JP2014532413A5 - - Google Patents
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- JP2014532413A5 JP2014532413A5 JP2014539033A JP2014539033A JP2014532413A5 JP 2014532413 A5 JP2014532413 A5 JP 2014532413A5 JP 2014539033 A JP2014539033 A JP 2014539033A JP 2014539033 A JP2014539033 A JP 2014539033A JP 2014532413 A5 JP2014532413 A5 JP 2014532413A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- segment
- animal
- endogenous
- segments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552582P | 2011-10-28 | 2011-10-28 | |
| US61/552,582 | 2011-10-28 | ||
| US201261621198P | 2012-04-06 | 2012-04-06 | |
| US61/621,198 | 2012-04-06 | ||
| US201261700908P | 2012-09-14 | 2012-09-14 | |
| US61/700,908 | 2012-09-14 | ||
| PCT/US2012/062065 WO2013063361A1 (en) | 2011-10-28 | 2012-10-26 | Genetically modified t cell receptor mice |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017205098A Division JP6532924B2 (ja) | 2011-10-28 | 2017-10-24 | 遺伝子改変ｔ細胞受容体マウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532413A JP2014532413A (ja) | 2014-12-08 |
| JP2014532413A5 true JP2014532413A5 (enExample) | 2015-12-17 |
| JP6254528B2 JP6254528B2 (ja) | 2017-12-27 |
Family
ID=47178340
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539033A Active JP6254528B2 (ja) | 2011-10-28 | 2012-10-26 | 遺伝子改変ｔ細胞受容体マウス |
| JP2017205098A Active JP6532924B2 (ja) | 2011-10-28 | 2017-10-24 | 遺伝子改変ｔ細胞受容体マウス |
| JP2018231026A Active JP6706311B2 (ja) | 2011-10-28 | 2018-12-10 | 遺伝子改変ｔ細胞受容体マウス |
| JP2020085787A Withdrawn JP2020146045A (ja) | 2011-10-28 | 2020-05-15 | 遺伝子改変ｔ細胞受容体マウス |
| JP2022075908A Active JP7305840B2 (ja) | 2011-10-28 | 2022-05-02 | 遺伝子改変ｔ細胞受容体マウス |
| JP2022208112A Active JP7656580B2 (ja) | 2011-10-28 | 2022-12-26 | 遺伝子改変ｔ細胞受容体マウス |
| JP2023214715A Withdrawn JP2024019646A (ja) | 2011-10-28 | 2023-12-20 | 遺伝子改変ｔ細胞受容体マウス |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017205098A Active JP6532924B2 (ja) | 2011-10-28 | 2017-10-24 | 遺伝子改変ｔ細胞受容体マウス |
| JP2018231026A Active JP6706311B2 (ja) | 2011-10-28 | 2018-12-10 | 遺伝子改変ｔ細胞受容体マウス |
| JP2020085787A Withdrawn JP2020146045A (ja) | 2011-10-28 | 2020-05-15 | 遺伝子改変ｔ細胞受容体マウス |
| JP2022075908A Active JP7305840B2 (ja) | 2011-10-28 | 2022-05-02 | 遺伝子改変ｔ細胞受容体マウス |
| JP2022208112A Active JP7656580B2 (ja) | 2011-10-28 | 2022-12-26 | 遺伝子改変ｔ細胞受容体マウス |
| JP2023214715A Withdrawn JP2024019646A (ja) | 2011-10-28 | 2023-12-20 | 遺伝子改変ｔ細胞受容体マウス |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US9113616B2 (enExample) |
| EP (3) | EP3424947B1 (enExample) |
| JP (7) | JP6254528B2 (enExample) |
| KR (5) | KR102321909B1 (enExample) |
| CN (5) | CN104011071B (enExample) |
| AU (5) | AU2012327204B2 (enExample) |
| BR (1) | BR112014009203B1 (enExample) |
| CA (1) | CA2853707A1 (enExample) |
| CY (2) | CY1120945T1 (enExample) |
| DK (2) | DK2771357T3 (enExample) |
| ES (2) | ES2858978T3 (enExample) |
| HR (2) | HRP20181626T1 (enExample) |
| HU (1) | HUE053444T2 (enExample) |
| IL (4) | IL305550B2 (enExample) |
| IN (1) | IN2014CN03890A (enExample) |
| LT (2) | LT2771357T (enExample) |
| MX (2) | MX379517B (enExample) |
| PL (2) | PL3424947T3 (enExample) |
| PT (2) | PT3424947T (enExample) |
| RS (2) | RS57893B1 (enExample) |
| RU (1) | RU2661106C2 (enExample) |
| SG (2) | SG10201914043XA (enExample) |
| SI (2) | SI3424947T1 (enExample) |
| SM (2) | SMT202100243T1 (enExample) |
| WO (1) | WO2013063361A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102321909B1 (ko) * | 2011-10-28 | 2021-11-05 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 ｔ 세포 수용체 마우스 |
| US20150073043A1 (en) * | 2012-01-19 | 2015-03-12 | Institut Pasteur Of Shanghai, Chinese Academy Of Sciences | Use of phosphorylation pathway-related factor in regulating function of regulatory t cell |
| US9834786B2 (en) | 2012-04-25 | 2017-12-05 | Regeneron Pharmaceuticals, Inc. | Nuclease-mediated targeting with large targeting vectors |
| GB2508414A (en) * | 2012-11-30 | 2014-06-04 | Max Delbrueck Centrum | Tumour specific T cell receptors (TCRs) |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| LT2986729T (lt) | 2013-04-16 | 2018-10-25 | Regeneron Pharmaceuticals, Inc. | Žiurkės genomo tikslinė modifikacija |
| CN110951779B (zh) | 2013-12-11 | 2024-04-16 | 瑞泽恩制药公司 | 用于靶向修饰基因组的方法和组合物 |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| SG11201609634YA (en) * | 2014-06-06 | 2016-12-29 | Regeneron Pharma | Methods and compositions for modifying a targeted locus |
| LT3157956T (lt) * | 2014-06-19 | 2020-05-11 | Regeneron Pharmaceuticals, Inc. | Nepriklausantys žmonėms gyvūnai, turintys humanizuotą užprogramuotos ląstelių žūties 1 geną |
| PL3161128T3 (pl) | 2014-06-26 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Sposoby i kompozycje do celowanych modyfikacji genetycznych i sposoby zastosowania |
| MX2017003640A (es) * | 2014-09-19 | 2017-10-31 | Regeneron Pharma | Receptores antigenicos quimericos. |
| CA3176380A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| SMT202100181T1 (it) * | 2014-11-24 | 2021-05-07 | Regeneron Pharma | Animali non umani esprimenti il complesso cd3 umanizzato |
| EP3653048B9 (en) | 2014-12-19 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification through single-step multiple targeting |
| CA2980771C (en) * | 2015-04-06 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Humanized t cell mediated immune responses in non-human animals |
| ES2905525T3 (es) | 2015-05-06 | 2022-04-11 | Snipr Tech Ltd | Alteración de poblaciones microbianas y modificación de la microbiota |
| RS61866B1 (sr) | 2015-11-20 | 2021-06-30 | Regeneron Pharma | Ne-humane životinje koje imaju humanizovani gen za aktivaciju limfocita 3 |
| JP2019510503A (ja) * | 2016-04-07 | 2019-04-18 | ブルーバード バイオ， インコーポレイテッド | キメラ抗原受容体ｔ細胞組成物 |
| DK3440105T3 (da) | 2016-04-08 | 2022-06-13 | Immunocore Ltd | T-cellereceptorer |
| PT4218408T (pt) | 2016-06-03 | 2025-03-26 | Regeneron Pharma | Roedores que expressam desoxinucleotidil-transferase terminal exógena |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| EP3638262A4 (en) * | 2017-06-16 | 2021-03-24 | Mayo Foundation for Medical Education and Research | MATERIALS AND METHODS FOR INCREASING IMMUNE REACTION |
| US11952408B2 (en) | 2017-10-03 | 2024-04-09 | Juno Therapeutics, Inc. | HPV-specific binding molecules |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| MX2020010459A (es) * | 2018-04-05 | 2021-01-20 | Juno Therapeutics Inc | Metodos para producir celulas que expresan un receptor recombinante y composiciones relacionadas. |
| JP7422365B2 (ja) * | 2018-07-26 | 2024-01-26 | 国立大学法人京都大学 | 外来抗原レセプター遺伝子導入細胞の製造方法 |
| US11851663B2 (en) | 2018-10-14 | 2023-12-26 | Snipr Biome Aps | Single-vector type I vectors |
| MX2022002984A (es) * | 2019-09-12 | 2022-06-16 | Tcr2 Therapeutics Inc | Composiciones y métodos para la reprogramación de tcr mediante el uso de proteínas de fusión. |
| KR20220110233A (ko) | 2019-12-02 | 2022-08-05 | 리제너론 파마슈티칼스 인코포레이티드 | 펩티드-mhc ii 단백질 작제물 및 그의 용도 |
| US20230124640A1 (en) * | 2020-03-27 | 2023-04-20 | 2Seventy Bio, Inc. | T cell receptors |
| CN113684258B (zh) * | 2020-05-18 | 2024-08-20 | 上海赛比曼生物科技有限公司 | 用于检测鼠源tcr转基因拷贝数的试剂盒及方法 |
| US12376573B2 (en) | 2021-03-31 | 2025-08-05 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of TCRB repertoire |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| WO2024035962A2 (en) * | 2022-08-12 | 2024-02-15 | Ingenious Targeting Laboratories | Genetically modified non-human having humanized gamma and delta tcr variable genes |
| US20240092859A1 (en) | 2022-08-18 | 2024-03-21 | Immunocore Ltd | T cell receptors and fusion proteins thereof |
| WO2024064860A1 (en) | 2022-09-22 | 2024-03-28 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing components of human cellular immune system |
| TW202520975A (zh) | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
| GB2640828A (en) | 2024-04-22 | 2025-11-12 | T Therapeutics Ltd | Methods and products for the generation and identification of T cells and TCRs |
| GB2642411A (en) | 2024-04-22 | 2026-01-14 | T Therapeutics Ltd | T Cell Receptor identification and provision |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0663952A4 (en) | 1992-09-11 | 1997-06-11 | Univ California | Transgenic non-human animals having targeted lymphocyte transduction genes. |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| WO1997032603A1 (en) | 1996-03-05 | 1997-09-12 | The Scripps Research Institute | Recombinant constructs encoding t cell receptors specific for human hla-restricted tumor antigens |
| US6320306B1 (en) * | 1996-08-05 | 2001-11-20 | Samsung Display Devices Co., Ltd. | Shadow mask with porous insulating layer and heavy metal layer |
| DK1500329T3 (da) | 1996-12-03 | 2012-07-09 | Amgen Fremont Inc | Humane antistoffer, der specifikt binder TNF-alfa |
| AU1023401A (en) | 1999-10-12 | 2001-04-23 | Institut Pasteur | Design of a polyepitopic construct for the induction of hla-a2.1 restricted hiv 1 specific ctl responses using hhd mice |
| US7462486B2 (en) | 2000-05-12 | 2008-12-09 | Oregon Health & Science University | Methods of selecting T cell receptor V peptides for therapeutic use |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| JPWO2002047474A1 (ja) | 2000-12-13 | 2004-04-15 | 住友製薬株式会社 | Ｈｌａ−ａ２４発現トランスジェニック動物及びその利用 |
| WO2002059263A2 (en) * | 2000-12-19 | 2002-08-01 | Sunol Molecular Corporation | Transgenic animals comprising a humanized immune system |
| FR2827302B1 (fr) | 2001-07-13 | 2003-10-10 | Genoway | Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations |
| CA2457652C (en) | 2001-08-31 | 2012-08-07 | Avidex Limited | Soluble t cell receptor |
| EP1452093A4 (en) | 2001-11-15 | 2007-08-15 | Kirin Brewery | CHIMESE NON-MENTAL ANIMAL |
| ATE279441T1 (de) * | 2001-12-22 | 2004-10-15 | 4Antibody Ag | Verfahren zur herstellung von genetisch veränderten lymphozyten vorläuferzellen von wirbeltieren und deren gebrauch zur produktion von heterologen bindeproteinen |
| CA2471392A1 (en) | 2001-12-22 | 2003-08-21 | 4-Antibody Ag | Method for the generation of genetically modified vertebrate precursor lymphocytes and use thereof for the production of heterologous binding proteins |
| DE10244457A1 (de) | 2002-09-24 | 2004-04-01 | Johannes-Gutenberg-Universität Mainz | Verfahren zur rationalen Mutagenese von alpha/beta T-Zell Rezeptoren und entsprechend mutierte MDM2-Protein spezifische alpha/beta T-Zell Rezeptoren |
| EP1549748B1 (en) | 2002-10-09 | 2014-10-01 | Immunocore Ltd. | Single chain recombinant t cell receptors |
| WO2004042004A2 (en) * | 2002-10-30 | 2004-05-21 | The Wistar Institute Of Anatomy And Biology | Mouse model for autoimmune disorders |
| US7663017B2 (en) * | 2003-07-30 | 2010-02-16 | Institut Pasteur | Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications |
| DK2767161T3 (en) | 2004-10-19 | 2018-05-07 | Regeneron Pharma | Method of generating an animal homozygous for genetic modification |
| PT2016102E (pt) | 2006-05-03 | 2012-05-15 | Us Gov Health & Human Serv | Recetores de célula t quimérica e materiais relacionados e métodos de uso |
| EP1878342A1 (en) | 2006-07-13 | 2008-01-16 | Institut Pasteur | Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses |
| US9388425B2 (en) | 2006-10-20 | 2016-07-12 | Trustees Of Boston University | Tunable genetic switch for regulating gene expression |
| JP2008159109A (ja) | 2006-12-21 | 2008-07-10 | Matsushita Electric Ind Co Ltd | データ転送装置 |
| US20090271884A1 (en) | 2008-03-07 | 2009-10-29 | Regeneron Pharmaceuticals, Inc. | ES Cell-Derived Mice From Diploid Host Embryo Injection |
| US20090328240A1 (en) | 2008-06-24 | 2009-12-31 | Sing George L | Genetically modified mice as predictors of immune response |
| WO2010107400A1 (en) * | 2009-03-20 | 2010-09-23 | Agency For Science, Technology And Research | Genetically modified animal and method of obtaining the same |
| PT2564695E (pt) * | 2009-07-08 | 2015-06-03 | Kymab Ltd | Modelos animais e moléculas terapêuticas |
| GB0917090D0 (en) | 2009-09-29 | 2009-11-11 | Ucl Biomedica Plc | T-cell receptor |
| EP2486049A1 (en) | 2009-10-06 | 2012-08-15 | The Board Of Trustees Of The UniversityOf Illinois | Human single-chain t cell receptors |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| US9557323B2 (en) | 2010-09-24 | 2017-01-31 | The United States Of America As Represented By The Secretary Of The Navy | Humanized transgenic mouse model |
| US10765093B2 (en) | 2010-11-27 | 2020-09-08 | James Zhu | Humanized transgenic animal |
| KR102321909B1 (ko) * | 2011-10-28 | 2021-11-05 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 ｔ 세포 수용체 마우스 |
| CA2980771C (en) | 2015-04-06 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Humanized t cell mediated immune responses in non-human animals |
-
2012
- 2012-10-26 KR KR1020207024033A patent/KR102321909B1/ko active Active
- 2012-10-26 SI SI201231885T patent/SI3424947T1/sl unknown
- 2012-10-26 PL PL18176096T patent/PL3424947T3/pl unknown
- 2012-10-26 BR BR112014009203-6A patent/BR112014009203B1/pt active IP Right Grant
- 2012-10-26 CN CN201280064216.3A patent/CN104011071B/zh active Active
- 2012-10-26 ES ES18176096T patent/ES2858978T3/es active Active
- 2012-10-26 IL IL305550A patent/IL305550B2/en unknown
- 2012-10-26 KR KR1020227015694A patent/KR102542272B1/ko active Active
- 2012-10-26 US US13/661,342 patent/US9113616B2/en active Active
- 2012-10-26 MX MX2017012602A patent/MX379517B/es unknown
- 2012-10-26 DK DK12784833.1T patent/DK2771357T3/en active
- 2012-10-26 HR HRP20181626TT patent/HRP20181626T1/hr unknown
- 2012-10-26 IL IL274914A patent/IL274914B2/en unknown
- 2012-10-26 CN CN202210507387.4A patent/CN114891798B/zh active Active
- 2012-10-26 ES ES12784833T patent/ES2691475T3/es active Active
- 2012-10-26 EP EP18176096.8A patent/EP3424947B1/en active Active
- 2012-10-26 KR KR1020217035333A patent/KR102397961B1/ko active Active
- 2012-10-26 HU HUE18176096A patent/HUE053444T2/hu unknown
- 2012-10-26 CN CN201710930555.XA patent/CN107858332A/zh active Pending
- 2012-10-26 EP EP12784833.1A patent/EP2771357B1/en active Active
- 2012-10-26 PT PT181760968T patent/PT3424947T/pt unknown
- 2012-10-26 PT PT12784833T patent/PT2771357T/pt unknown
- 2012-10-26 SM SM20210243T patent/SMT202100243T1/it unknown
- 2012-10-26 KR KR1020197008815A patent/KR102148387B1/ko active Active
- 2012-10-26 KR KR1020147014477A patent/KR101964776B1/ko active Active
- 2012-10-26 PL PL12784833T patent/PL2771357T3/pl unknown
- 2012-10-26 SG SG10201914043XA patent/SG10201914043XA/en unknown
- 2012-10-26 LT LTEP12784833.1T patent/LT2771357T/lt unknown
- 2012-10-26 RS RS20181207A patent/RS57893B1/sr unknown
- 2012-10-26 IN IN3890CHN2014 patent/IN2014CN03890A/en unknown
- 2012-10-26 LT LTEP18176096.8T patent/LT3424947T/lt unknown
- 2012-10-26 RU RU2014121160A patent/RU2661106C2/ru active
- 2012-10-26 WO PCT/US2012/062065 patent/WO2013063361A1/en not_active Ceased
- 2012-10-26 DK DK18176096.8T patent/DK3424947T3/da active
- 2012-10-26 CN CN201710930556.4A patent/CN107858333B/zh active Active
- 2012-10-26 EP EP20198394.7A patent/EP3795587A1/en active Pending
- 2012-10-26 AU AU2012327204A patent/AU2012327204B2/en active Active
- 2012-10-26 SM SM20180553T patent/SMT201800553T1/it unknown
- 2012-10-26 MX MX2014004894A patent/MX353134B/es active IP Right Grant
- 2012-10-26 SG SG11201401030WA patent/SG11201401030WA/en unknown
- 2012-10-26 CN CN202210507359.2A patent/CN114891797A/zh active Pending
- 2012-10-26 SI SI201231413T patent/SI2771357T1/sl unknown
- 2012-10-26 IL IL315445A patent/IL315445A/en unknown
- 2012-10-26 RS RS20210210A patent/RS61455B1/sr unknown
- 2012-10-26 CA CA2853707A patent/CA2853707A1/en active Pending
- 2012-10-26 JP JP2014539033A patent/JP6254528B2/ja active Active
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2014
- 2014-04-13 IL IL232098A patent/IL232098B/en active IP Right Grant
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2015
- 2015-07-14 US US14/799,355 patent/US11528895B2/en active Active
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2016
- 2016-04-20 AU AU2016202512A patent/AU2016202512C1/en active Active
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2017
- 2017-10-24 JP JP2017205098A patent/JP6532924B2/ja active Active
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2018
- 2018-06-28 AU AU2018204700A patent/AU2018204700C1/en active Active
- 2018-10-16 CY CY181101057T patent/CY1120945T1/el unknown
- 2018-12-10 JP JP2018231026A patent/JP6706311B2/ja active Active
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2020
- 2020-05-15 JP JP2020085787A patent/JP2020146045A/ja not_active Withdrawn
- 2020-10-27 US US17/081,470 patent/US20210051930A1/en active Pending
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2021
- 2021-02-15 HR HRP20210256TT patent/HRP20210256T1/hr unknown
- 2021-02-19 CY CY20211100142T patent/CY1123831T1/el unknown
- 2021-05-18 AU AU2021203192A patent/AU2021203192B2/en active Active
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2022
- 2022-05-02 JP JP2022075908A patent/JP7305840B2/ja active Active
- 2022-07-22 US US17/814,388 patent/US20220386575A1/en not_active Abandoned
- 2022-12-26 JP JP2022208112A patent/JP7656580B2/ja active Active
-
2023
- 2023-12-20 JP JP2023214715A patent/JP2024019646A/ja not_active Withdrawn
-
2024
- 2024-07-04 AU AU2024204645A patent/AU2024204645A1/en active Pending
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