JP2015506482A5 - - Google Patents
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- JP2015506482A5 JP2015506482A5 JP2014555777A JP2014555777A JP2015506482A5 JP 2015506482 A5 JP2015506482 A5 JP 2015506482A5 JP 2014555777 A JP2014555777 A JP 2014555777A JP 2014555777 A JP2014555777 A JP 2014555777A JP 2015506482 A5 JP2015506482 A5 JP 2015506482A5
- Authority
- JP
- Japan
- Prior art keywords
- blood
- inhibitor
- plasma
- instrument
- anticoagulant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004369 blood Anatomy 0.000 claims 20
- 239000008280 blood Substances 0.000 claims 20
- 239000003112 inhibitor Substances 0.000 claims 13
- 239000003146 anticoagulant agent Substances 0.000 claims 12
- 229940127219 anticoagulant drug Drugs 0.000 claims 12
- 229940127218 antiplatelet drug Drugs 0.000 claims 12
- 239000002904 solvent Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 5
- 150000003180 prostaglandins Chemical class 0.000 claims 5
- 229940122204 Cyclooxygenase inhibitor Drugs 0.000 claims 4
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 4
- 102000012479 Serine Proteases Human genes 0.000 claims 4
- 108010022999 Serine Proteases Proteins 0.000 claims 4
- 229960001123 epoprostenol Drugs 0.000 claims 4
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 claims 4
- 238000002955 isolation Methods 0.000 claims 4
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 4
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 claims 4
- 229920000858 Cyclodextrin Polymers 0.000 claims 3
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 claims 3
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 claims 3
- 102000018389 Exopeptidases Human genes 0.000 claims 3
- 108010091443 Exopeptidases Proteins 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 3
- 229960002240 iloprost Drugs 0.000 claims 3
- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 3
- 239000003001 serine protease inhibitor Substances 0.000 claims 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 229940098773 bovine serum albumin Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- -1 cyprosten Chemical compound 0.000 claims 2
- 229960002768 dipyridamole Drugs 0.000 claims 2
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 2
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 claims 1
- LGIPMFCHTFFLFR-PRYZLTTQSA-N 13,14-dehydro-15-cyclohexyl Carbaprostacyclin Chemical compound C([C@@H]1[C@H]2CC(/C[C@H]2C[C@H]1O)=C/CCCC(O)=O)#CC1(O)CCCCC1 LGIPMFCHTFFLFR-PRYZLTTQSA-N 0.000 claims 1
- IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 claims 1
- RJADQDXZYFCVHV-JQMWNLLFSA-N 5-[(2s,4r,5r,6ar)-5-hydroxy-4-[(e,3s)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-2h-cyclopenta[b]furan-2-yl]pentanoic acid Chemical compound O1[C@@H](CCCCC(O)=O)CC2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@H]21 RJADQDXZYFCVHV-JQMWNLLFSA-N 0.000 claims 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- XZFRIPGNUQRGPI-WBQKLGIQSA-N Carbaprostacyclin Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WBQKLGIQSA-N 0.000 claims 1
- 102000005927 Cysteine Proteases Human genes 0.000 claims 1
- 108010005843 Cysteine Proteases Proteins 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 229940122601 Esterase inhibitor Drugs 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 claims 1
- 101710090406 Meprin A subunit alpha Proteins 0.000 claims 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 229940122055 Serine protease inhibitor Drugs 0.000 claims 1
- 101710102218 Serine protease inhibitor Proteins 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 229960000711 alprostadil Drugs 0.000 claims 1
- 229960002890 beraprost Drugs 0.000 claims 1
- CTPOHARTNNSRSR-APJZLKAGSA-N beraprost Chemical compound O([C@H]1C[C@@H](O)[C@@H]([C@@H]21)/C=C/[C@@H](O)C(C)CC#CC)C1=C2C=CC=C1CCCC(O)=O CTPOHARTNNSRSR-APJZLKAGSA-N 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 238000004820 blood count Methods 0.000 claims 1
- 229940001468 citrate Drugs 0.000 claims 1
- 239000000701 coagulant Substances 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 229960001259 diclofenac Drugs 0.000 claims 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 1
- 229960002986 dinoprostone Drugs 0.000 claims 1
- QLBHNVFOQLIYTH-UHFFFAOYSA-L dipotassium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical group [K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O QLBHNVFOQLIYTH-UHFFFAOYSA-L 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000002329 esterase inhibitor Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- 229960000905 indomethacin Drugs 0.000 claims 1
- OJZYRQPMEIEQFC-UAWLTFRCSA-N limaprost Chemical compound CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCC\C=C\C(O)=O OJZYRQPMEIEQFC-UAWLTFRCSA-N 0.000 claims 1
- 229950009365 limaprost Drugs 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 229960001929 meloxicam Drugs 0.000 claims 1
- PZRHRDRVRGEVNW-UHFFFAOYSA-N milrinone Chemical compound N1C(=O)C(C#N)=CC(C=2C=CN=CC=2)=C1C PZRHRDRVRGEVNW-UHFFFAOYSA-N 0.000 claims 1
- 229960003574 milrinone Drugs 0.000 claims 1
- 229960002009 naproxen Drugs 0.000 claims 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 1
- 229960002702 piroxicam Drugs 0.000 claims 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 235000019419 proteases Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 229960003676 tenidap Drugs 0.000 claims 1
- LXIKEPCNDFVJKC-QXMHVHEDSA-N tenidap Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)\C1=C(/O)C1=CC=CS1 LXIKEPCNDFVJKC-QXMHVHEDSA-N 0.000 claims 1
- 229960002871 tenoxicam Drugs 0.000 claims 1
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 230000009974 thixotropic effect Effects 0.000 claims 1
- 229950005371 zaprinast Drugs 0.000 claims 1
- REZGGXNDEMKIQB-UHFFFAOYSA-N zaprinast Chemical compound CCCOC1=CC=CC=C1C1=NC(=O)C2=NNNC2=N1 REZGGXNDEMKIQB-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594152P | 2012-02-02 | 2012-02-02 | |
| US61/594,152 | 2012-02-02 | ||
| PCT/US2013/024416 WO2013116702A1 (en) | 2012-02-02 | 2013-02-01 | Sample collection devices with blood stabilizing agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015506482A JP2015506482A (ja) | 2015-03-02 |
| JP2015506482A5 true JP2015506482A5 (https=) | 2016-03-10 |
Family
ID=48905892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555777A Pending JP2015506482A (ja) | 2012-02-02 | 2013-02-01 | 血液安定剤を含んだサンプル採取器具 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20130209985A1 (https=) |
| EP (1) | EP2809289A4 (https=) |
| JP (1) | JP2015506482A (https=) |
| CN (1) | CN104244902A (https=) |
| AU (1) | AU2013214866A1 (https=) |
| BR (1) | BR112014018970A8 (https=) |
| CA (1) | CA2862544A1 (https=) |
| IN (1) | IN2014DN06981A (https=) |
| MX (1) | MX2014009256A (https=) |
| WO (1) | WO2013116702A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010117976A1 (en) | 2009-04-09 | 2010-10-14 | Entegrion, Inc | Spray-dried blood products and methods of making same |
| US20110142885A1 (en) | 2009-09-16 | 2011-06-16 | Velico Medical, Inc. | Spray-dried human plasma |
| US20140083628A1 (en) | 2012-09-27 | 2014-03-27 | Velico Medical, Inc. | Spray drier assembly for automated spray drying |
| CA2932548C (en) * | 2014-01-30 | 2020-10-27 | F. Hoffmann-La Roche Ag | Stabilization of whole blood at room temperature |
| US9561184B2 (en) | 2014-09-19 | 2017-02-07 | Velico Medical, Inc. | Methods and systems for multi-stage drying of plasma |
| US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
| ES2938089T3 (es) | 2015-08-13 | 2023-04-04 | Takeda Pharmaceuticals Co | Tubos de extracción de sangre al vacío que contienen inhibidores de proteasa para la evaluación de la activación del sistema de contacto |
| US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
| US10870110B2 (en) | 2015-12-11 | 2020-12-22 | Babson Diagnostics, Inc. | Specimen container and centrifugation method for separating serum or plasma from whole blood therewith |
| CN105372109A (zh) * | 2015-12-15 | 2016-03-02 | 苏州药明康德新药开发股份有限公司 | 添加稳定剂的生物基质的制备方法 |
| EP4656715A3 (en) | 2016-07-29 | 2026-02-25 | Streck LLC | Suspension composition for hematology analysis control |
| CN110291377B (zh) | 2016-11-14 | 2023-09-05 | 巴布森诊断公司 | 样本制备装置 |
| EP3684436B1 (en) | 2017-09-22 | 2024-11-27 | Becton, Dickinson and Company | 4% trisodium citrate solution for use as a catheter lock solution |
| CN115119829B (zh) | 2017-10-19 | 2024-07-12 | 斯特雷克股份有限公司 | 用于胞外囊泡的溶血和凝血调节以及稳定化的组合物 |
| US20200393345A1 (en) * | 2017-11-15 | 2020-12-17 | Radiometer Medical Aps | Heparin-based blood sampler without platelet activation |
| CN108311121B (zh) * | 2018-01-25 | 2021-05-14 | 健帆生物科技集团股份有限公司 | 一种血液灌流用吸附树脂及其制备方法和灌流器 |
| US12426815B2 (en) | 2018-04-27 | 2025-09-30 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Integrated device for self-collecting and automated pre-processing of biological fluids |
| JP7334468B2 (ja) * | 2018-05-29 | 2023-08-29 | 東ソー株式会社 | 血液試料保存剤 |
| JP7036670B2 (ja) * | 2018-05-31 | 2022-03-15 | アークレイ株式会社 | 血液中の稀少細胞検査、該検査ための血液処理方法及び採血管 |
| EP3937761B1 (en) * | 2019-03-11 | 2024-05-22 | Siemens Healthcare Diagnostics, Inc. | Syringe apparatus |
| EP3969901A1 (en) * | 2019-05-14 | 2022-03-23 | Radiometer Medical ApS | Methods for determining blood gas or metabolic parameters |
| JP7402727B2 (ja) * | 2020-03-26 | 2023-12-21 | テルモ株式会社 | リン脂質含有物質安定化剤およびそれを含む体液検査キット |
| CN111521455A (zh) * | 2020-04-27 | 2020-08-11 | 中国科学院西北生态环境资源研究院 | 一种取样注射器的夹持单元及夹持方法 |
| CN112063513A (zh) * | 2020-09-21 | 2020-12-11 | 湖南洪江嵩云禽业有限公司 | 新型冰鲜禽肉储运新鲜度安全示警卡 |
| CN116438435A (zh) * | 2020-11-25 | 2023-07-14 | 株式会社普欧威盖特 | 用于将血浆或血清分离并保管的介质、其制造方法、器件、试剂盒和糖化蛋白的测定方法 |
| WO2022136545A1 (en) * | 2020-12-22 | 2022-06-30 | Radiometer Medical Aps | Blood sampler containing anti-platelet agent and water-soluble matrix material |
| US12050052B1 (en) | 2021-08-06 | 2024-07-30 | Babson Diagnostics, Inc. | Refrigerated carrier device for biological samples |
| MX2024004522A (es) * | 2021-10-15 | 2024-05-08 | Becton Dickinson Co | Mezcla con aditivos para la recogida de muestras de sangre. |
| US12138054B2 (en) * | 2021-11-11 | 2024-11-12 | Prp Technologies Inc | Specimen collection device |
| KR20240168912A (ko) * | 2022-03-25 | 2024-12-02 | 세키스이 메디칼 가부시키가이샤 | 순환 종양 세포 분리 키트, 순환 종양 세포 분리 용기 및 순환 종양 세포의 분리 방법 |
| EP4505185A1 (en) | 2022-04-06 | 2025-02-12 | Babson Diagnostics, Inc. | Automated centrifuge loader |
| US12246266B2 (en) | 2022-09-15 | 2025-03-11 | Velico Medical, Inc. | Disposable for a spray drying system |
| WO2024059770A1 (en) | 2022-09-15 | 2024-03-21 | Velico Medical, Inc. | Rapid spray drying system |
| US12539355B2 (en) | 2022-09-15 | 2026-02-03 | Velico Medical, Inc. | Dryer for a spray drying system |
| US12246093B2 (en) | 2022-09-15 | 2025-03-11 | Velico Medical, Inc. | Methods for making spray dried plasma |
| US12083447B2 (en) | 2022-09-15 | 2024-09-10 | Velico Medical, Inc. | Alignment of a disposable for a spray drying plasma system |
| US11998861B2 (en) | 2022-09-15 | 2024-06-04 | Velico Medical, Inc. | Usability of a disposable for a spray drying plasma system |
| US12571587B2 (en) | 2022-09-15 | 2026-03-10 | Velico Medical, Inc. | Finishing apparatus for a spray drying system |
| US11975274B2 (en) | 2022-09-15 | 2024-05-07 | Velico Medical, Inc. | Blood plasma product |
| US11841189B1 (en) | 2022-09-15 | 2023-12-12 | Velico Medical, Inc. | Disposable for a spray drying system |
| WO2026018855A1 (ja) * | 2024-07-18 | 2026-01-22 | 株式会社AdipoSeeds | 血小板の機能を評価する方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4104606C1 (https=) * | 1991-02-12 | 1992-10-15 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
| FR2729823B1 (fr) * | 1995-01-31 | 2001-08-31 | Samama Meyer | Conservation de prelevements de sang, en particulier chez les malades traites par l'heparine |
| US6139878A (en) * | 1998-04-27 | 2000-10-31 | Aventis Behring, Llc | Method for preparing a diafiltered stabilized blood product |
| US6924114B2 (en) * | 2000-09-20 | 2005-08-02 | Surromed, Inc. | Method for monitoring resting and activated platelets in unfixed blood samples |
| KR100451485B1 (ko) * | 2002-03-28 | 2004-10-06 | 주식회사종근당 | 푸마질롤 유도체 또는 그 염의 포접 화합물, 및 이를포함하는 약제학적 조성물 |
| AU2003234382B2 (en) * | 2002-05-13 | 2010-07-08 | Becton, Dickinson And Company | Protease inhibitor sample collection system |
| CN101554601A (zh) * | 2003-08-05 | 2009-10-14 | 贝克顿·迪金森公司 | 收集生物流体样品及处理选定成分的装置和方法 |
| US20090123907A1 (en) * | 2004-07-22 | 2009-05-14 | Shanbrom Technologies, Llc | Lysine citrate for plasma protein and donor protection |
| US7700046B2 (en) * | 2004-09-14 | 2010-04-20 | Goldenberg Alec S | Controlled additive/reactant delivery system |
| DE102006020386A1 (de) * | 2006-04-28 | 2007-10-31 | Dade Behring Marburg Gmbh | Verfahren zur Bestimmung der Thrombozytenfunktion unter Flussbedingungen |
| DE102006045550A1 (de) * | 2006-09-25 | 2008-04-03 | Dade Behring Marburg Gmbh | Verfahren zur Herstellung von agglutionationsfähigen Thrombozytenfragmenten und deren Verwendung |
-
2013
- 2013-02-01 BR BR112014018970A patent/BR112014018970A8/pt not_active IP Right Cessation
- 2013-02-01 WO PCT/US2013/024416 patent/WO2013116702A1/en not_active Ceased
- 2013-02-01 US US13/757,080 patent/US20130209985A1/en not_active Abandoned
- 2013-02-01 JP JP2014555777A patent/JP2015506482A/ja active Pending
- 2013-02-01 IN IN6981DEN2014 patent/IN2014DN06981A/en unknown
- 2013-02-01 AU AU2013214866A patent/AU2013214866A1/en not_active Abandoned
- 2013-02-01 CA CA2862544A patent/CA2862544A1/en not_active Abandoned
- 2013-02-01 CN CN201380016577.5A patent/CN104244902A/zh active Pending
- 2013-02-01 MX MX2014009256A patent/MX2014009256A/es unknown
- 2013-02-01 EP EP13743592.1A patent/EP2809289A4/en not_active Withdrawn
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