AR088098A1 - Metodos de obtencion de la 5-[2-[7-(trifluorometil)-5-[4-(trifluorometil)fenil]pirazolo[1,5-a]pirimidin-3-il]etinil]-2-piridinamina - Google Patents
Metodos de obtencion de la 5-[2-[7-(trifluorometil)-5-[4-(trifluorometil)fenil]pirazolo[1,5-a]pirimidin-3-il]etinil]-2-piridinaminaInfo
- Publication number
- AR088098A1 AR088098A1 ARP120103667A ARP120103667A AR088098A1 AR 088098 A1 AR088098 A1 AR 088098A1 AR P120103667 A ARP120103667 A AR P120103667A AR P120103667 A ARP120103667 A AR P120103667A AR 088098 A1 AR088098 A1 AR 088098A1
- Authority
- AR
- Argentina
- Prior art keywords
- trifluorometil
- compound
- formula
- obtaining
- ethylin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 229940126062 Compound A Drugs 0.000 abstract 6
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000012442 inert solvent Substances 0.000 abstract 3
- 238000006482 condensation reaction Methods 0.000 abstract 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 abstract 2
- 235000003270 potassium fluoride Nutrition 0.000 abstract 1
- 239000011698 potassium fluoride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/083—Syntheses without formation of a Si-C bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542837P | 2011-10-04 | 2011-10-04 | |
| US201261684181P | 2012-08-17 | 2012-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088098A1 true AR088098A1 (es) | 2014-05-07 |
Family
ID=46963723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120103667A AR088098A1 (es) | 2011-10-04 | 2012-10-02 | Metodos de obtencion de la 5-[2-[7-(trifluorometil)-5-[4-(trifluorometil)fenil]pirazolo[1,5-a]pirimidin-3-il]etinil]-2-piridinamina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9447099B2 (enExample) |
| EP (1) | EP2763991B1 (enExample) |
| JP (1) | JP2014532058A (enExample) |
| KR (1) | KR20140071474A (enExample) |
| CN (1) | CN103857679A (enExample) |
| AR (1) | AR088098A1 (enExample) |
| AU (1) | AU2012320732A1 (enExample) |
| BR (1) | BR112014007850A2 (enExample) |
| CA (1) | CA2847092A1 (enExample) |
| IL (1) | IL231283A0 (enExample) |
| MX (1) | MX2014004062A (enExample) |
| RU (1) | RU2630700C2 (enExample) |
| SG (2) | SG10201507001RA (enExample) |
| WO (1) | WO2013050310A1 (enExample) |
| ZA (1) | ZA201401398B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160143853A (ko) * | 2014-04-23 | 2016-12-14 | 에프. 호프만-라 로슈 아게 | 지적 장애의 치료를 위한 mglu2/3 길항제 |
| EP3760233B1 (en) * | 2019-05-20 | 2023-07-12 | MabPlex International Co., Ltd. | One-pot preparation process for antibody drug conjugate intermediate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE495168T1 (de) | 2003-06-12 | 2011-01-15 | Hoffmann La Roche | Heteroarylsubstituierte imidazolderivate als glutamatrezeptorantagonisten |
| US7329662B2 (en) * | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
| CN1930144A (zh) * | 2004-03-09 | 2007-03-14 | 贝林格尔·英格海姆药物公司 | 可用作细胞因子产生抑制剂用于治疗慢性炎性疾病的3,4’－杂环基－1,2,3－三唑－1－基－n－芳基苯甲酰胺 |
| ES2365406T3 (es) * | 2005-02-11 | 2011-10-04 | F. Hoffmann-La Roche Ag | Derivados de pirazolo-pirimidina como antagonistas de mglur2. |
| KR100973609B1 (ko) * | 2005-03-23 | 2010-08-03 | 에프. 호프만-라 로슈 아게 | ｍＧｌｕＲ2 길항제로서 아세틸렌일-피라졸로-피리미딘유도체 |
| CA2623721C (en) * | 2005-09-27 | 2014-05-13 | F. Hoffmann-La Roche Ag | Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists |
| EP2384328B1 (en) * | 2008-11-27 | 2013-02-13 | Boehringer Ingelheim International GmbH | 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| WO2011014520A2 (en) * | 2009-07-29 | 2011-02-03 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
-
2012
- 2012-09-27 US US13/628,069 patent/US9447099B2/en not_active Expired - Fee Related
- 2012-10-01 RU RU2014116885A patent/RU2630700C2/ru not_active IP Right Cessation
- 2012-10-01 CA CA2847092A patent/CA2847092A1/en not_active Abandoned
- 2012-10-01 SG SG10201507001RA patent/SG10201507001RA/en unknown
- 2012-10-01 CN CN201280048837.2A patent/CN103857679A/zh active Pending
- 2012-10-01 AU AU2012320732A patent/AU2012320732A1/en not_active Abandoned
- 2012-10-01 SG SG2014014203A patent/SG2014014203A/en unknown
- 2012-10-01 MX MX2014004062A patent/MX2014004062A/es unknown
- 2012-10-01 EP EP12766655.0A patent/EP2763991B1/en not_active Not-in-force
- 2012-10-01 KR KR1020147011727A patent/KR20140071474A/ko not_active Ceased
- 2012-10-01 WO PCT/EP2012/069303 patent/WO2013050310A1/en not_active Ceased
- 2012-10-01 BR BR112014007850A patent/BR112014007850A2/pt active Search and Examination
- 2012-10-01 JP JP2014533842A patent/JP2014532058A/ja active Pending
- 2012-10-02 AR ARP120103667A patent/AR088098A1/es unknown
-
2014
- 2014-02-24 ZA ZA2014/01398A patent/ZA201401398B/en unknown
- 2014-03-03 IL IL231283A patent/IL231283A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014004062A (es) | 2014-06-05 |
| US9447099B2 (en) | 2016-09-20 |
| EP2763991B1 (en) | 2016-12-28 |
| IL231283A0 (en) | 2014-04-30 |
| NZ621156A (en) | 2016-01-29 |
| CN103857679A (zh) | 2014-06-11 |
| ZA201401398B (en) | 2017-04-26 |
| SG2014014203A (en) | 2014-05-29 |
| CA2847092A1 (en) | 2013-04-11 |
| EP2763991A1 (en) | 2014-08-13 |
| AU2012320732A1 (en) | 2014-02-27 |
| BR112014007850A2 (pt) | 2017-04-18 |
| JP2014532058A (ja) | 2014-12-04 |
| KR20140071474A (ko) | 2014-06-11 |
| WO2013050310A1 (en) | 2013-04-11 |
| US20130085278A1 (en) | 2013-04-04 |
| SG10201507001RA (en) | 2015-10-29 |
| RU2014116885A (ru) | 2015-11-10 |
| RU2630700C2 (ru) | 2017-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |