JP2015503552A - チロシンキナーゼ阻害剤としての新規イミダゾピリジン誘導体 - Google Patents

チロシンキナーゼ阻害剤としての新規イミダゾピリジン誘導体 Download PDF

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JP2015503552A
JP2015503552A JP2014550009A JP2014550009A JP2015503552A JP 2015503552 A JP2015503552 A JP 2015503552A JP 2014550009 A JP2014550009 A JP 2014550009A JP 2014550009 A JP2014550009 A JP 2014550009A JP 2015503552 A JP2015503552 A JP 2015503552A
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phenyl
disease
pyridin
imidazo
chloro
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JP2015503552A5 (enExample
Inventor
イ・キョンイク
シム・ジェイ
キム・ホソク
ハ・テヒ
ス・クィヒョン
Original Assignee
ハンミ ファーム． シーオー．， エルティーディー．
ハンミ ファーム． シーオー．， エルティーディー．
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Publication of JP2015503552A publication Critical patent/JP2015503552A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
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  • Neurosurgery (AREA)
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  • Neurology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
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JP2014550009A 2011-12-28 2012-12-27 チロシンキナーゼ阻害剤としての新規イミダゾピリジン誘導体 Ceased JP2015503552A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2011-0144450 2011-12-28
KR1020110144450A KR20130076046A (ko) 2011-12-28 2011-12-28 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체
PCT/KR2012/011570 WO2013100631A1 (en) 2011-12-28 2012-12-27 Novel imidazopyridine derivatives as a tyrosine kinase inhibitor

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JP2015503552A true JP2015503552A (ja) 2015-02-02
JP2015503552A5 JP2015503552A5 (enExample) 2016-02-12

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JP2014550009A Ceased JP2015503552A (ja) 2011-12-28 2012-12-27 チロシンキナーゼ阻害剤としての新規イミダゾピリジン誘導体

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Country Link
US (1) US20150299185A1 (enExample)
EP (1) EP2797909A4 (enExample)
JP (1) JP2015503552A (enExample)
KR (1) KR20130076046A (enExample)
CN (1) CN104024243A (enExample)
AU (1) AU2012363557A1 (enExample)
BR (1) BR112014016146A8 (enExample)
CA (1) CA2859664A1 (enExample)
HK (1) HK1200811A1 (enExample)
IL (1) IL233415A0 (enExample)
MX (1) MX2014007976A (enExample)
RU (1) RU2014131068A (enExample)
WO (1) WO2013100631A1 (enExample)
ZA (1) ZA201405505B (enExample)

Families Citing this family (6)

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CN105837572B (zh) * 2015-02-02 2019-04-19 四川大学 N-取代苯基酰胺衍生物及其制备方法和用途
ES2899113T3 (es) * 2016-07-11 2022-03-10 Kancera Ab Derivados de 2-fenilimidazo[4,5-b]piridin-7-amina útiles como inhibidores de la actividad tirosina quinasa ROR1 de mamíferos
CN110545826A (zh) 2016-12-03 2019-12-06 朱诺治疗学股份有限公司 用于与激酶抑制剂组合使用治疗性t细胞的方法和组合物
CA3141571A1 (en) * 2019-05-28 2020-12-03 Mankind Pharma Ltd. 1h-imidazo[4,5-b]pyridin-2(3h)-one compounds and derivatives for inhibition of janus kinase 1
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
WO2022199561A1 (zh) * 2021-03-23 2022-09-29 杭州阿诺生物医药科技有限公司 Hpk1激酶抑制剂化合物

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JP2001518470A (ja) * 1997-09-26 2001-10-16 メルク エンド カムパニー インコーポレーテッド 新規な血管形成阻害剤
JP2009523845A (ja) * 2006-01-23 2009-06-25 クリスタルゲノミクス インコーポレーテッド たんぱく質キナーゼの活性を阻害するイミダゾピリジン誘導体、これの製造方法およびこれを含む薬学組成物
WO2010129053A2 (en) * 2009-05-05 2010-11-11 Dana Farber Cancer Institute Egfr inhibitors and methods of treating disorders
CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途
JP2013529630A (ja) * 2010-06-23 2013-07-22 ハンミ・サイエンス・カンパニー・リミテッド チロシンキナーゼ活性阻害作用を有する新規な縮合ピリミジン誘導体

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IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
CN101379065A (zh) * 2006-01-23 2009-03-04 克里斯特尔吉诺密斯株式会社 抑制蛋白质激酶活性的咪唑并吡啶衍生物、其制备方法和包含它的药物组合物
CN101674834B (zh) * 2007-03-28 2013-06-12 环状药物公司 布鲁顿氏酪氨酸激酶(Bruton's tyrosine kinase)抑制剂
US20100113520A1 (en) * 2008-11-05 2010-05-06 Principia Biopharma, Inc. Kinase knockdown via electrophilically enhanced inhibitors
KR101483215B1 (ko) * 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001518470A (ja) * 1997-09-26 2001-10-16 メルク エンド カムパニー インコーポレーテッド 新規な血管形成阻害剤
JP2009523845A (ja) * 2006-01-23 2009-06-25 クリスタルゲノミクス インコーポレーテッド たんぱく質キナーゼの活性を阻害するイミダゾピリジン誘導体、これの製造方法およびこれを含む薬学組成物
WO2010129053A2 (en) * 2009-05-05 2010-11-11 Dana Farber Cancer Institute Egfr inhibitors and methods of treating disorders
JP2013529630A (ja) * 2010-06-23 2013-07-22 ハンミ・サイエンス・カンパニー・リミテッド チロシンキナーゼ活性阻害作用を有する新規な縮合ピリミジン誘導体
CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途

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AU2012363557A1 (en) 2014-07-17
BR112014016146A8 (pt) 2017-07-04
CA2859664A1 (en) 2013-07-04
MX2014007976A (es) 2014-08-21
HK1200811A1 (en) 2015-08-14
US20150299185A1 (en) 2015-10-22
IL233415A0 (en) 2014-08-31
WO2013100631A1 (en) 2013-07-04
RU2014131068A (ru) 2016-02-20
KR20130076046A (ko) 2013-07-08
EP2797909A1 (en) 2014-11-05
EP2797909A4 (en) 2015-06-10
BR112014016146A2 (pt) 2017-06-13
ZA201405505B (en) 2015-10-28

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