IL231283A0 - Methods for the preparation of 5 - [2 - [7 - (trifluoromethyl) - 5 - [4 - (trifluoromethyl) phenyl] pyrazolo [1, 5 - a] pyrimidine - 3 - yl] ethinyl] - 2 - pyridineamine - Google Patents

Methods for the preparation of 5 - [2 - [7 - (trifluoromethyl) - 5 - [4 - (trifluoromethyl) phenyl] pyrazolo [1, 5 - a] pyrimidine - 3 - yl] ethinyl] - 2 - pyridineamine

Info

Publication number
IL231283A0
IL231283A0 IL231283A IL23128314A IL231283A0 IL 231283 A0 IL231283 A0 IL 231283A0 IL 231283 A IL231283 A IL 231283A IL 23128314 A IL23128314 A IL 23128314A IL 231283 A0 IL231283 A0 IL 231283A0
Authority
IL
Israel
Prior art keywords
trifluoromethyl
pyridinamine
pyrazolo
pyrimidin
ethynyl
Prior art date
Application number
IL231283A
Other languages
English (en)
Hebrew (he)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL231283A0 publication Critical patent/IL231283A0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/0825Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/083Syntheses without formation of a Si-C bond
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL231283A 2011-10-04 2014-03-03 Methods for the preparation of 5 - [2 - [7 - (trifluoromethyl) - 5 - [4 - (trifluoromethyl) phenyl] pyrazolo [1, 5 - a] pyrimidine - 3 - yl] ethinyl] - 2 - pyridineamine IL231283A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161542837P 2011-10-04 2011-10-04
US201261684181P 2012-08-17 2012-08-17
PCT/EP2012/069303 WO2013050310A1 (en) 2011-10-04 2012-10-01 Methods for the preparation of 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]-2-pyridinamine

Publications (1)

Publication Number Publication Date
IL231283A0 true IL231283A0 (en) 2014-04-30

Family

ID=46963723

Family Applications (1)

Application Number Title Priority Date Filing Date
IL231283A IL231283A0 (en) 2011-10-04 2014-03-03 Methods for the preparation of 5 - [2 - [7 - (trifluoromethyl) - 5 - [4 - (trifluoromethyl) phenyl] pyrazolo [1, 5 - a] pyrimidine - 3 - yl] ethinyl] - 2 - pyridineamine

Country Status (15)

Country Link
US (1) US9447099B2 (enExample)
EP (1) EP2763991B1 (enExample)
JP (1) JP2014532058A (enExample)
KR (1) KR20140071474A (enExample)
CN (1) CN103857679A (enExample)
AR (1) AR088098A1 (enExample)
AU (1) AU2012320732A1 (enExample)
BR (1) BR112014007850A2 (enExample)
CA (1) CA2847092A1 (enExample)
IL (1) IL231283A0 (enExample)
MX (1) MX2014004062A (enExample)
RU (1) RU2630700C2 (enExample)
SG (2) SG10201507001RA (enExample)
WO (1) WO2013050310A1 (enExample)
ZA (1) ZA201401398B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160143853A (ko) * 2014-04-23 2016-12-14 에프. 호프만-라 로슈 아게 지적 장애의 치료를 위한 mglu2/3 길항제
EP3760233B1 (en) * 2019-05-20 2023-07-12 MabPlex International Co., Ltd. One-pot preparation process for antibody drug conjugate intermediate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE495168T1 (de) 2003-06-12 2011-01-15 Hoffmann La Roche Heteroarylsubstituierte imidazolderivate als glutamatrezeptorantagonisten
US7329662B2 (en) * 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine
CN1930144A (zh) * 2004-03-09 2007-03-14 贝林格尔·英格海姆药物公司 可用作细胞因子产生抑制剂用于治疗慢性炎性疾病的3,4’-杂环基-1,2,3-三唑-1-基-n-芳基苯甲酰胺
ES2365406T3 (es) * 2005-02-11 2011-10-04 F. Hoffmann-La Roche Ag Derivados de pirazolo-pirimidina como antagonistas de mglur2.
KR100973609B1 (ko) * 2005-03-23 2010-08-03 에프. 호프만-라 로슈 아게 mGluR2 길항제로서 아세틸렌일-피라졸로-피리미딘유도체
CA2623721C (en) * 2005-09-27 2014-05-13 F. Hoffmann-La Roche Ag Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists
EP2384328B1 (en) * 2008-11-27 2013-02-13 Boehringer Ingelheim International GmbH 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and process for preparing them
WO2011014520A2 (en) * 2009-07-29 2011-02-03 Irm Llc Compounds and compositions as modulators of gpr119 activity

Also Published As

Publication number Publication date
MX2014004062A (es) 2014-06-05
US9447099B2 (en) 2016-09-20
EP2763991B1 (en) 2016-12-28
NZ621156A (en) 2016-01-29
CN103857679A (zh) 2014-06-11
ZA201401398B (en) 2017-04-26
SG2014014203A (en) 2014-05-29
CA2847092A1 (en) 2013-04-11
EP2763991A1 (en) 2014-08-13
AU2012320732A1 (en) 2014-02-27
AR088098A1 (es) 2014-05-07
BR112014007850A2 (pt) 2017-04-18
JP2014532058A (ja) 2014-12-04
KR20140071474A (ko) 2014-06-11
WO2013050310A1 (en) 2013-04-11
US20130085278A1 (en) 2013-04-04
SG10201507001RA (en) 2015-10-29
RU2014116885A (ru) 2015-11-10
RU2630700C2 (ru) 2017-09-12

Similar Documents

Publication Publication Date Title
IL291489A (en) Preparation of (s)-4-(8-amino-3-(1-but-2-inoyl-pyrrolidin-2-yl)imidazo[5,1-a]pyrazin-1-yl)-n-(pyridine- 2-l) Benzamide and its acceptable pharmaceutical salts
LTPA2021504I1 (lt) 5-Fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai, kaip JAK slopikliai
HUS1800046I1 (hu) 8-fluor-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6H-azepino[5,4,3-CD]indol-6-on sói és polimorfjai
IL228158A0 (en) History of 7,6-dihydro-pyrazolo[5,1-a]pyrazine-4-ylamine used as betascartase inhibitors
ZA201306719B (en) 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace)
SG11201402197UA (en) [1, 2, 3] triazolo [4, 5 -d] pyrimidine derivatives as agonists of the cannabinoid receptor 2
EP2739627A4 (en) 2,3-DIHYDROIMIDAZO [1,2-C] PYRIMIDIN-5 (1H) -ONE COMPOUNDS AND USE AS INHIBITORS OF LP-PLA2
ZA201302128B (en) 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-ylamine derivatives useful as inhibitors of beta-secretase (bace)
EP2580217A4 (en) 6- (ETHYNYL-) PYRIDO- [2,3-D-] PYRIMIDIN-7- (8H) -ONE FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM
AP2013007147A0 (en) Use of substituted 2,3-dihydroimidazo[1,2-C]quinyzolines
IL229993A0 (en) A process for the preparation of 8-Alkoxy[1,2,4]triazolo[5,1-c]pyrimidine-2 amines 5-converted
IL232304A (en) [3,2,1] triazolo [5,4– d] pyrimidine derivatives as cannabinoid receptor type 2 agonists [3,2,1] triazolo [5,4– d] pyrimidine as cannabinoid receptor 2 agonists
BR112012016786A2 (pt) Processos para preparar 7-metil-5-(3-piperazin-1-ilmetil-[1,2,4]oxadiazol-5-il)-2-(4- trifluorometoxibenzil)-2
IL231283A0 (en) Methods for the preparation of 5 - [2 - [7 - (trifluoromethyl) - 5 - [4 - (trifluoromethyl) phenyl] pyrazolo [1, 5 - a] pyrimidine - 3 - yl] ethinyl] - 2 - pyridineamine
PL395783A1 (pl) Pochodna 1,2,4-triazolo[3,4-b]-1,3,4-tiadiazolu - 3-(3-chlorofenylo)-6-(4-chlorofenylo)amino-[1,2,4]triazolo[3,4-b]-1,3,4-tiadiazol, sposób jej wytwarzania oraz jej pierwsze zastosowanie medyczne
PL395784A1 (pl) Nowa pochodna 1,2,4-triazolo[3,4-b]-1,3,4-tiadiazolu-3-(3-chlorofenylo)-6-(4-bromofenylo)amino-1,2,4-triazolo[3,4-b]-1,3,4-tiadiazol, sposób jej wytwarzania oraz jej pierwsze zastosowanie medyczne
PL394218A1 (pl) Nowe zwiazki, pochodne pirydo[2",3":5', 6']pirazyno[2', 3' : 5,6][1,4]ditiino[2,3-b]chinoksaliny oraz sposób ich wytwarzania
HK1184444A (en) 6-(ethynyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders