JP2017508768A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017508768A5 JP2017508768A5 JP2016558399A JP2016558399A JP2017508768A5 JP 2017508768 A5 JP2017508768 A5 JP 2017508768A5 JP 2016558399 A JP2016558399 A JP 2016558399A JP 2016558399 A JP2016558399 A JP 2016558399A JP 2017508768 A5 JP2017508768 A5 JP 2017508768A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- pharmaceutical composition
- subject
- salvinorin
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OBSYBRPAKCASQB-AGQYDFLVSA-N salvinorin A Chemical group C=1([C@H]2OC(=O)[C@@H]3CC[C@]4(C)[C@@H]([C@]3(C2)C)C(=O)[C@@H](OC(C)=O)C[C@H]4C(=O)OC)C=COC=1 OBSYBRPAKCASQB-AGQYDFLVSA-N 0.000 claims description 49
- 239000000203 mixture Substances 0.000 claims description 30
- 239000008194 pharmaceutical composition Substances 0.000 claims description 30
- OBSYBRPAKCASQB-UHFFFAOYSA-N Episalvinorin A Natural products COC(=O)C1CC(OC(C)=O)C(=O)C(C2(C3)C)C1(C)CCC2C(=O)OC3C=1C=COC=1 OBSYBRPAKCASQB-UHFFFAOYSA-N 0.000 claims description 25
- IQXUYSXCJCVVPA-UHFFFAOYSA-N salvinorin A Natural products CC(=O)OC1CC(OC(=O)C)C2(C)CCC34CC(CC3(C)C2C1=O)(OC4=O)c5occc5 IQXUYSXCJCVVPA-UHFFFAOYSA-N 0.000 claims description 25
- 229920000858 Cyclodextrin Polymers 0.000 claims description 12
- 206010008089 Cerebral artery occlusion Diseases 0.000 claims description 10
- 208000010496 Heart Arrest Diseases 0.000 claims description 10
- 208000006011 Stroke Diseases 0.000 claims description 9
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 8
- 208000002381 Brain Hypoxia Diseases 0.000 claims description 6
- 201000006474 Brain Ischemia Diseases 0.000 claims description 6
- 206010008120 Cerebral ischaemia Diseases 0.000 claims description 6
- 206010008118 cerebral infarction Diseases 0.000 claims description 6
- 208000028389 Nerve injury Diseases 0.000 claims description 4
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims description 4
- 238000002680 cardiopulmonary resuscitation Methods 0.000 claims description 4
- 208000001286 intracranial vasospasm Diseases 0.000 claims description 4
- 230000008764 nerve damage Effects 0.000 claims description 4
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 4
- 230000002490 cerebral effect Effects 0.000 claims description 3
- 230000004083 survival effect Effects 0.000 claims description 3
- 230000024883 vasodilation Effects 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 210000004351 coronary vessel Anatomy 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 description 41
- 229930188950 salvinorin Natural products 0.000 description 24
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461968667P | 2014-03-21 | 2014-03-21 | |
| US61/968,667 | 2014-03-21 | ||
| PCT/US2015/021994 WO2015143429A2 (en) | 2014-03-21 | 2015-03-23 | Salvinorin compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019217715A Division JP2020045359A (ja) | 2014-03-21 | 2019-12-02 | サルビノリン組成物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017508768A JP2017508768A (ja) | 2017-03-30 |
| JP2017508768A5 true JP2017508768A5 (https=) | 2018-05-10 |
Family
ID=54145490
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558399A Pending JP2017508768A (ja) | 2014-03-21 | 2015-03-23 | サルビノリン組成物およびその使用 |
| JP2019217715A Pending JP2020045359A (ja) | 2014-03-21 | 2019-12-02 | サルビノリン組成物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019217715A Pending JP2020045359A (ja) | 2014-03-21 | 2019-12-02 | サルビノリン組成物およびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP3119411B1 (https=) |
| JP (2) | JP2017508768A (https=) |
| CN (1) | CN106604737B (https=) |
| WO (1) | WO2015143429A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106604737B (zh) | 2014-03-21 | 2020-07-21 | 宾夕法尼亚大学董事会 | 鼠尾草素组合物和其用途 |
| CN110664799B (zh) * | 2019-10-14 | 2020-06-19 | 河北医科大学第二医院 | 用于治疗脑缺血的药物组合物及其应用 |
| CN118267384B (zh) * | 2024-03-27 | 2024-12-20 | 徐州医科大学 | κ阿片受体激动剂在制备预防和/或治疗颞叶癫痫药物中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7531569B2 (en) * | 2003-12-02 | 2009-05-12 | Sanofi-Aventis Deutschland Gmbh | Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives |
| EP1729759A4 (en) | 2004-03-12 | 2008-04-02 | Mclean Hospital Corp | SALVINORINE DERIVATIVES AND ITS USES |
| AT505086B1 (de) | 2007-04-02 | 2009-06-15 | Planta Naturstoffe Vertriebsge | Pharmazeutisches mittel gegen juckreiz und juckreizbedingten schmerz |
| US20100093872A1 (en) * | 2008-10-15 | 2010-04-15 | Erimos Pharmaceuticals Llc | Stable aqueous formulations of water insoluble or poorly soluble drugs |
| US10973800B2 (en) * | 2010-06-29 | 2021-04-13 | The Trustees Of The University Of Pennsylvania | Salvinorin compositions and uses thereof |
| US11000505B2 (en) * | 2010-06-29 | 2021-05-11 | The Trustees Of The University Of Pennsylvania | Salvinorin compositions and uses thereof |
| US8563470B2 (en) * | 2010-12-13 | 2013-10-22 | E I Du Pont De Nemours And Company | Anthranilic diamide and cyclodextrin compositions for propagule coating |
| CN106604737B (zh) | 2014-03-21 | 2020-07-21 | 宾夕法尼亚大学董事会 | 鼠尾草素组合物和其用途 |
-
2015
- 2015-03-23 CN CN201580026976.9A patent/CN106604737B/zh active Active
- 2015-03-23 JP JP2016558399A patent/JP2017508768A/ja active Pending
- 2015-03-23 EP EP15765744.6A patent/EP3119411B1/en active Active
- 2015-03-23 WO PCT/US2015/021994 patent/WO2015143429A2/en not_active Ceased
- 2015-03-23 EP EP19210883.5A patent/EP3685843A3/en not_active Withdrawn
-
2019
- 2019-12-02 JP JP2019217715A patent/JP2020045359A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX393855B (es) | Terapia de combinación que comprende un inhibidor de raf y trametinib | |
| EA201650134A1 (ru) | Специфическая сочетанная терапия злокачественных опухолей цитостатиком и его модификатором | |
| JP2016510326A5 (https=) | ||
| JP2016508123A5 (https=) | ||
| JP2014139255A5 (https=) | ||
| MX370361B (es) | Preparación farmacéutica que contiene compuesto de ácido piridilaminoacético. | |
| JP2020524689A5 (https=) | ||
| JP2018526460A5 (https=) | ||
| PH12015502465A1 (en) | Use of landiolol hydrochloride in the long-term treatment of tachyarrhythmias | |
| JP2017508768A5 (https=) | ||
| EP4578461A3 (en) | Methods of treating parkinsons disease by administration of apomorphine to an oral mucosa | |
| RU2014112324A (ru) | Применение органического соединения для лечения синдрома нунан | |
| WO2019010301A8 (en) | Treatment of heart disease by inhibition of the action of muscle a-kinase anchoring protein (makap) | |
| Bilgi et al. | Sugammadex associated persistent bradycardia | |
| CO6260065A2 (es) | Uso de dronedarona o una sal aceptable farmaceuticamente de esta para la preparacion de un medicamento para regular el nivel de potasio en la sangre | |
| WO2016090107A3 (en) | Treatment of hepatitis delta virus infection | |
| WO2009003694A3 (en) | Method for treating diseases related to mitochondrial dysfunction | |
| EA201792565A1 (ru) | Бисамидное производное дикарбоновой кислоты в качестве средства, стимулирующего регенерацию тканей и восстановление сниженных функций тканей | |
| CN110755432A (zh) | 烟酰胺在制备治疗手足皮肤反应制剂中的应用 | |
| WO2016122288A3 (ko) | 베르베논 유도체 및 재관류 치료제를 포함하는 뇌혈관 질환, 동맥경화증 또는 심혈관 질환 치료 또는 예방용 병용 제제 | |
| JP2017061488A5 (https=) | ||
| Wu et al. | Post-resuscitation reperfusion injury: comparison of periodic Gz acceleration versus Thumper CPR | |
| Ackery et al. | Tranexamic acid for trauma-related hemorrhage | |
| CL2018003268A1 (es) | Ácidos carboxílicos para tratar/prevenir una enfermedad de la piel. | |
| Gold | Efficacy and tolerability of a fixed combination of clindamycin phosphate (1.2%) and benzoyl peroxide (3.75%) aqueous gel in moderate and severe acne vulgaris subpopulations |