JP2015500001A - 組換えｐｒｐｋ−ｔｐｒｋｂ及びその使用 - Google Patents

組換えｐｒｐｋ−ｔｐｒｋｂ及びその使用 Download PDF

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Publication number
JP2015500001A
JP2015500001A JP2014526320A JP2014526320A JP2015500001A JP 2015500001 A JP2015500001 A JP 2015500001A JP 2014526320 A JP2014526320 A JP 2014526320A JP 2014526320 A JP2014526320 A JP 2014526320A JP 2015500001 A JP2015500001 A JP 2015500001A
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JP
Japan
Prior art keywords
prpk
tprkb
recombinant
complex
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2014526320A
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English (en)
Japanese (ja)
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JP2015500001A5 (enExample
Inventor
和臣 深澤
和臣 深澤
石田　啓介
啓介 石田
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Taiho Pharmaceutical Co Ltd
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Taiho Pharmaceutical Co Ltd
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Publication of JP2015500001A publication Critical patent/JP2015500001A/ja
Publication of JP2015500001A5 publication Critical patent/JP2015500001A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2014526320A 2011-12-14 2012-12-14 組換えｐｒｐｋ−ｔｐｒｋｂ及びその使用 Pending JP2015500001A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161570420P 2011-12-14 2011-12-14
US61/570,420 2011-12-14
PCT/JP2012/083169 WO2013089278A1 (en) 2011-12-14 2012-12-14 Recombinant prpk-tprkb and uses thereof

Publications (2)

Publication Number Publication Date
JP2015500001A true JP2015500001A (ja) 2015-01-05
JP2015500001A5 JP2015500001A5 (enExample) 2015-11-19

Family

ID=47561744

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014526320A Pending JP2015500001A (ja) 2011-12-14 2012-12-14 組換えｐｒｐｋ−ｔｐｒｋｂ及びその使用

Country Status (3)

Country Link
US (1) US9200263B2 (enExample)
JP (1) JP2015500001A (enExample)
WO (1) WO2013089278A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9581612B2 (en) 2013-08-26 2017-02-28 EveryFit, Inc. Systems and methods for a power efficient method for detecting wear and non-wear of a sensor
US9947198B2 (en) 2013-08-26 2018-04-17 EveryFit, Inc. Systems and methods for context-aware transmission of longitudinal safety and wellness data wearable sensors
US9554747B2 (en) 2013-08-26 2017-01-31 EveryFit, Inc. Power efficient system and method for measuring physical activity in resource constrained devices
US10302644B2 (en) 2014-11-04 2019-05-28 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating multiple myeloma
EP3455218A4 (en) * 2016-05-10 2019-12-18 C4 Therapeutics, Inc. C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
CN118440096A (zh) 2017-06-20 2024-08-06 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
CN111372585A (zh) 2017-11-16 2020-07-03 C4医药公司 用于靶蛋白降解的降解剂和降解决定子
CN120698985A (zh) 2018-12-20 2025-09-26 C4医药公司 靶向蛋白降解

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007132156A2 (en) * 2006-05-02 2007-11-22 Ifom Fondazione Istituto Firc Di Oncologia Molecolare Materials and methods relating to cancer diagnosis, prognosis and treatment based on the determination of novel molecular markers in tumors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070134261A1 (en) 2001-12-03 2007-06-14 Hancock Robert E Effectors of innate immunity
US7973057B2 (en) 2003-09-17 2011-07-05 The United States Of America As Represented By The Department Of Health And Human Services Thalidomide analogs
US20070208057A1 (en) 2003-11-06 2007-09-06 Zeldis Jerome B Methods And Compositions Using Thalidomide For The Treatment And Management Of Cancers And Other Diseases
EP2582836B1 (en) * 2010-06-18 2018-03-07 Taiho Pharmaceutical Co., Ltd. Prpk-tprkb modulators and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007132156A2 (en) * 2006-05-02 2007-11-22 Ifom Fondazione Istituto Firc Di Oncologia Molecolare Materials and methods relating to cancer diagnosis, prognosis and treatment based on the determination of novel molecular markers in tumors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN6016024016; ＭＩＹＯＳＨＩ，　Ａ．　ｅｔ　ａｌ．: '"Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ　ｏｆ　ＣＧＩ-１２１，　ａ　ｎｏｖｅｌ　ＰＲＰＫ　（ｐ５３-ｒｅｌａｔｅｄ　ｐｒｏｔｅｉｎ　ｋｉｎａｓｅ）-ｂｉｎｄｉｎｇ　ｐｒｏｔｅｉｎ"' Ｂｉｏｃｈｅｍ．　Ｂｉｏｐｈｙｓ．　Ｒｅｓ．　Ｃｏｍｍｕｎ． Ｖｏｌ．　３０３, 2003, ｐｐ．　３９９-４０５ *
JPN6016024017; '"Ｔｈｅ　ＢａｃＰＡＫ　Ｓｙｓｔｅｍ-Ｓｉｍｐｌｉｃｉｔｙ　Ｍｅｅｔｓ　Ｇｒｅａｔ　Ｒｅｓｕｌｔｓ"' Ｃｌｏｎｔｅｃｈｎｉｑｕｅｓ , 200801, ｐｐ．　３６-３７ *
JPN6016024019; '"ＢＤ　ＢａｃＰＡＫ　Ｂａｃｕｌｏｖｉｒｕｓ　Ｅｘｐｒｅｓｓｉｏｎ　Ｓｙｓｔｅｍ"' ＢＤ　Ｂｉｏｓｃｉｅｎｃｅｓ　Ｃｌｏｎｔｅｃｈ　総合カタログ２００３ , 2003, ｐ．　２２６ *
JPN6016024021; 久武幸司: '"バキュロウイルスを用いたタンパク質発現系"' 実験医学別冊　新訂　新遺伝子工学ハンドブック　改訂第３版 , 1991, ｐｐ．　１９０-１９５ *
JPN6016045010; 川本進 ほか: '"バキュロウイルス・昆虫細胞系での組換えタンパク質の発現と精製"' 改訂 タンパク質実験ノート 上 抽出と分離精製 , 1996, ｐｐ． １８０-１８９ *

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Publication number Publication date
US9200263B2 (en) 2015-12-01
US20150004645A1 (en) 2015-01-01
WO2013089278A1 (en) 2013-06-20

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