JP2014531585A5 - - Google Patents
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- JP2014531585A5 JP2014531585A5 JP2014530910A JP2014530910A JP2014531585A5 JP 2014531585 A5 JP2014531585 A5 JP 2014531585A5 JP 2014530910 A JP2014530910 A JP 2014530910A JP 2014530910 A JP2014530910 A JP 2014530910A JP 2014531585 A5 JP2014531585 A5 JP 2014531585A5
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- JP
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- Prior art keywords
- protein
- ptsd
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- subfamily
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004169 proteins and genes Human genes 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 208000028173 post-traumatic stress disease Diseases 0.000 description 9
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 description 4
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 description 4
- 102000001317 Synaptotagmin I Human genes 0.000 description 4
- 108010055170 Synaptotagmin I Proteins 0.000 description 4
- 102100030434 Ubiquitin-protein ligase E3A Human genes 0.000 description 4
- 101710188886 Ubiquitin-protein ligase E3A Proteins 0.000 description 4
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 208000020016 psychiatric disease Diseases 0.000 description 4
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 3
- 206010003591 Ataxia Diseases 0.000 description 3
- 108091006146 Channels Proteins 0.000 description 3
- 206010010144 Completed suicide Diseases 0.000 description 3
- 102400000792 Endothelial monocyte-activating polypeptide 2 Human genes 0.000 description 3
- 101800000825 Endothelial monocyte-activating polypeptide 2 Proteins 0.000 description 3
- 101001098175 Homo sapiens P2X purinoceptor 7 Proteins 0.000 description 3
- 108010061100 Nucleoproteins Proteins 0.000 description 3
- 102000011931 Nucleoproteins Human genes 0.000 description 3
- 102100037602 P2X purinoceptor 7 Human genes 0.000 description 3
- 102000015439 Phospholipases Human genes 0.000 description 3
- 108010064785 Phospholipases Proteins 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 101710201186 Protein kinase C-like 1 Proteins 0.000 description 3
- 101710125350 Serine/threonine-protein kinase N1 Proteins 0.000 description 3
- 102100031206 Serine/threonine-protein kinase N1 Human genes 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 108700041286 delta Proteins 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000003511 endothelial effect Effects 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 210000001616 monocyte Anatomy 0.000 description 3
- 230000000683 nonmetastatic effect Effects 0.000 description 3
- 150000003906 phosphoinositides Chemical class 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 2
- 101710160621 Fusion glycoprotein F0 Proteins 0.000 description 2
- 102000006386 Myelin Proteins Human genes 0.000 description 2
- 108010083674 Myelin Proteins Proteins 0.000 description 2
- 208000028389 Nerve injury Diseases 0.000 description 2
- 102000008763 Neurofilament Proteins Human genes 0.000 description 2
- 108010088373 Neurofilament Proteins Proteins 0.000 description 2
- 102000001775 Neurogranin Human genes 0.000 description 2
- 108010015301 Neurogranin Proteins 0.000 description 2
- 101710141454 Nucleoprotein Proteins 0.000 description 2
- 102000013008 Semaphorin-3A Human genes 0.000 description 2
- 108010090319 Semaphorin-3A Proteins 0.000 description 2
- 102000004874 Synaptophysin Human genes 0.000 description 2
- 108090001076 Synaptophysin Proteins 0.000 description 2
- 102000044159 Ubiquitin Human genes 0.000 description 2
- 108090000848 Ubiquitin Proteins 0.000 description 2
- 102100025038 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Human genes 0.000 description 2
- 101710186825 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Proteins 0.000 description 2
- OPQRFPHLZZPCCH-PGMHBOJBSA-N [(z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate Chemical compound C12=CC=C(Cl)C=C2C(=N/OC(=O)C)/C(=O)N1CC1=CC(Cl)=CC=C1Cl OPQRFPHLZZPCCH-PGMHBOJBSA-N 0.000 description 2
- 102000003802 alpha-Synuclein Human genes 0.000 description 2
- 108090000185 alpha-Synuclein Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000008764 nerve damage Effects 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 210000005044 neurofilament Anatomy 0.000 description 2
- 108010055837 phosphocarrier protein HPr Proteins 0.000 description 2
- 229940124549 vasodilator Drugs 0.000 description 2
- 239000003071 vasodilator agent Substances 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161534560P | 2011-09-14 | 2011-09-14 | |
| US61/534,560 | 2011-09-14 | ||
| US201161569047P | 2011-12-09 | 2011-12-09 | |
| US61/569,047 | 2011-12-09 | ||
| PCT/US2012/055639 WO2013040502A2 (en) | 2011-09-14 | 2012-09-14 | Processes and kits to detect and monitor for diagnostic biomarkers for post traumatic stress disorder (ptsd) and to differentiate between suicidal and non-suicidal form of the disorder |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016241059A Division JP6371367B2 (ja) | 2011-09-14 | 2016-12-13 | 心的外傷後ストレス障害（ｐｔｓｄ）のための診断用バイオマーカーを検出及び監視するため、並びに同障害の自殺型と非自殺型とを識別するためのプロセス及びキット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531585A JP2014531585A (ja) | 2014-11-27 |
| JP2014531585A5 true JP2014531585A5 (enExample) | 2016-08-18 |
| JP6061935B2 JP6061935B2 (ja) | 2017-01-18 |
Family
ID=47884009
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530910A Expired - Fee Related JP6061935B2 (ja) | 2011-09-14 | 2012-09-14 | 心的外傷後ストレス障害（ｐｔｓｄ）のための診断用バイオマーカーを検出及び監視するため、並びに同障害の自殺型と非自殺型とを識別するためのプロセス及びキット |
| JP2016241059A Expired - Fee Related JP6371367B2 (ja) | 2011-09-14 | 2016-12-13 | 心的外傷後ストレス障害（ｐｔｓｄ）のための診断用バイオマーカーを検出及び監視するため、並びに同障害の自殺型と非自殺型とを識別するためのプロセス及びキット |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016241059A Expired - Fee Related JP6371367B2 (ja) | 2011-09-14 | 2016-12-13 | 心的外傷後ストレス障害（ｐｔｓｄ）のための診断用バイオマーカーを検出及び監視するため、並びに同障害の自殺型と非自殺型とを識別するためのプロセス及びキット |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20150259740A1 (enExample) |
| EP (1) | EP2756313A4 (enExample) |
| JP (2) | JP6061935B2 (enExample) |
| CN (2) | CN108593926A (enExample) |
| AU (2) | AU2012308305B2 (enExample) |
| CA (1) | CA2846625A1 (enExample) |
| WO (1) | WO2013040502A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| US8943539B2 (en) | 2007-11-21 | 2015-01-27 | Rovi Guides, Inc. | Enabling a friend to remotely modify user data |
| JP5781436B2 (ja) | 2008-08-11 | 2015-09-24 | バンヤン・バイオマーカーズ・インコーポレーテッド | 神経学的状態のバイオマーカー検出方法およびアッセイ |
| HUE040281T2 (hu) | 2009-09-14 | 2019-03-28 | Banyan Biomarkers Inc | Autoantitest markerek traumás agysérülés diagnózisára |
| US20140018299A1 (en) * | 2012-07-10 | 2014-01-16 | Banyan Biomarkers, Inc. | Method and device to detect, monitor and promote neural regeneration and improvement of cognitive function in a subject suffering from neural injury |
| WO2015066211A1 (en) * | 2013-10-29 | 2015-05-07 | Banyan Biomarkers, Inc. | Uch-l1 isoforms, assays and devices for detection of a neurological condition |
| EP3359969A4 (en) * | 2015-10-08 | 2019-05-22 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | METHOD FOR DIAGNOSIS OF POST-AUTOMATIC LOAD FAULTS |
| CN110366558A (zh) | 2016-10-28 | 2019-10-22 | 班扬生物标记公司 | 针对泛素c末端水解酶l1(uch-l1)和胶质纤维酸性蛋白(gfap)的抗体及相关方法 |
| EP3327134A1 (en) * | 2016-11-28 | 2018-05-30 | Carsten Korth | Method and biomarkers for in vitro diagnosis of mental disorders |
| EP3480597A1 (en) * | 2017-11-06 | 2019-05-08 | Stalicla S.A. | Biomarker assay for use in monitoring autism |
| WO2019202972A1 (ja) * | 2018-04-19 | 2019-10-24 | 国立大学法人 東京大学 | 対象における疾患の診断を補助するための方法及びキット |
| WO2020159965A1 (en) * | 2019-01-30 | 2020-08-06 | University Of South Florida | Method for detection and analysis of cerebrospinal fluid associated ube3a |
| CN115993387A (zh) * | 2021-10-20 | 2023-04-21 | 南开大学 | 一种抑郁症标志物的评估方法及其应用 |
| CN117451995A (zh) * | 2021-12-06 | 2024-01-26 | 上海市精神卫生中心（上海市心理咨询培训中心） | 用于预测应激后精神心理症状发生的免疫检测试剂盒及应用 |
| WO2024138187A1 (en) * | 2022-12-22 | 2024-06-27 | Trugenomix Health Inc. | Genetic biomarkers for identification of ptsd and major depression |
| WO2025166069A1 (en) * | 2024-01-30 | 2025-08-07 | Trugenomix Health Inc. | A novel biomarker for the identification of ptsd |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004135667A (ja) * | 2002-09-27 | 2004-05-13 | Japan Science & Technology Agency | 血液を用いた統合失調症の診断方法 |
| WO2004074513A1 (en) * | 2003-02-21 | 2004-09-02 | Novartis Ag | Methods for the prediction of suicidality during treatment |
| AU2005238446B2 (en) * | 2004-04-15 | 2009-07-30 | Banyan Biomarkers Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| WO2006013561A2 (en) * | 2004-08-02 | 2006-02-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions and methods for diagnosing and treating post traumatic stress disorder |
| CN101410518A (zh) * | 2006-03-24 | 2009-04-15 | 诺瓦提斯公司 | 治疗HPV感染的dsRNA组合物和方法 |
| EP1873527A1 (en) * | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| DE102007022669A1 (de) * | 2007-05-11 | 2008-11-20 | Carsten Dr. Korth | Verwendung von CRMP1 als Marker für chronisch psychiatrische Erkrankungen |
| US20090048288A1 (en) * | 2007-08-13 | 2009-02-19 | H. Lundbeck A/S | Method of treating stress-mediated depression |
| US8642341B2 (en) * | 2007-11-02 | 2014-02-04 | Cornell University | Materials and methods for gene mediated therapy of psychiatric disorders |
| CA2715248A1 (en) * | 2008-02-04 | 2009-08-13 | Banyan Biomarkers, Inc. | Process to diagnose or treat brain injury |
| EP2329260A4 (en) * | 2008-03-04 | 2011-08-03 | Ridge Diagnostics Inc | DIAGNOSIS AND MONITORING OF DEPRESSIVE DISORDERS BASED ON A PLURALITY OF BIOMARKER PANELS |
| EP2108657A1 (en) * | 2008-04-08 | 2009-10-14 | DKFZ Deutsches Krebsforschungszentrum | Peptides for inhibiting the HPV-E6 oncoprotein |
| WO2010009141A1 (en) * | 2008-07-14 | 2010-01-21 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Methods and devices for modulating cellular activity using ultrasound |
| EP2963129A3 (en) * | 2008-11-12 | 2016-05-11 | University of Utah Research Foundation | Autism associated genetic markers |
| US8715928B2 (en) * | 2009-02-13 | 2014-05-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Molecular-based method of cancer diagnosis and prognosis |
| WO2011011797A2 (en) * | 2009-07-24 | 2011-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Cytokine compositions and methods of use thereof |
| CA2773049C (en) * | 2009-09-08 | 2019-08-20 | Laboratory Corporation Of America Holdings | Compositions and methods for diagnosing autism spectrum disorders |
| EP2553466A4 (en) * | 2010-04-01 | 2013-10-16 | Banyan Biomarkers Inc | MARKERS AND ASSAYS FOR DETECTING NEUROTOXICITY |
-
2012
- 2012-09-14 CN CN201810274968.1A patent/CN108593926A/zh active Pending
- 2012-09-14 CA CA2846625A patent/CA2846625A1/en not_active Abandoned
- 2012-09-14 AU AU2012308305A patent/AU2012308305B2/en not_active Ceased
- 2012-09-14 JP JP2014530910A patent/JP6061935B2/ja not_active Expired - Fee Related
- 2012-09-14 EP EP12832428.2A patent/EP2756313A4/en not_active Withdrawn
- 2012-09-14 WO PCT/US2012/055639 patent/WO2013040502A2/en not_active Ceased
- 2012-09-14 US US13/618,589 patent/US20150259740A1/en not_active Abandoned
- 2012-09-14 CN CN201280044530.5A patent/CN103959067B/zh not_active Expired - Fee Related
-
2016
- 2016-12-13 JP JP2016241059A patent/JP6371367B2/ja not_active Expired - Fee Related
-
2017
- 2017-02-23 US US15/441,223 patent/US20170242036A1/en not_active Abandoned
-
2018
- 2018-02-21 AU AU2018201249A patent/AU2018201249B2/en not_active Ceased
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