JP2015504430A5 - - Google Patents

Info

Publication number

JP2015504430A5

JP2015504430A5 JP2014542299A JP2014542299A JP2015504430A5 JP 2015504430 A5 JP2015504430 A5 JP 2015504430A5 JP 2014542299 A JP2014542299 A JP 2014542299A JP 2014542299 A JP2014542299 A JP 2014542299A JP 2015504430 A5 JP2015504430 A5 JP 2015504430A5

Authority

JP

Japan

Prior art keywords

antagonist

allele

seq

patient

use according

Prior art date

2012-06-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 102000013691 Interleukin-17 Human genes 0.000 claims 41
• 108700028369 Alleles Proteins 0.000 claims 35
• 239000005557 antagonist Substances 0.000 claims 30
• 239000012472 biological sample Substances 0.000 claims 11
• 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 claims 9
• 108010039343 HLA-DRB1 Chains Proteins 0.000 claims 9
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 6
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 6
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 4
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 238000003556 assay Methods 0.000 claims 4
• 238000004458 analytical method Methods 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108060003951 Immunoglobulin Proteins 0.000 claims 2
• 108091034117 Oligonucleotide Proteins 0.000 claims 2
• 238000004128 high performance liquid chromatography Methods 0.000 claims 2
• 239000000710 homodimer Substances 0.000 claims 2
• 102000018358 immunoglobulin Human genes 0.000 claims 2
• 239000003550 marker Substances 0.000 claims 2
• 238000003752 polymerase chain reaction Methods 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 238000007894 restriction fragment length polymorphism technique Methods 0.000 claims 2
• 238000003757 reverse transcription PCR Methods 0.000 claims 2
• 238000000123 temperature gradient gel electrophoresis Methods 0.000 claims 2
• 101710099953 DNA mismatch repair protein msh3 Proteins 0.000 claims 1
• 238000002965 ELISA Methods 0.000 claims 1
• 102000006395 Globulins Human genes 0.000 claims 1
• 108010044091 Globulins Proteins 0.000 claims 1
• 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 1
• 108010052199 HLA-C Antigens Proteins 0.000 claims 1
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
• 102000003960 Ligases Human genes 0.000 claims 1
• 108090000364 Ligases Proteins 0.000 claims 1
• 238000000636 Northern blotting Methods 0.000 claims 1
• 238000002105 Southern blotting Methods 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 238000005251 capillar electrophoresis Methods 0.000 claims 1
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
• 210000003608 fece Anatomy 0.000 claims 1
• 238000000684 flow cytometry Methods 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 238000003018 immunoassay Methods 0.000 claims 1
• 238000003364 immunohistochemistry Methods 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 210000000265 leukocyte Anatomy 0.000 claims 1
• 238000004949 mass spectrometry Methods 0.000 claims 1
• 238000002844 melting Methods 0.000 claims 1
• 230000008018 melting Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 238000002731 protein assay Methods 0.000 claims 1
• 210000003296 saliva Anatomy 0.000 claims 1
• 229960004540 secukinumab Drugs 0.000 claims 1
• 238000012163 sequencing technique Methods 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 210000001179 synovial fluid Anatomy 0.000 claims 1
• 210000001138 tear Anatomy 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1
• 238000001262 western blot Methods 0.000 claims 1