JP2015509966A5 - - Google Patents
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- JP2015509966A5 JP2015509966A5 JP2014561430A JP2014561430A JP2015509966A5 JP 2015509966 A5 JP2015509966 A5 JP 2015509966A5 JP 2014561430 A JP2014561430 A JP 2014561430A JP 2014561430 A JP2014561430 A JP 2014561430A JP 2015509966 A5 JP2015509966 A5 JP 2015509966A5
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- JP
- Japan
- Prior art keywords
- formula
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 14
- 125000005647 linker group Chemical group 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 229910021645 metal ion Inorganic materials 0.000 claims 4
- 230000005298 paramagnetic effect Effects 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 239000002616 MRI contrast agent Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000005157 alkyl carboxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12159378.4 | 2012-03-14 | ||
| EP12159378.4A EP2639227A1 (en) | 2012-03-14 | 2012-03-14 | A new class of diazepine derivative chelating agents and complexes with paramagnetic metals as MRI contrast agents |
| PCT/EP2013/055094 WO2013135750A1 (en) | 2012-03-14 | 2013-03-13 | A new class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as mri contrast agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509966A JP2015509966A (ja) | 2015-04-02 |
| JP2015509966A5 true JP2015509966A5 (https=) | 2016-04-28 |
| JP6375231B2 JP6375231B2 (ja) | 2018-08-15 |
Family
ID=47846054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561430A Active JP6375231B2 (ja) | 2012-03-14 | 2013-03-13 | 新しいクラスのジアゼピン誘導体キレート化剤およびｍｒｉ造影剤としてのその常磁性金属との錯体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9259491B2 (https=) |
| EP (2) | EP2639227A1 (https=) |
| JP (1) | JP6375231B2 (https=) |
| CN (1) | CN104203926B (https=) |
| AU (1) | AU2013231301B2 (https=) |
| CA (1) | CA2863784C (https=) |
| WO (1) | WO2013135750A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014037498A2 (en) * | 2012-09-07 | 2014-03-13 | Bracco Imaging Spa | Paramagnetic solid lipid nanoparticles (pslns) containing metal amphiphilic complexes for mri. |
| CN105377309A (zh) | 2013-05-30 | 2016-03-02 | 伯拉考成像股份公司 | 荧光固体脂质纳米颗粒组合物及其制备 |
| IL260957B2 (en) | 2016-02-09 | 2023-11-01 | Bracco Suisse Sa | Chimeric, Recombinant Protein Glycoprotein Selectin-P Ligand-1 (PSGL-1) Conjugates, Preparations Containing Them and Uses Thereof |
| US11353533B2 (en) | 2016-02-24 | 2022-06-07 | Ohio State Innovation Foundation | Methods and devices for contrast agent magnetic resonance imaging |
| DE102017129405A1 (de) | 2017-12-11 | 2019-06-13 | Universitätsklinikum Jena | Neue DAZA-Chelatoren als Liganden in der Leberbildgebung |
| CN112996764B (zh) | 2018-11-12 | 2023-11-21 | 伯拉考成像股份公司 | 螯合aazta缀合物及其配合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
| US5833948A (en) | 1995-06-15 | 1998-11-10 | Bracco Research S.A. | Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant |
| WO2000009170A1 (en) * | 1998-08-10 | 2000-02-24 | Bracco Research S.A. | Combination of a positive mri contrast agent with a negative mri contrast agent |
| US6342598B1 (en) | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
| FR2795412B1 (fr) * | 1999-06-23 | 2001-07-13 | Adir | Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7893223B2 (en) * | 2001-07-17 | 2011-02-22 | Bracco Imaging S.P.A. | Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy |
| ITMI20011518A1 (it) | 2001-07-17 | 2003-01-17 | Bracco Imaging Spa | Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia |
| US7922998B2 (en) | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| GB0305422D0 (en) * | 2003-03-10 | 2003-04-16 | Univ Open | Detection, monitoring and treatment of cancer |
| JP5106107B2 (ja) * | 2004-07-02 | 2012-12-26 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | ポリヒドロキシル化置換基を有するキレート化部分を含む磁気共鳴画像法（ｍｒｉ）用高緩和能造影剤 |
| EP1964846A1 (en) * | 2007-02-27 | 2008-09-03 | Bracco Imaging, S.P.A. | Process for the preparation of contrast agents |
| FR2939318B1 (fr) * | 2008-12-10 | 2012-07-13 | Guerbet Sa | Systeme d'encapsulation pour imagerie cest avec quelate q superieur ou egal a 2 |
-
2012
- 2012-03-14 EP EP12159378.4A patent/EP2639227A1/en not_active Withdrawn
-
2013
- 2013-03-13 US US14/384,414 patent/US9259491B2/en active Active
- 2013-03-13 CA CA2863784A patent/CA2863784C/en active Active
- 2013-03-13 JP JP2014561430A patent/JP6375231B2/ja active Active
- 2013-03-13 EP EP13708844.9A patent/EP2834222B1/en active Active
- 2013-03-13 WO PCT/EP2013/055094 patent/WO2013135750A1/en not_active Ceased
- 2013-03-13 AU AU2013231301A patent/AU2013231301B2/en active Active
- 2013-03-13 CN CN201380014181.7A patent/CN104203926B/zh active Active
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