JP2015143248A5 - - Google Patents
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- Publication number
- JP2015143248A5 JP2015143248A5 JP2015057637A JP2015057637A JP2015143248A5 JP 2015143248 A5 JP2015143248 A5 JP 2015143248A5 JP 2015057637 A JP2015057637 A JP 2015057637A JP 2015057637 A JP2015057637 A JP 2015057637A JP 2015143248 A5 JP2015143248 A5 JP 2015143248A5
- Authority
- JP
- Japan
- Prior art keywords
- unit dose
- dha
- pharmaceutical composition
- composition
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 26
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 15
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims 10
- 229930195729 fatty acid Natural products 0.000 claims 10
- 239000000194 fatty acid Substances 0.000 claims 10
- 150000004665 fatty acids Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims 8
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims 4
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- ITNKVODZACVXDS-YNUSHXQLSA-N ethyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate Chemical compound CCOC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC ITNKVODZACVXDS-YNUSHXQLSA-N 0.000 claims 3
- -1 DHA ester Chemical class 0.000 claims 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 2
- 235000021342 arachidonic acid Nutrition 0.000 claims 2
- 229940114079 arachidonic acid Drugs 0.000 claims 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 claims 1
- 230000007000 age related cognitive decline Effects 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 1
- VCDLWFYODNTQOT-UHFFFAOYSA-N docosahexaenoic acid methyl ester Natural products CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC VCDLWFYODNTQOT-UHFFFAOYSA-N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14931009P | 2009-02-02 | 2009-02-02 | |
| US61/149,310 | 2009-02-02 | ||
| US18354809P | 2009-06-02 | 2009-06-02 | |
| US61/183,548 | 2009-06-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548414A Division JP2012516852A (ja) | 2009-02-02 | 2010-02-02 | 認知機能改善および心拍数低下のための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018073345A Division JP2018104477A (ja) | 2009-02-02 | 2018-04-05 | 認知機能改善および心拍数低下のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015143248A JP2015143248A (ja) | 2015-08-06 |
| JP2015143248A5 true JP2015143248A5 (enExample) | 2015-12-24 |
Family
ID=42041547
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548414A Withdrawn JP2012516852A (ja) | 2009-02-02 | 2010-02-02 | 認知機能改善および心拍数低下のための方法 |
| JP2015057637A Pending JP2015143248A (ja) | 2009-02-02 | 2015-03-20 | 認知機能改善および心拍数低下のための方法 |
| JP2018073345A Pending JP2018104477A (ja) | 2009-02-02 | 2018-04-05 | 認知機能改善および心拍数低下のための方法 |
| JP2019238726A Pending JP2020050675A (ja) | 2009-02-02 | 2019-12-27 | 認知機能改善および心拍数低下のための方法 |
| JP2022023007A Withdrawn JP2022059063A (ja) | 2009-02-02 | 2022-02-17 | 認知機能改善および心拍数低下のための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548414A Withdrawn JP2012516852A (ja) | 2009-02-02 | 2010-02-02 | 認知機能改善および心拍数低下のための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018073345A Pending JP2018104477A (ja) | 2009-02-02 | 2018-04-05 | 認知機能改善および心拍数低下のための方法 |
| JP2019238726A Pending JP2020050675A (ja) | 2009-02-02 | 2019-12-27 | 認知機能改善および心拍数低下のための方法 |
| JP2022023007A Withdrawn JP2022059063A (ja) | 2009-02-02 | 2022-02-17 | 認知機能改善および心拍数低下のための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20100203123A1 (enExample) |
| EP (2) | EP2939671A1 (enExample) |
| JP (5) | JP2012516852A (enExample) |
| CN (3) | CN104042600A (enExample) |
| AU (2) | AU2016201382A1 (enExample) |
| CA (1) | CA2751275A1 (enExample) |
| HK (1) | HK1202243A1 (enExample) |
| WO (1) | WO2010088700A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| US20110177061A1 (en) * | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
| WO2012159092A2 (en) * | 2011-05-19 | 2012-11-22 | The Regents Of The University Of California | Medical food for cognitive decline |
| US20130084272A1 (en) * | 2011-09-29 | 2013-04-04 | Philippe Perrin | Compositions, kits and methods for nutritional supplementation with twelve carbon chain fatty acids and twelve carbon chain acylglycerols |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| US9446141B2 (en) * | 2013-03-15 | 2016-09-20 | Genspera, Inc. | Methods of producing cancer compounds |
| BR112016014262B1 (pt) | 2013-12-20 | 2022-04-05 | MARA Renewables Corporation | Método para recuperar lipídeos de uma população de micro-organismos |
| TR201503136A2 (tr) * | 2015-03-16 | 2016-09-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Dronedaron ve esansiyel yağ asitlerinin farmasötik kompozisyonları. |
| US10851395B2 (en) | 2016-06-10 | 2020-12-01 | MARA Renewables Corporation | Method of making lipids with improved cold flow properties |
| EP3559206B1 (en) | 2016-12-22 | 2025-12-03 | Mara Renewables Corporation | Methods for producing biomass rich in dha, palmitic acid and protein using a eukaryotic microorganism |
| JP7101087B2 (ja) * | 2018-09-05 | 2022-07-14 | 株式会社 伊藤園 | 軽度認知障害に対する緑茶成分の有効性評価方法 |
| FR3092968B1 (fr) * | 2019-02-22 | 2021-05-21 | Microphyt | Complement alimentaire |
| AU2020325063B2 (en) * | 2019-08-08 | 2026-04-02 | Swinburne University Of Technology | Uses of long-chain polyunsaturated fatty acids |
| IL297000A (en) | 2020-04-03 | 2022-12-01 | Mara Renewables Corp | Microbial oils with high levels of omega-3 fatty acids |
| DE102020115238A1 (de) * | 2020-06-09 | 2021-12-09 | Pm-International Ag | Nahrungsergänzungsmittel und Nahrungsmittel |
| KR20220167321A (ko) * | 2020-07-02 | 2022-12-20 | 페어 테라퓨틱스 (유에스), 인코포레이티드 | 디지털 치료 위약 및 샴을 생성 및 관리하기 위한 시스템, 방법 및 디바이스 |
| CA3204546A1 (en) * | 2021-01-15 | 2022-07-21 | Cambridge Cognition Limited | Methods and systems of identifying individuals for perioperative neurocognitive disorder and/or post-viral cognitive impairment |
| WO2024155781A1 (en) * | 2023-01-18 | 2024-07-25 | Bioventures, Llc | Method of preventing and treating alzheimer's disease and related dementias with drugs inhibiting the interaction between 14-3-3g protein and hexokinase-1 protein |
| WO2025019424A1 (en) * | 2023-07-14 | 2025-01-23 | Dsm Ip Assets B.V. | Microbial oils having high epa content and methods of making the same |
| WO2025100476A1 (ja) * | 2023-11-10 | 2025-05-15 | 国立大学法人京都大学 | 生理機能改善用の組成物 |
| JP2025079778A (ja) * | 2023-11-10 | 2025-05-22 | ダイドーグループホールディングス株式会社 | 生理機能改善用の組成物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
| US20050027004A1 (en) * | 1993-06-09 | 2005-02-03 | Martek Biosciences Corporation | Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions |
| EP2140863A1 (en) * | 1993-06-09 | 2010-01-06 | Martek Biosciences Corporation | Use of docosahexaenoic acid for the manufacture of a medicament for the treatment of neurological disorders |
| ES2135756T3 (es) | 1994-08-16 | 1999-11-01 | Frische Gmbh | Procedimiento para la obtencion de productos nativos no solubles en agua a partir de mezclas de sustancias con ayuda de la fuerza centrifuga. |
| WO1996033263A1 (en) * | 1995-04-17 | 1996-10-24 | JAPAN, represented by DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY | Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms |
| JP3985035B2 (ja) * | 1995-09-14 | 2007-10-03 | 独立行政法人産業技術総合研究所 | （ｎ−６）系ドコサペンタエン酸含有油脂ならびに該油脂の製造方法および用途 |
| DE60012934T2 (de) | 1999-02-26 | 2005-08-25 | Martek Biosciences Corp. | Verfahren zum Abtrennen von einem Docosahexaensäure enthaltenden Triglycerid aus einem Triglyceridgemisch |
| US6395778B1 (en) * | 2000-01-11 | 2002-05-28 | Omegatech, Inc. | Process for making an enriched mixture of polyunsaturated fatty acid esters |
| KR101591834B1 (ko) | 2000-01-19 | 2016-02-18 | 마텍 바이오싸이언스스 코포레이션 | 무용매 추출 방법 |
| ATE395835T1 (de) | 2000-04-12 | 2008-06-15 | Westfalia Separator Gmbh | Verfahren zur fraktionierung von öl- und polar lipid-enthaltenden rohstoffen |
| EP1392278A4 (en) | 2001-05-14 | 2005-05-04 | Martek Biosciences Corp | PREPARATION AND USE OF A POLAR LIPIDREICH FRACTION WITH STEARIDONIC ACID AND GAMMA LINOLIC ACID FROM PLANT SEEDS AND MICROBES |
| EP1392623A4 (en) | 2001-05-14 | 2005-05-04 | Martek Biosciences Corp | PREPARATION AND USE OF A POLAR LIPID RICH FRACTION CONTAINING HIGHLY UNSATURATED OMEGA-3 AND / OR OMEGA-6 FATTY ACIDS FROM MICROBES, SEEDS OF GENETICALLY MODIFIED PLANTS AND MARINE ORGANISMS |
| WO2003003981A2 (en) * | 2001-07-05 | 2003-01-16 | Vital Basics, Inc. | Compositions for improving mental performance |
| US9101151B2 (en) | 2002-05-03 | 2015-08-11 | Dsm Ip Assets B.V. | High-quality lipids produced by enzymatic liberation from biomass |
| US8324276B2 (en) * | 2005-01-24 | 2012-12-04 | Pronova Biopharma Norge As | Fatty acid composition for treatment of alzheimer's disease and cognitive dysfunction |
| EP1845999A4 (en) * | 2005-01-24 | 2010-09-22 | Pronova Biocare As | USE OF A DHA-CONTAINING FATTY ACID COMPOSITION FOR THE PRODUCTION OF A PHARMACEUTICAL OR FOOD PRODUCT FOR THE TREATMENT OF AMYLOSIS RELATED DISEASES |
| WO2006116755A2 (en) * | 2005-04-28 | 2006-11-02 | Trustees Of Tufts College | Synergitic effects of docosahexaenoic acid (dha) and carotenoid absorption of cognitive function |
| CA2645645C (en) * | 2005-05-23 | 2015-07-14 | Massachusetts Institute Of Technology | Compositions containing pufa and methods of use thereof |
| KR20130101596A (ko) * | 2005-07-08 | 2013-09-13 | 마텍 바이오싸이언스스 코포레이션 | 치매 및 치매-전단계와 관련된 용태의 치료를 위한 다중불포화 지방산 |
| WO2009002145A1 (en) * | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Lipid composition for improving function of brain functioning |
| US20090023808A1 (en) | 2007-06-29 | 2009-01-22 | Martek Biosciences Corporation | Production and Purification of Esters of Polyunsaturated Fatty Acids |
| US20110177061A1 (en) * | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
-
2010
- 2010-02-02 CN CN201410152946.XA patent/CN104042600A/zh active Pending
- 2010-02-02 CA CA2751275A patent/CA2751275A1/en not_active Abandoned
- 2010-02-02 CN CN2010800157224A patent/CN102365087A/zh active Pending
- 2010-02-02 WO PCT/US2010/022952 patent/WO2010088700A1/en not_active Ceased
- 2010-02-02 EP EP15162676.9A patent/EP2939671A1/en not_active Withdrawn
- 2010-02-02 EP EP10703592A patent/EP2391361A1/en not_active Withdrawn
- 2010-02-02 US US12/699,009 patent/US20100203123A1/en not_active Abandoned
- 2010-02-02 JP JP2011548414A patent/JP2012516852A/ja not_active Withdrawn
- 2010-02-02 CN CN201810349154.XA patent/CN108324706A/zh active Pending
-
2012
- 2012-12-13 US US13/713,980 patent/US20130172412A1/en not_active Abandoned
-
2015
- 2015-03-17 HK HK15102730.4A patent/HK1202243A1/xx unknown
- 2015-03-20 JP JP2015057637A patent/JP2015143248A/ja active Pending
-
2016
- 2016-03-03 AU AU2016201382A patent/AU2016201382A1/en not_active Abandoned
-
2017
- 2017-10-10 AU AU2017245327A patent/AU2017245327A1/en not_active Abandoned
-
2018
- 2018-04-05 JP JP2018073345A patent/JP2018104477A/ja active Pending
-
2019
- 2019-12-27 JP JP2019238726A patent/JP2020050675A/ja active Pending
-
2022
- 2022-02-17 JP JP2022023007A patent/JP2022059063A/ja not_active Withdrawn
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