JP2015120685A5 - - Google Patents
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- Publication number
- JP2015120685A5 JP2015120685A5 JP2014236875A JP2014236875A JP2015120685A5 JP 2015120685 A5 JP2015120685 A5 JP 2015120685A5 JP 2014236875 A JP2014236875 A JP 2014236875A JP 2014236875 A JP2014236875 A JP 2014236875A JP 2015120685 A5 JP2015120685 A5 JP 2015120685A5
- Authority
- JP
- Japan
- Prior art keywords
- embolism
- thrombosis
- venous
- thromboembolic
- arterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000005189 Embolism Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 208000001435 Thromboembolism Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 8
- 230000009424 thromboembolic effect Effects 0.000 claims 8
- 208000007536 Thrombosis Diseases 0.000 claims 6
- 208000031104 Arterial Occlusive disease Diseases 0.000 claims 4
- 208000006011 Stroke Diseases 0.000 claims 4
- 206010047249 Venous thrombosis Diseases 0.000 claims 4
- 208000021328 arterial occlusion Diseases 0.000 claims 4
- 208000009190 disseminated intravascular coagulation Diseases 0.000 claims 4
- 230000002526 effect on cardiovascular system Effects 0.000 claims 4
- 230000000302 ischemic effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- DCBBOIFLGAMQFC-SFTDATJTSA-N 4-[[(2s,4s)-1-(4-carbamimidoylbenzoyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid Chemical compound C1CN(S(=O)(=O)C)CCN1[C@@H]1CN(C(=O)C=2C=CC(=CC=2)C(N)=N)[C@H](C(=O)NC=2C=CC(=CC=2)C(O)=O)C1 DCBBOIFLGAMQFC-SFTDATJTSA-N 0.000 claims 2
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 206010002388 Angina unstable Diseases 0.000 claims 2
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 2
- 206010003178 Arterial thrombosis Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 2
- 206010008088 Cerebral artery embolism Diseases 0.000 claims 2
- 206010008092 Cerebral artery thrombosis Diseases 0.000 claims 2
- 206010008132 Cerebral thrombosis Diseases 0.000 claims 2
- 206010011091 Coronary artery thrombosis Diseases 0.000 claims 2
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 2
- 206010014513 Embolism arterial Diseases 0.000 claims 2
- 201000001429 Intracranial Thrombosis Diseases 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 201000009454 Portal vein thrombosis Diseases 0.000 claims 2
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 2
- 208000006193 Pulmonary infarction Diseases 0.000 claims 2
- 206010063544 Renal embolism Diseases 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 208000007814 Unstable Angina Diseases 0.000 claims 2
- 230000007214 atherothrombosis Effects 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 230000001269 cardiogenic effect Effects 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 230000009852 coagulant defect Effects 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 208000002528 coronary thrombosis Diseases 0.000 claims 2
- 210000004351 coronary vessel Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 2
- 201000010849 intracranial embolism Diseases 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000003975 mesenteric artery Anatomy 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000003836 peripheral circulation Effects 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 230000007575 pulmonary infarction Effects 0.000 claims 2
- 210000001957 retinal vein Anatomy 0.000 claims 2
- 208000004644 retinal vein occlusion Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 2
- 208000015891 sexual disease Diseases 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 201000005060 thrombophlebitis Diseases 0.000 claims 2
- 230000001052 transient effect Effects 0.000 claims 2
- 230000002861 ventricular Effects 0.000 claims 2
- 229940122036 Factor XIa inhibitor Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014236875A JP6337750B2 (ja) | 2013-11-22 | 2014-11-21 | 化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013241680 | 2013-11-22 | ||
| JP2013241680 | 2013-11-22 | ||
| JP2014236875A JP6337750B2 (ja) | 2013-11-22 | 2014-11-21 | 化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015120685A JP2015120685A (ja) | 2015-07-02 |
| JP2015120685A5 true JP2015120685A5 (https=) | 2017-06-29 |
| JP6337750B2 JP6337750B2 (ja) | 2018-06-06 |
Family
ID=53532687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014236875A Expired - Fee Related JP6337750B2 (ja) | 2013-11-22 | 2014-11-21 | 化合物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6337750B2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014160668A1 (en) | 2013-03-25 | 2014-10-02 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
| NO2760821T3 (https=) | 2014-01-31 | 2018-03-10 | ||
| SG10201908467RA (en) | 2014-01-31 | 2019-10-30 | Bristol Myers Squibb Co | Macrocycles with hetrocyclic p2' groups as factor xia inhibitors |
| ES2714283T3 (es) | 2014-09-04 | 2019-05-28 | Bristol Myers Squibb Co | Macrociclos de diamida que son inhibidores de FXIa |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| PL3472149T3 (pl) | 2016-06-21 | 2024-02-12 | Orion Ophthalmology LLC | Heterocykliczne pochodne prolinamidu |
| US10526315B2 (en) | 2016-06-21 | 2020-01-07 | Orion Ophthalmology LLC | Carbocyclic prolinamide derivatives |
| WO2019028362A1 (en) | 2017-08-04 | 2019-02-07 | Dyax Corp. | INHIBITORS OF PLASMATIC KALLIKREIN AND USES THEREOF |
| WO2020059812A1 (ja) | 2018-09-20 | 2020-03-26 | 小野薬品工業株式会社 | ４－（｛（４ｓ）－１－（４－カルバムイミドイルベンゾイル）－４－［４－（メチルスルホニル）ピペラジン－１－イル］－ｌ－プロリル｝アミノ）安息香酸の新規塩およびその新規結晶形 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2426716A1 (en) * | 2000-11-07 | 2002-05-16 | Gregory S. Bisacchi | Acid derivatives useful as serine protease inhibitors |
| AU2004246766B2 (en) * | 2003-06-18 | 2009-09-17 | Merck Patent Gmbh | Pyrrolidin-1, 2- dicarboxylic acid- 1- [(4- ethinyl- phenyl) - amid]- 2- [(phenyl)- amid] derivative as inhibitors of coagulation factor Xa and VIIa for the treatment of thrombosis |
| EP2051975B1 (de) * | 2006-05-16 | 2012-09-12 | Boehringer Ingelheim International GmbH | Substituierte prolinamide, deren herstellung und deren verwendung als arzneimittel |
| TW201011006A (en) * | 2008-06-16 | 2010-03-16 | Nuevolution As | IAP binding compounds |
| GB201209138D0 (en) * | 2012-05-24 | 2012-07-04 | Ono Pharmaceutical Co | Compounds |
-
2014
- 2014-11-21 JP JP2014236875A patent/JP6337750B2/ja not_active Expired - Fee Related
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