JP2014532413A5 - - Google Patents
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- JP2014532413A5 JP2014532413A5 JP2014539033A JP2014539033A JP2014532413A5 JP 2014532413 A5 JP2014532413 A5 JP 2014532413A5 JP 2014539033 A JP2014539033 A JP 2014539033A JP 2014539033 A JP2014539033 A JP 2014539033A JP 2014532413 A5 JP2014532413 A5 JP 2014532413A5
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- Japan
- Prior art keywords
- human
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552582P | 2011-10-28 | 2011-10-28 | |
| US61/552,582 | 2011-10-28 | ||
| US201261621198P | 2012-04-06 | 2012-04-06 | |
| US61/621,198 | 2012-04-06 | ||
| US201261700908P | 2012-09-14 | 2012-09-14 | |
| US61/700,908 | 2012-09-14 | ||
| PCT/US2012/062065 WO2013063361A1 (en) | 2011-10-28 | 2012-10-26 | Genetically modified t cell receptor mice |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017205098A Division JP6532924B2 (ja) | 2011-10-28 | 2017-10-24 | 遺伝子改変ｔ細胞受容体マウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532413A JP2014532413A (ja) | 2014-12-08 |
| JP2014532413A5 true JP2014532413A5 (enExample) | 2015-12-17 |
| JP6254528B2 JP6254528B2 (ja) | 2017-12-27 |
Family
ID=47178340
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539033A Active JP6254528B2 (ja) | 2011-10-28 | 2012-10-26 | 遺伝子改変ｔ細胞受容体マウス |
| JP2017205098A Active JP6532924B2 (ja) | 2011-10-28 | 2017-10-24 | 遺伝子改変ｔ細胞受容体マウス |
| JP2018231026A Active JP6706311B2 (ja) | 2011-10-28 | 2018-12-10 | 遺伝子改変ｔ細胞受容体マウス |
| JP2020085787A Withdrawn JP2020146045A (ja) | 2011-10-28 | 2020-05-15 | 遺伝子改変ｔ細胞受容体マウス |
| JP2022075908A Active JP7305840B2 (ja) | 2011-10-28 | 2022-05-02 | 遺伝子改変ｔ細胞受容体マウス |
| JP2022208112A Active JP7656580B2 (ja) | 2011-10-28 | 2022-12-26 | 遺伝子改変ｔ細胞受容体マウス |
| JP2023214715A Withdrawn JP2024019646A (ja) | 2011-10-28 | 2023-12-20 | 遺伝子改変ｔ細胞受容体マウス |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017205098A Active JP6532924B2 (ja) | 2011-10-28 | 2017-10-24 | 遺伝子改変ｔ細胞受容体マウス |
| JP2018231026A Active JP6706311B2 (ja) | 2011-10-28 | 2018-12-10 | 遺伝子改変ｔ細胞受容体マウス |
| JP2020085787A Withdrawn JP2020146045A (ja) | 2011-10-28 | 2020-05-15 | 遺伝子改変ｔ細胞受容体マウス |
| JP2022075908A Active JP7305840B2 (ja) | 2011-10-28 | 2022-05-02 | 遺伝子改変ｔ細胞受容体マウス |
| JP2022208112A Active JP7656580B2 (ja) | 2011-10-28 | 2022-12-26 | 遺伝子改変ｔ細胞受容体マウス |
| JP2023214715A Withdrawn JP2024019646A (ja) | 2011-10-28 | 2023-12-20 | 遺伝子改変ｔ細胞受容体マウス |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US9113616B2 (enExample) |
| EP (3) | EP3424947B1 (enExample) |
| JP (7) | JP6254528B2 (enExample) |
| KR (5) | KR102397961B1 (enExample) |
| CN (5) | CN114891798B (enExample) |
| AU (5) | AU2012327204B2 (enExample) |
| BR (1) | BR112014009203B1 (enExample) |
| CA (1) | CA2853707A1 (enExample) |
| CY (2) | CY1120945T1 (enExample) |
| DK (2) | DK3424947T3 (enExample) |
| ES (2) | ES2691475T3 (enExample) |
| HR (2) | HRP20181626T1 (enExample) |
| HU (1) | HUE053444T2 (enExample) |
| IL (4) | IL305550B2 (enExample) |
| IN (1) | IN2014CN03890A (enExample) |
| LT (2) | LT3424947T (enExample) |
| MX (2) | MX353134B (enExample) |
| PL (2) | PL3424947T3 (enExample) |
| PT (2) | PT2771357T (enExample) |
| RS (2) | RS57893B1 (enExample) |
| RU (1) | RU2661106C2 (enExample) |
| SG (2) | SG11201401030WA (enExample) |
| SI (2) | SI3424947T1 (enExample) |
| SM (2) | SMT201800553T1 (enExample) |
| WO (1) | WO2013063361A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE053444T2 (hu) * | 2011-10-28 | 2021-06-28 | Regeneron Pharma | Genetikailag módosított T-sejt receptoros egerek |
| US20150073043A1 (en) * | 2012-01-19 | 2015-03-12 | Institut Pasteur Of Shanghai, Chinese Academy Of Sciences | Use of phosphorylation pathway-related factor in regulating function of regulatory t cell |
| RU2645475C2 (ru) | 2012-04-25 | 2018-02-21 | Регенерон Фармасьютикалз, Инк. | Опосредованное нуклеазой нацеливание с большими нацеливающими векторами |
| GB2508414A (en) * | 2012-11-30 | 2014-06-04 | Max Delbrueck Centrum | Tumour specific T cell receptors (TCRs) |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| DK2986729T3 (en) | 2013-04-16 | 2018-10-29 | Regeneron Pharma | TARGETED MODIFICATION OF ROOT THROUGH |
| WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| RU2704283C9 (ru) | 2014-06-06 | 2020-02-07 | Регенерон Фармасьютикалз, Инк. | Способы и композиции для модификации целевого локуса |
| EP3683238A1 (en) * | 2014-06-19 | 2020-07-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| PT3161128T (pt) | 2014-06-26 | 2018-11-21 | Regeneron Pharma | Métodos e composições para modificações genéticas alvejadas e métodos de utilização |
| KR20170083534A (ko) * | 2014-09-19 | 2017-07-18 | 리제너론 파마슈티칼스 인코포레이티드 | 키메라 항원 수용체 |
| CA2968440A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| KR102659123B1 (ko) * | 2014-11-24 | 2024-04-22 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 cd3 복합체를 발현하는 비인간 동물 |
| BR112017013104A2 (en) | 2014-12-19 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | methods for modifying a target genomic locus in a cell, for enhancing homologous recombination at a target genomic locus in a cell, and for producing an f0 generation from a nonhuman animal. |
| RU2732628C2 (ru) * | 2015-04-06 | 2020-09-21 | Регенерон Фармасьютикалз, Инк. | Опосредованные гуманизированными т-клетками иммунные ответы у не относящихся к человеку животных |
| KR20200091499A (ko) | 2015-05-06 | 2020-07-30 | 스니프르 테크놀로지스 리미티드 | 미생물 개체군 변경 및 미생물군 변형 |
| KR102454546B1 (ko) * | 2015-11-20 | 2022-10-14 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 림프구 활성화 유전자 3을 갖는 비인간 동물 |
| CA3020330A1 (en) * | 2016-04-07 | 2017-10-12 | Bluebird Bio, Inc. | Chimeric antigen receptor t cell compositions |
| MA44608B1 (fr) | 2016-04-08 | 2022-06-30 | Immunocore Ltd | Récepteurs des lymphocytes t |
| KR102483193B1 (ko) * | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| AU2018283319B2 (en) | 2017-06-16 | 2023-11-09 | Mayo Foundation For Medical Education And Research | Materials and methods for increasing immune responses |
| EP3692063A1 (en) | 2017-10-03 | 2020-08-12 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| EP3775238A1 (en) * | 2018-04-05 | 2021-02-17 | Juno Therapeutics, Inc. | Methods of producing cells expressing a recombinant receptor and related compositions |
| AU2019312008B2 (en) * | 2018-07-26 | 2026-04-23 | Kyoto University | Method for generating cells into which an exogenous antigen receptor is introduced |
| US11851663B2 (en) | 2018-10-14 | 2023-12-26 | Snipr Biome Aps | Single-vector type I vectors |
| AU2020344628A1 (en) * | 2019-09-12 | 2022-04-07 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| IL293330A (en) | 2019-12-02 | 2022-07-01 | Regeneron Pharma | mhc ii peptide protein structures and uses thereof |
| WO2021195503A1 (en) * | 2020-03-27 | 2021-09-30 | 2Seventy Bio, Inc. | T cell receptors |
| CN113684258B (zh) | 2020-05-18 | 2024-08-20 | 上海赛比曼生物科技有限公司 | 用于检测鼠源tcr转基因拷贝数的试剂盒及方法 |
| US12376573B2 (en) | 2021-03-31 | 2025-08-05 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of TCRB repertoire |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| CN120019068A (zh) * | 2022-08-12 | 2025-05-16 | 独创目标实验室 | 具有人源化γ和δTCR可变基因的经遗传修饰的非人类 |
| JP2025527575A (ja) | 2022-08-18 | 2025-08-22 | イミュノコア リミテッド | Ｍａｇｅ ａ４に特異的なｔ細胞受容体融合タンパク質 |
| US20240099279A1 (en) * | 2022-09-22 | 2024-03-28 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing components of human cellular immune system |
| TW202520975A (zh) | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
| GB2640828A (en) | 2024-04-22 | 2025-11-12 | T Therapeutics Ltd | Methods and products for the generation and identification of T cells and TCRs |
| GB2642411A (en) | 2024-04-22 | 2026-01-14 | T Therapeutics Ltd | T Cell Receptor identification and provision |
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| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1994006908A1 (en) | 1992-09-11 | 1994-03-31 | The Regents Of The University Of California | Transgenic non-human animals having targeted lymphocyte transduction genes |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| AU728794B2 (en) | 1996-03-05 | 2001-01-18 | Scripps Research Institute, The | Recombinant constructs encoding T cell receptors specific for human HLA-restricted tumor antigens |
| US6320306B1 (en) * | 1996-08-05 | 2001-11-20 | Samsung Display Devices Co., Ltd. | Shadow mask with porous insulating layer and heavy metal layer |
| ATE549918T1 (de) | 1996-12-03 | 2012-04-15 | Amgen Fremont Inc | Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden |
| WO2001027291A1 (en) | 1999-10-12 | 2001-04-19 | Institut Pasteur | Design of a polyepitopic construct for the induction of hla-a2.1 restricted hiv 1 specific ctl responses using hhd mice |
| US7462486B2 (en) | 2000-05-12 | 2008-12-09 | Oregon Health & Science University | Methods of selecting T cell receptor V peptides for therapeutic use |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
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| AU2002222610A1 (en) * | 2000-12-13 | 2002-06-24 | Sumitomo Pharmaceuticals Company, Limited | Transgenic animal expressing hla-a24 and utilization thereof |
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| IL162111A0 (en) | 2001-12-22 | 2005-11-20 | 4Antibody Ag | Method for the generation of generically modified vertebrate precursor lymphocytes and use thereof for the production of heterologo |
| DK1321477T3 (da) | 2001-12-22 | 2005-02-14 | 4Antibody Ag | Fremgangsmåde til frembringelsen af genetisk modificerede vertebrate precursor-lymfocytter og anvendelse deraf til fremstillingen af heterologe bindende proteiner |
| DE10244457A1 (de) | 2002-09-24 | 2004-04-01 | Johannes-Gutenberg-Universität Mainz | Verfahren zur rationalen Mutagenese von alpha/beta T-Zell Rezeptoren und entsprechend mutierte MDM2-Protein spezifische alpha/beta T-Zell Rezeptoren |
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| US7663017B2 (en) * | 2003-07-30 | 2010-02-16 | Institut Pasteur | Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications |
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| AU2007248019B2 (en) * | 2006-05-03 | 2012-10-11 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Chimeric T cell receptors and related materials and methods of use |
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| WO2010107400A1 (en) * | 2009-03-20 | 2010-09-23 | Agency For Science, Technology And Research | Genetically modified animal and method of obtaining the same |
| CN102638971B (zh) * | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| RU2425880C2 (ru) | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
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| PL3251503T3 (pl) | 2010-03-31 | 2024-07-08 | Ablexis, Llc | Modyfikacja myszy metodami inżynierii genetycznej w celu wytworzenia przeciwciał chimerycznych |
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| CN105950654B (zh) | 2010-11-27 | 2020-03-20 | 朱坚 | 一种人源化的转基因动物 |
| HUE053444T2 (hu) * | 2011-10-28 | 2021-06-28 | Regeneron Pharma | Genetikailag módosított T-sejt receptoros egerek |
| RU2732628C2 (ru) | 2015-04-06 | 2020-09-21 | Регенерон Фармасьютикалз, Инк. | Опосредованные гуманизированными т-клетками иммунные ответы у не относящихся к человеку животных |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
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2012
- 2012-10-26 HU HUE18176096A patent/HUE053444T2/hu unknown
- 2012-10-26 SI SI201231885T patent/SI3424947T1/sl unknown
- 2012-10-26 US US13/661,342 patent/US9113616B2/en active Active
- 2012-10-26 DK DK18176096.8T patent/DK3424947T3/da active
- 2012-10-26 LT LTEP18176096.8T patent/LT3424947T/lt unknown
- 2012-10-26 IN IN3890CHN2014 patent/IN2014CN03890A/en unknown
- 2012-10-26 WO PCT/US2012/062065 patent/WO2013063361A1/en not_active Ceased
- 2012-10-26 KR KR1020217035333A patent/KR102397961B1/ko active Active
- 2012-10-26 CN CN202210507387.4A patent/CN114891798B/zh active Active
- 2012-10-26 SG SG11201401030WA patent/SG11201401030WA/en unknown
- 2012-10-26 EP EP18176096.8A patent/EP3424947B1/en active Active
- 2012-10-26 BR BR112014009203-6A patent/BR112014009203B1/pt active IP Right Grant
- 2012-10-26 ES ES12784833T patent/ES2691475T3/es active Active
- 2012-10-26 SM SM20180553T patent/SMT201800553T1/it unknown
- 2012-10-26 MX MX2014004894A patent/MX353134B/es active IP Right Grant
- 2012-10-26 IL IL305550A patent/IL305550B2/en unknown
- 2012-10-26 IL IL274914A patent/IL274914B2/en unknown
- 2012-10-26 CN CN202210507359.2A patent/CN114891797A/zh active Pending
- 2012-10-26 LT LTEP12784833.1T patent/LT2771357T/lt unknown
- 2012-10-26 PT PT12784833T patent/PT2771357T/pt unknown
- 2012-10-26 CA CA2853707A patent/CA2853707A1/en active Pending
- 2012-10-26 PL PL18176096T patent/PL3424947T3/pl unknown
- 2012-10-26 CN CN201710930555.XA patent/CN107858332A/zh active Pending
- 2012-10-26 PL PL12784833T patent/PL2771357T3/pl unknown
- 2012-10-26 JP JP2014539033A patent/JP6254528B2/ja active Active
- 2012-10-26 HR HRP20181626TT patent/HRP20181626T1/hr unknown
- 2012-10-26 RS RS20181207A patent/RS57893B1/sr unknown
- 2012-10-26 KR KR1020227015694A patent/KR102542272B1/ko active Active
- 2012-10-26 MX MX2017012602A patent/MX379517B/es unknown
- 2012-10-26 RU RU2014121160A patent/RU2661106C2/ru active
- 2012-10-26 EP EP12784833.1A patent/EP2771357B1/en active Active
- 2012-10-26 KR KR1020197008815A patent/KR102148387B1/ko active Active
- 2012-10-26 AU AU2012327204A patent/AU2012327204B2/en active Active
- 2012-10-26 SM SM20210243T patent/SMT202100243T1/it unknown
- 2012-10-26 KR KR1020147014477A patent/KR101964776B1/ko active Active
- 2012-10-26 CN CN201280064216.3A patent/CN104011071B/zh active Active
- 2012-10-26 ES ES18176096T patent/ES2858978T3/es active Active
- 2012-10-26 SI SI201231413T patent/SI2771357T1/sl unknown
- 2012-10-26 SG SG10201914043XA patent/SG10201914043XA/en unknown
- 2012-10-26 IL IL315445A patent/IL315445A/en unknown
- 2012-10-26 RS RS20210210A patent/RS61455B1/sr unknown
- 2012-10-26 CN CN201710930556.4A patent/CN107858333B/zh active Active
- 2012-10-26 EP EP20198394.7A patent/EP3795587A1/en active Pending
- 2012-10-26 KR KR1020207024033A patent/KR102321909B1/ko active Active
- 2012-10-26 PT PT181760968T patent/PT3424947T/pt unknown
- 2012-10-26 DK DK12784833.1T patent/DK2771357T3/en active
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2014
- 2014-04-13 IL IL232098A patent/IL232098B/en active IP Right Grant
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2015
- 2015-07-14 US US14/799,355 patent/US11528895B2/en active Active
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2016
- 2016-04-20 AU AU2016202512A patent/AU2016202512C1/en active Active
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2017
- 2017-10-24 JP JP2017205098A patent/JP6532924B2/ja active Active
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2018
- 2018-06-28 AU AU2018204700A patent/AU2018204700C1/en active Active
- 2018-10-16 CY CY181101057T patent/CY1120945T1/el unknown
- 2018-12-10 JP JP2018231026A patent/JP6706311B2/ja active Active
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2020
- 2020-05-15 JP JP2020085787A patent/JP2020146045A/ja not_active Withdrawn
- 2020-10-27 US US17/081,470 patent/US12582105B2/en active Active
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2021
- 2021-02-15 HR HRP20210256TT patent/HRP20210256T1/hr unknown
- 2021-02-19 CY CY20211100142T patent/CY1123831T1/el unknown
- 2021-05-18 AU AU2021203192A patent/AU2021203192B2/en active Active
-
2022
- 2022-05-02 JP JP2022075908A patent/JP7305840B2/ja active Active
- 2022-07-22 US US17/814,388 patent/US20220386575A1/en not_active Abandoned
- 2022-12-26 JP JP2022208112A patent/JP7656580B2/ja active Active
-
2023
- 2023-12-20 JP JP2023214715A patent/JP2024019646A/ja not_active Withdrawn
-
2024
- 2024-07-04 AU AU2024204645A patent/AU2024204645A1/en active Pending
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