JP2015509483A - 線維症を治療するためのｐｉ３ｋ阻害剤 - Google Patents

線維症を治療するためのｐｉ３ｋ阻害剤 Download PDF

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Publication number
JP2015509483A
JP2015509483A JP2014555239A JP2014555239A JP2015509483A JP 2015509483 A JP2015509483 A JP 2015509483A JP 2014555239 A JP2014555239 A JP 2014555239A JP 2014555239 A JP2014555239 A JP 2014555239A JP 2015509483 A JP2015509483 A JP 2015509483A
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Prior art keywords
pyridazinyl
pharmaceutically acceptable
methyloxy
pyridinyl
difluoro
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Pending
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JP2014555239A
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English (en)
Japanese (ja)
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JP2015509483A5 (enExample
Inventor
フランシス ウースター，リチャード
フランシス ウースター，リチャード
テレサ ルーキー，ポーリーン
テレサ ルーキー，ポーリーン
ジョン トンプソン ヴァランス，パトリック
ジョン トンプソン ヴァランス，パトリック
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GlaxoSmithKline Intellectual Property No 2 Ltd
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GlaxoSmithKline Intellectual Property No 2 Ltd
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Application filed by GlaxoSmithKline Intellectual Property No 2 Ltd filed Critical GlaxoSmithKline Intellectual Property No 2 Ltd
Publication of JP2015509483A publication Critical patent/JP2015509483A/ja
Publication of JP2015509483A5 publication Critical patent/JP2015509483A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2014555239A 2012-02-06 2013-02-04 線維症を治療するためのｐｉ３ｋ阻害剤 Pending JP2015509483A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261595293P 2012-02-06 2012-02-06
US61/595,293 2012-02-06
US201261702854P 2012-09-19 2012-09-19
US61/702,854 2012-09-19
PCT/EP2013/052112 WO2013117503A2 (en) 2012-02-06 2013-02-04 Novel use

Publications (2)

Publication Number Publication Date
JP2015509483A true JP2015509483A (ja) 2015-03-30
JP2015509483A5 JP2015509483A5 (enExample) 2016-03-24

Family

ID=47633093

Family Applications (1)

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JP2014555239A Pending JP2015509483A (ja) 2012-02-06 2013-02-04 線維症を治療するためのｐｉ３ｋ阻害剤

Country Status (10)

Country Link
US (2) US20150051215A1 (enExample)
EP (1) EP2812002A2 (enExample)
JP (1) JP2015509483A (enExample)
KR (1) KR20140127307A (enExample)
CN (1) CN104093408A (enExample)
AU (1) AU2013218148A1 (enExample)
BR (1) BR112014018106A2 (enExample)
CA (1) CA2861521A1 (enExample)
RU (1) RU2014128387A (enExample)
WO (1) WO2013117503A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017123811A (ja) * 2016-01-14 2017-07-20 学校法人東京農業大学 ヤマノイモ属植物からのディオスコリンの製造方法
JP2018527330A (ja) * 2015-07-30 2018-09-20 モナシュ ユニバーシティー 線維症の処置

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190269675A1 (en) 2014-01-28 2019-09-05 Buck Institute for Research and Aging Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
EP3099380B1 (en) 2014-01-28 2021-08-11 Buck Institute for Research on Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
WO2018177301A1 (zh) 2017-04-01 2018-10-04 郑州大学 15-亚基-14-脱氧-11,12-脱氢穿心莲内酯衍生物及其在制备抗纤维化药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010532320A (ja) * 2007-06-14 2010-10-07 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｐｉ３キナーゼ阻害剤としてのキナゾリン誘導体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010532320A (ja) * 2007-06-14 2010-10-07 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｐｉ３キナーゼ阻害剤としてのキナゾリン誘導体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ACS MED. CHEM LETT. 2010, 1, 39-43, JPN6016041464, ISSN: 0003429247 *
HEPATOLOGY, 2009 NOVEMBER ; 50(5): 1512-1523, JPN6016041467, ISSN: 0003429249 *
THE AMERICAN JOURNAL OF PATHOLOGY, VOL. 176, NO. 2, FEBRUARY 2010, JPN6016041465, ISSN: 0003429248 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018527330A (ja) * 2015-07-30 2018-09-20 モナシュ ユニバーシティー 線維症の処置
JP2020189845A (ja) * 2015-07-30 2020-11-26 モナシュ ユニバーシティー 線維症の処置
JP2023030022A (ja) * 2015-07-30 2023-03-07 モナシュ ユニバーシティー 線維症の処置
JP7457360B2 (ja) 2015-07-30 2024-03-28 モナシュ ユニバーシティー 線維症の処置
JP2017123811A (ja) * 2016-01-14 2017-07-20 学校法人東京農業大学 ヤマノイモ属植物からのディオスコリンの製造方法

Also Published As

Publication number Publication date
US20160067247A1 (en) 2016-03-10
RU2014128387A (ru) 2016-03-27
EP2812002A2 (en) 2014-12-17
CA2861521A1 (en) 2013-08-15
WO2013117503A2 (en) 2013-08-15
BR112014018106A2 (pt) 2017-06-27
WO2013117503A3 (en) 2013-10-03
KR20140127307A (ko) 2014-11-03
CN104093408A (zh) 2014-10-08
US20150051215A1 (en) 2015-02-19
AU2013218148A1 (en) 2014-07-24

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