JP2016505159A5 - - Google Patents
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- Publication number
- JP2016505159A5 JP2016505159A5 JP2015556160A JP2015556160A JP2016505159A5 JP 2016505159 A5 JP2016505159 A5 JP 2016505159A5 JP 2015556160 A JP2015556160 A JP 2015556160A JP 2015556160 A JP2015556160 A JP 2015556160A JP 2016505159 A5 JP2016505159 A5 JP 2016505159A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- factor
- blood
- additive
- kallikrein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000654 additive Substances 0.000 claims 15
- 230000000996 additive effect Effects 0.000 claims 15
- 210000004369 blood Anatomy 0.000 claims 14
- 239000008280 blood Substances 0.000 claims 14
- 101000975003 Homo sapiens Kallistatin Proteins 0.000 claims 13
- 101001077723 Homo sapiens Serine protease inhibitor Kazal-type 6 Proteins 0.000 claims 13
- 229940122920 Kallikrein inhibitor Drugs 0.000 claims 13
- 102100023012 Kallistatin Human genes 0.000 claims 13
- 239000003112 inhibitor Substances 0.000 claims 13
- 229940105278 Factor XI inhibitor Drugs 0.000 claims 11
- 230000037361 pathway Effects 0.000 claims 11
- 229940123835 Factor XII inhibitor Drugs 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 108010039627 Aprotinin Proteins 0.000 claims 7
- 229960004405 aprotinin Drugs 0.000 claims 7
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical group C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims 7
- 102100030563 Coagulation factor XI Human genes 0.000 claims 6
- 108090000190 Thrombin Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229960004072 thrombin Drugs 0.000 claims 6
- 108090000631 Trypsin Proteins 0.000 claims 5
- 102000004142 Trypsin Human genes 0.000 claims 5
- 240000008042 Zea mays Species 0.000 claims 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 5
- 239000003146 anticoagulant agent Substances 0.000 claims 5
- 229940127219 anticoagulant drug Drugs 0.000 claims 5
- 235000005822 corn Nutrition 0.000 claims 5
- 239000012588 trypsin Substances 0.000 claims 5
- 239000012503 blood component Substances 0.000 claims 3
- 108010080865 Factor XII Proteins 0.000 claims 2
- 102000000429 Factor XII Human genes 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 210000004623 platelet-rich plasma Anatomy 0.000 claims 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 2
- 239000001509 sodium citrate Substances 0.000 claims 2
- 108010074864 Factor XI Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000306 component Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759742P | 2013-02-01 | 2013-02-01 | |
| US61/759,742 | 2013-02-01 | ||
| PCT/US2014/014089 WO2014121041A1 (en) | 2013-02-01 | 2014-01-31 | Blood collection devices containing contact pathway inhibition additives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016505159A JP2016505159A (ja) | 2016-02-18 |
| JP2016505159A5 true JP2016505159A5 (https=) | 2017-02-23 |
Family
ID=51259520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556160A Withdrawn JP2016505159A (ja) | 2013-02-01 | 2014-01-31 | 接触経路抑制添加剤を含む血液採集装置 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140220552A1 (https=) |
| EP (1) | EP2950718A4 (https=) |
| JP (1) | JP2016505159A (https=) |
| KR (1) | KR20150141940A (https=) |
| CN (1) | CN105188535A (https=) |
| AU (1) | AU2014212194A1 (https=) |
| BR (1) | BR112015018077A2 (https=) |
| CA (1) | CA2899594A1 (https=) |
| MX (1) | MX2015009914A (https=) |
| RU (1) | RU2015136025A (https=) |
| SG (1) | SG11201505978PA (https=) |
| WO (1) | WO2014121041A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014113712A1 (en) | 2013-01-20 | 2014-07-24 | Dyax Corp. | Evaluation and treatment of bradykinin-mediated disorders |
| JP6757252B2 (ja) | 2013-10-21 | 2020-09-16 | ダイアックス コーポレーション | 血漿カリクレイン系バイオマーカーを決定するためのアッセイ |
| CA2927695C (en) | 2013-10-21 | 2022-03-01 | Dyax Corp. | Diagnosis and treatment of autoimmune diseases |
| CN107567306B (zh) * | 2015-05-14 | 2020-06-26 | 通用电气公司 | 用于血浆的分离和收集的装置 |
| ES2938089T3 (es) | 2015-08-13 | 2023-04-04 | Takeda Pharmaceuticals Co | Tubos de extracción de sangre al vacío que contienen inhibidores de proteasa para la evaluación de la activación del sistema de contacto |
| KR20240133761A (ko) | 2015-10-19 | 2024-09-04 | 다케다 파머수티컬 컴패니 리미티드 | 절단된 고분자량 키니노겐의 검출을 위한 면역검정법 |
| JP6844890B2 (ja) * | 2016-01-07 | 2021-03-17 | 藤森工業株式会社 | 採血管、試薬及びそれらを利用した血液性状分析方法 |
| CN108342381A (zh) * | 2017-01-24 | 2018-07-31 | 梁建国 | 一种用于稳定保存外周血中循环游离dna的溶剂 |
| US11672733B2 (en) * | 2017-07-21 | 2023-06-13 | Amgen Inc. | Gas permeable sealing member for drug container and methods of assembly |
| US12485412B2 (en) * | 2021-08-05 | 2025-12-02 | Lance Liberti | Kit including biotin for harvesting platelet-rich plasma |
| CN115555070B (zh) * | 2022-10-18 | 2024-11-05 | 北京积水潭医院 | 一种prf离心管 |
| GB202219505D0 (en) * | 2022-12-22 | 2023-02-08 | Turzi Antoine | Medical composition |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1084270B1 (en) * | 1998-06-08 | 2004-08-25 | The University Of Vermont And State Agricultural College | Methods for assaying clotting in plasma |
| US20030064414A1 (en) * | 2001-03-30 | 2003-04-03 | Benecky Michael J. | Rapid assessment of coagulation activity in whole blood |
| AU2003234382B2 (en) * | 2002-05-13 | 2010-07-08 | Becton, Dickinson And Company | Protease inhibitor sample collection system |
| US8603345B2 (en) * | 2003-02-13 | 2013-12-10 | Becton, Dickinson And Company | Devices for component removal during blood collection, and uses thereof |
| US7235377B2 (en) * | 2003-06-09 | 2007-06-26 | The University Of Vermont And State Agriculture College | Global test of the hemostatic system |
| GB0711779D0 (en) * | 2007-06-18 | 2007-07-25 | Univ Singapore | Thrombin inhibitor |
| PT3002298T (pt) * | 2007-11-21 | 2019-11-20 | Univ Oregon Health & Science | Anticorpos monoclonais anti-fator xi e métodos de utilização dos mesmos |
| US10299714B2 (en) * | 2010-12-02 | 2019-05-28 | Becton, Dickinson And Company | Blood collection devices containing blood stabilization agent including variegin or analog thereof and/or a polysulfated disaccharide |
| CN103415301A (zh) * | 2011-03-09 | 2013-11-27 | 德国杰特贝林生物制品有限公司 | 用于与包括与人造表面接触的医疗操作一起施用的fxii抑制剂 |
-
2014
- 2014-01-31 JP JP2015556160A patent/JP2016505159A/ja not_active Withdrawn
- 2014-01-31 MX MX2015009914A patent/MX2015009914A/es unknown
- 2014-01-31 CN CN201480019680.XA patent/CN105188535A/zh active Pending
- 2014-01-31 EP EP14746597.5A patent/EP2950718A4/en not_active Withdrawn
- 2014-01-31 AU AU2014212194A patent/AU2014212194A1/en not_active Abandoned
- 2014-01-31 SG SG11201505978PA patent/SG11201505978PA/en unknown
- 2014-01-31 BR BR112015018077A patent/BR112015018077A2/pt not_active IP Right Cessation
- 2014-01-31 US US14/169,290 patent/US20140220552A1/en not_active Abandoned
- 2014-01-31 KR KR1020157023653A patent/KR20150141940A/ko not_active Withdrawn
- 2014-01-31 WO PCT/US2014/014089 patent/WO2014121041A1/en not_active Ceased
- 2014-01-31 RU RU2015136025A patent/RU2015136025A/ru not_active Application Discontinuation
- 2014-01-31 CA CA2899594A patent/CA2899594A1/en not_active Abandoned
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