JP2014533357A5 - - Google Patents

Info

Publication number

JP2014533357A5

JP2014533357A5 JP2014540007A JP2014540007A JP2014533357A5 JP 2014533357 A5 JP2014533357 A5 JP 2014533357A5 JP 2014540007 A JP2014540007 A JP 2014540007A JP 2014540007 A JP2014540007 A JP 2014540007A JP 2014533357 A5 JP2014533357 A5 JP 2014533357A5

Authority

JP

Japan

Prior art keywords

synuclein

level

subject

antibody

alpha

Prior art date

2012-10-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 102000003802 alpha-Synuclein Human genes 0.000 claims description 128
• 108090000185 alpha-Synuclein Proteins 0.000 claims description 128
• 239000012634 fragment Substances 0.000 claims description 72
• 238000000034 method Methods 0.000 claims description 71
• 239000000427 antigen Substances 0.000 claims description 50
• 102000036639 antigens Human genes 0.000 claims description 50
• 108091007433 antigens Proteins 0.000 claims description 50
• 210000004556 brain Anatomy 0.000 claims description 50
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
• 201000010099 disease Diseases 0.000 claims description 19
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
• 102000019355 Synuclein Human genes 0.000 claims description 15
• 108050006783 Synuclein Proteins 0.000 claims description 15
• 230000002093 peripheral effect Effects 0.000 claims description 14
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 12
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
• 208000024827 Alzheimer disease Diseases 0.000 claims description 6
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• 239000008280 blood Substances 0.000 claims description 6
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• 208000001089 Multiple system atrophy Diseases 0.000 claims description 5
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
• 206010003840 Autonomic nervous system imbalance Diseases 0.000 claims description 3
• 206010012289 Dementia Diseases 0.000 claims description 3
• 201000010374 Down Syndrome Diseases 0.000 claims description 3
• 201000011240 Frontotemporal dementia Diseases 0.000 claims description 3
• 208000009829 Lewy Body Disease Diseases 0.000 claims description 3
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 3
• 208000030886 Traumatic Brain injury Diseases 0.000 claims description 3
• 206010044688 Trisomy 21 Diseases 0.000 claims description 3
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• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
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• 201000007601 neurodegeneration with brain iron accumulation Diseases 0.000 claims 1
• 208000002593 pantothenate kinase-associated neurodegeneration Diseases 0.000 description 3
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