JP2015143248A5 - - Google Patents
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- Publication number
- JP2015143248A5 JP2015143248A5 JP2015057637A JP2015057637A JP2015143248A5 JP 2015143248 A5 JP2015143248 A5 JP 2015143248A5 JP 2015057637 A JP2015057637 A JP 2015057637A JP 2015057637 A JP2015057637 A JP 2015057637A JP 2015143248 A5 JP2015143248 A5 JP 2015143248A5
- Authority
- JP
- Japan
- Prior art keywords
- unit dose
- dha
- pharmaceutical composition
- composition
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 26
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 15
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims 10
- 229930195729 fatty acid Natural products 0.000 claims 10
- 239000000194 fatty acid Substances 0.000 claims 10
- 150000004665 fatty acids Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims 8
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims 4
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- ITNKVODZACVXDS-YNUSHXQLSA-N ethyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate Chemical compound CCOC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC ITNKVODZACVXDS-YNUSHXQLSA-N 0.000 claims 3
- -1 DHA ester Chemical class 0.000 claims 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 2
- 235000021342 arachidonic acid Nutrition 0.000 claims 2
- 229940114079 arachidonic acid Drugs 0.000 claims 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 claims 1
- 230000007000 age related cognitive decline Effects 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 1
- VCDLWFYODNTQOT-UHFFFAOYSA-N docosahexaenoic acid methyl ester Natural products CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC VCDLWFYODNTQOT-UHFFFAOYSA-N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14931009P | 2009-02-02 | 2009-02-02 | |
| US61/149,310 | 2009-02-02 | ||
| US18354809P | 2009-06-02 | 2009-06-02 | |
| US61/183,548 | 2009-06-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548414A Division JP2012516852A (ja) | 2009-02-02 | 2010-02-02 | 認知機能改善および心拍数低下のための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018073345A Division JP2018104477A (ja) | 2009-02-02 | 2018-04-05 | 認知機能改善および心拍数低下のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015143248A JP2015143248A (ja) | 2015-08-06 |
| JP2015143248A5 true JP2015143248A5 (enExample) | 2015-12-24 |
Family
ID=42041547
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548414A Withdrawn JP2012516852A (ja) | 2009-02-02 | 2010-02-02 | 認知機能改善および心拍数低下のための方法 |
| JP2015057637A Pending JP2015143248A (ja) | 2009-02-02 | 2015-03-20 | 認知機能改善および心拍数低下のための方法 |
| JP2018073345A Pending JP2018104477A (ja) | 2009-02-02 | 2018-04-05 | 認知機能改善および心拍数低下のための方法 |
| JP2019238726A Pending JP2020050675A (ja) | 2009-02-02 | 2019-12-27 | 認知機能改善および心拍数低下のための方法 |
| JP2022023007A Withdrawn JP2022059063A (ja) | 2009-02-02 | 2022-02-17 | 認知機能改善および心拍数低下のための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548414A Withdrawn JP2012516852A (ja) | 2009-02-02 | 2010-02-02 | 認知機能改善および心拍数低下のための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018073345A Pending JP2018104477A (ja) | 2009-02-02 | 2018-04-05 | 認知機能改善および心拍数低下のための方法 |
| JP2019238726A Pending JP2020050675A (ja) | 2009-02-02 | 2019-12-27 | 認知機能改善および心拍数低下のための方法 |
| JP2022023007A Withdrawn JP2022059063A (ja) | 2009-02-02 | 2022-02-17 | 認知機能改善および心拍数低下のための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20100203123A1 (enExample) |
| EP (2) | EP2939671A1 (enExample) |
| JP (5) | JP2012516852A (enExample) |
| CN (3) | CN102365087A (enExample) |
| AU (2) | AU2016201382A1 (enExample) |
| CA (1) | CA2751275A1 (enExample) |
| HK (1) | HK1202243A1 (enExample) |
| WO (1) | WO2010088700A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| US20110177061A1 (en) * | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
| CN103732223A (zh) * | 2011-05-19 | 2014-04-16 | 加利福尼亚大学董事会 | 用于认知能力下降的医疗食品 |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| US20130084272A1 (en) * | 2011-09-29 | 2013-04-04 | Philippe Perrin | Compositions, kits and methods for nutritional supplementation with twelve carbon chain fatty acids and twelve carbon chain acylglycerols |
| WO2014145035A1 (en) * | 2013-03-15 | 2014-09-18 | Genspera, Inc. | Methods of making cancer compositions |
| ES2984970T3 (es) | 2013-12-20 | 2024-10-31 | Mara Renewables Corp | Métodos para recuperar aceite de microorganismos |
| TR201503136A2 (tr) * | 2015-03-16 | 2016-09-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Dronedaron ve esansiyel yağ asitlerinin farmasötik kompozisyonları. |
| US10851395B2 (en) | 2016-06-10 | 2020-12-01 | MARA Renewables Corporation | Method of making lipids with improved cold flow properties |
| AU2017380721B2 (en) | 2016-12-22 | 2021-04-01 | MARA Renewables Corporation | Methods for producing biomass rich in DHA, palmitic acid and protein using a eukaryotic microorganism |
| JP7101087B2 (ja) * | 2018-09-05 | 2022-07-14 | 株式会社 伊藤園 | 軽度認知障害に対する緑茶成分の有効性評価方法 |
| FR3092968B1 (fr) * | 2019-02-22 | 2021-05-21 | Microphyt | Complement alimentaire |
| EP4009965A4 (en) | 2019-08-08 | 2023-11-15 | Swinburne University of Technology | USES OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS |
| MX2022012322A (es) | 2020-04-03 | 2022-11-10 | Mara Renewables Corp | Aceites microbianos con niveles altos de ácidos grasos omega-3. |
| DE102020115238A1 (de) * | 2020-06-09 | 2021-12-09 | Pm-International Ag | Nahrungsergänzungsmittel und Nahrungsmittel |
| US20220005581A1 (en) * | 2020-07-02 | 2022-01-06 | Pear Therapeutics, Inc. | Systems, Methods, and Devices for Generating and Administering Digital Therapeutic Placebos and Shams |
| CA3204546A1 (en) * | 2021-01-15 | 2022-07-21 | Cambridge Cognition Limited | Methods and systems of identifying individuals for perioperative neurocognitive disorder and/or post-viral cognitive impairment |
| EP4637824A1 (en) * | 2023-01-18 | 2025-10-29 | Bioventures, Llc | Method of preventing and treating alzheimer's disease and related dementias with drugs inhibiting the interaction between 14-3-3g protein and hexokinase-1 protein |
| WO2025100476A1 (ja) * | 2023-11-10 | 2025-05-15 | 国立大学法人京都大学 | 生理機能改善用の組成物 |
| JP2025079778A (ja) * | 2023-11-10 | 2025-05-22 | ダイドーグループホールディングス株式会社 | 生理機能改善用の組成物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
| JPH08511533A (ja) * | 1993-06-09 | 1996-12-03 | マーテック・バイオサイエンスィズ・コーポレーション | 神経学的障害の治療に有用な方法および医薬用組成物 |
| US20050027004A1 (en) * | 1993-06-09 | 2005-02-03 | Martek Biosciences Corporation | Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions |
| WO1996005278A1 (de) | 1994-08-16 | 1996-02-22 | Dr. Frische Gmbh | Verfahren zur gewinnung von nicht wasserlöslichen, nativen produkten aus nativen stoffgemengen mit hilfe der zentrifugalkraft |
| WO1996033263A1 (en) * | 1995-04-17 | 1996-10-24 | JAPAN, represented by DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY | Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms |
| JP3985035B2 (ja) * | 1995-09-14 | 2007-10-03 | 独立行政法人産業技術総合研究所 | （ｎ−６）系ドコサペンタエン酸含有油脂ならびに該油脂の製造方法および用途 |
| WO2000050547A1 (en) | 1999-02-26 | 2000-08-31 | Monsanto Company | Process for separating a triglyceride comprising a docosahexaenoic acid residue from a mixture of triglycerides |
| US6395778B1 (en) * | 2000-01-11 | 2002-05-28 | Omegatech, Inc. | Process for making an enriched mixture of polyunsaturated fatty acid esters |
| KR101429236B1 (ko) | 2000-01-19 | 2014-08-12 | 마텍 바이오싸이언스스 코포레이션 | 무용매 추출 방법 |
| AU2001258705A1 (en) | 2000-04-12 | 2001-10-23 | Westfalia Separator Industry Gmbh | Method for the fractionation of oil and polar lipid-containing native raw materials using alcohol and centrifugation |
| WO2002092540A1 (en) | 2001-05-14 | 2002-11-21 | Martek Biosciences Corporation | Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsatruated fatty acids from microbes, genetically modified plant seeds and marine organisms |
| AU2002318135B2 (en) | 2001-05-14 | 2007-08-02 | Dsm Ip Assets B.V. | Production and use of a polar lipid-rich fraction containing stearidonic acid and gamma linolenic acid from plant seeds and microbes |
| WO2003003981A2 (en) * | 2001-07-05 | 2003-01-16 | Vital Basics, Inc. | Compositions for improving mental performance |
| CA2484334C (en) | 2002-05-03 | 2013-01-22 | Martek Biosciences Corporation | High-quality lipids and methods for producing by enzymatic liberation from biomass |
| JP5503846B2 (ja) * | 2005-01-24 | 2014-05-28 | プロノヴァ・バイオファーマ・ノルゲ・アーエス | アミロイドーシス関連疾患の治療のための医療品又は食料品の製造における、ｄｈａを含有する脂肪酸組成物の使用 |
| US8324276B2 (en) * | 2005-01-24 | 2012-12-04 | Pronova Biopharma Norge As | Fatty acid composition for treatment of alzheimer's disease and cognitive dysfunction |
| WO2006116755A2 (en) * | 2005-04-28 | 2006-11-02 | Trustees Of Tufts College | Synergitic effects of docosahexaenoic acid (dha) and carotenoid absorption of cognitive function |
| ES2624702T5 (es) * | 2005-05-23 | 2020-12-11 | Massachusetts Inst Technology | Composiciones que contienen PUFA y/o uridina y métodos para su uso |
| CN101262863B (zh) * | 2005-07-08 | 2016-08-31 | Dsmip资产公司 | 用于治疗痴呆和前痴呆相关病症的多不饱和脂肪酸 |
| WO2009002145A1 (en) * | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Lipid composition for improving function of brain functioning |
| MX374545B (es) | 2007-06-29 | 2025-03-06 | Dsm Ip Assets Bv | Produccion y purificacion de esteres de acidos grasos poliinsaturados. |
| US20110177061A1 (en) * | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
-
2010
- 2010-02-02 CN CN2010800157224A patent/CN102365087A/zh active Pending
- 2010-02-02 EP EP15162676.9A patent/EP2939671A1/en not_active Withdrawn
- 2010-02-02 WO PCT/US2010/022952 patent/WO2010088700A1/en not_active Ceased
- 2010-02-02 CA CA2751275A patent/CA2751275A1/en not_active Abandoned
- 2010-02-02 CN CN201810349154.XA patent/CN108324706A/zh active Pending
- 2010-02-02 CN CN201410152946.XA patent/CN104042600A/zh active Pending
- 2010-02-02 EP EP10703592A patent/EP2391361A1/en not_active Withdrawn
- 2010-02-02 US US12/699,009 patent/US20100203123A1/en not_active Abandoned
- 2010-02-02 JP JP2011548414A patent/JP2012516852A/ja not_active Withdrawn
-
2012
- 2012-12-13 US US13/713,980 patent/US20130172412A1/en not_active Abandoned
-
2015
- 2015-03-17 HK HK15102730.4A patent/HK1202243A1/xx unknown
- 2015-03-20 JP JP2015057637A patent/JP2015143248A/ja active Pending
-
2016
- 2016-03-03 AU AU2016201382A patent/AU2016201382A1/en not_active Abandoned
-
2017
- 2017-10-10 AU AU2017245327A patent/AU2017245327A1/en not_active Abandoned
-
2018
- 2018-04-05 JP JP2018073345A patent/JP2018104477A/ja active Pending
-
2019
- 2019-12-27 JP JP2019238726A patent/JP2020050675A/ja active Pending
-
2022
- 2022-02-17 JP JP2022023007A patent/JP2022059063A/ja not_active Withdrawn
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