JP2015164972A5 - - Google Patents
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- JP2015164972A5 JP2015164972A5 JP2015129154A JP2015129154A JP2015164972A5 JP 2015164972 A5 JP2015164972 A5 JP 2015164972A5 JP 2015129154 A JP2015129154 A JP 2015129154A JP 2015129154 A JP2015129154 A JP 2015129154A JP 2015164972 A5 JP2015164972 A5 JP 2015164972A5
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- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- acceptable salt
- pharmacologically acceptable
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 13
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 71
- 150000003839 salts Chemical class 0.000 claims 61
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 49
- 150000001875 compounds Chemical class 0.000 claims 46
- -1 [(isopropoxycarbonyl) oxy] ethyl group Chemical group 0.000 claims 33
- 125000003118 aryl group Chemical group 0.000 claims 32
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 29
- 208000005189 Embolism Diseases 0.000 claims 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 22
- 229940002612 prodrug Drugs 0.000 claims 21
- 239000000651 prodrug Chemical group 0.000 claims 21
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 20
- 201000010099 disease Diseases 0.000 claims 20
- 125000004043 oxo group Chemical group O=* 0.000 claims 20
- 208000007536 Thrombosis Diseases 0.000 claims 19
- 125000004423 acyloxy group Chemical group 0.000 claims 16
- 125000003277 amino group Chemical group 0.000 claims 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 14
- 239000004480 active ingredient Substances 0.000 claims 13
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 12
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 12
- 125000002252 acyl group Chemical group 0.000 claims 11
- 229940124597 therapeutic agent Drugs 0.000 claims 11
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- 125000006239 protecting group Chemical group 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- 230000000069 prophylactic effect Effects 0.000 claims 8
- 208000011580 syndromic disease Diseases 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- 208000009190 disseminated intravascular coagulation Diseases 0.000 claims 6
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 5
- 206010040047 Sepsis Diseases 0.000 claims 5
- 206010047249 Venous thrombosis Diseases 0.000 claims 5
- 206010008118 cerebral infarction Diseases 0.000 claims 5
- 208000026106 cerebrovascular disease Diseases 0.000 claims 5
- 208000010125 myocardial infarction Diseases 0.000 claims 5
- 230000002093 peripheral effect Effects 0.000 claims 5
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 5
- 206010002383 Angina Pectoris Diseases 0.000 claims 4
- 206010014513 Embolism arterial Diseases 0.000 claims 4
- 102000009123 Fibrin Human genes 0.000 claims 4
- 108010073385 Fibrin Proteins 0.000 claims 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 4
- 206010016654 Fibrosis Diseases 0.000 claims 4
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 230000008021 deposition Effects 0.000 claims 4
- 229950003499 fibrin Drugs 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 238000001356 surgical procedure Methods 0.000 claims 4
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 230000004761 fibrosis Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000000405 phenylalanyl group Chemical group 0.000 claims 3
- AEHFUSPLVGWEEP-FFAOXRCVSA-N C1C[C@@H](C)CC[C@@H]1N1C=C(CC(CCCN)C(O)=O)N=C1 Chemical compound C1C[C@@H](C)CC[C@@H]1N1C=C(CC(CCCN)C(O)=O)N=C1 AEHFUSPLVGWEEP-FFAOXRCVSA-N 0.000 claims 2
- 206010052895 Coronary artery insufficiency Diseases 0.000 claims 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims 2
- 206010038470 Renal infarct Diseases 0.000 claims 2
- 208000001435 Thromboembolism Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003435 aroyl group Chemical group 0.000 claims 2
- 125000005101 aryl methoxy carbonyl group Chemical group 0.000 claims 2
- 125000005002 aryl methyl group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000020764 fibrinolysis Effects 0.000 claims 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 201000008383 nephritis Diseases 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- ZJFZGDDSKVVKNV-SQCBITNQSA-N C([C@H](CCCNC(=O)OC(C)OC(=O)C1CCCCC1)C(O)=O)C(N=C1)=CN1[C@H]1CC[C@H](C)CC1 Chemical compound C([C@H](CCCNC(=O)OC(C)OC(=O)C1CCCCC1)C(O)=O)C(N=C1)=CN1[C@H]1CC[C@H](C)CC1 ZJFZGDDSKVVKNV-SQCBITNQSA-N 0.000 claims 1
- IHCAPMBMIUJMCW-LYKJFQGKSA-N C1=NC(CC(CCCNC(=O)[C@@H](N)CCCC)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 Chemical compound C1=NC(CC(CCCNC(=O)[C@@H](N)CCCC)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 IHCAPMBMIUJMCW-LYKJFQGKSA-N 0.000 claims 1
- SXFRUTCVXKOOAP-TVAMOIRASA-N C1=NC(CC(O[C@@H](CN)C)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 Chemical compound C1=NC(CC(O[C@@H](CN)C)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 SXFRUTCVXKOOAP-TVAMOIRASA-N 0.000 claims 1
- MTKDYJGCJYLATD-OLOOMHLZSA-N C1=NC(C[C@H](CCCNC(=O)OC(C)OC(=O)C(C)(C)C)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 Chemical compound C1=NC(C[C@H](CCCNC(=O)OC(C)OC(=O)C(C)(C)C)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 MTKDYJGCJYLATD-OLOOMHLZSA-N 0.000 claims 1
- JVFGCZHYUYGTHV-RNSKZVDZSA-N C1=NC(C[C@H](CCCNC(=O)OC(OC(C)=O)C)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 Chemical compound C1=NC(C[C@H](CCCNC(=O)OC(OC(C)=O)C)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 JVFGCZHYUYGTHV-RNSKZVDZSA-N 0.000 claims 1
- OOBXCCFBQYXWIP-LNLFQRSKSA-N C1=NC(C[C@H](CCCNC(=O)OCOC(=O)C(C)C)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 Chemical compound C1=NC(C[C@H](CCCNC(=O)OCOC(=O)C(C)C)C(O)=O)=CN1[C@@H]1CC[C@@H](C)CC1 OOBXCCFBQYXWIP-LNLFQRSKSA-N 0.000 claims 1
- RHNOAECEDASGIK-JLWWHIBLSA-N C1C[C@@H](C)CC[C@@H]1N1C=C(CC(CCCNC(=O)[C@@H](N)CC=2C=CC=CC=2)C(O)=O)N=C1 Chemical compound C1C[C@@H](C)CC[C@@H]1N1C=C(CC(CCCNC(=O)[C@@H](N)CC=2C=CC=CC=2)C(O)=O)N=C1 RHNOAECEDASGIK-JLWWHIBLSA-N 0.000 claims 1
- VWNRFOAGDPZBET-ALLFYKQTSA-N C1C[C@@H](C)CC[C@@H]1N1C=C(CC(N2C[C@@H](N)CC2)C(O)=O)N=C1 Chemical compound C1C[C@@H](C)CC[C@@H]1N1C=C(CC(N2C[C@@H](N)CC2)C(O)=O)N=C1 VWNRFOAGDPZBET-ALLFYKQTSA-N 0.000 claims 1
- MYFSJRVPQSXHMT-LTXMZBCZSA-N C1C[C@@H](C)CC[C@@H]1N1C=C(CC(OCCN)C(O)=O)N=C1 Chemical compound C1C[C@@H](C)CC[C@@H]1N1C=C(CC(OCCN)C(O)=O)N=C1 MYFSJRVPQSXHMT-LTXMZBCZSA-N 0.000 claims 1
- PUIRNHDAZVXILG-ZVZYQTTQSA-N C1C[C@@H](C)CC[C@@H]1N1C=C(C[C@H](CCCNC(=O)OCC2=C(OC(=O)O2)C)C(O)=O)N=C1 Chemical compound C1C[C@@H](C)CC[C@@H]1N1C=C(C[C@H](CCCNC(=O)OCC2=C(OC(=O)O2)C)C(O)=O)N=C1 PUIRNHDAZVXILG-ZVZYQTTQSA-N 0.000 claims 1
- MIWPLEQRYCOZEN-LNLFQRSKSA-N C1C[C@@H](C)CC[C@@H]1N1C=C(C[C@H](CCCNC(=O)OCOC(=O)C(C)(C)C)C(O)=O)N=C1 Chemical compound C1C[C@@H](C)CC[C@@H]1N1C=C(C[C@H](CCCNC(=O)OCOC(=O)C(C)(C)C)C(O)=O)N=C1 MIWPLEQRYCOZEN-LNLFQRSKSA-N 0.000 claims 1
- JHZDNFZCZSQEMT-VCOUNFBDSA-N C1C[C@@H](C)CC[C@@H]1N1C=C(C[C@H](CCCNC(=O)OCOC(=O)C2CCCCC2)C(O)=O)N=C1 Chemical compound C1C[C@@H](C)CC[C@@H]1N1C=C(C[C@H](CCCNC(=O)OCOC(=O)C2CCCCC2)C(O)=O)N=C1 JHZDNFZCZSQEMT-VCOUNFBDSA-N 0.000 claims 1
- WWQOMQUEBAYDCG-ZVZYQTTQSA-N C1C[C@@H](C)CC[C@@H]1N1C=C(C[C@H](CCCNC(=O)OCOC(C)=O)C(O)=O)N=C1 Chemical compound C1C[C@@H](C)CC[C@@H]1N1C=C(C[C@H](CCCNC(=O)OCOC(C)=O)C(O)=O)N=C1 WWQOMQUEBAYDCG-ZVZYQTTQSA-N 0.000 claims 1
- 208000026151 Chronic thromboembolic pulmonary hypertension Diseases 0.000 claims 1
- 206010014522 Embolism venous Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010018366 Glomerulonephritis acute Diseases 0.000 claims 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 208000007718 Stable Angina Diseases 0.000 claims 1
- 208000034841 Thrombotic Microangiopathies Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N Valeric acid Natural products CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 231100000851 acute glomerulonephritis Toxicity 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 230000003510 anti-fibrotic effect Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 229940127088 antihypertensive drug Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940127218 antiplatelet drug Drugs 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 239000002473 artificial blood Substances 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims 1
- 229940077388 benzenesulfonate Drugs 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 238000001631 haemodialysis Methods 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000000322 hemodialysis Effects 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 238000011540 hip replacement Methods 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 239000005555 hypertensive agent Substances 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940124589 immunosuppressive drug Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 238000013150 knee replacement Methods 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000018341 negative regulation of fibrinolysis Effects 0.000 claims 1
- 230000004768 organ dysfunction Effects 0.000 claims 1
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 238000002271 resection Methods 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 230000000250 revascularization Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical group CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 229940070710 valerate Drugs 0.000 claims 1
- 229940005605 valeric acid Drugs 0.000 claims 1
- 208000004043 venous thromboembolism Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015129154A JP6153971B2 (ja) | 2010-03-18 | 2015-06-26 | シクロアルキル基で置換されたイミダゾール誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010062155 | 2010-03-18 | ||
| JP2010062155 | 2010-03-18 | ||
| JP2015129154A JP6153971B2 (ja) | 2010-03-18 | 2015-06-26 | シクロアルキル基で置換されたイミダゾール誘導体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012505676A Division JP5807006B2 (ja) | 2010-03-18 | 2011-03-14 | シクロアルキル基で置換されたイミダゾール誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017080427A Division JP2017122128A (ja) | 2010-03-18 | 2017-04-14 | シクロアルキル基で置換されたイミダゾール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015164972A JP2015164972A (ja) | 2015-09-17 |
| JP2015164972A5 true JP2015164972A5 (https=) | 2015-11-12 |
| JP6153971B2 JP6153971B2 (ja) | 2017-06-28 |
Family
ID=44649149
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012505676A Expired - Fee Related JP5807006B2 (ja) | 2010-03-18 | 2011-03-14 | シクロアルキル基で置換されたイミダゾール誘導体 |
| JP2015129154A Expired - Fee Related JP6153971B2 (ja) | 2010-03-18 | 2015-06-26 | シクロアルキル基で置換されたイミダゾール誘導体 |
| JP2017080427A Pending JP2017122128A (ja) | 2010-03-18 | 2017-04-14 | シクロアルキル基で置換されたイミダゾール誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012505676A Expired - Fee Related JP5807006B2 (ja) | 2010-03-18 | 2011-03-14 | シクロアルキル基で置換されたイミダゾール誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017080427A Pending JP2017122128A (ja) | 2010-03-18 | 2017-04-14 | シクロアルキル基で置換されたイミダゾール誘導体 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8609710B2 (https=) |
| EP (1) | EP2548871B1 (https=) |
| JP (3) | JP5807006B2 (https=) |
| KR (2) | KR101704095B1 (https=) |
| CN (2) | CN105801489B (https=) |
| AU (1) | AU2011228237B2 (https=) |
| BR (1) | BR112012017474A2 (https=) |
| CA (1) | CA2791505C (https=) |
| CO (1) | CO6511269A2 (https=) |
| CY (1) | CY1119423T1 (https=) |
| DK (1) | DK2548871T3 (https=) |
| ES (1) | ES2643132T3 (https=) |
| HR (1) | HRP20171560T1 (https=) |
| HU (1) | HUE035072T2 (https=) |
| IL (1) | IL221903B (https=) |
| LT (1) | LT2548871T (https=) |
| MX (1) | MX358628B (https=) |
| NZ (1) | NZ601658A (https=) |
| PH (1) | PH12012501473A1 (https=) |
| PL (1) | PL2548871T3 (https=) |
| PT (1) | PT2548871T (https=) |
| RS (1) | RS56445B1 (https=) |
| RU (1) | RU2572814C2 (https=) |
| SG (2) | SG10201502026XA (https=) |
| SI (1) | SI2548871T1 (https=) |
| SM (1) | SMT201700455T1 (https=) |
| TW (1) | TWI609857B (https=) |
| WO (1) | WO2011115064A1 (https=) |
| ZA (1) | ZA201206968B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130006620A (ko) | 2010-03-18 | 2013-01-17 | 다이이찌 산쿄 가부시키가이샤 | 시클로프로판카르복실산 유도체 |
| DK2548871T3 (da) | 2010-03-18 | 2017-11-06 | Daiichi Sankyo Co Ltd | Cycloalkylsubstitueret imidazolderivat |
| US9562029B2 (en) | 2011-06-25 | 2017-02-07 | Xuanzhu Pharma Co., Ltd. | C-glycoside derivatives |
| WO2013039202A1 (ja) * | 2011-09-15 | 2013-03-21 | 第一三共株式会社 | 新規アクリル酸誘導体 |
| US9315438B2 (en) | 2014-01-03 | 2016-04-19 | Xuanzhu Pharma Co., Ltd | Optically pure benzyl-4-chlorophenyl-C-glucoside derivative |
| CN104761522B (zh) * | 2014-01-03 | 2017-02-15 | 山东轩竹医药科技有限公司 | 光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物 |
| JPWO2016043254A1 (ja) * | 2014-09-18 | 2017-07-27 | 第一三共株式会社 | 光学活性吉草酸誘導体の製法 |
| KR20170054378A (ko) * | 2014-09-18 | 2017-05-17 | 다이이찌 산쿄 가부시키가이샤 | 광학 활성 발레르산 유도체의 제조 방법 |
| US20170368037A1 (en) * | 2014-12-26 | 2017-12-28 | Daiichi Sankyo Company, Limited | Pharmaceutical composition for promotion of fibrinolysis |
| US10517850B2 (en) | 2015-06-17 | 2019-12-31 | Daiichi Sankyo Company, Limited | Combination of TAFIa inhibitor with plasminogen activator |
| JPWO2016208709A1 (ja) * | 2015-06-26 | 2018-04-19 | 第一三共株式会社 | １−（アシルオキシ）アルキルカルバメート誘導体の新規な製造方法 |
| WO2017155025A1 (ja) * | 2016-03-10 | 2017-09-14 | 第一三共株式会社 | 酵素による光学分割を用いた光学活性吉草酸誘導体の製造方法 |
| EP3437641A4 (en) * | 2016-03-29 | 2019-11-20 | Daiichi Sankyo Company, Limited | THERAPEUTIC AGENT AGAINST INFLAMMATORY DARMER DISEASE |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| WO2020191503A1 (en) * | 2019-03-27 | 2020-10-01 | Algernon Pharmaceuticals Inc. | Methods and uses of bromantane and derivatives thereof for treating lung disease, fatty liver disease, and kidney disorders |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3856816B2 (ja) * | 1992-05-20 | 2006-12-13 | ノースウェスターン ユニヴァーシティ | 抗発作治療用のｇａｂａ及びｌ−グルタミン酸類縁体 |
| PL361054A1 (en) * | 2000-08-17 | 2004-09-20 | Pfizer Inc. | Substituted imidazoles as tafia inhibitors |
| US6949577B2 (en) * | 2000-09-13 | 2005-09-27 | Pfizer, Inc. | Pharmaceuticals |
| WO2003013526A1 (en) | 2001-08-08 | 2003-02-20 | Merck & Co. Inc. | Anticoagulant compounds |
| US6897208B2 (en) * | 2001-10-26 | 2005-05-24 | Aventis Pharmaceuticals Inc. | Benzimidazoles |
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| DE102004020186A1 (de) * | 2004-04-22 | 2005-11-17 | Aventis Pharma Deutschland Gmbh | Heterocyclylessigsäuren als Inhibitoren von TAFla |
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