JP2015161559A - Clinical examination device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a clinical examination device capable of improving the dispensing efficiency of a sample.SOLUTION: In a clinical examination device in an embodiment, the first moving mechanism makes a first rope move along an arcuate first trajectory between a first sucking position for sucking a first sample and a first ejecting position for ejecting the first sample. The second moving mechanism makes a second rope move along an arcuate second trajectory between a second sucking position for sucking a second rope and a second ejecting position for ejecting the second sample. The first sucking position is arranged off the end of the second sucking position at one end of the second trajectory, and the first ejecting position is arranged off the end of the second ejecting position at the other end of the second trajectory. The movement control mechanism makes the second movement mechanism allow the second rope to move along the second trajectory between the first sucking position and the first ejecting position instead of the movement of the first rope by the first movement mechanisms and/or the movement of the second rope by the second movement mechanism and further the movement of the first rope by the first movement mechanism.

Description

  Embodiments described herein relate generally to a clinical testing apparatus.

  A clinical test is performed in order to objectively evaluate the state of a subject such as a patient. A clinical laboratory apparatus is mainly used for this clinical examination. An example of a clinical examination apparatus is an automatic analyzer.

  The automatic analyzer dispenses a test sample including a patient's blood and urine and a reagent into a reaction container according to a measurement item. A reaction solution is generated from the test sample and the reagent, and the components of the reaction solution are analyzed. Note that the test sample may be simply referred to as “sample”. A sample dispensing probe is used to dispense the sample. Further, the sample dispensing probe may be simply referred to as “probe”.

  In a conventional automatic analyzer, one probe is used for dispensing a sample. However, when an abnormal state including clogging occurs in one probe, dispensing of the sample must be stopped and dispensing cannot be continued. In this respect, it becomes a factor of reducing the dispensing efficiency of the sample.

  In addition, when dispensing both a serum specimen and a whole blood specimen as samples, there is a case where one probe is also used. In dispensing the serum sample, the supernatant serum sample is aspirated by the probe. In dispensing a whole blood sample, blood cells are aspirated by a probe. Therefore, the probe is lowered to a depth where blood cells float. As a result, when dispensing a whole blood sample, the probe is lowered more deeply than when dispensing a serum sample, so that the outer wall of the probe is extensively contaminated and the cleaning time of the probe is several times longer.

  When a serum sample is dispensed after dispensing a whole blood sample, the serum sample is dispensed by the washed probe after washing the probe used for dispensing the whole blood sample for a long time. As compared with the case where the serum sample is continuously dispensed, the sample dispensing efficiency is lowered.

  In order to improve the dispensing efficiency of the sample, the first probe used for dispensing the serum sample and the second probe used for dispensing the whole blood sample are used, and the serum sample is dispensed after dispensing the whole blood sample. There is an automatic analyzer configured to dispense the serum sample with the first probe without waiting for the washing of the second probe used for dispensing the whole blood sample (for example, Patent Document 1).

JP 2007-12687 A

However, in the automatic analyzer described in the above document, when an instruction for dispensing a serum sample is received, if the first probe is in an abnormal state including clogging, dispensing of the serum sample must be stopped. Cannot dispense continuously.
Similarly, even if an instruction to dispense a whole blood sample is received, if the second probe is in an abnormal state including clogging, dispensing of the whole blood sample must be stopped and continued dispensing. I can't. As a result, there has been a problem that the sample dispensing efficiency is reduced.

  This embodiment is intended to solve the above-described problem and to provide a clinical test apparatus capable of improving the sample dispensing efficiency.

  In order to solve the above-described problem, in the clinical examination apparatus according to the embodiment, the first moving mechanism includes a first probe, a first suction position for sucking the first sample, and a first probe for discharging the first sample. It moves along a circular arc-shaped first locus between one discharge position. The second moving mechanism moves the second probe along a circular arc-shaped second locus between a second suction position for sucking the second sample and a second discharge position for discharging the second sample. Move. The first suction position is disposed at an end from the second suction position at one end of the second locus, and the first discharge position is disposed at an end from the second discharge position at the other end of the second locus. The movement control unit replaces the movement of the first probe by the first movement mechanism and / or the movement of the second probe by the second movement mechanism, and the movement of the first probe by the first movement mechanism. The second probe is moved between the first suction position and the first discharge position along the second locus.

The top view which shows notionally the automatic analyzer which concerns on 1st Embodiment. The top view which shows a rack sampler notionally. The block diagram which shows the partial structure of an automatic analyzer. The figure which shows the probe moved to the washing position. The figure which shows an example of the state of the probe displayed on the display part. The figure which shows an example of the dispensing object displayed on the display part. The figure of the table showing the relationship between the state of a probe, and a dispensing object and a movement object. The figure which shows the 1st locus | trajectory and 2nd locus | trajectory which concern on 1st Embodiment. The figure which shows the arrangement | positioning relationship of a 1st locus | trajectory, a 2nd locus | trajectory, a 1st discharge position, and a 2nd discharge position. The flowchart which shows a series of operation | movement from receiving the instruction | indication of sample dispensing until sample dispensing is performed. The flowchart which shows a series of operation | movement in dispensing of a 1st sample. The figure which shows the 1st locus | trajectory and 2nd locus | trajectory which concern on a modification. The top view which shows notionally the automatic analyzer which concerns on 2nd Embodiment. The block diagram which shows the partial structure of an automatic analyzer. The figure which shows an example of the state of the probe displayed on the display part. The figure of the table showing the relationship between the state of a probe, and a dispensing object and a movement object. The figure which shows the 1st locus | trajectory and 2nd locus | trajectory which concern on 2nd Embodiment.

The gist of the embodiment of the present application is as follows.
In order to improve the dispensing efficiency of the sample, when the first probe is in an abnormal state including clogging and the dispensing target is a serum sample (first sample), the second probe is replaced with the first probe. It is configured to continue dispensing one sample (complementation with the second probe). Similarly, when the second probe is in an abnormal state including clogging and the dispensing target is a whole blood sample (second sample), the first probe continues dispensing the second sample instead of the second probe. (Complementation with the first probe). In short, the first probe and the second probe are configured to complement each other.
That is, between the two types of samples to be dispensed and the two probes to be dispensed, (a) two combinations of the dispensing object and the probe are operated in parallel, and (b) dispensing from the combination of (a) above. The combination of the target and the probe is changed, and at least one combination is operated.

Hereafter, an example having the following configuration will be described.
(1) When the first probe is in an abnormal state and the dispensing target is the first sample, a structure is provided in which the second probe continues to dispense the first sample instead of the first probe. Furthermore, means are provided for driving the probe in that way. (2) Furthermore, means for detecting the state of the first probe and means for determining whether the first probe is in an abnormal state based on the detection result are provided. (3) Similarly, when the second probe is in an abnormal state and the dispensing target is the second sample, a structure is provided in which the first probe continues to dispense the second sample instead of the second probe. Furthermore, means are provided for driving the probe in that way. (4) Further, means for detecting the state of the second probe and means for determining whether or not the second probe is in an abnormal state based on the detection result are provided.

  By configuring the automatic analyzer as described in (1) to (4) above, the first probe and the second probe complement each other. Thereby, even when the first probe is in an abnormal state, it is not necessary to stop the dispensing of the first sample, and even when the second probe is in an abnormal state, the second sample is dispensed. It is not necessary to stop, and the sample dispensing efficiency can be improved.

  Further, by configuring the automatic analyzer as described in (1) and (3) above, the second probe is complemented by the second probe. Thereby, even when the first probe is in an abnormal state, it is not necessary to stop the dispensing of the first sample, and the dispensing efficiency of the sample can be improved.

  Hereinafter, the former configuration will be described in the first embodiment, and then the latter configuration will be described in the second embodiment.

<First Embodiment>
Next, the automatic analyzer according to the first embodiment will be described with reference to FIGS. 1 is a plan view conceptually showing an automatic analyzer, FIG. 2 is a plan view conceptually showing a rack sampler, and FIG. 3 is a block diagram showing a partial configuration of the automatic analyzer.

  As shown in FIGS. 1 to 3, the automatic analyzer 100 includes a reagent rack 1, a first reagent storage 2, a second reagent storage 3, a reagent container 4, a reaction storage 5, a rack sampler 6, and a first sample dispensing probe. (Simply referred to as “first probe”) 71, second sample dispensing probe (simply referred to as “second probe”) 72, first detection means 81, second detection means 82, first moving mechanism 9A, second Movement mechanism 9B, movement control unit 10, display unit 11, control unit 12, first reagent dispensing probe (not shown), second reagent dispensing probe (not shown), agitation unit (not shown), and photometric unit (Not shown).

(Reagent container 4)
The first reagent store 2 and the second reagent store 3 contain a rotatable circular reagent rack 1. Each reagent container 4 is accommodated in the reagent rack 1 in a ring shape. The reagent container 4 containing the first reagent is placed in the first reagent container 2, and the reagent container 4 containing the second reagent is placed in the second reagent container 3. The first reagent and the second reagent are selected according to the measurement item.

(Reaction vessel 51)
The reaction chamber 5 has a rotatable circular cassette member (not shown). A reaction vessel 51 is placed on the cassette member. By rotating the cassette member, the reaction container 51 is moved to the first discharge position (first dispensing position), the second discharge position (second dispensing position), the stirring position, the measurement position, and the cleaning / drying position. It is conveyed to. “Washing” at the washing / drying position means washing of the reaction vessel 51 and does not mean washing of the probe. Here, the first discharge position and the second discharge position are indicated by reference numerals “DP1” and “DP2” in FIG.

(Rack sampler 6, sample container 61)
The rack sampler 6 is disposed along the front edge of the front surface of the automatic analyzer 100. The rack sampler 6 is configured to store a plurality of racks 62 in a line and to transport each rack 62 to a predetermined position. The direction in which the rack 62 is transported to a predetermined position is shown in FIG. A plurality of (for example, five) sample containers 61 are accommodated in the rack 62. The sample container 61 stores the first sample and the second sample.

  The rack sampler 6 is configured to be able to transport one or more of the plurality of racks 62 in a horizontal direction (direction from the front edge to the center) orthogonal to the direction in which the racks are arranged. As a result, the rack sampler 6 transports the sample container 61 containing the first sample to the first suction position according to the first measurement item. Similarly, the rack sampler 6 transports the sample container 61 storing the second sample to the second suction position according to the second measurement item.

  The direction in which each sample container 61 is sequentially transported to each suction position is indicated by the Y direction in FIG. Further, the first suction position and the second suction position are indicated by reference numerals “AP1” and “AP2” in FIGS. Further, the sample container transported to the first suction position AP1 and the second suction position AP2 is indicated by the symbol “61A” in FIG. Further, in the first locus L1, the first cleaning position disposed between the first suction position AP1 and the first discharge position DP1 is indicated by the symbol “WP1” in FIG. Further, in the second locus L2, the second cleaning position disposed between the second suction position AP2 and the second discharge position DP2 is indicated by the sign “WP2” in FIG. The first cleaning position and / or the second cleaning position may be simply referred to as a cleaning position.

(First probe 71, second probe 72)
The first probe 71 is provided at the tip of the arm 73. The base end portion of the arm 73 is supported on the first vertical axis S1. The first probe is mainly for dispensing the first sample.
The second probe 72 is provided at the tip of the arm 74. The base end portion of the arm 74 is supported on the second vertical axis S2. The second probe is mainly for dispensing the second sample.
In the following description, the first probe 71 and / or the second probe 72 may be simply referred to as “probe”. Further, the first sample and / or the second sample may be simply referred to as “sample”.

(First detection means 81, second detection means 82)
Next, the first detection means 81 and the second detection means 82 will be described with reference to FIG. FIG. 3 is a block diagram showing a partial configuration of the automatic analyzer. Here, the first detection means 81 and / or the second detection means 82 may be simply referred to as “detection means”.
Since the basic configuration of the first detection unit 81 and the second detection unit 82 is the same, the first detection unit 81 will be mainly described below and the description of the second detection unit 82 will be substituted.

  The first detection means 81 detects an abnormal state including clogging of the first probe 71. Here, the “abnormal state of the first probe 71” means that the mechanism for dispensing the first sample including the first probe 71, the arm 73, and the first moving mechanism 9A (described later) is caused by some cause. The state in which the first sample cannot be dispensed.

  An example of an abnormal state of the first probe 71 is a malfunction of the first probe 71. The malfunction of the first probe 71 is determined by measuring a load of a stepping motor (described later) and comparing the measured value with a reference value. The description of the malfunction of the first probe 71 is omitted. When and where the malfunction of the first probe 71 is detected is not particularly limited.

  Another example of the abnormal state of the first probe 71 is a clogging of the first probe 71. When and where the clogging is detected is not particularly limited. For example, the probe moved to the cleaning position may be when sucking / discharging the liquid, or the probe moved to the suction position / discharging position may be when sucking / discharging the sample.

  Next, with reference to FIGS. 3 and 4, the determination and notification of the “abnormal state” of the probe will be described with reference to the former example in which clogging of the probe is detected during cleaning.

  FIG. 4 shows the probe moved to the cleaning position. The cleaning position is shown as a cleaning tank in FIG. Further, FIG. 4 shows that the first probe 71 moved to the first cleaning position WP1 (see FIG. 1), the tube 75 connected to the first probe 71, and the liquid (cleaning liquid: A pressure gauge 77 connected to a pump 76 and a tube 75 for supplying liquid (detergent, water) to the first probe 71 and discharging the liquid (waste liquid: measured reaction liquid) in the first probe 71 to the outside is shown.

  The result detected by the first detection means 81, that is, the value (measured value) measured by the pressure gauge 77 is sent to the movement control unit 10. The movement control unit 10 compares the measured value with the reference value (allowable range) to determine whether the first probe 71 is clogged when the measured value exceeds the allowable range. Although clogging of the probe is detected based on the pressure inside the probe, the present invention is not limited to this. For example, the clogging of the probe may be determined by measuring the capacitance inside the probe and comparing the measured value with a reference value. The clogging of the probe may be determined by comparing the provided image. Furthermore, the state when the probe vibrates may be detected, for example, the vibration frequency and amplitude may be measured, and clogging of the probe may be determined based on comparison with a reference value.

(Notification of probe status)
As described above, the movement control unit 10 determines the state of the probe. The determined state of the probe is stored in the storage unit 13 (see FIG. 3) of the movement control unit 10.

  FIG. 5 is a diagram illustrating an example of the state of the probe displayed on the display unit 11. In FIG. 5, “normal” indicates that the probe is in a normal state, and “abnormal” characters indicate that the probe is in an abnormal state. The display unit 11 represents the state of the probe stored in the storage unit 13 with black and white inversion. As shown in FIG. 5, when “abnormal” characters are displayed on the display unit 11 by reversing black and white, it is notified that the first probe 71 is in an abnormal state.

(Control unit 12, notification of dispensing target)
Samples and reagents are determined according to the measurement items and dispensed into the reaction vessel 51. The measurement items are stored in advance in a storage unit (not shown) of the control unit based on an operation of an input unit (not shown) by the user. When the apparatus is activated, the control unit 12 reads the measurement item and sends the sample (first sample, second sample) corresponding to the measurement item to the movement control unit 10 as a dispensing target. The dispensing target is stored in the storage unit 13 of the movement control unit 10.

  FIG. 6 is a diagram illustrating an example of a dispensing target displayed on the display unit 11. The display unit 11 represents the dispensing object stored in the storage unit 13 with black and white inversion. As shown in FIG. 6, when the dispensing object is displayed on the display unit 11 in black and white inversion, it is notified that the dispensing object is the first sample.

(First movement mechanism 9A, second movement mechanism 9B, movement control unit 10)
As shown in FIG. 3, the first moving mechanism 9 </ b> A includes a power unit 91 and a power transmission unit 93. Similarly, the second moving mechanism 9 </ b> B includes a power unit 91 and a power transmission unit 93. Here, the first moving mechanism 9A and / or the second moving mechanism 9B may be simply referred to as “moving mechanism”.

FIG. 7 is a table showing the relationship between the probe state (see FIG. 5) and the dispensing target (see FIG. 6) and the probe used at that time.
The movement control unit 10 generates a drive signal for driving the probe to be moved based on the probe state and the dispensing target stored in the storage unit 13 with reference to the table shown in FIG. A signal is sent to the power unit 91.

  The power unit 91 has a rotating stepping motor (not shown). The stepping motor for rotation supplies power for rotating the probe to the power transmission unit 93 by rotating in a predetermined direction by a rotation amount corresponding to the drive signal. Furthermore, the power unit 91 has a stepping motor (not shown) for raising / lowering. The ascending / descending stepping motor supplies power for raising / lowering the probe to the power transmission unit 93 by rotating in a predetermined direction by a rotation amount corresponding to the drive signal.

  The power transmission unit 93 includes a rotation power transmission unit (not shown). The power transmission unit for rotation receives power to rotate the probe in a clockwise direction / counterclockwise direction by a predetermined angle. Furthermore, the power transmission unit 93 includes a power transmission unit (not shown) for ascending / descending. The ascending / descending power transmission unit receives power to raise / lower the probe by a predetermined amount.

(Relationship between probe and moving mechanism)
The first moving mechanism 9A moves the first probe 71 via the arm 73 between the first suction position AP1 and the first discharge position DP1 along the arc-shaped first locus L1 around the first vertical axis S1. Configured to let

  Further, the first moving mechanism 9A moves the first probe 71 at the second suction position AP2 disposed at the end from the first suction position AP1 at one end of the first locus L1, and at the other end of the first locus L1. The first discharge position DP1 is configured to move to the second discharge position DP2 disposed at the end. FIG. 1 shows the second suction position AP2 arranged on one end side (left side) from the first suction position AP1. Further, FIG. 1 shows a second discharge position DP2 arranged on the other end side (left side) from the first discharge position DP1.

  FIG. 8 is a diagram showing the first locus L1 and the second locus L2. FIG. 8 shows a first locus L1 having a path from the second suction position AP2 to the first suction position AP1 to the first cleaning position WP1 to the first discharge position DP1 to the second discharge position DP2. That is, the first moving mechanism 9A moves the first probe 71 between the second suction position AP2 disposed at one end of the first locus L1 and the second discharge position DP2 disposed at the other end of the first locus L1. Configured to move. Accordingly, the second sample can be dispensed by the first probe 71 instead of the second probe 72.

  The second moving mechanism 9B moves the second probe 72 between the second suction position AP2 and the second discharge position DP2 via the arm 74 along the arc-shaped second locus L2 around the second vertical axis S2. Configured to let

  Further, the second moving mechanism 9B moves the second probe 72 at the first suction position AP1 disposed at the end from the second suction position AP2 at one end of the second locus L2, and at the other end of the second locus L2. The second discharge position DP2 is configured to move to the first discharge position DP1 disposed at the end. FIG. 1 shows the first suction position AP1 arranged on one end side (right side) from the second suction position AP2. Further, FIG. 1 shows a first discharge position DP1 disposed on the other end side (right side) from the second discharge position DP2.

  FIG. 8 shows a second locus L2 that takes the path from the first suction position AP1 to the second suction position AP2 to the second cleaning position WP2 to the second discharge position DP2 to the first discharge position DP1. That is, the second moving mechanism 9B moves the second probe 72 between the first suction position AP1 disposed at one end of the second locus L2 and the first discharge position DP1 disposed at the other end of the second locus L2. Configured to move. As a result, the first sample can be dispensed by the second probe 72 instead of the first probe 71.

(First trajectory L1, second trajectory L2, etc.)
Next, the arrangement relationship between the first locus L1, the second locus L2, the first discharge position DP1, and the second discharge position DP2 will be described. In addition, since it is the same also about the arrangement | positioning relationship of 1st locus | trajectory L1, 2nd locus | trajectory L2, 1st suction position AP1, and 2nd suction position AP2, the description is abbreviate | omitted here.

  FIG. 9 is a diagram showing an arrangement relationship of the first locus L1, the second locus L2, the first discharge position DP1, and the second discharge position DP2. In FIG. 9, the first discharge position DP1 and the second discharge position DP2 on the first locus L1 are indicated by “◯” marks. Further, the first discharge position DP1 and the second discharge position DP2 on the second locus L2 are indicated by “Δ” marks.

  As can be seen from FIG. 9, the first vertical axis S1 that is the center of the arc-shaped first locus L1 and the second vertical axis S2 that is the center of the arc-shaped second locus L2 are arranged at different positions. The first locus L1 and the second locus L2 do not overlap. Therefore, the first discharge position DP1 on the first locus L1 and the first discharge position DP1 on the second locus L2 are strictly different. Similarly, the second discharge position DP2 on the first locus L1 and the second discharge position DP2 on the second locus L2 are strictly different.

  However, any first discharge position DP1 is included in the entrance region of the reaction vessel 51 and the region in which the probe can be inserted. Accordingly, although all the first discharge positions DP1 are strictly different from each other, it can be said that the first discharge positions DP1 are functionally the same positions. Therefore, in the description of the present embodiment, they are treated as the same positions for convenience. Further, since the second discharge position DP2 can be said to be the same as the first discharge position DP1, in the description of the present embodiment, it is treated as the same position for convenience.

  In addition, said arrangement | positioning relationship can also be said that the 1st locus | trajectory L1 (1st vertical axis S1) and the 2nd locus | trajectory L2 (2nd vertical axis S2) have shifted | deviated so that a mutual discharge position may shift | deviate within an allowable range. .

  If the first vertical axis S1 and the second vertical axis S2 are arranged at the same position, the first trajectory L1 and the second trajectory L2 overlap each other, and the mounting space around the vertical axis is reduced, so that the entire apparatus is small. Can be achieved. However, it is difficult to configure each moving mechanism to move two probes around the same axis.

  In the present embodiment, since the first vertical axis S1 and the second vertical axis S2 are arranged at different positions, it is easy to configure each moving mechanism, and the first vertical axis S1 and the second vertical axis S2 are also configured. For the above reasons, it does not deviate greatly, and the vertical mounting space is reduced to some extent, which contributes to downsizing of the entire apparatus.

  Next, how the probe is moved by the movement control unit 10 and the movement mechanism will be described with reference to FIG.

  In addition, information on the sample as a dispensing target is sent from the control unit 12 to the movement control unit 10. Further, the state of the probe is sent to the movement control unit 10 from the detection means. The movement control unit 10 determines the state of the probe and the dispensing target. Here, the movement control part 10 shall control a moving mechanism based on a discrimination | determination result.

  (A) The movement control unit 10 refers to the table based on the determination result (shown by (a) in FIG. 7) that the first probe 71 is in a normal state and the dispensing target is the first sample. Then, the first moving mechanism 9A is controlled to move the first probe 71 between the first suction position AP1 and the first discharge position DP1 along the first locus L1. Accordingly, the first probe 71 sucks the first sample from the sample container 61 transported to the first suction position AP1 by the rack sampler 6, and puts the first sample into the reaction container 51 transported to the first discharge position DP1. Discharge. That is, the first sample is dispensed.

  (B) The movement control unit 10 refers to the table based on the determination result (shown by (b) in FIG. 7) that the second probe 72 is in a normal state and the dispensing target is the second sample. Then, the second moving mechanism 9B is controlled to move the second probe 72 between the second suction position AP2 and the second discharge position DP2 along the second locus L2. Thereby, the second probe 72 sucks the second sample from the sample container 61 transported to the second suction position AP2 by the rack sampler 6, and puts the second sample into the reaction container 51 transported to the second discharge position DP2. Discharge. That is, the second sample is dispensed. The above (A) and (B) can be executed in parallel. That is, when the first probe 71 is in the normal state, the second probe 72 is in the normal state, and the dispensing objects are the first sample and the second sample, the above (A) and (B) are executed in parallel. Is done.

  (C) The movement control unit 10 determines that the first probe 71 is in an abnormal state, the second probe 72 is in a normal state, and the dispensing target is the first sample and the second sample (FIG. 7 (shown in (c)), the second moving mechanism 9B is controlled by referring to the table, and the second probe 72 is moved along the second locus L2 to the first suction position AP1 and the first discharge position DP1. Move between. Thereby, the second probe 72 sucks the first sample from the sample container 61 transported to the first suction position AP1 by the rack sampler 6, and puts the first sample into the reaction container 51 transported to the first discharge position DP1. Discharge. That is, when the second probe 72 is used instead of the first probe 71 for dispensing the first sample, that is, when the second probe 72 complements the first probe 71, the first sample is dispensed. It is possible to continue without stopping.

  Further, the movement control unit 10 controls the second moving mechanism 9B to move the second probe 72 between the second suction position AP2 and the second discharge position DP2 along the second locus L2. That is, the second moving mechanism 9B moves the second probe 72 so that both the first sample and the second sample can be dispensed.

  (D) Based on the determination result that the state of the first probe 71 is clogged, the movement control unit 10 controls the first moving mechanism 9A to move the first probe 71 to the first cleaning position WP1. By operating the pump 76, the liquid is supplied / discharged with respect to the first probe 71 moved to the first cleaning position WP1. Thereby, the first probe 71 is cleaned at the first cleaning position WP1.

  (E) After the first probe 71 is cleaned at the first cleaning position WP1, the movement control unit 10 determines that the state of the first probe 71 is a normal state without clogging, and the dispensing target is the first sample. Based on the determination result, the table is referred to, the first moving mechanism 9A is controlled, and the first probe 71 is moved along the first locus L1 between the first suction position AP1 and the first discharge position DP1. Move. At this time, the movement control unit 10 controls the second moving mechanism 9B to move the second probe 72 to a position on the second locus L2 excluding the first suction position AP1 and the first discharge position DP1. Needless to say.

  In the above description, the movement of the first probe 71 is mainly described, and the second probe 72 is moved in relation to the first probe 71. However, the same applies to the opposite mode. This will be described below.

  (F) The movement control unit 10 determines that the first probe 71 is in a normal state, the second probe 72 is in an abnormal state, and the dispensing target is the first sample and the second sample (FIG. 7 (refer to (f)), the table is referred to, the first moving mechanism 9A is controlled, and the first probe 71 is moved along the first locus L1 to the second suction position AP2 and the second discharge position DP2. Move between. Accordingly, the first probe 71 sucks the second sample from the sample container 61 transported to the second suction position AP2 by the rack sampler 6, and puts the second sample into the reaction container 51 transported to the second discharge position DP2. Discharge. That is, when the first probe 71 is used for dispensing the second sample instead of the second probe 72, that is, the first probe 71 complements the second probe 72, thereby dispensing the second sample. It is possible to continue without stopping. That is, as can be seen from (C) and (F), the movement control unit 10 controls the first moving mechanism 9A and the second moving mechanism 9B so that the first probe 71 and the second probe 72 complement each other. To do.

  Furthermore, the movement control unit 10 controls the first moving mechanism 9A to move the first probe 71 between the first suction position AP1 and the first discharge position DP1 along the first locus L1. That is, the first moving mechanism 9A moves the first probe 71 so that both the first sample and the second sample can be dispensed.

  (G) Based on the determination result that the state of the second probe 72 is clogged, the movement control unit 10 controls the second moving mechanism 9B to move the second probe 72 to the second cleaning position WP2. By operating the pump 76, the liquid is supplied / discharged with respect to the second probe 72 moved to the second cleaning position WP2. Thereby, the second probe 72 is cleaned at the second cleaning position WP2.

  (H) After the second probe 72 is cleaned at the second cleaning position WP2, the movement control unit 10 determines that the state of the second probe 72 is a normal state without clogging and the dispensing target is the second sample. Based on the determination result, the second moving mechanism 9B is controlled with reference to the table, and the second probe 72 is moved between the second suction position AP2 and the second discharge position DP2 along the second locus L2. Move. At this time, the movement control unit 10 controls the first moving mechanism 9A to move the first probe 71 to a position on the first locus L1 excluding the second suction position AP2 and the second discharge position DP2. Needless to say.

(Operation)
The configuration of the automatic analyzer according to the first embodiment has been briefly described above.
Next, the operation of the automatic analyzer will be described with reference to FIG. FIG. 10 is a flowchart showing a series of operations from when a sample dispensing instruction is received until sample dispensing is executed. Here, it is assumed that either one of the first sample and the second sample is sent from the control unit 12 to the movement control unit 10.

(Distinguishing target: S101)
As illustrated in FIG. 10, the movement control unit 10 determines whether the dispensing target is the first sample.

(Dispensing the first sample: S102)
When the movement control unit 10 determines that the dispensing target is the first sample (S101: Yes), the movement control unit 10 controls the first moving mechanism 9A and the second moving mechanism 9B to perform dispensing of the first sample.

(Second sample dispensing: S103)
When it is determined that the dispensing target is not the first sample, that is, the second sample (S101: No), the movement control unit 10 controls the first moving mechanism 9A and the second moving mechanism 9B to control the second sample. Execute dispensing of.

  Next, a description will be given with reference to FIG. FIG. 11 is a flowchart showing a series of operations in sample dispensing. Here, the dispensing target is the first sample.

(Determination of probe state: S201)
The movement control unit 10 receives the results detected by the first detection means 81 and the second detection means 82 and determines the states of the first probe 71 and the second probe 72 in advance.

(Dispensing with the first probe 71: S202)
The movement control unit 10 refers to the table based on the determination result (S201: No) that the first probe 71 is in the normal state and the dispensing target is the first sample, and the first moving mechanism 9A. And the first probe 71 is moved between the first suction position AP1 and the first discharge position DP1 along the first locus L1. Thereby, the dispensing of the first sample by the first probe 71 is executed.

(Cleaning of the first probe 71: S203)
The movement control unit 10 refers to the table based on the determination result (S201: Yes) that the first probe 71 is in an abnormal state and the dispensing target is the first sample, and the first movement mechanism 9A. And the first probe 71 is moved to the first cleaning position WP1. Thereby, the first probe 71 is washed.

(Dispensing with the second probe 72: S204)
Next, the movement control unit 10 controls the second moving mechanism 9B to move the second probe 72 between the first suction position AP1 and the first discharge position DP1 along the second locus L2. Thereby, instead of the first probe 71, dispensing of the first sample by the second probe 72 is executed.

  In the above description, the movement of the first probe 71 is mainly described, and the second probe 72 is moved in relation to the first probe 71. However, it goes without saying that the same applies to the opposite mode.

  Next, each operation of reagent dispensing, sample / reagent stirring, reaction liquid measurement, and washing / drying of the reaction vessel 51 will be described.

(Reagent dispensing)
The first reagent dispensing probe sucks the first reagent from the reagent container 4 transported to the specified suction position by the rotation of the reagent rack 1 of the first reagent storage 2, and the reaction transported to the first discharge position DP1. The first reagent is discharged into the container 51.

  The second reagent dispensing probe sucks the second reagent from the reagent container 4 transported to the specified suction position by the rotation of the reagent rack 1 of the second reagent storage 3 and transports the reaction to the second discharge position DP2. The second reagent is discharged into the container 51.

(Stirring)
The stirring unit stirs the reaction liquid of the sample (first sample, second sample) and the reagent (first reagent, second reagent) in the reaction vessel 51 stopped at the stirring position for each cycle.

(Measurement)
The photometric unit measures the reaction solution from the photometric position. The photometric unit measures the absorbance of the reaction solution, and then outputs the measurement result data to a data processing unit (not shown). The data processing unit obtains the concentration of the reaction solution from the absorbance based on the calibration curve. Thereby, it becomes possible to measure the components of the reaction solution.

(Washing, drying)
The cleaning / drying unit aspirates the reaction liquid that has been measured in the reaction vessel 51 stopped at the cleaning / drying position, and cleans / drys the reaction vessel 51.

<Modification 1>
Next, an automatic analyzer according to a modification of the first embodiment will be described with reference to FIG. 1 and FIG. In the first modification, the same components as those in the first embodiment are denoted by the same reference numerals, the description thereof is omitted, and different components are mainly described.

  In the first embodiment, the first probe 71 for mainly dispensing the first sample and the second probe 72 for mainly dispensing the second sample are configured to complement each other. . Thereby, for example, when the dispensing target is the first sample, even if the first probe 71 is in an abnormal state, the second probe 72 is used instead of the first probe 71, thereby dispensing the first sample. It is possible to continue without stopping. Conversely, when the dispensing target is the second sample, even if the second probe 72 is in an abnormal state, the dispensing of the second sample is stopped by using the first probe 71 instead of the second probe 72. It became possible to continue without doing.

  On the other hand, in the first modification, one probe is configured to be complemented by the other probe. Hereinafter, a configuration in which the first probe 71 is complemented by the second probe 72 will be described as a representative.

  The first moving mechanism 9A is configured to move the first probe 71 between the first suction position AP1 and the first discharge position DP1 along the first locus L1. FIG. 12 shows a first locus L1 having a route from the first suction position AP1 to the first cleaning position WP1 to the first discharge position DP1. That is, only the first sample can be dispensed by the second probe 72, and the second sample cannot be dispensed by the first probe 71 instead of the second probe 72.

  In contrast, the second moving mechanism 9B moves the second probe 72 between the first suction position AP1 disposed at one end of the second locus L2 and the first discharge position DP1 disposed at the other end of the second locus L2. Configured to move between. FIG. 12 is a diagram illustrating the first locus L1 and the second locus L2 according to the modification. FIG. 12 shows a second locus L2 having a path from the first suction position AP1 to the second suction position AP2 to the second cleaning position WP2 to the second discharge position DP2 to the first discharge position DP1. As a result, the first sample can be dispensed by the second probe 72 instead of the first probe 71. Needless to say, the second sample can be dispensed by the second probe 72.

  The movement control unit 10 controls the second moving mechanism 9B with reference to the table based on the determination result that the first probe 71 is in an abnormal state and the dispensing target is the first sample, The second probe 72 is moved between the first suction position AP1 and the first discharge position DP1 along the second locus L2. Thereby, the second probe 72 sucks the first sample from the sample container 61 transported to the first suction position AP1 by the rack sampler 6, and puts the first sample into the reaction container 51 transported to the first discharge position DP1. Discharge. That is, even if the first probe 71 is in an abnormal state, the dispensing of the first sample is continued.

  In the first embodiment, the first suction position AP1 and the second suction position AP2 are arranged at different positions. Thereby, in the case of one sample (specimen), and when the number of samples placed on the rack sampler 6 is an even number, the time required for dispensing the sample is shortened (for example, About half).

  Further, in the first embodiment, the second suction position AP2 is disposed at one end of the first locus L1 at the end from the first suction position AP1, and the first suction at the end from the second suction position AP2 at one end of the second locus L2. The position AP1 is shown. Not only this but 1st suction position AP1 and 2nd suction position AP2 may be arrange | positioned in the same position.

  In the first embodiment, when the distance between the first suction position AP1 and the second suction position AP2 is shortened, the first suction position AP1 and the second suction position AP2 are finally arranged at the same position. Will be. That is, a common suction position is arranged at the end of the first locus L1 and the end of the second locus L2. At this time, the path of the first locus L1 is the shared suction position to the first cleaning position WP1 to the first discharge position DP1 to the second discharge position DP2. The path of the second locus L2 is from the shared suction position to the second cleaning position WP2 to the second discharge position DP2 to the first discharge position DP1. When the first suction position AP1 and the second suction position AP2 are arranged at the same position, since one sample (specimen) is dispensed by two probes, the time required for dispensing is shortened.

Second Embodiment
Next, a second embodiment of the automatic analyzer will be described with reference to FIGS. Note that in the second embodiment, the same components as those in the first embodiment are denoted by the same reference numerals, description thereof is omitted, and different components are mainly described.

In the first embodiment, the first probe 71 for mainly dispensing the first sample and the second probe 72 for mainly dispensing the second sample are configured to complement each other. .
Further, in the first modification, one probe is configured to be complemented by the other probe. However, in both cases, the complementary probe can mainly dispense its own sample.

  In contrast, in the second embodiment, one probe is configured to be complemented by the other probe, but the other probe does not dispense its own sample, and only the target sample to be supplemented is dispensed. Configure as a note. Hereinafter, a configuration in which the first probe 71 is complemented by the second probe 72 will be described as a representative.

  FIG. 13 is a plan view conceptually showing the automatic analyzer. In FIG. 13, the first suction position is indicated by the symbol “AP1”. Further, the first discharge position is indicated by the sign “DP1”. Further, the first cleaning position arranged at a position deviating from between the first suction position AP1 and the first discharge position DP1 in the first locus L1 is indicated by a symbol “WP1”. Furthermore, the second cleaning position arranged at a position deviating from between the first suction position AP1 and the first discharge position DP1 in the second locus L2 is indicated by the sign “WP2”.

(First detection means 81)
FIG. 14 is a block diagram showing a partial configuration of the automatic analyzer. As shown in FIG. 14, the first detection means 81 detects an abnormal state including the clogging of the first probe 71. The result detected by the first detection means 81 is sent to the movement control unit 10. The movement control unit 10 compares the detection result with a reference value (allowable range) to determine whether the first probe 71 is clogged when the detection result exceeds the allowable range. The determined state of the probe is stored in the storage unit 13 (see FIG. 14) of the movement control unit 10.

(Notification of probe status)
FIG. 15 is a diagram illustrating an example of the state of the probe displayed on the display unit 11. In FIG. 15, “normal” indicates that the probe is in a normal state, and “abnormal” characters indicate that the probe is in an abnormal state. The display unit 11 represents the state of the probe stored in the storage unit 13 with black and white inversion. As shown in FIG. 15, when the characters “abnormal” are displayed on the display unit 11 by reversing black and white, it is notified that the first probe 71 is in an abnormal state.

(First movement mechanism 9A, second movement mechanism 9B, movement control unit 10)
As shown in FIG. 14, the first moving mechanism 9 </ b> A includes a power unit 91 and a power transmission unit 93. Similarly, the second moving mechanism 9 </ b> B includes a power unit 91 and a power transmission unit 93.
FIG. 16 is a table showing the relationship between the state of the probe (see FIG. 15) and the dispensing target (here, the first sample) and the probe used at that time.
The movement control unit 10 generates a driving signal for driving the probe to be moved based on the probe state and the dispensing target stored in the storage unit 13 with reference to the table shown in FIG. A signal is sent to the power unit 91.

(Relationship between probe and moving mechanism)
The first moving mechanism 9A moves the first probe 71 between the first suction position AP1 and the first discharge position DP1 via the arm 73 along the first locus L1 around the first vertical axis S1. Composed.

  FIG. 17 is a diagram illustrating the first locus L1 and the second locus L2. FIG. 17 shows a first locus L1 having a path from the first cleaning position WP1 to the first suction position AP1 to the first discharge position DP1. That is, the first moving mechanism 9A moves the first probe 71 between the first cleaning position WP1 disposed at one end of the first locus L1 and the first discharge position DP1 disposed at the other end of the first locus L1. Configured to move.

  The second moving mechanism 9B moves the second probe 72 via the arm 74 between the first suction position AP1 and the first discharge position DP1 along the second locus L2 around the second vertical axis S2. Composed. FIG. 17 shows a second locus L2 having a path from the second cleaning position WP2 to the first discharge position DP1 to the first suction position AP1. That is, the second moving mechanism 9B moves the second probe 72 between the second cleaning position WP2 arranged at one end of the second locus L2 and the first suction position AP1 arranged at the other end of the second locus L2. Configured to move. As a result, the first sample can be dispensed by the second probe 72 instead of the first probe 71.

  Next, how the probe is moved by the movement control unit 10 and the movement mechanism will be described with reference to FIG.

  In addition, information on the sample as a dispensing target is sent from the control unit 12 to the movement control unit 10. Further, the state of the first probe 71 is sent from the first detection means 81 to the movement control unit 10. The movement control unit 10 determines the state of the first probe 71 and the dispensing target (here, the first sample). The movement control unit 10 controls the movement mechanism based on the determination result.

  (I) The movement control unit 10 refers to the table based on the determination result (shown by (i) in FIG. 16) that the first probe 71 is in a normal state and the dispensing target is the first sample. Then, the first moving mechanism 9A is controlled to move the first probe 71 between the first suction position AP1 and the first discharge position DP1 along the first locus L1. Accordingly, the first probe 71 sucks the first sample from the sample container 61 transported to the first suction position AP1 by the rack sampler 6, and puts the first sample into the reaction container 51 transported to the first discharge position DP1. Discharge. That is, the first sample is dispensed.

  (J) The movement control unit 10 refers to the table based on the determination result (indicated by (j) in FIG. 16) that the first probe 71 is in an abnormal state and the dispensing target is the first sample. Then, the second moving mechanism 9B is controlled to move the second probe 72 between the first suction position AP1 and the first discharge position DP1 along the second locus L2. Thereby, the second probe 72 sucks the first sample from the sample container 61 transported to the first suction position AP1 by the rack sampler 6, and puts the first sample into the reaction container 51 transported to the first discharge position DP1. Discharge. That is, when the second probe 72 is used instead of the first probe 71 for dispensing the first sample, that is, when the second probe 72 complements the first probe 71, the first sample is dispensed. It is possible to continue without stopping.

  (K) The movement control unit 10 controls the first moving mechanism 9A based on the determination result that the state of the first probe 71 is clogged, and moves the first probe 71 to the first cleaning position WP1. By operating the pump 76, the liquid is supplied / discharged with respect to the first probe 71 moved to the first cleaning position WP1. Thereby, the first probe 71 is cleaned at the first cleaning position WP1.

  (L) After the first probe 71 is cleaned at the first cleaning position WP1, the movement control unit 10 determines that the state of the first probe 71 is a normal state without clogging, and the dispensing target is the first sample. Based on the determination result, the table is referred to, the first moving mechanism 9A is controlled, and the first probe 71 is moved along the first locus L1 between the first suction position AP1 and the first discharge position DP1. Move. At this time, the movement control unit 10 controls the second moving mechanism 9B to move the second probe 72 to a position on the second locus L2 excluding the first suction position AP1 and the first discharge position DP1 (for example, the second Needless to say, it is moved to the cleaning position WP2).

(Operation)
Next, the operation of the automatic analyzer according to the second embodiment will be described with reference to FIG.

(Determination of probe state: S201)
As illustrated in FIG. 11, the movement control unit 10 receives the result detected by the first detection unit 81 and determines the state of the first probe 71 in advance.

(Dispensing with the first probe 71: S202)
The movement control unit 10 refers to the table based on the determination result (S201: No) that the first probe 71 is in the normal state and the dispensing target is the first sample, and the first moving mechanism 9A. And the first probe 71 is moved between the first suction position AP1 and the first discharge position DP1 along the first locus L1. Thereby, the dispensing of the first sample by the first probe 71 is executed.

(Cleaning of the first probe 71: S203)
The movement control unit 10 refers to the table based on the determination result (S201: Yes) that the first probe 71 is in an abnormal state and the dispensing target is the first sample, and the first movement mechanism 9A. And the first probe 71 is moved to the first cleaning position WP1. Thereby, the first probe 71 is washed.

(Dispensing with the second probe 72: S204)
Next, the movement control unit 10 controls the second moving mechanism 9B to move the second probe 72 between the first suction position AP1 and the first discharge position DP1 along the second locus L2. Thereby, instead of the first probe 71, dispensing of the first sample by the second probe 72 is executed.

  In the above-described embodiment, the condition that one probe is complemented by the other probe has been described as one probe being in an abnormal state, but the complement condition is not limited thereto. For example, when checking the condition of one probe, cleaning one probe (excluding cleaning in case of abnormality), when one probe is operating, and when the other probe is idle (the other Or the like may be used as a supplementary condition. These complementary conditions are stored in the storage unit of the control unit 12. The control unit 12 sends control information to the movement control unit 10. The movement control unit 10 controls the movement mechanism based on the control information.

  In this embodiment, the first vertical axis S1 and the second vertical axis S2 are arranged at different positions, but may be arranged at the same position. By arranging at the same position, the mounting space for the first vertical axis S1 and the second vertical axis S2 is reduced, which contributes to downsizing of the entire apparatus.

  Examples of clinical testing apparatuses include clinical analyzers such as automatic analyzers, blood gas analyzers, electrophoresis apparatuses, and liquid chromatography apparatuses, nuclear medicine apparatuses such as radioimmunoassay apparatuses, latex agglutination reaction measuring apparatuses, and nephelometers. Blood test equipment such as immune serum test equipment, automatic blood cell counter, blood coagulation measurement equipment, microbe classification and identification equipment, bacteria culture test equipment such as blood culture test equipment and DNA / RNA measurement equipment, urine analysis equipment, fecal occult blood measurement equipment, etc. Urinalysis equipment, pathological examination equipment such as automatic tissue cell staining equipment, physiological function testing equipment, other clinical examination equipment such as micropipette, washing device dispensing device, and centrifuge.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the spirit of the invention. These embodiments and their modifications are included in the scope and gist of the invention, and are also included in the invention described in the claims and the equivalents thereof.

AP1 1st suction position AP2 2nd suction position DP1 1st discharge position DP2 2nd discharge position L1 1st locus L2 2nd locus WP1 1st washing position WP2 2nd washing position 100 Automatic analyzer 1 reagent rack 2 1st reagent storage 3 Second reagent storage 4 Reagent container 5 Reaction storage 6 Rack sampler 71 First sample dispensing probe (first probe)
72 Second sample dispensing probe (second probe)
81 First detection means 82 Second detection means 9A First movement mechanism 9B Second movement mechanism 91 Power section 93 Power transmission section 10 Movement control section 13 Storage section 11 Display section 12 Control section

Claims (10)

In a clinical laboratory device that generates a reaction solution with samples and reagents and analyzes the components of the reaction solution,
First movement for moving the first probe along a circular arc-shaped first locus between a first suction position for sucking the first sample and a first discharge position for discharging the first sample. Mechanism,
Second movement for moving the second probe along a circular arc-shaped second locus between a second suction position for sucking the second sample and a second discharge position for discharging the second sample. Mechanism,
Have
The first suction position is disposed at an end from the second suction position at one end of the second locus, and the first discharge position is disposed at an end from the second discharge position at the other end of the second locus. ,
Instead of the movement of the first probe by the first movement mechanism and / or the movement of the second probe by the second movement mechanism, and the movement of the first probe by the first movement mechanism, the second movement is performed. The clinical examination apparatus characterized in that the mechanism has a movement control unit that moves the second probe between the first suction position and the first discharge position along the second locus. A first detecting means for detecting an abnormal state including clogging of the first probe;
The movement control unit receives an instruction to dispense the first sample and receives a result of detecting an abnormal state of the first probe, and instead of moving the first probe by the first movement mechanism. The clinical examination apparatus according to claim 1, wherein the second probe moves the second probe between the first suction position and the first discharge position. The first trajectory includes a first cleaning position for cleaning the first probe;
Further, the movement control unit receives the result of detecting the clogging of the first probe, and causes the first moving mechanism to move the first probe to the first cleaning position. The clinical test apparatus described in 1.   The movement control unit receives a dispensing instruction of the first sample after the first probe is washed at the first washing position, and receives a result that clogging of the first probe is not detected, Instead of the movement of the second probe between the first suction position and the first discharge position by the second movement mechanism, the first probe is moved to the first movement mechanism by the first suction position and the first suction position. The clinical examination apparatus according to claim 3, wherein the clinical examination apparatus is moved between one discharge position. The second suction position is disposed at an end from the first suction position at one end of the first locus, and the second discharge position is disposed at an end from the first discharge position at the other end of the first locus. ,
The movement control unit moves the first probe to the first movement mechanism instead of moving the second probe between the second suction position and the second discharge position by the second movement mechanism. The clinical examination apparatus according to any one of claims 1 to 4, wherein the clinical inspection apparatus moves between a second suction position and the second discharge position. A second detecting means for detecting an abnormal state including clogging of the second probe;
The movement control unit receives the instruction to dispense the second sample and receives the result of detecting the abnormal state of the second probe, and the second suction of the second probe by the second movement mechanism. The first probe is moved by the first moving mechanism between the second suction position and the second discharge position, instead of moving between a position and the second discharge position. Item 6. The clinical examination apparatus according to Item 5. The second trajectory includes a second cleaning position for cleaning the second probe;
Furthermore, the movement control unit receives the result of detecting the clogging of the second probe, and causes the second moving mechanism to move the second probe to the second cleaning position. The clinical test apparatus described in 1.   The movement control unit receives a dispensing instruction of the second sample after the second probe is washed at the second washing position, and receives a result that clogging of the second probe is not detected, Instead of moving the first probe between the second suction position and the second discharge position by the first movement mechanism, the second probe is moved to the second movement mechanism by the second suction position and the second suction position. The clinical examination apparatus according to claim 7, wherein the clinical examination apparatus is moved between two discharge positions.   The information processing apparatus according to claim 2, further comprising: a notification unit that receives a result of detecting the abnormal state of at least one of the first probe and the second probe and notifies the fact. Clinical laboratory equipment.   At least one of the first detection means and the second detection means is based on any one or more of pressure, capacitance, and image inside the probe to be detected, and / or the probe is The clinical examination apparatus according to claim 6, wherein clogging of the probe is detected based on a state when vibrating.

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