JP2015500884A - 癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤 - Google Patents
癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤 Download PDFInfo
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201161579607P | 2011-12-22 | 2011-12-22 | |
| US61/579,607 | 2011-12-22 | ||
| US201261617579P | 2012-03-29 | 2012-03-29 | |
| US61/617,579 | 2012-03-29 | ||
| PCT/US2012/071070 WO2013096684A1 (en) | 2011-12-22 | 2012-12-20 | Hypoxia activated prodrugs and mtor inhibitors for treating cancer |
Publications (2)
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| JP2015500884A true JP2015500884A (ja) | 2015-01-08 |
| JP2015500884A5 JP2015500884A5 (enExample) | 2016-02-18 |
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| EP (1) | EP2793899A4 (enExample) |
| JP (1) | JP2015500884A (enExample) |
| WO (1) | WO2013096684A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160132259A (ko) * | 2015-05-08 | 2016-11-17 | 계명대학교 산학협력단 | m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200800314B (en) | 2005-06-29 | 2009-09-30 | Threshold Pharmaceuticals Inc | Phosphoramidate alkylator prodrugs |
| EP2793882A4 (en) | 2011-12-22 | 2015-04-29 | Threshold Pharmaceuticals Inc | ADMINISTRATION OF HYPOXIA-ACTIVATED PRODRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER |
| US20160158253A1 (en) | 2013-07-26 | 2016-06-09 | Threshold Pharmaceuticals, Inc. | Treatment of pancreatic cancer with a combination of a hypoxia-activated prodrug and a taxane |
| US10071109B2 (en) | 2013-11-06 | 2018-09-11 | Molecular Templates, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
| AU2016260317B2 (en) * | 2015-05-13 | 2021-02-04 | Memorial Sloan Kettering Cancer Center | Macropinocytosis in cancer |
| WO2023025291A1 (zh) | 2021-08-27 | 2023-03-02 | 深圳艾欣达伟医药科技有限公司 | 冻干制剂溶液及冻干制剂、方法和用途 |
| JP7762796B2 (ja) | 2021-08-27 | 2025-10-30 | アセンタウィッツ ファーマシューティカルズ リミテッド | Ｐａｒｐ阻害剤に耐性のある患者のｔｈ－３０２による治療 |
| US20250186468A1 (en) | 2022-03-15 | 2025-06-12 | Ascentawits Pharmaceuticals, Ltd. | Method for treating patient with brca-mutated cancer |
| EP4509127A4 (en) | 2022-04-15 | 2026-07-15 | Ascentawits Pharmaceuticals Ltd | CANCER TREATMENT METHOD USING TH-302 ALONE OR IN COMBINATION WITH A PARP INHIBITOR |
| EP4529926A4 (en) | 2022-05-23 | 2026-07-01 | Ascentawits Pharmaceuticals Ltd | CANCER TREATMENT METHOD BY COMBINATION OF AN ALKYLATING AGENT PRODRUGATION AND A CELL CYCLE INHIBITOR |
| CN119894521A (zh) | 2022-09-22 | 2025-04-25 | 深圳艾欣达伟医药科技有限公司 | 乏氧激活的化合物在制备治疗癌症患者的药物中的用途 |
| EP4674418A1 (en) | 2023-02-27 | 2026-01-07 | Ascentawits Pharmaceuticals, Ltd. | Solution, freeze-dried formulation, freeze-dried formulation unit package, injection, and injection preparation method |
| EP4755396A1 (en) | 2023-07-28 | 2026-06-10 | Ascentawits Pharmaceuticals, Ltd. | Treatment of p53 gene mutation or defect negative cancer and tumor patients |
| CN121985960A (zh) | 2023-10-18 | 2026-05-05 | 深圳艾欣达伟医药科技有限公司 | 治疗p53基因突变阴性、kras基因突变阳性、brca突变阳性患者 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200800314B (en) * | 2005-06-29 | 2009-09-30 | Threshold Pharmaceuticals Inc | Phosphoramidate alkylator prodrugs |
| WO2010048330A1 (en) * | 2008-10-21 | 2010-04-29 | Threshold Pharmaceuticals, Inc. | Treatment of cancer using hypoxia activated prodrugs |
| US20120114637A1 (en) * | 2009-05-04 | 2012-05-10 | Santen Pharmaceutical Co., Ltd. | Mtor pathway inhibitors for treating ocular disorders |
| WO2011057222A1 (en) * | 2009-11-06 | 2011-05-12 | Infinity Pharmaceuticals, Inc. | Oral formulations of a hedgehog pathway inhibitor |
| RU2597844C2 (ru) * | 2010-07-12 | 2016-09-20 | Тресхолд Фармасьютикалз, Инк. | Введение гипоксически активируемых пролекарств и средств, препятствующих ангиогенезу, для лечения рака |
| JP2014510795A (ja) * | 2011-04-15 | 2014-05-01 | スレッショルド ファーマシューティカルズ、インク． | 経口投与用の単位用量形態物 |
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2012
- 2012-12-20 EP EP12859382.9A patent/EP2793899A4/en not_active Withdrawn
- 2012-12-20 US US14/367,152 patent/US20150005262A1/en not_active Abandoned
- 2012-12-20 JP JP2014548915A patent/JP2015500884A/ja not_active Withdrawn
- 2012-12-20 WO PCT/US2012/071070 patent/WO2013096684A1/en not_active Ceased
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160132259A (ko) * | 2015-05-08 | 2016-11-17 | 계명대학교 산학협력단 | m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물 |
| KR101692150B1 (ko) | 2015-05-08 | 2017-01-03 | 계명대학교 산학협력단 | m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2793899A4 (en) | 2015-06-17 |
| WO2013096684A1 (en) | 2013-06-27 |
| US20150005262A1 (en) | 2015-01-01 |
| EP2793899A1 (en) | 2014-10-29 |
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