JP2017513937A5 - - Google Patents
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- JP2017513937A5 JP2017513937A5 JP2017504289A JP2017504289A JP2017513937A5 JP 2017513937 A5 JP2017513937 A5 JP 2017513937A5 JP 2017504289 A JP2017504289 A JP 2017504289A JP 2017504289 A JP2017504289 A JP 2017504289A JP 2017513937 A5 JP2017513937 A5 JP 2017513937A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- air marker
- patient
- antagonist
- air
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000003550 marker Substances 0.000 claims description 74
- 238000000034 method Methods 0.000 claims description 56
- 239000005557 antagonist Substances 0.000 claims description 43
- 239000012472 biological sample Substances 0.000 claims description 17
- 208000006673 asthma Diseases 0.000 claims description 12
- 238000003556 assay Methods 0.000 claims description 10
- 238000004458 analytical method Methods 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 108091034117 Oligonucleotide Proteins 0.000 claims description 4
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 4
- 238000003752 polymerase chain reaction Methods 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 claims description 4
- 238000003757 reverse transcription PCR Methods 0.000 claims description 4
- 238000000123 temperature gradient gel electrophoresis Methods 0.000 claims description 4
- 108700028369 Alleles Proteins 0.000 claims description 2
- 101710099953 DNA mismatch repair protein msh3 Proteins 0.000 claims description 2
- 238000002965 ELISA Methods 0.000 claims description 2
- 102000003960 Ligases Human genes 0.000 claims description 2
- 108090000364 Ligases Proteins 0.000 claims description 2
- 238000000636 Northern blotting Methods 0.000 claims description 2
- 238000002105 Southern blotting Methods 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 230000005540 biological transmission Effects 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 238000005251 capillar electrophoresis Methods 0.000 claims description 2
- 238000000684 flow cytometry Methods 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 238000003364 immunohistochemistry Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 238000002731 protein assay Methods 0.000 claims description 2
- 230000004043 responsiveness Effects 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000001138 tear Anatomy 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 238000001262 western blot Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 239000003814 drug Substances 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461978604P | 2014-04-11 | 2014-04-11 | |
| US61/978,604 | 2014-04-11 | ||
| PCT/IB2015/052551 WO2015155710A1 (en) | 2014-04-11 | 2015-04-08 | Methods of selectively treating asthma using il-13 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019229495A Division JP2020079241A (ja) | 2014-04-11 | 2019-12-19 | Il−13アンアゴニストを用いて喘息を選択的に治療する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017513937A JP2017513937A (ja) | 2017-06-01 |
| JP2017513937A5 true JP2017513937A5 (cg-RX-API-DMAC7.html) | 2018-04-26 |
Family
ID=52997487
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504289A Ceased JP2017513937A (ja) | 2014-04-11 | 2015-04-08 | Il−13アンアゴニストを用いて喘息を選択的に治療する方法 |
| JP2019229495A Pending JP2020079241A (ja) | 2014-04-11 | 2019-12-19 | Il−13アンアゴニストを用いて喘息を選択的に治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019229495A Pending JP2020079241A (ja) | 2014-04-11 | 2019-12-19 | Il−13アンアゴニストを用いて喘息を選択的に治療する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10066267B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3129497B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2017513937A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20160138095A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106536754B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2015246037B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016023238A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2943326A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2016013372A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2694980C2 (cg-RX-API-DMAC7.html) |
| TW (1) | TW201542227A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015155710A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109526229B (zh) * | 2016-07-08 | 2022-06-03 | Tak循环株式会社 | 筛选疾病的预防或治疗剂的方法、及用于制造该制剂的应用 |
| US11312956B2 (en) | 2016-07-08 | 2022-04-26 | Tak-Circulator Co., Ltd | Nucleic acid inhibiting expression of the MEX3B gene, MEX3B gene expression inhibitor, method for inhibiting MEX3B gene expression, and prophylactic or therapeutic agent for disease caused by MEX3B gene expression |
| US10650928B1 (en) * | 2017-12-18 | 2020-05-12 | Clarify Health Solutions, Inc. | Computer network architecture for a pipeline of models for healthcare outcomes with machine learning and artificial intelligence |
| US10811139B1 (en) | 2018-06-13 | 2020-10-20 | Clarify Health Solutions, Inc. | Computer network architecture with machine learning and artificial intelligence and dynamic patient guidance |
| US11763950B1 (en) | 2018-08-16 | 2023-09-19 | Clarify Health Solutions, Inc. | Computer network architecture with machine learning and artificial intelligence and patient risk scoring |
| US11625789B1 (en) | 2019-04-02 | 2023-04-11 | Clarify Health Solutions, Inc. | Computer network architecture with automated claims completion, machine learning and artificial intelligence |
| US11621085B1 (en) | 2019-04-18 | 2023-04-04 | Clarify Health Solutions, Inc. | Computer network architecture with machine learning and artificial intelligence and active updates of outcomes |
| US11238469B1 (en) | 2019-05-06 | 2022-02-01 | Clarify Health Solutions, Inc. | Computer network architecture with machine learning and artificial intelligence and risk adjusted performance ranking of healthcare providers |
| US10726359B1 (en) | 2019-08-06 | 2020-07-28 | Clarify Health Solutions, Inc. | Computer network architecture with machine learning and artificial intelligence and automated scalable regularization |
| US10643751B1 (en) | 2019-09-26 | 2020-05-05 | Clarify Health Solutions, Inc. | Computer network architecture with benchmark automation, machine learning and artificial intelligence for measurement factors |
| US10643749B1 (en) | 2019-09-30 | 2020-05-05 | Clarify Health Solutions, Inc. | Computer network architecture with machine learning and artificial intelligence and automated insight generation |
| US11270785B1 (en) * | 2019-11-27 | 2022-03-08 | Clarify Health Solutions, Inc. | Computer network architecture with machine learning and artificial intelligence and care groupings |
| CN113215245A (zh) * | 2021-05-21 | 2021-08-06 | 广州合一生物科技有限公司 | 一种用于儿童哮喘个体化用药的基因检测试剂盒及其应用 |
| US20250270627A1 (en) * | 2021-10-22 | 2025-08-28 | Illumina, Inc. | Genotyping Methods and Systems |
| US12079230B1 (en) | 2024-01-31 | 2024-09-03 | Clarify Health Solutions, Inc. | Computer network architecture and method for predictive analysis using lookup tables as prediction models |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| WO2000044407A2 (en) | 1999-02-01 | 2000-08-03 | Amgen Canada | Materials and methods to inhibit hodgkin and reed sternberg cell growth |
| US6645486B1 (en) | 2000-01-25 | 2003-11-11 | Ludwig Institute For Cancer Research | Method of treatment with IL-9 conjugate |
| US7049069B2 (en) | 2001-07-17 | 2006-05-23 | University Of Florida | Detecting and treating reproductive tract disorders |
| US20030143199A1 (en) | 2001-10-09 | 2003-07-31 | Carson Dennis A. | Use of STAT-6 inhibitors as therapeutic agents |
| CA2675409A1 (en) | 2001-10-19 | 2003-05-01 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders |
| US20040023337A1 (en) | 2001-10-26 | 2004-02-05 | Heavner George A. | IL-13 mutein proteins, antibodies, compositions, methods and uses |
| US20040248260A1 (en) | 2001-10-26 | 2004-12-09 | Heavner George A. | IL-13 mutein proteins, antibodies, compositions, methods and uses |
| WO2004082362A2 (en) | 2003-03-18 | 2004-09-30 | Nitto Denko Corporation | Methods for extending amorphous photorefractive material lifetimes |
| GB0407315D0 (en) | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
| LT2805728T (lt) * | 2003-12-23 | 2020-05-25 | Genentech, Inc. | Nauji anti-il 13 antikūnai ir jų naudojimai |
| US20070048785A1 (en) | 2004-06-09 | 2007-03-01 | Lin Laura L | Anti-IL-13 antibodies and complexes |
| TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| AU2005307831A1 (en) | 2004-11-17 | 2006-05-26 | Amgen, Inc. | Fully human monoclonal antibodies to IL-13 |
| US20080044420A1 (en) | 2005-05-11 | 2008-02-21 | Heavner George A | Anti-IL-13 antibodies, compositions, methods and uses |
| CA2623429C (en) | 2005-09-30 | 2015-01-13 | Medimmune Limited | Interleukin-13 antibody composition |
| KR101461263B1 (ko) * | 2005-10-21 | 2014-11-17 | 노파르티스 아게 | Il-13에 대항한 인간 항체 및 치료적 용도 |
| GB0600488D0 (en) | 2006-01-11 | 2006-02-22 | Glaxo Group Ltd | Immunoglobulins |
| CA2636854A1 (en) | 2006-01-24 | 2007-08-02 | Domantis Limited | Ligands that bind il-4 and/or il-13 |
| US20100136030A1 (en) | 2007-02-27 | 2010-06-03 | Lamhamedi-Cherradi Salah-Eddine | Antagonist ox40 antibodies and their use in the treatment of inflammatory and autoimmune diseases |
| WO2011156000A2 (en) * | 2010-06-07 | 2011-12-15 | Aerovance, Inc. | Use of il-4/il-13 antagonists to treat eosinophilic disorders |
| RU2013122123A (ru) | 2010-10-15 | 2014-11-20 | Медиммьюн Лимитед | Терапевтические средства для улучшения легочной функции |
| EP2652498B1 (en) | 2010-12-16 | 2018-04-18 | F.Hoffmann-La Roche Ag | Diagnosis and treatments relating to th2 inhibition |
-
2015
- 2015-04-08 AU AU2015246037A patent/AU2015246037B2/en not_active Ceased
- 2015-04-08 CA CA2943326A patent/CA2943326A1/en not_active Abandoned
- 2015-04-08 JP JP2017504289A patent/JP2017513937A/ja not_active Ceased
- 2015-04-08 WO PCT/IB2015/052551 patent/WO2015155710A1/en not_active Ceased
- 2015-04-08 MX MX2016013372A patent/MX2016013372A/es unknown
- 2015-04-08 BR BR112016023238A patent/BR112016023238A2/pt not_active Application Discontinuation
- 2015-04-08 US US15/302,348 patent/US10066267B2/en not_active Expired - Fee Related
- 2015-04-08 KR KR1020167027724A patent/KR20160138095A/ko not_active Ceased
- 2015-04-08 RU RU2016144177A patent/RU2694980C2/ru not_active IP Right Cessation
- 2015-04-08 CN CN201580031348.XA patent/CN106536754B/zh not_active Expired - Fee Related
- 2015-04-08 EP EP15717969.8A patent/EP3129497B1/en not_active Not-in-force
- 2015-04-09 TW TW104111463A patent/TW201542227A/zh unknown
-
2018
- 2018-03-29 AU AU2018202260A patent/AU2018202260B2/en not_active Ceased
-
2019
- 2019-12-10 US US16/709,892 patent/US20200178741A1/en not_active Abandoned
- 2019-12-19 JP JP2019229495A patent/JP2020079241A/ja active Pending
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