 0.000 claims 6
- 210000000287 oocyte Anatomy 0.000 claims 5
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 3
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 230000003078 antioxidant effect Effects 0.000 claims 3
- 235000006708 antioxidants Nutrition 0.000 claims 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 2
- 208000031404 Chromosome Aberrations Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims 2
- 229930003316 Vitamin D Natural products 0.000 claims 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 2
- 235000021342 arachidonic acid Nutrition 0.000 claims 2
- 229940114079 arachidonic acid Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 235000019166 vitamin D Nutrition 0.000 claims 2
- 239000011710 vitamin D Substances 0.000 claims 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 2
- 229940046008 vitamin d Drugs 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- 208000010543 22q11.2 deletion syndrome Diseases 0.000 claims 1
- 208000009575 Angelman syndrome Diseases 0.000 claims 1
- 102100022548 Beta-hexosaminidase subunit alpha Human genes 0.000 claims 1
- 208000022526 Canavan disease Diseases 0.000 claims 1
- 208000010693 Charcot-Marie-Tooth Disease Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000006992 Color Vision Defects Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 1
- 208000000398 DiGeorge Syndrome Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- SHWNNYZBHZIQQV-UHFFFAOYSA-J EDTA monocalcium diisodium salt Chemical compound [Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-J 0.000 claims 1
- 102000002322 Egg Proteins Human genes 0.000 claims 1
- 108010000912 Egg Proteins Proteins 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 208000018565 Hemochromatosis Diseases 0.000 claims 1
- 208000031220 Hemophilia Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 208000009905 Neurofibromatoses Diseases 0.000 claims 1
- 201000011252 Phenylketonuria Diseases 0.000 claims 1
- 201000010769 Prader-Willi syndrome Diseases 0.000 claims 1
- 208000022292 Tay-Sachs disease Diseases 0.000 claims 1
- 208000026928 Turner syndrome Diseases 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 229940087168 alpha tocopherol Drugs 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 201000007254 color blindness Diseases 0.000 claims 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 230000035558 fertility Effects 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 230000009245 menopause Effects 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- 230000000394 mitotic effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000004931 neurofibromatosis Diseases 0.000 claims 1
- 210000004681 ovum Anatomy 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 208000030761 polycystic kidney disease Diseases 0.000 claims 1
- 239000000473 propyl gallate Substances 0.000 claims 1
- 235000010388 propyl gallate Nutrition 0.000 claims 1
- 229940075579 propyl gallate Drugs 0.000 claims 1
- 230000001850 reproductive effect Effects 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229960000984 tocofersolan Drugs 0.000 claims 1
- 229940042585 tocopherol acetate Drugs 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
- 235000004835 α-tocopherol Nutrition 0.000 claims 1
- 125000001020 α-tocopherol group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607884P | 2012-03-07 | 2012-03-07 | |
| US61/607,884 | 2012-03-07 | ||
| US201261695510P | 2012-08-31 | 2012-08-31 | |
| US61/695,510 | 2012-08-31 | ||
| PCT/US2013/029553 WO2013134482A1 (en) | 2012-03-07 | 2013-03-07 | Methods for enhancing, improving, or increasing fertility or reproductive function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510760A JP2015510760A (ja) | 2015-04-13 |
| JP2015510760A5 true JP2015510760A5 (enExample) | 2016-04-21 |
| JP6424091B2 JP6424091B2 (ja) | 2018-11-14 |
Family
ID=47892067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561103A Active JP6424091B2 (ja) | 2012-03-07 | 2013-03-07 | 妊孕能または生殖機能を向上させるか、改善するか、または増大させるための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9295662B2 (enExample) |
| EP (1) | EP2822403B1 (enExample) |
| JP (1) | JP6424091B2 (enExample) |
| AU (1) | AU2013230896B2 (enExample) |
| CA (1) | CA2866606C (enExample) |
| WO (1) | WO2013134482A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6284768B2 (ja) * | 2014-01-16 | 2018-02-28 | 株式会社紀州ほそ川 | 不妊治療剤 |
| US10004711B2 (en) * | 2014-05-08 | 2018-06-26 | Dsm Ip Assets B.V. | Methods and compositions comprising 10-hydroxy-2-decenoic acid |
| BR112017002553A2 (pt) * | 2014-09-30 | 2017-12-05 | Nestec Sa | composição nutricional a ser usada para tratar ou prevenir condições relacionadas à gravidez |
| JP6788381B2 (ja) * | 2016-05-30 | 2020-11-25 | 岩手県 | 酸化ストレス抑制剤 |
| GR1009657B (el) * | 2016-11-07 | 2019-11-28 | Βαρβαρα Γεωργιου Γελαδακη | Συνθεσεις για χορηγηση απο το στομα με ανοσοτροποποιητικη δραση στα φυσικα φονικα κυτταρα |
| WO2025231097A1 (en) * | 2024-05-02 | 2025-11-06 | Cold Spring Harbor Laboratory | Use of arachidonic acid for promoting endometrial epithelium regeneration and stem cell plasticity |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY118354A (en) | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
| IL125097A (en) | 1998-06-25 | 2003-01-12 | Israel State | Dietary manipulation to increase fertility |
| US6576253B2 (en) * | 2000-12-05 | 2003-06-10 | Pbm Pharmaceuticals, Inc. | Food bars containing nutritional supplements |
| US20030060509A1 (en) * | 2001-08-24 | 2003-03-27 | Elswyk Mary Van | Products containing highly unsaturated fatty acids for use by women and their children during stages of preconception, pregnancy and lactation/post-partum |
| US6576667B2 (en) * | 2001-11-14 | 2003-06-10 | Norel Acquisition Corp. | Method for manufacturing fatty acid calcium salts from high glyceride content oils |
| US20040254357A1 (en) | 2002-12-19 | 2004-12-16 | Zaloga Gary P. | Fatty acid phenolic conjugates |
| US8263137B2 (en) * | 2005-08-04 | 2012-09-11 | Vertical Pharmaceuticals, Inc. | Nutritional supplement for women |
| US8652508B2 (en) | 2007-05-25 | 2014-02-18 | Children's Medical Center Corporation | Dietary formulations and methods for treatment of inflammation and other disorders |
-
2013
- 2013-03-07 EP EP13710265.3A patent/EP2822403B1/en active Active
- 2013-03-07 JP JP2014561103A patent/JP6424091B2/ja active Active
- 2013-03-07 AU AU2013230896A patent/AU2013230896B2/en active Active
- 2013-03-07 CA CA2866606A patent/CA2866606C/en active Active
- 2013-03-07 US US14/383,269 patent/US9295662B2/en active Active
- 2013-03-07 WO PCT/US2013/029553 patent/WO2013134482A1/en not_active Ceased
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