JP2015501791A5 - - Google Patents

Info

Publication number

JP2015501791A5

JP2015501791A5 JP2014540950A JP2014540950A JP2015501791A5 JP 2015501791 A5 JP2015501791 A5 JP 2015501791A5 JP 2014540950 A JP2014540950 A JP 2014540950A JP 2014540950 A JP2014540950 A JP 2014540950A JP 2015501791 A5 JP2015501791 A5 JP 2015501791A5

Authority

JP

Japan

Prior art keywords

methoxyethyl

gataparsen

m5ru

manufactured

thoxyethyl

Prior art date

2012-11-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 6
• BZRZNGDLBBZGMQ-UHFFFAOYSA-N gataparsen Chemical compound O1C(N2C(NC(=O)C(C)=C2)=O)C(OCCOC)C(O)C1COP(O)(=S)OC(C(C(O1)N2C(NC(=O)C(C)=C2)=O)OCCOC)C1COP(O)(=S)OC(C(C(O1)N2C3=NC=NC(N)=C3N=C2)OCCOC)C1COP(O)(=S)OC(C(C(O1)N2C3=NC=NC(N)=C3N=C2)OCCOC)C1COP(S)(=O)OC1CC(N2C3=C(C(NC(N)=N3)=O)N=C2)OC1COP(O)(=S)OC(C(O1)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(C(OC2COP(O)(=S)OC2C(C(OC2COP(O)(=S)OC2C(C(OC2COP(O)(=S)OC2C(C(OC2CO)N2C(NC(=O)C(C)=C2)=O)OCCOC)N2C3=C(C(NC(N)=N3)=O)N=C2)OCCOC)N2C(NC(=O)C(C)=C2)=O)OCCOC)N2C3=C(C(NC(N)=N3)=O)N=C2)OCCOC)CC1N1C=C(C)C(=O)NC1=O BZRZNGDLBBZGMQ-UHFFFAOYSA-N 0.000 description 4
• 229950006421 gataparsen Drugs 0.000 description 3
• 239000000243 solution Substances 0.000 description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
• 102000007327 Protamines Human genes 0.000 description 2
• 108010007568 Protamines Proteins 0.000 description 2
• 108010002687 Survivin Proteins 0.000 description 2
• 102000000763 Survivin Human genes 0.000 description 2
• 230000000692 anti-sense effect Effects 0.000 description 2
• 239000012153 distilled water Substances 0.000 description 2
• 239000000203 mixture Substances 0.000 description 2
• 108090000623 proteins and genes Proteins 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• 229920001661 Chitosan Polymers 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 230000005540 biological transmission Effects 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 150000003904 phospholipids Chemical class 0.000 description 1
• 229940048914 protamine Drugs 0.000 description 1
• 229950008679 protamine sulfate Drugs 0.000 description 1
• SRLOHQKOADWDBV-NRONOFSHSA-M sodium;[(2r)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCCCCCC SRLOHQKOADWDBV-NRONOFSHSA-M 0.000 description 1
• 229960002363 thiamine pyrophosphate Drugs 0.000 description 1
• 235000008170 thiamine pyrophosphate Nutrition 0.000 description 1
• 239000011678 thiamine pyrophosphate Substances 0.000 description 1
• YXVCLPJQTZXJLH-UHFFFAOYSA-N thiamine(1+) diphosphate chloride Chemical compound [Cl-].CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N YXVCLPJQTZXJLH-UHFFFAOYSA-N 0.000 description 1