JP2015500884A - 癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤 - Google Patents
癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤 Download PDFInfo
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201161579607P | 2011-12-22 | 2011-12-22 | |
| US61/579,607 | 2011-12-22 | ||
| US201261617579P | 2012-03-29 | 2012-03-29 | |
| US61/617,579 | 2012-03-29 | ||
| PCT/US2012/071070 WO2013096684A1 (en) | 2011-12-22 | 2012-12-20 | Hypoxia activated prodrugs and mtor inhibitors for treating cancer |
Publications (2)
| Publication Number | Publication Date |
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| JP2015500884A true JP2015500884A (ja) | 2015-01-08 |
| JP2015500884A5 JP2015500884A5 (enExample) | 2016-02-18 |
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| EP (1) | EP2793899A4 (enExample) |
| JP (1) | JP2015500884A (enExample) |
| WO (1) | WO2013096684A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160132259A (ko) * | 2015-05-08 | 2016-11-17 | 계명대학교 산학협력단 | m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102746336B (zh) | 2005-06-29 | 2015-08-19 | 施瑞修德制药公司 | 氨基磷酸酯烷化剂前体药物 |
| WO2013096687A1 (en) | 2011-12-22 | 2013-06-27 | Threshold Pharmaceuticals, Inc. | Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer |
| WO2015013448A1 (en) | 2013-07-26 | 2015-01-29 | Threshold Pharmaceuticals, Inc. | Treatment of pancreatic cancer with a combination of a hypoxia-acti vated prodrug and a taxane |
| WO2015069489A1 (en) | 2013-11-06 | 2015-05-14 | Merck Patent Gmbh | Predictive biomarker for hypoxia-activated prodrug therapy |
| EP3294338A4 (en) * | 2015-05-13 | 2019-07-17 | Memorial Sloan Kettering Cancer Center | MACROPINOCYTOSIS IN CANCER |
| US20240366640A1 (en) | 2021-08-27 | 2024-11-07 | Ascentawits Pharmaceuticals, Ltd. | Lyophilized formulation solution and lyophilized formulation, and method and use thereof |
| KR20240051965A (ko) | 2021-08-27 | 2024-04-22 | 아센타위츠 파마슈티컬즈 리미티드 | Th-302를 이용한 parp 억제제에 내성이 있는 환자의 치료 |
| EP4494643A4 (en) | 2022-03-15 | 2025-09-10 | Ascentawits Pharmaceuticals Ltd | METHOD OF TREATING A PATIENT WITH BRCA MUTATION CANCER |
| WO2023198188A1 (zh) | 2022-04-15 | 2023-10-19 | 深圳艾欣达伟医药科技有限公司 | 使用th-302单药或联用parp抑制剂治疗癌症的方法 |
| WO2023226959A1 (zh) | 2022-05-23 | 2023-11-30 | 深圳艾欣达伟医药科技有限公司 | 烷化剂前药与细胞周期抑制剂联用治疗癌症的方法 |
| EP4591866A1 (en) | 2022-09-22 | 2025-07-30 | Ascentawits Pharmaceuticals, Ltd. | Use of hypoxia-activated compound in preparation of medicament for treating cancer patient |
| KR20250160163A (ko) | 2023-02-27 | 2025-11-11 | 아센타위츠 파마슈티컬즈 리미티드 | 용액, 동결건조 제형, 동결건조 제형 단위 패키지, 주사제, 및 주사제 제조 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102746336B (zh) * | 2005-06-29 | 2015-08-19 | 施瑞修德制药公司 | 氨基磷酸酯烷化剂前体药物 |
| ES2884674T3 (es) * | 2008-10-21 | 2021-12-10 | Immunogenesis Inc | Tratamiento del cáncer con el profármaco activado por hipoxia TH-302 en combinación con docetaxel o pemetrexed |
| EP2427174A4 (en) * | 2009-05-04 | 2014-01-15 | Santen Pharmaceutical Co Ltd | HEMMER OF THE MTOR SIGNAL PATH FOR THE TREATMENT OF EYE TROUBLE |
| KR20120099715A (ko) * | 2009-11-06 | 2012-09-11 | 인피니티 파마슈티칼스, 인코포레이티드 | 헷지혹 경로 억제제의 경구용 포뮬레이션 |
| ES2877629T3 (es) * | 2010-07-12 | 2021-11-17 | Immunogenesis Inc | Administración de profármacos activados por hipoxia y agentes antiangiogénicos para el tratamiento del cáncer |
| MX2013011655A (es) * | 2011-04-15 | 2013-11-01 | Threshold Pharmaceuticals Inc | Forma de dosis unitaria para administracion oral. |
-
2012
- 2012-12-20 EP EP12859382.9A patent/EP2793899A4/en not_active Withdrawn
- 2012-12-20 JP JP2014548915A patent/JP2015500884A/ja not_active Withdrawn
- 2012-12-20 US US14/367,152 patent/US20150005262A1/en not_active Abandoned
- 2012-12-20 WO PCT/US2012/071070 patent/WO2013096684A1/en not_active Ceased
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160132259A (ko) * | 2015-05-08 | 2016-11-17 | 계명대학교 산학협력단 | m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물 |
| KR101692150B1 (ko) | 2015-05-08 | 2017-01-03 | 계명대학교 산학협력단 | m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013096684A1 (en) | 2013-06-27 |
| US20150005262A1 (en) | 2015-01-01 |
| EP2793899A4 (en) | 2015-06-17 |
| EP2793899A1 (en) | 2014-10-29 |
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