JP2015502740A5 - - Google Patents
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- JP2015502740A5 JP2015502740A5 JP2014537335A JP2014537335A JP2015502740A5 JP 2015502740 A5 JP2015502740 A5 JP 2015502740A5 JP 2014537335 A JP2014537335 A JP 2014537335A JP 2014537335 A JP2014537335 A JP 2014537335A JP 2015502740 A5 JP2015502740 A5 JP 2015502740A5
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- Prior art keywords
- sample
- ibd
- antibody
- value
- panca2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 68
- 208000011231 Crohn disease Diseases 0.000 claims 27
- 238000000034 method Methods 0.000 claims 26
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 claims 19
- 239000003550 marker Substances 0.000 claims 14
- 238000002965 ELISA Methods 0.000 claims 12
- 238000007637 random forest analysis Methods 0.000 claims 9
- 238000007619 statistical method Methods 0.000 claims 9
- 206010009900 Colitis ulcerative Diseases 0.000 claims 8
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 8
- 238000003066 decision tree Methods 0.000 claims 5
- 230000002068 genetic effect Effects 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 102100031758 Extracellular matrix protein 1 Human genes 0.000 claims 4
- 101000866526 Homo sapiens Extracellular matrix protein 1 Proteins 0.000 claims 4
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 4
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 claims 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 4
- 230000000405 serological effect Effects 0.000 claims 4
- 102100040355 Autophagy-related protein 16-1 Human genes 0.000 claims 3
- 102100027890 Homeobox protein Nkx-2.3 Human genes 0.000 claims 3
- 101000964092 Homo sapiens Autophagy-related protein 16-1 Proteins 0.000 claims 3
- 101000632181 Homo sapiens Homeobox protein Nkx-2.3 Proteins 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 230000035945 sensitivity Effects 0.000 claims 3
- 108010040721 Flagellin Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 102100031051 Cysteine and glycine-rich protein 1 Human genes 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 108091006374 cAMP receptor proteins Proteins 0.000 claims 1
- 238000003205 genotyping method Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550293P | 2011-10-21 | 2011-10-21 | |
| US61/550,293 | 2011-10-21 | ||
| US201161553853P | 2011-10-31 | 2011-10-31 | |
| US61/553,853 | 2011-10-31 | ||
| US201161567096P | 2011-12-05 | 2011-12-05 | |
| US61/567,096 | 2011-12-05 | ||
| US201161570271P | 2011-12-13 | 2011-12-13 | |
| US61/570,271 | 2011-12-13 | ||
| PCT/US2012/061202 WO2013059732A1 (en) | 2011-10-21 | 2012-10-19 | Methods for improving inflammatory bowel disease diagnosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015502740A JP2015502740A (ja) | 2015-01-29 |
| JP2015502740A5 true JP2015502740A5 (https=) | 2015-12-10 |
Family
ID=48141435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537335A Pending JP2015502740A (ja) | 2011-10-21 | 2012-10-19 | 炎症性腸疾患の診断を改善するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8715943B2 (https=) |
| EP (1) | EP2769321B1 (https=) |
| JP (1) | JP2015502740A (https=) |
| AU (1) | AU2012325798B2 (https=) |
| CA (1) | CA2852954A1 (https=) |
| IL (1) | IL232167A0 (https=) |
| MX (1) | MX352274B (https=) |
| SG (1) | SG11201401536QA (https=) |
| WO (1) | WO2013059732A1 (https=) |
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| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| CA2758531C (en) | 2009-04-14 | 2018-11-13 | Derren Barken | Inflammatory bowel disease prognostics |
| WO2015067913A1 (en) | 2013-11-07 | 2015-05-14 | Diagnodus Limited | Biomarkers |
| JP2014517279A (ja) | 2011-05-10 | 2014-07-17 | ネステク ソシエテ アノニム | 個別治療管理のための疾患活動性プロファイリングの方法 |
| KR102343212B1 (ko) | 2013-03-27 | 2021-12-23 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| WO2014182689A1 (en) * | 2013-05-06 | 2014-11-13 | Yacyshyn Bruce R | Method of using biomarkers in predicting inflammatory bowel disease |
| WO2014186750A2 (en) | 2013-05-17 | 2014-11-20 | Cedars-Sinai Medical Center | Variants of tnfsf15 and dcr3 associated with crohn's disease |
| SG11201509371XA (en) * | 2013-05-24 | 2015-12-30 | Nestec Sa | Pathway specific markers for diagnosing irritable bowel syndrome |
| WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| US11568982B1 (en) | 2014-02-17 | 2023-01-31 | Health at Scale Corporation | System to improve the logistics of clinical care by selectively matching patients to providers |
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| CN104131102B (zh) * | 2014-08-07 | 2016-06-15 | 马飞 | 一种判断nsclc患者对吉非替尼治疗反应性的试剂盒 |
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| CN107548498A (zh) | 2015-01-20 | 2018-01-05 | 南托米克斯有限责任公司 | 用于反应预测高级别膀胱癌中的化疗的系统和方法 |
| JP6356359B2 (ja) * | 2015-03-03 | 2018-07-11 | ナントミクス，エルエルシー | アンサンブルに基づいたリサーチ・レコメンデーションシステムおよび方法 |
| US11037070B2 (en) * | 2015-04-29 | 2021-06-15 | Siemens Healthcare Gmbh | Diagnostic test planning using machine learning techniques |
| US10663473B2 (en) | 2016-02-02 | 2020-05-26 | Maximus Diagnostic Technologies Llc | Method of identifying a status of a mucosal intestinal epithelial barrier to improve treatment of inflammatory bowel disease |
| US10295527B2 (en) | 2016-03-14 | 2019-05-21 | Bruce Yacyshyn | Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis |
| US11946927B2 (en) | 2016-03-14 | 2024-04-02 | Musidora Biotechnology Llc | Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment |
| US11186872B2 (en) | 2016-03-17 | 2021-11-30 | Cedars-Sinai Medical Center | Methods of diagnosing inflammatory bowel disease through RNASET2 |
| KR102481305B1 (ko) * | 2016-05-20 | 2022-12-26 | 세다르스-신나이 메디칼 센터 | 유전자에 기반한 염증성 장 질환의 진단 |
| JP7111322B2 (ja) * | 2016-12-02 | 2022-08-02 | 国立大学法人 東京大学 | 線維化関連分子に対する抗体およびその医療応用 |
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| EP3554362A4 (en) * | 2016-12-14 | 2020-08-12 | Warren, Tracy | SYSTEM AND METHODS FOR DEVELOPING AND USING A MICROBIOME-BASED ACTION COMPONENT FOR PATIENT HEALTH |
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| EP3818544B1 (en) | 2018-07-05 | 2025-05-28 | Boston Scientific Scimed, Inc. | Devices, systems, and methods for determining inflammation and/or fibrosis |
| CA3108719A1 (en) * | 2018-08-21 | 2020-02-27 | Bruce R. Yacyshyn | Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment |
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| CA3121167A1 (en) * | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Methods of stratifying and treating a sub-population of inflammatory bowel disease patients |
| WO2020117795A1 (en) * | 2018-12-04 | 2020-06-11 | Prometheus Biosciences, Inc. | Assessment and monitoring of mucosal healing in children and adults with crohn's disease |
| CA3128973A1 (en) | 2019-03-04 | 2020-09-10 | Bhaskar Bhattacharyya | Data compression and communication using machine learning |
| EP3958732A4 (en) * | 2019-04-23 | 2023-01-18 | Cedars-Sinai Medical Center | METHODS AND SYSTEMS FOR ASSESSING INFLAMMATORY DISEASE WITH DEEP LEARNING |
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| CN111417124A (zh) * | 2019-06-28 | 2020-07-14 | 西南交通大学 | 在认知无线网络环境下频谱感知的方法 |
| EP4114976B1 (en) * | 2020-03-06 | 2025-10-22 | Laboratory Corporation of America Holdings | Assay for hemoglobin a (hba) detection and genotyping |
| US11610679B1 (en) * | 2020-04-20 | 2023-03-21 | Health at Scale Corporation | Prediction and prevention of medical events using machine-learning algorithms |
| EP4162076A4 (en) * | 2020-06-03 | 2024-10-02 | Cedars-Sinai Medical Center | TREATMENTS FOR A SUBPOPULATION OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE |
| US12094582B1 (en) | 2020-08-11 | 2024-09-17 | Health at Scale Corporation | Intelligent healthcare data fabric system |
| US12080428B1 (en) | 2020-09-10 | 2024-09-03 | Health at Scale Corporation | Machine intelligence-based prioritization of non-emergent procedures and visits |
| US20230363695A1 (en) * | 2020-09-16 | 2023-11-16 | Northwestern University | Classification of functional lumen imaging probe data |
| WO2022076372A1 (en) * | 2020-10-05 | 2022-04-14 | Cedars-Sinai Medical Center | Methods and systems for stratifying inflammatory bowel disease patients |
| CA3201128A1 (en) * | 2020-12-04 | 2022-06-09 | Manish Arora | Systems and methods for dynamic immunohistochemistry profiling of biological disorders |
| WO2022125867A1 (en) * | 2020-12-11 | 2022-06-16 | Icahn School Of Medicine At Mount Sinai | Methods of monitoring inflammatory bowel diseases |
| JP7655720B2 (ja) * | 2020-12-18 | 2025-04-02 | 花王株式会社 | ストレスマーカー及びそれを用いた慢性ストレスレベルの検出方法 |
| JP7655721B2 (ja) * | 2020-12-18 | 2025-04-02 | 花王株式会社 | 疲労マーカー及びそれを用いた疲労の検出方法 |
| WO2022177963A1 (en) | 2021-02-17 | 2022-08-25 | Prometheus Biosciences, Inc. | Anti-cd30l antibodies and uses thereof |
| US20240404053A1 (en) * | 2021-09-22 | 2024-12-05 | Janssen Research & Development, Llc | Automatic Estimation of Ulcerative Colitis Severity from Endoscopy Videos USING ORDINAL MULTI-INSTANCE LEARNING |
| EP4469788A4 (en) * | 2022-01-28 | 2025-12-24 | Univ Southern California | IDENTIFICATION OF NON-DISEALED PATIENTS USING DISEASE-ASSOCIATED ASSAY AND ANALYSIS IN LIQUID BIOPSY |
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| BR112012012513A2 (pt) * | 2009-11-25 | 2017-01-10 | Prometheus Lab Inc | método para diagnosticar síndrome do intestino irritável em um paciente, método para monitorar a progressão ou regressão da síndrome do intestino irritável em um paciente, e para designar uma terapia contra síndrome do intestino irritável a um paciente em necessidade do mesmo |
| CA2801575A1 (en) | 2010-06-04 | 2011-12-08 | Prometheus Laboratories Inc. | Methods for improving inflammatory bowel disease diagnosis |
-
2012
- 2012-10-19 SG SG11201401536QA patent/SG11201401536QA/en unknown
- 2012-10-19 WO PCT/US2012/061202 patent/WO2013059732A1/en not_active Ceased
- 2012-10-19 EP EP12841790.4A patent/EP2769321B1/en active Active
- 2012-10-19 CA CA2852954A patent/CA2852954A1/en not_active Abandoned
- 2012-10-19 AU AU2012325798A patent/AU2012325798B2/en not_active Ceased
- 2012-10-19 JP JP2014537335A patent/JP2015502740A/ja active Pending
- 2012-10-19 MX MX2014004712A patent/MX352274B/es active IP Right Grant
-
2013
- 2013-03-15 US US13/840,779 patent/US8715943B2/en active Active
-
2014
- 2014-03-28 US US14/229,715 patent/US20150072879A1/en not_active Abandoned
- 2014-04-22 IL IL232167A patent/IL232167A0/en unknown
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