JP2014532058A5 - - Google Patents
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- Publication number
- JP2014532058A5 JP2014532058A5 JP2014533842A JP2014533842A JP2014532058A5 JP 2014532058 A5 JP2014532058 A5 JP 2014532058A5 JP 2014533842 A JP2014533842 A JP 2014533842A JP 2014533842 A JP2014533842 A JP 2014533842A JP 2014532058 A5 JP2014532058 A5 JP 2014532058A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- inert solvent
- reacting
- prepared
- providing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 238000000034 method Methods 0.000 claims 11
- 239000012442 inert solvent Substances 0.000 claims 5
- LQZMLBORDGWNPD-UHFFFAOYSA-N N-iodosuccinimide Chemical group IN1C(=O)CCC1=O LQZMLBORDGWNPD-UHFFFAOYSA-N 0.000 claims 2
- 238000003477 Sonogashira cross-coupling reaction Methods 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000012336 iodinating agent Substances 0.000 claims 2
- JVVRJMXHNUAPHW-UHFFFAOYSA-N 1h-pyrazol-5-amine Chemical compound NC=1C=CNN=1 JVVRJMXHNUAPHW-UHFFFAOYSA-N 0.000 claims 1
- MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 claims 1
- CEBKHWWANWSNTI-UHFFFAOYSA-N 2-methylbut-3-yn-2-ol Chemical compound CC(C)(O)C#C CEBKHWWANWSNTI-UHFFFAOYSA-N 0.000 claims 1
- STSCVKRWJPWALQ-UHFFFAOYSA-N TRIFLUOROACETIC ACID ETHYL ESTER Chemical compound CCOC(=O)C(F)(F)F STSCVKRWJPWALQ-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542837P | 2011-10-04 | 2011-10-04 | |
| US61/542,837 | 2011-10-04 | ||
| US201261684181P | 2012-08-17 | 2012-08-17 | |
| US61/684,181 | 2012-08-17 | ||
| PCT/EP2012/069303 WO2013050310A1 (en) | 2011-10-04 | 2012-10-01 | Methods for the preparation of 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]-2-pyridinamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014532058A JP2014532058A (ja) | 2014-12-04 |
| JP2014532058A5 true JP2014532058A5 (enExample) | 2015-11-19 |
Family
ID=46963723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014533842A Pending JP2014532058A (ja) | 2011-10-04 | 2012-10-01 | ５−［２−［７−（トリフルオロメチル）−５−［４−（トリフルオロメチル）フェニル］ピラゾロ［１，５−ａ］ピリミジン−３−イル］エチニル］−２−ピリジンアミンの製造方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9447099B2 (enExample) |
| EP (1) | EP2763991B1 (enExample) |
| JP (1) | JP2014532058A (enExample) |
| KR (1) | KR20140071474A (enExample) |
| CN (1) | CN103857679A (enExample) |
| AR (1) | AR088098A1 (enExample) |
| AU (1) | AU2012320732A1 (enExample) |
| BR (1) | BR112014007850A2 (enExample) |
| CA (1) | CA2847092A1 (enExample) |
| IL (1) | IL231283A0 (enExample) |
| MX (1) | MX2014004062A (enExample) |
| RU (1) | RU2630700C2 (enExample) |
| SG (2) | SG10201507001RA (enExample) |
| WO (1) | WO2013050310A1 (enExample) |
| ZA (1) | ZA201401398B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160143853A (ko) * | 2014-04-23 | 2016-12-14 | 에프. 호프만-라 로슈 아게 | 지적 장애의 치료를 위한 mglu2/3 길항제 |
| EP3760233B1 (en) * | 2019-05-20 | 2023-07-12 | MabPlex International Co., Ltd. | One-pot preparation process for antibody drug conjugate intermediate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE495168T1 (de) | 2003-06-12 | 2011-01-15 | Hoffmann La Roche | Heteroarylsubstituierte imidazolderivate als glutamatrezeptorantagonisten |
| US7329662B2 (en) * | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
| CN1930144A (zh) * | 2004-03-09 | 2007-03-14 | 贝林格尔·英格海姆药物公司 | 可用作细胞因子产生抑制剂用于治疗慢性炎性疾病的3,4’－杂环基－1,2,3－三唑－1－基－n－芳基苯甲酰胺 |
| ES2365406T3 (es) * | 2005-02-11 | 2011-10-04 | F. Hoffmann-La Roche Ag | Derivados de pirazolo-pirimidina como antagonistas de mglur2. |
| KR100973609B1 (ko) * | 2005-03-23 | 2010-08-03 | 에프. 호프만-라 로슈 아게 | ｍＧｌｕＲ2 길항제로서 아세틸렌일-피라졸로-피리미딘유도체 |
| CA2623721C (en) * | 2005-09-27 | 2014-05-13 | F. Hoffmann-La Roche Ag | Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists |
| EP2384328B1 (en) * | 2008-11-27 | 2013-02-13 | Boehringer Ingelheim International GmbH | 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| WO2011014520A2 (en) * | 2009-07-29 | 2011-02-03 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
-
2012
- 2012-09-27 US US13/628,069 patent/US9447099B2/en not_active Expired - Fee Related
- 2012-10-01 RU RU2014116885A patent/RU2630700C2/ru not_active IP Right Cessation
- 2012-10-01 CA CA2847092A patent/CA2847092A1/en not_active Abandoned
- 2012-10-01 SG SG10201507001RA patent/SG10201507001RA/en unknown
- 2012-10-01 CN CN201280048837.2A patent/CN103857679A/zh active Pending
- 2012-10-01 AU AU2012320732A patent/AU2012320732A1/en not_active Abandoned
- 2012-10-01 SG SG2014014203A patent/SG2014014203A/en unknown
- 2012-10-01 MX MX2014004062A patent/MX2014004062A/es unknown
- 2012-10-01 EP EP12766655.0A patent/EP2763991B1/en not_active Not-in-force
- 2012-10-01 KR KR1020147011727A patent/KR20140071474A/ko not_active Ceased
- 2012-10-01 WO PCT/EP2012/069303 patent/WO2013050310A1/en not_active Ceased
- 2012-10-01 BR BR112014007850A patent/BR112014007850A2/pt active Search and Examination
- 2012-10-01 JP JP2014533842A patent/JP2014532058A/ja active Pending
- 2012-10-02 AR ARP120103667A patent/AR088098A1/es unknown
-
2014
- 2014-02-24 ZA ZA2014/01398A patent/ZA201401398B/en unknown
- 2014-03-03 IL IL231283A patent/IL231283A0/en unknown
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