JP2015504432A - アシル−ヒドラゾンおよびオキサジアゾール化合物、これらを含有する医薬組成物およびその使用 - Google Patents

アシル−ヒドラゾンおよびオキサジアゾール化合物、これらを含有する医薬組成物およびその使用 Download PDF

Info

Publication number
JP2015504432A
JP2015504432A JP2014542646A JP2014542646A JP2015504432A JP 2015504432 A JP2015504432 A JP 2015504432A JP 2014542646 A JP2014542646 A JP 2014542646A JP 2014542646 A JP2014542646 A JP 2014542646A JP 2015504432 A JP2015504432 A JP 2015504432A
Authority
JP
Japan
Prior art keywords
phenyl
och
compound
cells
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014542646A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015504432A5 (OSRAM
Inventor
ホセ ヌネス,リカルド
ホセ ヌネス,リカルド
マスカレッロ,アレサンドラ
アウグスト ユネス,ロセンド
アウグスト ユネス,ロセンド
レジーナ シュトゥンプ,タイサ
レジーナ シュトゥンプ,タイサ
セザル レアル,パウロ
セザル レアル,パウロ
アンドレス ユネス,ホセ
アンドレス ユネス,ホセ
デ ソウザ メーロ,カロリナ ペレイラ
デ ソウザ メーロ,カロリナ ペレイラ
レナチーニョ カネヴァローロ,ラファエウ
レナチーニョ カネヴァローロ,ラファエウ
シアラディア,ルイーズ ドメネギニ
シアラディア,ルイーズ ドメネギニ
シルべイラ,アンドレ ボルトリーニ
シルべイラ,アンドレ ボルトリーニ
ブルネッリ アルベルトーニ ラランジェイラ,アンジェロ
ブルネッリ アルベルトーニ ラランジェイラ,アンジェロ
Original Assignee
ウニベルシダージ フェデラル デ サンタ カタリーナ
ウニベルシダージ フェデラル デ サンタ カタリーナ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウニベルシダージ フェデラル デ サンタ カタリーナ, ウニベルシダージ フェデラル デ サンタ カタリーナ filed Critical ウニベルシダージ フェデラル デ サンタ カタリーナ
Publication of JP2015504432A publication Critical patent/JP2015504432A/ja
Publication of JP2015504432A5 publication Critical patent/JP2015504432A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72Hydrazones
    • C07C251/86Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/101,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/1071,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with two aryl or substituted aryl radicals attached in positions 2 and 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/36Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2014542646A 2011-11-25 2012-11-26 アシル−ヒドラゾンおよびオキサジアゾール化合物、これらを含有する医薬組成物およびその使用 Pending JP2015504432A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BRPI1107312-8A BRPI1107312B1 (pt) 2011-11-25 2011-11-25 Composto de acil-hidrazona
BRPI1107312-8 2011-11-25
PCT/BR2012/000480 WO2013075199A1 (pt) 2011-11-25 2012-11-26 "compostos acil-hidrazonas e oxadiazóis, composições farmacêuticas compreendendo os mesmos e seus usos

Publications (2)

Publication Number Publication Date
JP2015504432A true JP2015504432A (ja) 2015-02-12
JP2015504432A5 JP2015504432A5 (OSRAM) 2016-01-21

Family

ID=48468927

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014542646A Pending JP2015504432A (ja) 2011-11-25 2012-11-26 アシル−ヒドラゾンおよびオキサジアゾール化合物、これらを含有する医薬組成物およびその使用

Country Status (9)

Country Link
US (1) US20150191445A1 (OSRAM)
EP (1) EP2784061B1 (OSRAM)
JP (1) JP2015504432A (OSRAM)
KR (1) KR102189562B1 (OSRAM)
CN (1) CN104159887A (OSRAM)
BR (2) BRPI1107312B1 (OSRAM)
CA (1) CA2869807C (OSRAM)
RU (1) RU2664327C2 (OSRAM)
WO (1) WO2013075199A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101719541B1 (ko) 2015-08-13 2017-03-24 연세대학교 산학협력단 항암용 약학 조성물 및 ano1 활성억제제
KR20170141542A (ko) * 2016-06-15 2017-12-26 국립암센터 위암을 예방 및 치료하는 rhoa 억제제의 약학적 조성물
CN110498809B (zh) * 2018-05-17 2022-04-05 香港科技大学深圳研究院 基于酰腙配体类的有机硼化合物及其制备方法和应用
KR102131331B1 (ko) 2018-09-19 2020-07-07 연세대학교 산학협력단 항암용 신규 약학 조성물 및 ano1 활성억제제
CN113336729B (zh) * 2021-05-31 2022-05-27 四川大学华西医院 硝呋齐特类衍生物及其制备方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824657A (zh) * 2006-04-05 2006-08-30 贵州大学 3-取代-2-芳基取代-5-(3,4,5-三烷氧基苯基)-1,3,4-噁二唑衍生物及制备方法和用途
US20110189306A1 (en) * 2010-01-13 2011-08-04 Norbert Kartner COMPOUNDS, COMPOSITIONS AND TREATMENTS FOR V-ATPase RELATED DISEASES

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60105621A (ja) * 1983-11-14 1985-06-11 Agency Of Ind Science & Technol 細胞の分化誘導作用を有する生理活性物質およびその製法
IL94389A0 (en) * 1989-06-01 1991-03-10 Health Research Inc Monoclonal antibody reactive to a unique antigen widely present on various human leukemia and lymphoma cells and method of using same for diagnosis and treatment
US5372808A (en) * 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
US6197806B1 (en) * 1995-12-20 2001-03-06 Nippon Zoki Pharmaceutical Co., Ltd. Eliminating agent for activated oxygen and free radicals
CA2400996A1 (en) 2002-09-03 2004-03-03 Lisa Mckerracher 1,4-substituted cyclohexane derivatives
KR101155883B1 (ko) 2003-12-23 2012-06-20 아제닉스 유에스에이 인코포레이티드 사이클린 의존적 키나제 저해제, 그 조성물 및 그의 용도
DE102004010207A1 (de) 2004-03-02 2005-09-15 Aventis Pharma S.A. Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate
WO2005097763A2 (en) * 2004-04-01 2005-10-20 Aventis Pharmaceuticals Inc. 1,3,4-oxadiazol-2-ones as ppar delta
AR052559A1 (es) 2005-01-21 2007-03-21 Astex Therapeutics Ltd Derivados de pirazol para inhibir cdk's y gsk's
WO2006101937A1 (en) 2005-03-18 2006-09-28 Janssen Pharmaceutica N.V. Acylhydrazones as kinase modulators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824657A (zh) * 2006-04-05 2006-08-30 贵州大学 3-取代-2-芳基取代-5-(3,4,5-三烷氧基苯基)-1,3,4-噁二唑衍生物及制备方法和用途
US20110189306A1 (en) * 2010-01-13 2011-08-04 Norbert Kartner COMPOUNDS, COMPOSITIONS AND TREATMENTS FOR V-ATPase RELATED DISEASES

Also Published As

Publication number Publication date
US20150191445A1 (en) 2015-07-09
RU2014125519A (ru) 2015-12-27
CN104159887A (zh) 2014-11-19
BRPI1107312B1 (pt) 2021-09-08
CA2869807A1 (en) 2013-05-30
CA2869807C (en) 2021-03-09
EP2784061A4 (en) 2015-05-27
KR102189562B1 (ko) 2020-12-14
BRPI1107312A2 (pt) 2016-09-20
RU2664327C2 (ru) 2018-08-16
EP2784061A1 (en) 2014-10-01
EP2784061B1 (en) 2018-11-07
KR20140112489A (ko) 2014-09-23
BR112014012582A2 (pt) 2017-06-06
WO2013075199A1 (pt) 2013-05-30

Similar Documents

Publication Publication Date Title
JP4989976B2 (ja) 翻訳開始阻害剤としての3−3−二置換オキシインドール
US10765660B2 (en) Agent containing flavonoid derivatives for treating cancer and inflammation
CN106565686B (zh) 微管蛋白抑制剂
JP2001501590A (ja) 有意なホルモン活性のないチロキシン類縁体による悪性腫瘍の治療方法
JP5649652B2 (ja) 置換ヒドラジド類化合物及びその応用
JP2015504432A (ja) アシル−ヒドラゾンおよびオキサジアゾール化合物、これらを含有する医薬組成物およびその使用
KR20210027382A (ko) 접히지 않은 단백질 반응의 활성화제
CN106565685B (zh) 微管蛋白抑制剂
CN108191770A (zh) 2,3-二氮杂萘酮或2,3-二氮杂萘酚衍生物及其用途
US10450295B2 (en) Method of using an indolinone molecule and derivatives for inhibiting liver fibrosis and hepatitis
CN102020638A (zh) 具有蛋白激酶抑制活性和组蛋白去乙酰化酶抑制活性的2-吲哚满酮衍生物、其制备方法及应用
CN106995368B (zh) 一种非atp竞争性fgfr1抑制剂及其应用
WO2022020605A1 (en) Treatment of metastasized estrogen receptor positive breast cancer
WO2021222738A1 (en) Compounds for estrogen receptor positive cancers
JP7283699B2 (ja) 黒色腫の治療または予防において使用するためのフェニル-ヘテロ環-フェニル誘導体
WO2004039797A1 (en) A special kind of indole compounds, their preparation, and their use in treatment and prevention of those disease such as cancer
Schatten The Impact of Centrosome Pathologies on Ovarian Cancer Development and Progression with a Focus on Centrosomes as Therapeutic Target
KR101738080B1 (ko) 페닐설포닐옥사졸 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암 또는 천식 치료용 약학적 조성물
CN102020607B (zh) 具有组蛋白去乙酰化酶抑制活性的6-氨基烟酰胺衍生物、其制备方法及应用
CN117756742B (zh) 苯并噻唑类化合物或其盐、其制备方法及应用
WO2018076537A1 (zh) D-3-磷酸甘油酸脱氢酶别构抑制剂及其应用
CN102432544B (zh) 5-取代苄亚甲基咪唑烷-2,4-二酮类衍生物及其应用
CN103298344B (zh) 整链蛋白偶联性激酶抑制剂
WO2024000615A1 (zh) 一种酪氨酸蛋白激酶抑制剂及其用途
CN108186630A (zh) 靛红类似物在制备抗肿瘤药物中的应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151124

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151124

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160728

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160809

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161108

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161109

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170407