JP2014533681A5 - - Google Patents

Info

Publication number

JP2014533681A5

JP2014533681A5 JP2014541807A JP2014541807A JP2014533681A5 JP 2014533681 A5 JP2014533681 A5 JP 2014533681A5 JP 2014541807 A JP2014541807 A JP 2014541807A JP 2014541807 A JP2014541807 A JP 2014541807A JP 2014533681 A5 JP2014533681 A5 JP 2014533681A5

Authority

JP

Japan

Prior art keywords

peptide

seq

set forth

sequence set

pharmaceutical composition

Prior art date

2012-11-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 19
• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 206010018338 Glioma Diseases 0.000 claims 9
• 208000032612 Glial tumor Diseases 0.000 claims 6
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims 6
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 239000003937 drug carrier Substances 0.000 claims 4
• IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 2
• 206010003571 Astrocytoma Diseases 0.000 claims 2
• 108010069514 Cyclic Peptides Proteins 0.000 claims 2
• 102000001189 Cyclic Peptides Human genes 0.000 claims 2
• 206010014967 Ependymoma Diseases 0.000 claims 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
• 201000010133 Oligodendroglioma Diseases 0.000 claims 2
• 239000002202 Polyethylene glycol Substances 0.000 claims 2
• 239000007864 aqueous solution Substances 0.000 claims 2
• 208000005017 glioblastoma Diseases 0.000 claims 2
• 235000011187 glycerol Nutrition 0.000 claims 2
• 210000002540 macrophage Anatomy 0.000 claims 2
• 229920001223 polyethylene glycol Polymers 0.000 claims 2
• 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
• 239000008158 vegetable oil Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000019034 Chemokines Human genes 0.000 claims 1
• 108010012236 Chemokines Proteins 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 206010057249 Phagocytosis Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 201000004058 mixed glioma Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 230000004899 motility Effects 0.000 claims 1
• 230000008782 phagocytosis Effects 0.000 claims 1
• 230000000770 proinflammatory effect Effects 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 230000000722 protumoral effect Effects 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1