JP2016119915A5 - - Google Patents
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- Publication number
- JP2016119915A5 JP2016119915A5 JP2016074921A JP2016074921A JP2016119915A5 JP 2016119915 A5 JP2016119915 A5 JP 2016119915A5 JP 2016074921 A JP2016074921 A JP 2016074921A JP 2016074921 A JP2016074921 A JP 2016074921A JP 2016119915 A5 JP2016119915 A5 JP 2016119915A5
- Authority
- JP
- Japan
- Prior art keywords
- cytochrome
- isoform
- cyp
- seq
- cyp2b6
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims 17
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 17
- 238000000034 method Methods 0.000 claims 13
- 102000001708 Protein Isoforms Human genes 0.000 claims 8
- 108010029485 Protein Isoforms Proteins 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000009666 Cytochrome P-450 CYP2B6 Human genes 0.000 claims 5
- 108010020070 Cytochrome P-450 CYP2B6 Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 claims 2
- 238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- 210000001589 microsome Anatomy 0.000 claims 2
- 238000002552 multiple reaction monitoring Methods 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 230000007704 transition Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000004885 tandem mass spectrometry Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25243009P | 2009-10-16 | 2009-10-16 | |
| US61/252,430 | 2009-10-16 | ||
| US25264809P | 2009-10-17 | 2009-10-17 | |
| US61/252,648 | 2009-10-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534356A Division JP5936273B2 (ja) | 2009-10-16 | 2010-10-14 | 肝実質細胞中のｐ４５０タンパク質のアイソフォームの質量分析による定量 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016119915A JP2016119915A (ja) | 2016-07-07 |
| JP2016119915A5 true JP2016119915A5 (enExample) | 2016-09-23 |
| JP6116730B2 JP6116730B2 (ja) | 2017-04-19 |
Family
ID=43876537
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534356A Expired - Fee Related JP5936273B2 (ja) | 2009-10-16 | 2010-10-14 | 肝実質細胞中のｐ４５０タンパク質のアイソフォームの質量分析による定量 |
| JP2016074921A Active JP6116730B2 (ja) | 2009-10-16 | 2016-04-04 | 肝実質細胞中のｐ４５０タンパク質のアイソフォームの質量分析による定量 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534356A Expired - Fee Related JP5936273B2 (ja) | 2009-10-16 | 2010-10-14 | 肝実質細胞中のｐ４５０タンパク質のアイソフォームの質量分析による定量 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8940545B2 (enExample) |
| EP (2) | EP2862870B1 (enExample) |
| JP (2) | JP5936273B2 (enExample) |
| CA (1) | CA2777690C (enExample) |
| WO (1) | WO2011047150A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012056880A (ja) * | 2010-09-08 | 2012-03-22 | Idemitsu Kosan Co Ltd | インドロカルバゾール化合物、有機エレクトロルミネッセンス素子用材料、及びそれを用いた有機エレクトロルミネッセンス素子 |
| WO2014096914A1 (en) * | 2012-12-20 | 2014-06-26 | Dh Technologies Development Pte. Ltd. | Scheduled ms3 for quantitation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007538262A (ja) * | 2004-05-19 | 2007-12-27 | アプレラ コーポレイション | 質量分析を使用する発現の定量化 |
| US20080206737A1 (en) | 2004-05-19 | 2008-08-28 | Hunter Christie L | Expression quantification using mass spectrometry |
| US20080020673A1 (en) * | 2005-03-08 | 2008-01-24 | Cara Sills | Doll having hand-assemblable costume |
| US20070092926A1 (en) | 2005-10-14 | 2007-04-26 | Alterman Michail A | Analysis of protein isoforms using unique tryptic peptides by mass spectrometry and immunochemistry |
| JP5299956B2 (ja) * | 2008-09-29 | 2013-09-25 | 国立大学法人東北大学 | 質量分析装置を用いた代謝酵素群の一斉タンパク質定量に用いるペプチド |
-
2010
- 2010-10-14 CA CA2777690A patent/CA2777690C/en not_active Expired - Fee Related
- 2010-10-14 EP EP14193907.4A patent/EP2862870B1/en active Active
- 2010-10-14 WO PCT/US2010/052665 patent/WO2011047150A1/en not_active Ceased
- 2010-10-14 EP EP10824088.8A patent/EP2488545B1/en active Active
- 2010-10-14 US US12/904,520 patent/US8940545B2/en active Active
- 2010-10-14 JP JP2012534356A patent/JP5936273B2/ja not_active Expired - Fee Related
-
2014
- 2014-08-21 US US14/465,460 patent/US20150045256A1/en not_active Abandoned
-
2015
- 2015-01-22 US US14/602,917 patent/US9546393B2/en not_active Expired - Fee Related
-
2016
- 2016-04-04 JP JP2016074921A patent/JP6116730B2/ja active Active
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