JP2011511271A5 - - Google Patents

Info

Publication number

JP2011511271A5

JP2011511271A5 JP2010544460A JP2010544460A JP2011511271A5 JP 2011511271 A5 JP2011511271 A5 JP 2011511271A5 JP 2010544460 A JP2010544460 A JP 2010544460A JP 2010544460 A JP2010544460 A JP 2010544460A JP 2011511271 A5 JP2011511271 A5 JP 2011511271A5

Authority

JP

Japan

Prior art keywords

protein

tissue sample

decrease

level

cancerous

Prior art date

2009-01-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims description 36
• 102000004169 proteins and genes Human genes 0.000 claims description 26
• 108090000623 proteins and genes Proteins 0.000 claims description 26
• 230000033115 angiogenesis Effects 0.000 claims description 8
• 230000006907 apoptotic process Effects 0.000 claims description 8
• 230000022131 cell cycle Effects 0.000 claims description 8
• 206010061309 Neoplasm progression Diseases 0.000 claims description 7
• 230000005751 tumor progression Effects 0.000 claims description 7
• 102000012936 Angiostatins Human genes 0.000 claims description 4
• 108010079709 Angiostatins Proteins 0.000 claims description 4
• 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 4
• 102000003952 Caspase 3 Human genes 0.000 claims description 4
• 108090000397 Caspase 3 Proteins 0.000 claims description 4
• 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims description 4
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims description 4
• 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims description 4
• 108090001005 Interleukin-6 Proteins 0.000 claims description 4
• 206010028980 Neoplasm Diseases 0.000 claims description 4
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 4
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 4
• FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims description 4
• 201000011510 cancer Diseases 0.000 claims description 4
• -1 Bid Proteins 0.000 claims description 3
• 238000003556 assay Methods 0.000 claims description 3
• 230000033077 cellular process Effects 0.000 claims description 3
• 230000007365 immunoregulation Effects 0.000 claims description 3
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 2
• 102100030497 Cytochrome c Human genes 0.000 claims description 2
• 108010052832 Cytochromes Proteins 0.000 claims description 2
• 102000018832 Cytochromes Human genes 0.000 claims description 2
• 108010075031 Cytochromes c Proteins 0.000 claims description 2
• 238000002965 ELISA Methods 0.000 claims description 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
• 230000002519 immonomodulatory effect Effects 0.000 claims description 2
• 230000003247 decreasing effect Effects 0.000 claims 2
• 230000003832 immune regulation Effects 0.000 claims 1
• 231100000588 tumorigenic Toxicity 0.000 claims 1
• 230000000381 tumorigenic effect Effects 0.000 claims 1
• 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 description 2
• 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 description 2