JP2014533960A5 - - Google Patents
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- Publication number
- JP2014533960A5 JP2014533960A5 JP2014542865A JP2014542865A JP2014533960A5 JP 2014533960 A5 JP2014533960 A5 JP 2014533960A5 JP 2014542865 A JP2014542865 A JP 2014542865A JP 2014542865 A JP2014542865 A JP 2014542865A JP 2014533960 A5 JP2014533960 A5 JP 2014533960A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- patient
- treatment
- egfr
- egfr inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 19
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 201000011510 cancer Diseases 0.000 claims 12
- 229940121647 egfr inhibitor Drugs 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 238000011282 treatment Methods 0.000 claims 8
- 102000001301 EGF receptor Human genes 0.000 claims 5
- 108060006698 EGF receptor Proteins 0.000 claims 5
- 108091070501 miRNA Proteins 0.000 claims 5
- 239000002679 microRNA Substances 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
- 108091070395 Homo sapiens miR-31 stem-loop Proteins 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 239000013610 patient sample Substances 0.000 claims 3
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 2
- 238000011394 anticancer treatment Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000002525 vasculotropin inhibitor Substances 0.000 claims 2
- YXTKHLHCVFUPPT-YYFJYKOTSA-N (2s)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid;(1r,2r)-1,2-dimethanidylcyclohexane;5-fluoro-1h-pyrimidine-2,4-dione;oxalic acid;platinum(2+) Chemical compound [Pt+2].OC(=O)C(O)=O.[CH2-][C@@H]1CCCC[C@H]1[CH2-].FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 YXTKHLHCVFUPPT-YYFJYKOTSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- UZUUQCBCWDBYCG-UHFFFAOYSA-N Mitomycin B Natural products O=C1C(OC)=C(C)C(=O)C2=C1C(COC(N)=O)C1(O)N2CC2C1N2C UZUUQCBCWDBYCG-UHFFFAOYSA-N 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- JYEFSHLLTQIXIO-SMNQTINBSA-N folfiri regimen Chemical compound FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 JYEFSHLLTQIXIO-SMNQTINBSA-N 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- UZUUQCBCWDBYCG-DQRAMIIBSA-N mitomycin B Chemical compound O=C1C(OC)=C(C)C(=O)C2=C1[C@H](COC(N)=O)[C@]1(O)N2C[C@H]2[C@@H]1N2C UZUUQCBCWDBYCG-DQRAMIIBSA-N 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11306568 | 2011-11-25 | ||
| EP11306568.4 | 2011-11-25 | ||
| EP12306042.8 | 2012-08-31 | ||
| EP12306042 | 2012-08-31 | ||
| PCT/EP2012/073535 WO2013076282A1 (en) | 2011-11-25 | 2012-11-23 | A method for predicting responsiveness to a treatment with an egfr inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533960A JP2014533960A (ja) | 2014-12-18 |
| JP2014533960A5 true JP2014533960A5 (cg-RX-API-DMAC7.html) | 2016-01-14 |
| JP6342329B2 JP6342329B2 (ja) | 2018-06-13 |
Family
ID=47297187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542865A Expired - Fee Related JP6342329B2 (ja) | 2011-11-25 | 2012-11-23 | Ｅｇｆｒ阻害剤による治療に対する応答性を予測するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10400284B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2783017B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6342329B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140104419A (cg-RX-API-DMAC7.html) |
| CN (1) | CN104160038B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012342397B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014012495A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2856594A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2014006182A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013076282A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2016006782A (es) * | 2013-11-26 | 2016-08-19 | Integragen Sa | Un metodo para predecir la capacidad de respuesta a un tratamiento con un inhibidor del egfr. |
| KR101622454B1 (ko) | 2014-03-04 | 2016-05-18 | 연세대학교 산학협력단 | Egfr 티로신 키나아제 억제제에 대한 항암 치료 반응 예측 마커 |
| WO2015160868A1 (en) * | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
| EP3000895A1 (en) | 2014-09-26 | 2016-03-30 | Integragen | A method for predicting responsiveness to a treatment with an EGFR inhibitor |
| CN107850599B (zh) * | 2015-07-23 | 2021-02-09 | 新加坡国立大学 | Wbp2与her2作为共预后因子对患者分层以进行治疗 |
| WO2017187937A1 (ja) * | 2016-04-28 | 2017-11-02 | デンカ株式会社 | 上皮性細胞成長因子受容体阻害剤に対する癌細胞の耐性を判定する方法 |
| EP3948274A1 (en) * | 2019-03-29 | 2022-02-09 | Rakuten Medical, Inc. | Methods for photoimmunotherapy and related biomarkers |
| KR102251864B1 (ko) * | 2019-10-18 | 2021-05-14 | 지니너스 주식회사 | miR-320c를 유효성분으로 포함하는 백금계 항암제에 대한 삼중음성유방암 환자의 약물 반응성 예측용 바이오마커 조성물 |
| CN111798918A (zh) * | 2020-05-28 | 2020-10-20 | 中山大学孙逸仙纪念医院 | 一种免疫治疗疗效预测的血肿瘤突变算法及其构建方法 |
| CN111863159B (zh) * | 2020-06-01 | 2022-02-25 | 中山大学孙逸仙纪念医院 | 一种肿瘤免疫治疗疗效预测的列线图模型的建立方法 |
| CN118804987A (zh) * | 2022-03-01 | 2024-10-18 | 冠科生物技术(苏州)有限公司 | 用于确定癌症患者的西妥昔单抗敏感性的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100523216C (zh) | 2001-03-02 | 2009-08-05 | 匹兹堡大学 | Pcr方法 |
| CA2702637A1 (en) * | 2007-10-22 | 2009-04-30 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
| WO2009080437A1 (en) | 2007-12-21 | 2009-07-02 | Exiqon A/S | Micro-rna based drug resistance analysis method |
| WO2010015538A2 (en) * | 2008-08-05 | 2010-02-11 | F. Hoffmann-La Roche Ag | Predictive marker for egfr inhibitor treatment |
| WO2010121238A2 (en) * | 2009-04-17 | 2010-10-21 | Translational Genomics Research Institute (Tgen) | Methods and kits to predict therapeutic outcome of tyrosine kinase inhibitors |
| EP2504014A4 (en) * | 2009-11-24 | 2013-04-17 | Univ Western Australia | MODULATION OF EPIDERMAL GROWTH FACTOR RECEPTOR LIGANDS |
| CA2800557A1 (en) | 2010-04-29 | 2011-11-03 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy |
-
2012
- 2012-11-23 WO PCT/EP2012/073535 patent/WO2013076282A1/en not_active Ceased
- 2012-11-23 EP EP12797814.6A patent/EP2783017B1/en not_active Not-in-force
- 2012-11-23 CN CN201280067832.4A patent/CN104160038B/zh not_active Expired - Fee Related
- 2012-11-23 US US14/360,311 patent/US10400284B2/en not_active Expired - Fee Related
- 2012-11-23 JP JP2014542865A patent/JP6342329B2/ja not_active Expired - Fee Related
- 2012-11-23 MX MX2014006182A patent/MX2014006182A/es unknown
- 2012-11-23 KR KR1020147014013A patent/KR20140104419A/ko not_active Ceased
- 2012-11-23 CA CA2856594A patent/CA2856594A1/en not_active Abandoned
- 2012-11-23 AU AU2012342397A patent/AU2012342397B2/en not_active Ceased
- 2012-11-23 BR BR112014012495A patent/BR112014012495A2/pt active Search and Examination
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