JP2015500884A - 癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤 - Google Patents
癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤 Download PDFInfo
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A61K31/66—Phosphorus compounds
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- A—HUMAN NECESSITIES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201161579607P | 2011-12-22 | 2011-12-22 | |
| US61/579,607 | 2011-12-22 | ||
| US201261617579P | 2012-03-29 | 2012-03-29 | |
| US61/617,579 | 2012-03-29 | ||
| PCT/US2012/071070 WO2013096684A1 (en) | 2011-12-22 | 2012-12-20 | Hypoxia activated prodrugs and mtor inhibitors for treating cancer |
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| JP2015500884A true JP2015500884A (ja) | 2015-01-08 |
| JP2015500884A5 JP2015500884A5 (enExample) | 2016-02-18 |
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| US (1) | US20150005262A1 (enExample) |
| EP (1) | EP2793899A4 (enExample) |
| JP (1) | JP2015500884A (enExample) |
| WO (1) | WO2013096684A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160132259A (ko) * | 2015-05-08 | 2016-11-17 | 계명대학교 산학협력단 | m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8003625B2 (en) | 2005-06-29 | 2011-08-23 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| US9254299B2 (en) | 2011-12-22 | 2016-02-09 | Threshold Pharmaceuticals, Inc. | Administration of hypoxia activated prodrugs in combination with Chk1 inhibitors for treating cancer |
| JP2016528217A (ja) | 2013-07-26 | 2016-09-15 | スレッショルド ファーマシューティカルズ，インコーポレイテッド | 低酸素活性化プロドラッグおよびタキサンの組合せを用いた膵臓癌の治療 |
| US10071109B2 (en) | 2013-11-06 | 2018-09-11 | Molecular Templates, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
| AU2016260317B2 (en) * | 2015-05-13 | 2021-02-04 | Memorial Sloan Kettering Cancer Center | Macropinocytosis in cancer |
| JP7762796B2 (ja) | 2021-08-27 | 2025-10-30 | アセンタウィッツ ファーマシューティカルズ リミテッド | Ｐａｒｐ阻害剤に耐性のある患者のｔｈ－３０２による治療 |
| US20240366640A1 (en) | 2021-08-27 | 2024-11-07 | Ascentawits Pharmaceuticals, Ltd. | Lyophilized formulation solution and lyophilized formulation, and method and use thereof |
| WO2023174319A1 (zh) | 2022-03-15 | 2023-09-21 | 深圳艾欣达伟医药科技有限公司 | 治疗brca突变癌症患者的方法 |
| CN119384281A (zh) | 2022-04-15 | 2025-01-28 | 深圳艾欣达伟医药科技有限公司 | 使用th-302单药或联用parp抑制剂治疗癌症的方法 |
| EP4529926A1 (en) | 2022-05-23 | 2025-04-02 | Ascentawits Pharmaceuticals, Ltd. | Method for treating cancer by combining alkylating agent prodrug and cell cycle inhibitor |
| WO2024061346A1 (zh) | 2022-09-22 | 2024-03-28 | 深圳艾欣达伟医药科技有限公司 | 乏氧激活的化合物在制备治疗癌症患者的药物中的用途 |
| WO2024179467A1 (zh) | 2023-02-27 | 2024-09-06 | 深圳艾欣达伟医药科技有限公司 | 溶液、冻干制剂、冻干制剂单位包装、注射液及注射液配制方法 |
| CN121646480A (zh) | 2023-07-28 | 2026-03-10 | 深圳艾欣达伟医药科技有限公司 | 治疗p53基因突变或缺陷阴性癌症、肿瘤患者 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8003625B2 (en) * | 2005-06-29 | 2011-08-23 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| EP2350664B1 (en) * | 2008-10-21 | 2021-05-19 | ImmunoGenesis, Inc. | Treatment of cancer using the hypoxia activated prodrug th-302 in combination with docetaxel or pemetrexed |
| EP2427174A4 (en) * | 2009-05-04 | 2014-01-15 | Santen Pharmaceutical Co Ltd | HEMMER OF THE MTOR SIGNAL PATH FOR THE TREATMENT OF EYE TROUBLE |
| EP2501237A1 (en) * | 2009-11-06 | 2012-09-26 | Infinity Pharmaceuticals, Inc. | Oral formulations of a hedgehog pathway inhibitor |
| US20140010805A1 (en) * | 2010-07-12 | 2014-01-09 | Karen Curd | Administration of hypoxia activated prodrugs and antiangiogenic agents for the treatment of cancer |
| KR20140045931A (ko) * | 2011-04-15 | 2014-04-17 | 쓰레솔드 파마슈티컬스, 인코포레이티드 | 경구 투여를 위한 단위투여량 형태 |
-
2012
- 2012-12-20 US US14/367,152 patent/US20150005262A1/en not_active Abandoned
- 2012-12-20 JP JP2014548915A patent/JP2015500884A/ja not_active Withdrawn
- 2012-12-20 WO PCT/US2012/071070 patent/WO2013096684A1/en not_active Ceased
- 2012-12-20 EP EP12859382.9A patent/EP2793899A4/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160132259A (ko) * | 2015-05-08 | 2016-11-17 | 계명대학교 산학협력단 | m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물 |
| KR101692150B1 (ko) | 2015-05-08 | 2017-01-03 | 계명대학교 산학협력단 | m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2793899A4 (en) | 2015-06-17 |
| US20150005262A1 (en) | 2015-01-01 |
| WO2013096684A1 (en) | 2013-06-27 |
| EP2793899A1 (en) | 2014-10-29 |
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