JP2015500833A5 - - Google Patents

Info

Publication number

JP2015500833A5

JP2015500833A5 JP2014545985A JP2014545985A JP2015500833A5 JP 2015500833 A5 JP2015500833 A5 JP 2015500833A5 JP 2014545985 A JP2014545985 A JP 2014545985A JP 2014545985 A JP2014545985 A JP 2014545985A JP 2015500833 A5 JP2015500833 A5 JP 2015500833A5

Authority

JP

Japan

Prior art keywords

salt

compound

composition

hydrogen

effective amount

Prior art date

2012-12-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims description 27
• 150000003839 salts Chemical class 0.000 claims description 21
• 229910052739 hydrogen Inorganic materials 0.000 claims description 15
• 239000001257 hydrogen Substances 0.000 claims description 15
• 239000000203 mixture Substances 0.000 claims description 15
• 150000004712 monophosphates Chemical group 0.000 claims description 11
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
• 239000001177 diphosphate Substances 0.000 claims description 8
• XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 8
• 235000011180 diphosphates Nutrition 0.000 claims description 8
• 239000001226 triphosphate Substances 0.000 claims description 6
• 235000011178 triphosphate Nutrition 0.000 claims description 6
• UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 5
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
• 150000002431 hydrogen Chemical class 0.000 claims description 4
• 206010012335 Dependence Diseases 0.000 claims description 3
• 125000000217 alkyl group Chemical group 0.000 claims description 2
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
• 125000002264 triphosphate group Chemical group [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 claims description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 125000000753 cycloalkyl group Chemical group 0.000 claims 2
• 125000001072 heteroaryl group Chemical group 0.000 claims 2
• 125000005842 heteroatom Chemical group 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 239000001301 oxygen Substances 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 239000011593 sulfur Substances 0.000 claims 2
• 229910019142 PO4 Inorganic materials 0.000 description 2
• 235000021317 phosphate Nutrition 0.000 description 2
• 239000010452 phosphate Substances 0.000 description 1
• -1 phosphate ester Chemical class 0.000 description 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
• 150000003014 phosphoric acid esters Chemical class 0.000 description 1