JP2015164424A5 - - Google Patents
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- Publication number
- JP2015164424A5 JP2015164424A5 JP2015075517A JP2015075517A JP2015164424A5 JP 2015164424 A5 JP2015164424 A5 JP 2015164424A5 JP 2015075517 A JP2015075517 A JP 2015075517A JP 2015075517 A JP2015075517 A JP 2015075517A JP 2015164424 A5 JP2015164424 A5 JP 2015164424A5
- Authority
- JP
- Japan
- Prior art keywords
- allergen
- polypeptide according
- polypeptide
- group
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 239000013566 allergen Substances 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 241000238740 Dermatophagoides pteronyssinus Species 0.000 claims 1
- 108010061629 Dermatophagoides pteronyssinus antigen p 1 Proteins 0.000 claims 1
- 108010061608 Dermatophagoides pteronyssinus antigen p 2 Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200800827 | 2008-03-25 | ||
| ES200800827 | 2008-03-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501318A Division JP5793073B2 (ja) | 2008-03-25 | 2009-03-24 | アレルギーの治療に用いるための、主要グループ１ダニアレルゲンおよび主要グループ２ダニアレルゲンの低アレルゲン性ハイブリッドタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015164424A JP2015164424A (ja) | 2015-09-17 |
| JP2015164424A5 true JP2015164424A5 (OSRAM) | 2016-04-07 |
| JP6068544B2 JP6068544B2 (ja) | 2017-01-25 |
Family
ID=41110539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501318A Expired - Fee Related JP5793073B2 (ja) | 2008-03-25 | 2009-03-24 | アレルギーの治療に用いるための、主要グループ１ダニアレルゲンおよび主要グループ２ダニアレルゲンの低アレルゲン性ハイブリッドタンパク質 |
| JP2015075517A Expired - Fee Related JP6068544B2 (ja) | 2008-03-25 | 2015-04-02 | アレルギーの治療に用いるための、主要グループ１ダニアレルゲンおよび主要グループ２ダニアレルゲンの低アレルゲン性ハイブリッドタンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501318A Expired - Fee Related JP5793073B2 (ja) | 2008-03-25 | 2009-03-24 | アレルギーの治療に用いるための、主要グループ１ダニアレルゲンおよび主要グループ２ダニアレルゲンの低アレルゲン性ハイブリッドタンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8951530B2 (OSRAM) |
| EP (3) | EP2268662A2 (OSRAM) |
| JP (2) | JP5793073B2 (OSRAM) |
| CN (2) | CN101977929B (OSRAM) |
| BR (1) | BRPI0908848A2 (OSRAM) |
| CA (1) | CA2718994C (OSRAM) |
| ES (2) | ES2638308T3 (OSRAM) |
| MX (1) | MX2010010353A (OSRAM) |
| WO (1) | WO2009118642A2 (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2575832B1 (en) * | 2010-06-03 | 2017-07-26 | ALK-Abelló A/S | Pharmaceutical product comprising mite allergen extract(s) and a method for the manufacture thereof |
| EP2460824A1 (en) * | 2010-12-01 | 2012-06-06 | Biomay Ag | Hypoallergenic polypeptides for the treatment of house dust mite allergy |
| CN102676568A (zh) * | 2012-05-08 | 2012-09-19 | 崔玉宝 | 一种生产重组粉尘螨变应原Der f1和Der f2融合蛋白的方法 |
| WO2014045084A1 (es) | 2012-09-20 | 2014-03-27 | Universidad De Cartagena | Proteínas de fusión con representación de diferentes alergenos: propuesta de vacuna para alergia a los ácaros |
| TWI710569B (zh) * | 2014-12-02 | 2020-11-21 | 日商大鵬藥品工業股份有限公司 | 新穎美洲室塵蟎蛋白質 |
| NL2014882B1 (en) * | 2015-05-29 | 2017-01-31 | Citeq B V | Allergy-specific immunotherapy compositions for use in the treatment of house-dust mite allergy. |
| MX2018003850A (es) * | 2015-09-30 | 2018-06-15 | Boehringer Ingelheim Vetmedica Gmbh | Moleculas de transporte de antigeno modular mejoradas y sus usos en animales. |
| KR101858840B1 (ko) * | 2016-01-15 | 2018-05-16 | 단국대학교 천안캠퍼스 산학협력단 | 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제 |
| GB201602850D0 (en) * | 2016-02-18 | 2016-04-06 | Bial Ind Farmaceutica S A | Fusion proteins |
| CN108265056B (zh) * | 2016-12-31 | 2019-08-30 | 江苏众红生物工程创药研究院有限公司 | 一种重组户尘螨1类变应原蛋白及其制备方法和应用 |
| CN109852652B (zh) * | 2017-11-30 | 2023-05-02 | 江苏众红生物工程创药研究院有限公司 | 重组尘螨Ⅰ型变应原Der p1和Der f1蛋白的制备与应用 |
| EP3569612A1 (en) * | 2018-05-18 | 2019-11-20 | Biomay Ag | Treatment and prevention of house dust mite allergies |
| CN113831400A (zh) * | 2021-07-29 | 2021-12-24 | 沈阳医学院 | 一种尘螨致敏蛋白Der p 1的分离纯化方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU624077B2 (en) * | 1987-06-17 | 1992-06-04 | Institute For Child Health Research | Cloning of mite allergens |
| US5433948A (en) * | 1990-02-13 | 1995-07-18 | Thomas; Wayne R. | Cloning and sequencing of allergens of dermatophagoides (house dust mite) |
| US7288256B1 (en) | 1991-10-16 | 2007-10-30 | Merck Patent Gmbh | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
| GB9724531D0 (en) | 1997-11-19 | 1998-01-21 | Smithkline Biolog | Novel compounds |
| EP1221317A1 (en) | 2000-12-28 | 2002-07-10 | SHAN-Beteiligungsgesellschaft m.b.H. | Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins |
| FR2841906B1 (fr) | 2002-07-05 | 2006-08-18 | Stallergenes Sa | Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes |
| ATE307141T1 (de) | 2003-01-21 | 2005-11-15 | Biomay Prod & Handel | Verfahren zur vorbereitung von hypoallergenen mosaikproteine |
| CN1780852A (zh) * | 2003-04-25 | 2006-05-31 | 诺和酶股份有限公司 | 组1螨多肽变体 |
| ITRM20040103A1 (it) | 2004-02-27 | 2004-05-27 | Consiglio Nazionale Ricerche | Proteine di fusione comprendenti allergeni della famiglia delle ns-ltps, loro usi e composizioni farmaceutiche che le comprendono. |
| AT501101B1 (de) | 2004-12-02 | 2008-01-15 | Biomay Ag | Protein-allergen-derivat |
| US20070065468A1 (en) * | 2005-08-29 | 2007-03-22 | National University Of Singapore | Chimeric allergens for immunotherapy |
| CN100374152C (zh) * | 2005-12-23 | 2008-03-12 | 中国农业大学 | 一种过敏性反应抑制剂 |
| GB0607377D0 (en) | 2006-04-12 | 2006-05-24 | Glaxosmithkline Biolog Sa | Novel Methods |
| EP1908777B1 (en) * | 2006-10-06 | 2016-02-03 | Stallergenes | Mite fusion proteins |
| EP1908776A1 (en) * | 2006-10-06 | 2008-04-09 | Stallergenes Sa | Mite fusion proteins |
-
2009
- 2009-03-24 BR BRPI0908848A patent/BRPI0908848A2/pt not_active IP Right Cessation
- 2009-03-24 CA CA2718994A patent/CA2718994C/en not_active Expired - Fee Related
- 2009-03-24 ES ES11179765.0T patent/ES2638308T3/es active Active
- 2009-03-24 ES ES11179771.8T patent/ES2638271T3/es active Active
- 2009-03-24 EP EP09724998A patent/EP2268662A2/en not_active Ceased
- 2009-03-24 CN CN200980110215.6A patent/CN101977929B/zh not_active Expired - Fee Related
- 2009-03-24 MX MX2010010353A patent/MX2010010353A/es active IP Right Grant
- 2009-03-24 US US12/934,418 patent/US8951530B2/en not_active Expired - Fee Related
- 2009-03-24 WO PCT/IB2009/005114 patent/WO2009118642A2/en not_active Ceased
- 2009-03-24 CN CN201610835971.7A patent/CN107118265A/zh active Pending
- 2009-03-24 EP EP11179765.0A patent/EP2436691B1/en not_active Not-in-force
- 2009-03-24 EP EP11179771.8A patent/EP2436692B1/en not_active Not-in-force
- 2009-03-24 JP JP2011501318A patent/JP5793073B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-09 US US14/617,136 patent/US20150152148A1/en not_active Abandoned
- 2015-04-02 JP JP2015075517A patent/JP6068544B2/ja not_active Expired - Fee Related
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