JP6337750B2 - 化合物 - Google Patents
化合物 Download PDFInfo
- Publication number
- JP6337750B2 JP6337750B2 JP2014236875A JP2014236875A JP6337750B2 JP 6337750 B2 JP6337750 B2 JP 6337750B2 JP 2014236875 A JP2014236875 A JP 2014236875A JP 2014236875 A JP2014236875 A JP 2014236875A JP 6337750 B2 JP6337750 B2 JP 6337750B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- carbonyl
- methyl
- phenyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 **(CCCCCC1)CC1c1c(*)nc(C(CC(C2)*3CCCC*(*C4NC4)CCCC3)N2C(C(CC2)CCN2C(N)=N)=O)[n]1 Chemical compound **(CCCCCC1)CC1c1c(*)nc(C(CC(C2)*3CCCC*(*C4NC4)CCCC3)N2C(C(CC2)CCN2C(N)=N)=O)[n]1 0.000 description 11
- WJTPRLSAIKXTGV-GCJKJVERSA-N COC(Nc(cc1)ccc1-c([nH]c([C@H](C[C@H](CN(CC1)CCN1S(C)(=O)=O)C1)N1C(C(CC1)CCN1C(N)=N)=O)n1)c1Cl)=O Chemical compound COC(Nc(cc1)ccc1-c([nH]c([C@H](C[C@H](CN(CC1)CCN1S(C)(=O)=O)C1)N1C(C(CC1)CCN1C(N)=N)=O)n1)c1Cl)=O WJTPRLSAIKXTGV-GCJKJVERSA-N 0.000 description 1
- VSOLTJNUHVOYPN-UDKICSLYSA-N CS(N(CC1)CCN1[C@@H](C[C@H]1C(Nc(cc2)ccc2C(O)=O)=O)CN1C([C@H]1CC[C@@H](CN)CC1)=O)(=O)=O Chemical compound CS(N(CC1)CCN1[C@@H](C[C@H]1C(Nc(cc2)ccc2C(O)=O)=O)CN1C([C@H]1CC[C@@H](CN)CC1)=O)(=O)=O VSOLTJNUHVOYPN-UDKICSLYSA-N 0.000 description 1
- HOZGZYGJQHIPQC-HQWHMXMESA-N CS(c(cc1)ccc1NC([C@H](C[C@@H](C1)N2CCOCC2)N1C(/C=C/c(cc(cc1)Cl)c1-[n]1nnnc1)=O)=O)(=O)=O Chemical compound CS(c(cc1)ccc1NC([C@H](C[C@@H](C1)N2CCOCC2)N1C(/C=C/c(cc(cc1)Cl)c1-[n]1nnnc1)=O)=O)(=O)=O HOZGZYGJQHIPQC-HQWHMXMESA-N 0.000 description 1
- VAVHQOMKCAVBHG-GMAHTHKFSA-N CSN(CC1)CCC1[C@@H](C[C@H]1c2ncc(-c3cc(C(O)=O)ccc3)[nH]2)CN1C(C(CC1)CCN1C(N)=N)=O Chemical compound CSN(CC1)CCC1[C@@H](C[C@H]1c2ncc(-c3cc(C(O)=O)ccc3)[nH]2)CN1C(C(CC1)CCN1C(N)=N)=O VAVHQOMKCAVBHG-GMAHTHKFSA-N 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014236875A JP6337750B2 (ja) | 2013-11-22 | 2014-11-21 | 化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013241680 | 2013-11-22 | ||
| JP2013241680 | 2013-11-22 | ||
| JP2014236875A JP6337750B2 (ja) | 2013-11-22 | 2014-11-21 | 化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015120685A JP2015120685A (ja) | 2015-07-02 |
| JP2015120685A5 JP2015120685A5 (https=) | 2017-06-29 |
| JP6337750B2 true JP6337750B2 (ja) | 2018-06-06 |
Family
ID=53532687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014236875A Expired - Fee Related JP6337750B2 (ja) | 2013-11-22 | 2014-11-21 | 化合物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6337750B2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014160668A1 (en) | 2013-03-25 | 2014-10-02 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
| NO2760821T3 (https=) | 2014-01-31 | 2018-03-10 | ||
| SG10201908467RA (en) | 2014-01-31 | 2019-10-30 | Bristol Myers Squibb Co | Macrocycles with hetrocyclic p2' groups as factor xia inhibitors |
| ES2714283T3 (es) | 2014-09-04 | 2019-05-28 | Bristol Myers Squibb Co | Macrociclos de diamida que son inhibidores de FXIa |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| PL3472149T3 (pl) | 2016-06-21 | 2024-02-12 | Orion Ophthalmology LLC | Heterocykliczne pochodne prolinamidu |
| US10526315B2 (en) | 2016-06-21 | 2020-01-07 | Orion Ophthalmology LLC | Carbocyclic prolinamide derivatives |
| WO2019028362A1 (en) | 2017-08-04 | 2019-02-07 | Dyax Corp. | INHIBITORS OF PLASMATIC KALLIKREIN AND USES THEREOF |
| WO2020059812A1 (ja) | 2018-09-20 | 2020-03-26 | 小野薬品工業株式会社 | ４－（｛（４ｓ）－１－（４－カルバムイミドイルベンゾイル）－４－［４－（メチルスルホニル）ピペラジン－１－イル］－ｌ－プロリル｝アミノ）安息香酸の新規塩およびその新規結晶形 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2426716A1 (en) * | 2000-11-07 | 2002-05-16 | Gregory S. Bisacchi | Acid derivatives useful as serine protease inhibitors |
| AU2004246766B2 (en) * | 2003-06-18 | 2009-09-17 | Merck Patent Gmbh | Pyrrolidin-1, 2- dicarboxylic acid- 1- [(4- ethinyl- phenyl) - amid]- 2- [(phenyl)- amid] derivative as inhibitors of coagulation factor Xa and VIIa for the treatment of thrombosis |
| EP2051975B1 (de) * | 2006-05-16 | 2012-09-12 | Boehringer Ingelheim International GmbH | Substituierte prolinamide, deren herstellung und deren verwendung als arzneimittel |
| TW201011006A (en) * | 2008-06-16 | 2010-03-16 | Nuevolution As | IAP binding compounds |
| GB201209138D0 (en) * | 2012-05-24 | 2012-07-04 | Ono Pharmaceutical Co | Compounds |
-
2014
- 2014-11-21 JP JP2014236875A patent/JP6337750B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015120685A (ja) | 2015-07-02 |
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